Pharmaceutical Technology

OCTOBER 18, 2022

Last week, Nature magazine published a paper detailing an in-situ study of Parkinson’s disease (PD), showing protein structural changes in cerebrospinal fluid (CSF) between healthy individuals and Parkinson’s patients. In PD clinical research, many biomarkers, such as neurofilament, can be measured within the CSF using a lumbar puncture.

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Protein Genetics Gene Clinical Research 264

AuroBlog - Aurous Healthcare Clinical Trials blog

JANUARY 23, 2023

Six minutes of high-intensity exercise is enough to produce a key protein in the brain, one that’s important in brain formation, function, and memory, and which has been implicated in the progress of neurodegenerative disorders such as Alzheimer’s disease.

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Protein Clinical Trials Clinical Trials Clinical Research 243

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 5, 2024

The first twin study of its kind suggests that taking daily protein and prebiotic supplements can improve scores on memory tests in people over the age of 60. What’s good for your aging gut may also be good for your aging brain. The findings are food for thought, especially as the same visual memory and […]

Protein 246

Protein Clinical Trials Clinical Trials Clinical Research 246

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 1, 2023

The team, led by researchers from Stanford University, adapted a technique used for analyzing eye fluid. Almost 6,000 proteins detected in the fluid could be traced […]

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Protein Scientist Research Development 245

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 30, 2023

Key to this newly discovered process is GRP78, and it’s what’s known as a chaperone protein. One of the challenges in treating cancer is stopping it from metastasizing, and a new study reveals one of the fundamental mechanisms through which this happens. Now we know about this mechanism, perhaps we can stop it.

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Scientist Protein Clinical Trials Clinical Trials 246

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 2, 2024

Alzheimer’s disease is commonly associated with clumps and tangles of proteins building up in brain cells. A study led by researchers from the Stanford University School of Medicine returned to observations of large fat drops […]

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Protein Medicine Research Clinical Trials 233

AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 21, 2022

In July 2022, Science magazine reported that a key 2006 research paper, published in the prestigious journal Nature, which identified a subtype of brain protein called beta-amyloid as the cause of Alzheimer’s, […].

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Protein Research Clinical Trials Clinical Trials 236

XTalks

DECEMBER 10, 2024

Rilzabrutinib works by targeting BTK, a protein involved in immune cell communication. By inhibiting this protein, the drug disrupts pathways that contribute to platelet destruction and insufficient production. Its selective mechanism aims to minimize off-target effects, making it a potential first-in-class treatment for ITP.

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Trials Protein Clinical Development Drugs 104

Medical Xpress

MAY 10, 2023

Inhibiting a protein on the surface of immune cells could offer new strategies for treating severe asthma, Cleveland Clinic researchers found.

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Research Protein Clinical Research 94

BioSpace

JUNE 2, 2022

Proxygen partnered with Germany-based Merck to jointly identify and develop molecular glue degraders for clinical research.

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Protein Clinical Research Development Research 74

Roots Analysis

MARCH 2, 2022

Orally administrable protein / peptide-based therapeutics offer several advantages including, effective treatment of numerous clinical conditions and degenerative disorders. Pipeline Overview of Oral Peptide and Protein-based Therapeutics. Oral Protein / Peptide-based Drugs. Oral Protein / Peptide-based Drugs.

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Protein Drugs Drug Delivery Drug Delivery Systems 52

XTalks

JUNE 11, 2024

Askanase shares her insights on the crucial role of patient voices in shaping research, offering hope for new, more effective lupus treatments. This magazine immerses you in a world where industry leaders, patient advocates and top researchers converge to provide the most insightful perspectives on clinical trials.

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Clinical Research Research Clinical Trials Clinical Trials 52

XTalks

OCTOBER 24, 2024

Trends in Psoriasis Research: Biologics, Biosimilars and New Therapies Recent innovations in biologics and biosimilars have transformed psoriasis care. The Psoriasis Diet Diet has long been an area of research as a potential factor in managing psoriasis.

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Research Dermatology Clinical Trials Clinical Trials 105

Pharmaceutical Technology

DECEMBER 7, 2022

Some are beginning to be incorporated into clinical research, and identifying new biomarkers is now becoming an essential part of analysing disease pathology and improving diagnostic processes. The pathology of certain neurodegenerative disorders has been linked to proteins like alpha-synuclein and TAR DNA-binding protein- 43 (TDP-43).

