Clinical Trials, Dermatology and Trials - Clinical Research Informer

ICON and LEO Pharma join forces on clinical trial mission

Pharma Times

MARCH 10, 2023

Collaboration will concentrate on launching and running studies within medical dermatology

Clinical Trials

Bridging Innovation & Patient Care: The Growing Role of AI

Digital tools driving innovative clinical trials

pharmaphorum

JULY 8, 2022

The COVID-19 pandemic has catalysed significant changes in the way pharma develops drugs, particularly in the clinical trial space. Hybrid or decentralised clinical trials (DCTs) have gained traction as technology, infrastructure and knowledge have evolved to support their use. Source: Izmailova et al, 2017.

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Regulator and Funder? FDA’s Orphan Products Grants Program awards significant funding to help move promising treatments through clinical development

FDA Law Blog

NOVEMBER 10, 2024

Each year, FDA selects a limited number of clinical trials to fund to help sponsors pursue development of medical products for rare diseases and advance their field. In October, FDA announced seven new clinical trial grants awarded in fiscal year (FY) 2024 – including one for a Phase 3 trial – totaling $17.2

Production

Production Clinical Development Development Regulation

PI Focus: Building Relationships Through Clinical Trials in the United Kingdom

Velocity Clinical Research

JULY 18, 2023

Born and trained in Egypt, he moved to the UK several years ago after working as a general practitioner there and deciding he loved the country and the clinical trial opportunities it offered. To join a clinical trial at Velocity, visit velocityclinicaltrials.com. By 2018, she was directing seven sites.

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June 26, 2024: Using ChatGPT to Facilitate Informed Medical Consent, in This Week’s PCT Grand Rounds

Rethinking Clinical Trials

JUNE 26, 2024

Mirza is chief resident in the Department of Dermatology at the Warren Alpert Medical School of Brown University. The post June 26, 2024: Using ChatGPT to Facilitate Informed Medical Consent, in This Week’s PCT Grand Rounds appeared first on Rethinking Clinical Trials. Join the online meeting.

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Ensuring successful digital outreach and retention in atopic dermatitis trials

pharmaphorum

JULY 5, 2022

Trial organisers face intense competition to find and recruit eligible patients for atopic dermatitis studies. With more than 500 dermatology clinical trials currently underway, it is often heard that there is a ‘’competition for participants’’. Patient recruitment for moderate or severe atopic dermatitis.

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STAT+: Pharmalittle: Private equity moving to buy clinical trials firms; data provider limits media access to drug prices

STAT News

DECEMBER 2, 2022

And a fragmented clinical trials industry has made it a prime target for private equity, which often consolidates markets by merging companies.

Clinical Trials

Subjective Measures, Objective Outcomes: Data Quality in Atopic Dermatitis Clinical Trials

VirTrial

JULY 7, 2024

In recent years, there has been significant activity in the AD clinical trial landscape, including the approval of novel systemic therapies. Accurate measurement of AD severity over time is crucial for evaluating treatment efficacy in these trials. In these ways, the two assessments measure BSA quite differently.

Clinical Trials

Treatment options for Crohn’s disease expand after Rinvoq approval

Pharmaceutical Technology

MAY 19, 2023

Clinical response was observed after just two weeks in some cases. The FDA nod means Rinvoq is now approved for seven indications in gastroenterology, rheumatology and dermatology. A maintenance study showed the same effects at 52 weeks. In patients with severe symptoms, a dosage of 30mg can be considered.

FDA Approval

FDA Approval Dermatology Sales Clinical Trials

Health Canada to review Arcutis’ roflumilast cream NDS for plaque psoriasis

Pharmaceutical Technology

JULY 12, 2022

A validated target in dermatology, PDE4 is an enzyme that induces overactive immune responses. The NDS submission by Arcutis is based on positive findings from the company’s pivotal Phase III programme and two long-term open-label clinical trials. Furthermore, roflumilast met the primary endpoint in these trials.

