Rethinking Clinical Trials

JANUARY 3, 2024

In this Friday's PCT Grand Rounds, Rui Wang of Harvard Medical School will offer the final session in our special series, Advances in the Design and Analysis of Pragmatic Clinical Trials, with "Methods for Handling Missing Data in Cluster Randomized Trials." The session will be held on Friday, January 5, at 1:00 pm eastern.

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Trials Clinical Trials Clinical Trials Medicine 298

Rethinking Clinical Trials

AUGUST 9, 2023

Data Sharing and Pragmatic Clinical Trials: Law & Ethics Amidst a Changing Policy Landscape Description Kayte Spector-Bagdady and Stephanie Morain discuss the impact of a changing policy landscape on data sharing and pragmatic clinical trials.

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Clinical Trials Clinical Trials Trials Medicine 130

pharmaphorum

JANUARY 17, 2023

Late last year, pharmaphorum spoke with AstraZeneca’s Ben Challis, VP and head of translational science and experimental medicine, cardiovascular, renal, and metabolism (CVRM), together with Magnus Jörnten-Karlsson, executive director of Unify. Unify, launched in December 2020, is AstraZeneca’s patient app and clinical trial support tool.

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Clinical Trials Clinical Trials Medicine Trials 98

pharmaphorum

MAY 24, 2024

Exciting advancements in the world of clinical trials - Arecor Therapeutics, Faron, AstraZeneca, Volta Medical, J&J, Pneumagen, and Nimbus Therapeutics make headlines. Dive into this week's top stories impacting the future of medicine.

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Clinical Trials Clinical Trials Trials Medicine 104

Rethinking Clinical Trials

JULY 10, 2024

Miguel Hernán In this Friday’s PCT Grand Rounds, Miguel Hernán of Harvard University will present “Causal Estimands: Should We Ask Different Causal Questions in Randomized Trials and in the Observational Studies That Emulate Them?” ” The Grand Rounds session will be held on Friday, July 12, 2024, at 1:00 pm eastern.

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Trials Clinical Trials Clinical Trials Medicine 182

Drug Discovery World

JUNE 25, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers three articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. and Choosing the right site solution for clinical trials.

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Clinical Trials Clinical Trials Trials Drugs 59

Rethinking Clinical Trials

JUNE 28, 2023

In this Friday’s PCT Grand Rounds, Adrian Hernandez, Pamela Tenaerts, and Craig Lipset will present “Decentralized Trials – From Guidance to Reality & What’s Left.” Tenaerts is the chief scientific officer of Medable, a cloud computing platform for decentralized clinical trials. Join the online meeting.

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Clinical Trials Clinical Trials Trials Clinical Research 130

Rethinking Clinical Trials

FEBRUARY 28, 2024

In this Friday’s PCT Grand Rounds, Joseph Doyle of the Massachusetts Institute of Technology (MIT) will present “Effect of an Intensive Food-as-Medicine Program on Health and Healthcare Use: Evidence From a Randomized Clinical Trial.” Doyle is the Erwin H. Join the online meeting.

Medicine 147

Medicine Trials Clinical Trials Clinical Trials 147

Rethinking Clinical Trials

JUNE 13, 2024

Diana Burgess Diana Burgess, a co–principal investigator of the NIH Pragmatic Trials Collaboratory’s RAMP trial, will present the results of the precursor LAMP trial as part of the Veterans Affairs (VA) Health Systems Research Cyberseminars series.

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Trials Clinical Trials Clinical Trials Research 162

Rethinking Clinical Trials

JULY 31, 2023

Building a Study Team for a Pragmatic Clinical Trial Description NIH Collaboratory investigator Dr. Lesley Curtis shares tips for building effective study teams for pragmatic clinical trials.

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Clinical Trials Clinical Trials Trials Clinical Research 130

pharmaphorum

FEBRUARY 27, 2024

Looking to the future of clinical trials: Gene therapy, precision medicine, and the ongoing quest for rare disease solutions Mike.Hammerton Tue, 27/02/2024 - 12:30 Bookmark this

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Gene Therapy Clinical Trials Clinical Trials Gene 107

Pharmaceutical Technology

NOVEMBER 21, 2023

The new scheme will launch in 2024 and aims to save the National Health Service (NHS) £14bn over five years.