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Development Drugs Clinical Trials Clinical Trials 264

Pharmaceutical Technology

APRIL 28, 2023

Generate Biomedicines has signed a co-development and commercialisation agreement with the University of Texas MD Anderson Cancer Center to expedite the development of new protein therapeutics for oncology using generative AI.

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Development Clinical Trials Clinical Trials Protein 130

Pharmaceutical Technology

DECEMBER 7, 2022

Some are beginning to be incorporated into clinical research, and identifying new biomarkers is now becoming an essential part of analysing disease pathology and improving diagnostic processes. The pathology of certain neurodegenerative disorders has been linked to proteins like alpha-synuclein and TAR DNA-binding protein- 43 (TDP-43).

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Development Drugs Clinical Trials Clinical Trials 246

My Local Study

DECEMBER 4, 2024

Alzheimer’s disease occurs when abnormal protein deposits in the. Read more The post Alzheimer’s Disease and The Role of Research appeared first on MyLocalStudy.com. It is the most common cause of dementia, a general term for memory loss and cognitive decline severe enough to interfere with daily life.

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Research Protein Clinical Research 59

Medical Xpress

DECEMBER 1, 2022

In 2021, a group of scientists led by researchers at the University of North Carolina at Chapel Hill, Weill Cornell Medicine and NewYork-Presbyterian reported that the Moderna mRNA vaccine and a protein-based vaccine candidate containing an adjuvant, a substance that enhances immune responses, elicited durable neutralizing antibody responses to SARS-CoV-2 (..)

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Vaccination Vaccine Immune Response Containment 72

Bioengineer

JANUARY 22, 2025

He suggests that increasing physical activity and protein intake in the weeks leading up to surgery can markedly shorten the post-operative recovery period for patients. Her insights have been pivotal in aligning the research objectives with patient expectations and realities, making the prehabilitation journey more relatable and accessible.

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Trials Clinical Trials Clinical Trials Research 59

XTalks

MARCH 11, 2025

Vepdegestrant, an investigational oral therapy, utilizes PROteolysis TArgeting Chimera (PROTAC) technology a mechanism that harnesses the bodys natural protein disposal system to selectively target and degrade the estrogen receptor.

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Trials Clinical Trials Clinical Trials Protein 59

XTalks

DECEMBER 26, 2024

The BROADWAY trial tested obicetrapib, a novel cholesteryl ester transfer protein (CETP) inhibitor, as a monotherapy in adult patients with heterozygous familial hypercholesterolemia (HeFH) or atherosclerotic cardiovascular disease (ASCVD). Unlike CETP inhibitors, PCSK9 inhibitors block a protein that regulates cholesterol levels.

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Trials Life Science Clinical Trials Clinical Trials 52

XTalks

MARCH 18, 2025

By inhibiting this protein, povorcitinib reduces the inflammatory signals that contribute to abscess and nodule formation. In earlier Phase II studies , about 48% to 50% of patients achieved at least a 50% reduction in lesions a measure known as HS (hidradenitis suppurativa) clinical response at 50% (HiSCR50).

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Trials Clinical Trials Clinical Trials Hormones 59

Velocity Clinical Research

AUGUST 8, 2024

Before that, he’d spent 36 years in primary care, treating patients skewed toward the age group most at risk of Alzheimer’s, and it was this experience that, in part, encouraged him to cross over into clinical research. “It If you took a pill today, that was backed by research.”

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Clinical Trials Clinical Trials Genetics Clinical Research 105

Pharmaceutical Technology

MAY 31, 2023

Aprea Therapeutics overview Aprea Therapeutics is a biopharmaceutical company that develops cancer therapeutics that reactivate mutant tumor suppressor protein, p53. It also has pre-clinical research and development to extend its product development. Its DDR products pipeline includes ATRN-119 and ATRN-W1051.

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Production Clinical Trials Clinical Trials Development 100

Trialfacts

MARCH 7, 2025

This study offers a simple blood test to detect an abnormal protein associated with Alzheimers disease in adults aged 65 to 80. The majority of participants (about 96%) will not have this abnormal protein and will not progress further in the study. Interested? Take our questionnaire and find out if this study is right for you.