Dermatology

Dermatology Immune Response Trials Clinical Trials

Subjective Measures, Objective Outcomes: Data Quality in Atopic Dermatitis Clinical Trials

VirTrial

JULY 7, 2024

In recent years, there has been significant activity in the AD clinical trial landscape, including the approval of novel systemic therapies. Accurate measurement of AD severity over time is crucial for evaluating treatment efficacy in these trials. In these ways, the two assessments measure BSA quite differently.

Clinical Trials

Subjective Measures, Objective Outcomes: Data Quality in Atopic Dermatitis Clinical Trials

VirTrial

JULY 7, 2024

In recent years, there has been significant activity in the AD clinical trial landscape, including the approval of novel systemic therapies. Accurate measurement of AD severity over time is crucial for evaluating treatment efficacy in these trials. In these ways, the two assessments measure BSA quite differently.

Clinical Trials

UNION Therapeutics-Innovent’s collaboration; Delix Therapeutics bags $ 70 M; Biohaven’s Verdiperstat clinical trial result; Intra-Cellular’s CAPLYTA Phase III study

Delveinsight

SEPTEMBER 28, 2021

Innovent, UNION Therapeutics Set to Advance Dermatology Market in China. Innovent Biologics and UNION therapeutics have announced a strategic and licensing collaboration to develop and commercialize Orismilast , a next-generation PDE4 inhibitor for inflammatory dermatology conditions in China.

Clinical Trials

4 Benefits Of Clinical Trial Participation

Olympian Clinical Research

FEBRUARY 26, 2021

Clinical trials are research studies designed to evaluate or test a medical, surgical, or behavioral intervention. Most recently, clinical trials have gained recognition through the development and testing of Covid-19 vaccines. Today we’re taking some time to highlight a few of the biggest ones!

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Use of medical imaging in clinical trials expanding

Outsourcing Pharma

FEBRUARY 2, 2021

While the technology has been found mostly in dermatological applications, its use in studies is expanding, according to Illingworth Research Group.

Clinical Trials

Povorcitinib Phase III Results Stir Mixed Signals for Incyte and Investors

XTalks

MARCH 18, 2025

Incytes recent announcement on the topline results from two Phase III clinical trials of povorcitinib in patients with hidradenitis suppurativa has stirred both hope and caution in the market. These promising figures had set high expectations for subsequent trials. The other Phase III trial, STOP-HS2, showed a 42.3%

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KFA-115 by Novartis for Melanoma: Likelihood of Approval

Pharmaceutical Technology

FEBRUARY 28, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data.

Generic Pharmaceutical Dermatology Clinical Trials Clinical Trials

Standardized Rater Training to Meet the Demands of Dermatology Growth and Complexities

WCG Clinical

OCTOBER 9, 2023

The dermatology market is embarking on tremendous growth and sponsors need to be ready. Over the last 12 months, dermatology-focused studies have increased by roughly 20%, with top focus areas including psoriasis, atopic dermatitis, and alopecia. This rapid growth brings new challenges. Efficiency and speed are critical.

Dermatology

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Orismilast Closer to Phase III as a Promising Oral Treatment for Atopic Dermatitis

XTalks

SEPTEMBER 30, 2024

Presented at the European Academy of Dermatology and Venereology (EADV) Congress 2024, the study highlighted significant improvements in key disease markers, positioning orismilast as a potential breakthrough in atopic dermatitis management.

Clinical Trials

Zoryve Produces Promising Results in Dermatologic Conditions Across Recent Trials

Pharmaceutical Commerce

JANUARY 16, 2024

Zoryve (roflumilast) shows efficacy in seborrheic dermatitis and atopic dermatitis in clinical trials.

Dermatology

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Subjective Measures, Objective Outcomes: Data Quality in Atopic Dermatitis Clinical Trials

VirTrial

JULY 7, 2024

In recent years, there has been significant activity in the AD clinical trial landscape, including the approval of novel systemic therapies. Accurate measurement of AD severity over time is crucial for evaluating treatment efficacy in these trials. In these ways, the two assessments measure BSA quite differently.