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Clinical Trials Clinical Trials Medicine Trials 246

Rethinking Clinical Trials

DECEMBER 20, 2023

Yet enrollment of ethnic minorities in NIH clinical trials and for trials studying approved devices and drugs remains low. There are several strategies that will help increase diversity in CVD trials. The biggest barrier for CV medicine is the lack of women leaders in CV. We have to change how we are practicing.

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Clinical Trials Clinical Trials Trials Cardiology 182

Antidote

OCTOBER 3, 2023

Clinical trials are an integral part of the medical industry, as they are required for any new treatment to be approved. Every medicine used today, whether prescription or over the counter, is a result of the rigorous research process that is a clinical trial — and for these trials to take place, volunteers are vital.

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Clinical Trials Clinical Trials Trials Medicine 119

Rethinking Clinical Trials

JUNE 27, 2022

A special series of articles addressing pragmatic and virtual trials appears this week in the journal Contemporary Clinical Trials and offers practical approaches to the many challenges clinical trials face. The special issue can be found on the Contemporary Clinical Trials website.

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Clinical Trials Clinical Trials Trials Clinical Research 147

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 15, 2024

Some scientists suspect these neural knots can harm and even kill brain cells, but so far in clinical trials, drugs that have tried to target the tangles have shown limited success. A promising new medicine has now […]

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Clinical Trials Clinical Trials Protein Scientist 193

Drug Discovery World

JUNE 25, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers three articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. and Choosing the right site solution for clinical trials.

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Clinical Trials Clinical Trials Trials Drugs 52

Rethinking Clinical Trials

JULY 17, 2024

Deborah Wexler In this Friday’s PCT Grand Rounds, Brendan Everett and Deborah Wexler of Harvard Medical School will present “Lessons From PRECIDENTD: A Pragmatic Comparative Effectiveness Trial.” Everett is an associate professor of medicine at Brigham and Women’s Hospital and Harvard Medical School.

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Trials Clinical Trials Clinical Trials Medicine 147

Pharmaceutical Technology

JUNE 15, 2023

But before pharmaceutical companies can go to market with a breakthrough drug, they need to ensure safety and efficacy through clinical trials. Pharma R&D teams are solving this problem by leveraging the power of artificial intelligence (AI) in clinical trials to save time and money.

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Clinical Trials Clinical Trials Trials Development 130

Pharmaceutical Technology

MARCH 23, 2023

This week, the Medicines and Healthcare products Regulatory Agency (MHRA) is introducing major changes to clinical trial regulation in the UK with expedited timelines at several stages. The MHRA hopes this new framework “will remove obstacles to innovation” and “streamline the regulation of clinical trials” amongst other things.

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Clinical Trials Clinical Trials Regulation Trials 147

Pharmaceutical Technology

APRIL 13, 2023

Following the increased use of telemedicine during the Covid-19 pandemic, the potential of digital technologies in communication, data collection, and analysis has become increasingly realised by patients, healthcare systems, and clinical trial sponsors.

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Clinical Trials Clinical Trials Trials Dermatology 130

Rethinking Clinical Trials

AUGUST 17, 2022

Michelle Kelsey will present “Inclusion and Diversity in Clinical Trials: Actionable Steps to Drive Lasting Change.” Dr. Bloomfield is an associate professor of medicine and global health and Dr. Kelsey is an assistant professor of medicine at Duke University. Join the online meeting. Join the online meeting.

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Clinical Trials Clinical Trials Trials Medicine 130

Drug Discovery World

MAY 17, 2023

Leveraging historical trial databases has become commonplace in assessing the feasibility of trials in therapeutic areas with a large breadth of clinical development history. EHR data also has a key role to play in designing future clinical trials.

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Clinical Trials Clinical Trials Medicine Trials 52

Bio Pharma Dive

JUNE 17, 2024

Elevate precision medicine: dose optimization and immune monitoring through advanced liquid biopsies.

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Clinical Trials Clinical Trials RNA Trials 265

Rethinking Clinical Trials

MARCH 6, 2024

Schell Professor of Management and Applied Economics MIT Sloan School of Management Slides Keywords Food-as-Medicine, Randomized Clinical Trial, Diabetes Key Points Diabetes is common and costly. Food-as-Medicine observational studies have had a large correlation with improved health. 9% of the U.S.