Protein 52

Protein Clinical Research Research Nurses 52

Olympian Clinical Research

JUNE 27, 2023

Your diet should feature: Fruits and vegetables Lean proteins like fish and chicken Whole grains, legumes, nuts, and seeds Potassium-rich foods like bananas, avocados, acorn squash, and sweet potatoes Foods to Avoid Some foods are more likely to trigger skin irritation and eczema flare-ups. appeared first on Olympian Clinical Research.

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Clinical Research Packaging Packaging Research 52

pharmaphorum

DECEMBER 16, 2020

The antibody targets a conserved region of the SARS-CoV-2 spike protein and has been developed through a collaboration between Harbour (HBM) and Utrecht University (UU). From these ABBV-47D11 was selected because of its cross-reactive neutralising nature.

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Antibody Trials Licensing Licensing 98

Pharmaceutical Technology

JULY 18, 2022

CFTR modulators work by binding to the defective CFTR protein, improving its function, and in turn reducing the build-up of thick mucus. As such, the opportunity remains for developers to continue to conduct clinical research in this area, with the hopes of more MOAs to enter the space in the future.

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Marketing Trials Development Protein 147

Camargo

APRIL 28, 2021

The first tasks in striking this balance are dose selection and dosing interval determination, and this blog post offers an overview on how PK modeling and simulation can be applied to optimize the safety and efficacy of a product for pediatric populations in clinical trials. First Steps Toward Initiating Pediatric Clinical Studies.

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Clinical Trials Clinical Trials In-Vivo Drugs 130

pharmaphorum

OCTOBER 21, 2022

The acquisition of DJS Antibodies, a privately-held UK-based biotechnology company dedicated to discovering and developing antibody medicines that target difficult-to-drug disease-causing proteins – such as G protein-coupled receptors (GPCRs) – will extend AbbVie’s present discovery research capabilities, through DJS’ proprietary HEPTAD platform.

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Antibody Protein Research Medicine 59

Cloudbyz

MARCH 5, 2024

Biologics: Biologics are large, complex molecules, often proteins, that are produced using living cells. Mode of Action : Small Molecules: They often work by binding to specific sites on target proteins to inhibit or activate their function, which can affect various biological pathways inside the cell.

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Development Drugs Immune Response Manufacturing 97

XTalks

OCTOBER 23, 2024

The primary endpoint of the trial was a reduction in 24-hour urine protein-to-creatinine ratio (uPCR) compared to placebo after nine months of treatment, which indicates improved kidney function. All participants were receiving standard care, including ACE inhibitors or angiotensin II receptor blockers (ARBs).

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Trials Clinical Trials Clinical Trials Antibody 101

Trialfacts

SEPTEMBER 15, 2022

About the Research Center: Study Location. Research Center: Crossroads Clinical Research. Location: Crossroads Clinical Research, 2700 Citizens Plaza, Suite 100, Victoria, TX, 77901. Lead Researcher: Richard H. About the Research Center: Crossroads Clinical Research. Your Rights.

Vaccination 52

Vaccination Vaccine Clinical Research Research 52

XTalks

DECEMBER 29, 2023

It targets delta-like ligand 3 (DLL3), a protein usually found inside normal cells but abnormally present on the surface of SCLC cells. Tarlatamab differs from conventional chemotherapy as it’s an immunotherapy designed to help immune cells detect, attach to and fight cancer cells.

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Clinical Trials Clinical Trials FDA Approval Trials 119

Trialfacts

JANUARY 11, 2023

Researchers are exploring a potential new treatment for CIPN and are looking for volunteers to participate in a multi-site research study in Australia. This study is exploring a medication that is nearly identical to a natural protein already produced by the body when we exercise in order to help reduce inflammation.

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Research Clinical Research Allergies Protein 52

pharmaphorum

FEBRUARY 10, 2021

HER-2+ breast cancer is a type of cancer with a high presence of human epidemic growth factor receptor 2 (HER2), a protein that promotes the growth of cancer cells. Antonio Llombart, head of the Medical Oncology Service at the Arnau de Vilanova Hospital (Valencia) and principal investigator of the study.

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Clinical Trials Clinical Trials Trials Protein 98

Trialfacts

FEBRUARY 1, 2023

lbs Must not be diagnosed with cow’s milk protein allergy by a healthcare professional Must be able to participate in this study for 28 days Parent or legal guardian must be fluent in English This research study is taking place in several locations. To see if there is a research site near you, please see below.

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Research Clinical Research Allergies Protein 52