XTalks

DECEMBER 13, 2024

Petrelintide, administered once a week under the skin, targets obesity through its action as an amylin analog, a hormone co-secreted with insulin from the pancreas. The study will assess the drugs effects on body weight, safety and tolerability over a 42-week period.

Drugs 102

Drugs Hormones Trials Clinical Trials 102

XTalks

JULY 17, 2024

Octreotide is a synthetic analog of somatostatin, a hormone in the body that inhibits the release of several other hormones, including growth hormone (GH), glucagon and insulin. Excess GH stimulates the secretion of insulin-like growth factor-1 (IGF-1) from the liver, which causes most of the clinical manifestations of acromegaly.

Trials 59

Trials Hormones Clinical Trials Clinical Trials 59

pharmaphorum

JUNE 14, 2021

This can lead to metabolic abnormalities including insulin resistance, diabetes, and elevated levels of blood lipids (such as high cholesterol). Partial lipodystrophy results in a partial loss, but the fat that remains is redistributed in inappropriate places around the body.

Drugs 105

Drugs Pharma Companies Licensing Licensing 105

The Pharma Data

DECEMBER 15, 2020

As the world’s first PPAR pan agonist that completed two confirmatory phase III clinical trials, Chiglitazar Sodium has shown significant and long-lasting hypoglycemic effects in a series of clinical studies, as well as other comprehensive effects including significant insulin sensitization and blood lipid regulation.

Insulin 40

Insulin Drugs Production Clinical Trials 40

The Pharma Data

FEBRUARY 18, 2022

Depending on the infrastructure, workforce and clinical research and regulatory capacity in place, WHO and partners will work with the beneficiary countries to develop a roadmap and put in place the necessary training and support so that they can start producing vaccines as soon as possible. .”

Vaccination 52

Vaccination Vaccine Manufacturing Production 52

Trialfacts

JULY 15, 2024

People aged 55 and older who are diagnosed with type 2 diabetes mellitus Must not use insulin Must not have type 1 diabetes mellitus Must not have had any cardiovascular incident or event (e.g., Any information that you provide will be kept strictly confidential, except as required by law. Who Can Participate?

Research 52

Research Insulin Compliance Engineer 52

XTalks

APRIL 29, 2021

Maislin points to the lack of participant diversity in clinical trials conducted by Gilead Sciences for its COVID-19 treatment Veklury (remdesivir) as one example of this issue. If the people who would benefit most from a treatment aren’t included in clinical research, there’s a risk that drugs won’t be effective for that patient population.

Clinical Trials 95

Clinical Trials Clinical Trials Trials Drugs 95

XTalks

SEPTEMBER 17, 2020

While clinical researchers occasionally need to identify and validate a new surrogate endpoint for a given trial, choosing endpoints that have been previously used as the basis of NDAs and BLAs can clear the path to eventual approval. Also known as Berardinelli-Seip syndrome, there are four subtypes of lipodystrophy.

Trials 98

Trials Gene Hormones Clinical Trials 98

The Pharma Data

DECEMBER 13, 2020

7.1%) levels were well controlled, and in this context, significant placebo-adjusted decreases were observed in both glycemic parameters along with improvements in commonly used fasting indexes of insulin sensitivity (HOMA-IR and QUICKI scores). Harrison, MD, Director, Summit Clinical Research. .

Trials 40

Trials In-Vitro Insulin Protein 40

Pharmaceutical Technology

JANUARY 30, 2023

The drug increases insulin synthesis and release. Mounjaro heavily relied on CROs during its development, as evidenced by the fact that it has an associated 36 clinical research agreements recorded on GlobalData’s Deals database, suggesting that it may also turn to contractors for manufacturing.

Drugs 130

Drugs Manufacturing Contract Manufacturing FDA Approval 130

XTalks

JUNE 10, 2024

The study explored efruxifermin’s potential in reducing liver fat, reversing fibrosis, enhancing insulin sensitivity and improving lipid profiles, representing a comprehensive treatment strategy for MASH. It not only reduces liver fat and inflammation but can also reverse fibrosis, enhance insulin sensitivity and improve lipid profiles.

Insulin 52

Insulin Life Science Regulation Hormones 52

The Pharma Data

DECEMBER 15, 2020

The Phase III trial evaluated the use of the diabetes vaccine Diamyd ® , an antigen-specific immunotherapy based on the auto-antigen GAD (glutamic acid decarboxylase), to induce immunological tolerance and stop the autoimmune destruction of insulin producing cells. People with type 1 diabetes cannot produce insulin.

Development 40

Development Insulin Drugs Clinical Trials 40

XTalks

DECEMBER 15, 2022

Register for this free webinar to learn ways to gain the trust of patients through community-based clinical research. Attendees will learn methods to ensure decentralized clinical trial technology is designed to meet the needs of underrepresented patients. The US Clinical Hold on the Diamyd Trial is Lifted, Now What?

Clinical Trials 97

Clinical Trials Clinical Trials Vaccination Vaccine 97

The Pharma Data

APRIL 4, 2023

Merck has the industry’s largest immuno-oncology clinical research program. The KEYTRUDA clinical program seeks to understand the role of KEYTRUDA across cancers and the factors that may predict a patient’s likelihood of benefitting from treatment with KEYTRUDA, including exploring several different biomarkers.

FDA Approval 40

FDA Approval Containment Hormones Dermatology 40

The Pharma Data

MAY 13, 2021

Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms. Experimental Diabetes Research. Ectopic lipid storage and insulin resistance: a harmful relationship. Relationship between disease severity, hyperinsulinemia, and impaired insulin clearance in patients with nonalcoholic steatohepatitis.

Insulin 52

Insulin Production Hormones Medicine 52

pharmaphorum

SEPTEMBER 1, 2020

The first was insulin – Frederick Banting and colleagues managed to isolate insulin that could treat diabetes, up until that point a fatal condition. The period between 1918 and 1939 was marked by two breakthroughs that presaged the arrival of the pharma industry as we know it today.

Medicine 145

Medicine Insulin Drugs Pharmacy 145