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Clinical Trials Clinical Trials Medicine Trials 147

Rethinking Clinical Trials

AUGUST 24, 2022

Areef Ishani of the University of Minnesota will present “The Diuretic Comparison Project: A Large Pragmatic Clinical Trial.” The post August 24, 2022: Diuretic Comparison Project, a Point-of-Care Clinical Trial, to Be Featured in PCT Grand Rounds appeared first on Rethinking Clinical Trials.

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Clinical Trials Clinical Trials Trials Medicine 130

Rethinking Clinical Trials

AUGUST 7, 2023

Keynote: Diverse Representation Among Clinical Trial Participants: Why It’s Important and How Can We Improve Description Dr. Clyde Yancy presents the keynote session for the Diversity Workshop Grand Rounds series. Biography Clyde W.

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Clinical Trials Clinical Trials Trials Medicine 130

ACRP blog

JANUARY 3, 2024

Historically, patient recruitment and retention have been pressing issues within the clinical trial space. Eighty-five percent of trials fail to recruit enough patients, while 80% are delayed due to other factors like participant dropouts.

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Clinical Trials Clinical Trials Trials Medicine 122

XTalks

JANUARY 17, 2024

Given this hotbed of activity, innovation in the space to drive faster decisions and more efficient trials is intense. They discussed the top new trends in oncology trial design that sponsors are either incorporating into clinical trials or need to start planning to include.

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Clinical Trials Clinical Trials Trials Gene Therapy 124

Pharmaceutical Technology

APRIL 20, 2023

The face of clinical research is evolving. Rather than bringing patients to sites, study teams are now exploring ways they can bring the trial to patients using a varying combination of direct-to-patient drug shipments, home nursing, video conferencing, and electronic data collection. Everybody got used to doing things remotely.

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Clinical Trials Clinical Trials Trials Nurses 130

BioSpace

APRIL 29, 2024

The FDA has cleared a clinical trial of an ex vivo prime editing candidate in patients with a rare disease, Prime Medicine announced Monday. The technique taps CRISPR technology to rewrite defective genes without breaking DNA double helix strands.

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Gene Editing Gene Medicine In-Vivo 105

XTalks

AUGUST 22, 2023

Recruiting participants is perhaps the most challenging aspect of any clinical trial, regardless of the therapeutic area. Yet this one piece is also the most vital, with a trial’s ability to enroll and retain participants being a key predictor of a study’s future success. What is Clinical Trials For All?

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Clinical Trials Clinical Trials Trials Clinical Research 97

Drug Discovery World

APRIL 4, 2024

EnteroBiotix, a Glasgow, UK based biotechnology company, has dosed the first patient in a clinical trial designed to evaluate EBX-102-02 for the treatment of irritable bowel syndrome (IBS). The trial will be delivered in partnership with the Functional Gut Clinic, a leading IBS diagnosis and treatment centre.

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Clinical Trials Clinical Trials Trials Drugs 98

Rethinking Clinical Trials

FEBRUARY 28, 2024

            Speakers Adrian Hernandez, MD Executive Director, Duke Clinical Research Institute Vice Dean, Duke University School of Medicine Christopher J. The global decentralized clinical trial market is expected to grow at a compound annual growth rate of 30.1% from 2021 to 2026.

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Clinical Trials Clinical Trials Trials Clinical Research 147

Outsourcing Pharma

JUNE 13, 2024

To guide sponsors, investigators, CROs, and other parties in clinical research, the European Medicines Agency (EMA) has consolidated the contemporary requirements for using computerized systems and electronic data in clinical trials.

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Clinical Trials Clinical Trials Trials Clinical Research 52

Rethinking Clinical Trials

MAY 29, 2024

Shruti Gohil In this Friday’s PCT Grand Rounds, Shruti Gohil of the University of California, Irvine, will present “The INSPIRE Abdominal and Skin/Soft Tissue Infection Trials: Intelligent Stewardship Prompts to Improve Real-Time Empiric Antibiotic Selection for Patients.” Join the online meeting.

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Trials Clinical Trials Clinical Trials Medicine 147

Rethinking Clinical Trials

APRIL 18, 2023

The 5 platform protocols are integrated rather than siloed, disparate studies to achieve efficiencies, allow researchers to rapidly assess targeted therapeutics and pivot as needed to new treatment arms, maximize knowledge gained from patient participation, and to enable cross-trial analysis and accelerated knowledge acquisition.

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Clinical Trials Clinical Trials Trials Immune Response 219