Clinical Trials

Grand Rounds June 28, 2024: Using ChatGPT to Facilitate Truly Informed Medical Consent (Fatima N. Mirza, MD, MPH)

Rethinking Clinical Trials

SEPTEMBER 24, 2024

Mirza, MD, MPH Chief Resident Department of Dermatology Warren Alpert Medical School of Brown University Slides Keywords Artificial Intelligence; ChatGPT; Informed Consent Key Points Artificial Intelligence (AI), when implemented thoughtfully in clinical settings, can lead to meaningful results for patients.

Clinical Trials

Lebrikizumab Could Soon Be a New Treatment for Atopic Dermatitis

XTalks

APRIL 17, 2023

In clinical trials, patients experienced significantly clearer skin and less interference with sleep due to itch when taking lebrikizumab compared to placebo. The ADvocate1 and ADvocate2 Phase III studies were published in the New England Journal of Medicine and the British Journal of Dermatology , respectively.

Dermatology

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Animated and Live Action Content Delivers Precise Training for Dermatology Studies

WCG Clinical

MARCH 30, 2023

Uniform Live Action Training Using InvestigatorSpace Speeds Up Study Start Times In one case, a global pharmaceutical company used WCG’s training solutions to support two dermatology studies they were running. Study teams engaged with the training content throughout the trial and asked questions through the InvestigatorSpace platform.

Dermatology

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Nemolizumab Delivers Significant Itch-Relief in Phase III Clinical Trials

XTalks

AUGUST 2, 2024

These trials reveal nemolizumab’s potential to significantly improve key aspects of atopic dermatitis, including skin lesions, itch and sleep disturbance, in both adolescent and adult patients with moderate-to-severe cases. Nemolizumab is a monoclonal antibody that targets IL-31, a cytokine responsible for many atopic dermatitis symptoms.

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The siRNA STP705 by Sirnaomics Has Promise for Treating in situ Squamous Cell Carcinoma (isSCC)

XTalks

JUNE 20, 2022

The results of their Phase IIa STP705 clinical study were published in the Journal of Drugs in Dermatology , a peer-reviewed medical journal of dermatology that was established in 2002. Clinical Trial Outcomes of isSCC Treatment with STP705. STP705 — A Promising siRNA Candidate Against isSCC.

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Pivotal results from Trinity clinical trial for the chronic condition atopic dermatitis

Scienmag

MAY 21, 2021

The findings of a clinical trial by Trinity College Dublin researchers of treatment for atopic dermatitis have been published today in The Lancet journal (Friday, 21st May, 2021). Results of the clinical trial at […].

Clinical Trials

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Optimizing Endpoint Assessments for Dermatology Studies

WCG Clinical

SEPTEMBER 20, 2023

Welcome to the recorded session of ‘Optimizing Endpoint Assessments for Dermatology Studies.’ In this insightful webinar, we take a deep dive into dermatology trials and discuss how standardizing rater qualification and training can solve common challenges and protect the quality and integrity of endpoint data.

Dermatology

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Rebuilding Clinical Trials in the Image of Patient Need: Key Takeaways from Reuters Pharma Clinical 2021

Pharma Marketing Network

APRIL 30, 2021

Clinical trials may be one of the very last bastions of a non-customer-focused approach within the pharmaceutical industry. Across the board, from rheumatology to neurology, outcomes that matter most to patients, have traditionally not been captured in clinical trials. How do we increase the diversity of clinical trials?

Clinical Trials

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Sofdra for Sweat Relief: A New Breakthrough in Primary Axilliary Hyperhidrosis Treatment

XTalks

JUNE 26, 2024

Hyperhidrosis is the third most prevalent dermatological condition in the US, affecting roughly 15.3 While Sofdra stands out as the first new chemical entity approved for primary axillary hyperhidrosis, the market for hyperhidrosis treatments includes other medications and clinical trials.

Clinical Trials

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Vtama (tapinarof) Cream Gains FDA Approval for the Treatment of Plaque Psoriasis in Adults

XTalks

MAY 31, 2022

XTALKS WEBINAR: All Means All: The Road to Inclusivity in Clinical Trials. Register for this free webinar to learn what the FDA’s new draft guidance means for diverse and inclusive trials. Clinical Trials of Vtama. At Dermavant, we are committed to advancing novel, patient-focused innovation in immuno-dermatology.

FDA Approval

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Clariness, DailyBreath partner to drive recruitment in asthma trials

pharmaphorum

AUGUST 12, 2022

Patient recruitment specialist Clariness will deploy an app aimed at helping asthma patients monitor environment triggers and report symptoms in the clinical trials its support, thanks to a partnership with digital health firm DailyBreath.

Trials

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Topical steroid withdrawal diagnostic criteria defined by researchers

Medical Xpress

MARCH 14, 2025

Scientists from NIH's National Institute of Allergy and Infectious Diseases (NIAID) identified treatments that could be studied in clinical trials for the condition based on their potential to lower levels of the chemical compoundcalled nicotinamide adenine dinucleotide (NAD+), a form of vitamin B3.

Research

Research Dermatology Allergies Clinical Trials

A Closer Look At Hidradenitis Suppurativa: Disease, Causes, & Treatment

Olympian Clinical Research

AUGUST 5, 2020

Although severe cases of HS can appear unsightly, with intense bruising or discoloration, pus, and boils; the condition is merely a type of dermatological condition the same as acne, psoriasis, and countless other skin conditions. . HS is not caused by lack of hygiene.

Clinical Trials

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Verrica’s Dr. Lawrence Eichenfield Speaks About FDA Approval of New Drug for Common Skin Infection – Xtalks Life Science Podcast Ep. 121

XTalks

AUGUST 2, 2023

Eichenfield was also the principal investigator on clinical trials evaluating YCANTH. Verrica Pharmaceuticals is a dermatology therapeutics company developing medications for skin diseases that require medical interventions.

Life Science

Life Science FDA Approval Dermatology Pharmacy

KFA-115 by Novartis for Malignant Mesothelioma: Likelihood of Approval

Pharmaceutical Technology

FEBRUARY 28, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data.

Generic Pharmaceutical Dermatology Clinical Trials Clinical Trials

Ycanth (Cantharidin) Revolutionizes Molluscum Contagiosum Treatment with FDA Approval

XTalks

AUGUST 7, 2023

Verrica, a company specializing in dermatology therapeutics, has designed Ycanth to be delivered through a single-use applicator. Efficacy and Safety of Ycanth The effectiveness of Ycanth was evaluated in two randomized, double-blind, placebo-controlled Phase III clinical trials, identified as Trial 1 and Trial 2.

FDA Approval

FDA Approval Dermatology Trials Clinical Trials

Breaking News: German CRO Opens Office In North Carolina

ECRG Media's Clinical Research Podcast

SEPTEMBER 11, 2018

A german CRO that specializes in Dermatology clinical trials has decided to open an office in North Carolina. Not in the Biotech and clinical research hub of the Raleigh/Durham Triangle but in the coast near Wilmington. Have you heard about ProInnovera before or have an interest in Dermatology?

Dermatology

Dermatology Clinical Trials Clinical Trials Clinical Research

Breaking News: German CRO Opens Office In North Carolina

ECRG Media's Clinical Research Podcast

SEPTEMBER 11, 2018

A german CRO that specializes in Dermatology clinical trials has decided to open an office in North Carolina. Not in the Biotech and clinical research hub of the Raleigh/Durham Triangle but in the coast near Wilmington. Have you heard about ProInnovera before or have an interest in Dermatology?

Dermatology

Dermatology Clinical Trials Clinical Trials Clinical Research

Iptacopan hydrochloride by Novartis for Paroxysmal Nocturnal Hemoglobinuria: Likelihood of Approval

Pharmaceutical Technology

FEBRUARY 28, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data.

Generic Pharmaceutical Dermatology Drugs Clinical Trials

Iptacopan hydrochloride by Novartis for Glomerulonephritis: Likelihood of Approval

Pharmaceutical Technology

FEBRUARY 28, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data.