Pharma Times

APRIL 2, 2025

GMP certification enables 4basebio to supply DNA for clinical trials

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Worldwide Clinical Trials

JUNE 13, 2024

Pharmacogenomics (PGx), the study of how genes affect a person’s response to drugs, has brought significant changes to the clinical trial industry. At Worldwide, our recent study delved into the intricacies of PGx, comparing two common methods of DNA sample collection: buccal swabs and blood samples. for buccal swabs and 93.2%

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Worldwide Clinical Trials

DECEMBER 12, 2022

Genetic testing provides patients with a diagnosis for their illness, helps patients and family members to understand risks of developing new diseases, and can be used to support clinical trial advancement. Why should you use a centralized genetic testing provider for a clinical trial?

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AuroBlog - Aurous Healthcare Clinical Trials blog

DECEMBER 24, 2024

It all started with research on a sugar that naturally occurs in the body and helps form DNA: the ‘deoxyribose‘ part of deoxyribonucleic acid. Earlier this year, scientists stumbled upon a potential new treatment for hereditary-patterned baldness, the most common cause of hair loss in both men and women worldwide.

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AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 30, 2024

Silently tucked away in our genomes, some of these bits of foreign DNA can get passed down through the generations. When viruses pay us a visit, they sometimes leave parts of themselves behind. They were long thought inactive, but we’ve since learned these stowaway sequences can be turned back on to wreak all sorts of […]

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XTalks

JANUARY 8, 2024

Whether it’s for a treatment for a chronic ambulatory condition, precision medicine or cell and gene therapy, there is a massive uptick in clinical trial complexity. It’s important to make sure that with this increase in clinical trial complexity, we don’t make our trials overly burdensome to sites or patients,” says Markham.

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Pharmaceutical Technology

MARCH 28, 2024

Boundless has two assets in clinical trials targeting extrachromosomal DNA in cancer patients.

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pharmaphorum

JULY 2, 2021

Zydus Cadila has filed for emergency use approval (EUA) in India of its plasmid DNA-based vaccine for COVID-19, which if given a green light could become the first shot of its type to be cleared for widespread use in humans. . The post Zydus Cadila nears world-first human plasmid DNA vaccine approval appeared first on.

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DNA Vaccine Vaccination Clinical Trials 98

Scienmag

MAY 26, 2022

A team of researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), have shown that they can use methylation patterns in cell-free DNA (cfDNA) extracted from blood samples to predict which patients with muscle-invasive bladder cancer are likely to benefit from chemotherapy before their (..)

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DNA Clinical Trials Clinical Trials Trials 86

Pharmaceutical Technology

APRIL 3, 2023

The deal will see Polyplus join the German life science group’s portfolio allowing the latter to leverage expertise in transfection reagents and plasmid DNA for gene therapy. to complete an in-house plasmid DNA facility in Marburg, Germany. “In In February 2023, the mRNA specialist BioNTech invested $43.8m

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XTalks

NOVEMBER 6, 2020

Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The first healthy volunteer was dosed with the vaccine in Australia as part of the bacTRL-Spike COVID-19 Phase I clinical trial. COVID-19 Clinical Trials.

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Clinical Trials Clinical Trials Vaccine Vaccination 75

BioPharma Reporter

FEBRUARY 17, 2022

Start-up biotech Alvea has started pre-clinical testing for its DNA vaccine: with clinical trials set to begin as soon as March.

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DNA Vaccine Vaccination Clinical Trials 75

XTalks

NOVEMBER 7, 2022

Liquid biopsy tests in oncology involve isolating entities such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and tumor-derived exosomes. Gleich, MD, FACS, Senior Vice President, Medical Department, and Dr. Christopher Huth, PhD, Senior Clinical Trial Manager, Clinical Trial Management.

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Pharmaceutical Technology

MARCH 10, 2023

In an email to Pharmaceutical Technology , an NHSBT spokesperson said the centre will “support early phase clinical trials and preclinical work, providing a route to eventual commercial scale production”. In the past, researchers have often had to seek help from outside the UK, thus delaying clinical trials and patient access.

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Gene Therapy Manufacturing Gene Clinical Trials 264

STAT News

FEBRUARY 28, 2023

Wheeler is missing the DNA needed to recycle a waste product called lipofuscin that his cells naturally produce. My toddler, Wheeler, will probably not live to adulthood. Juvenile Batten disease — he has the type known as CLN3 — is stealing his childhood. And then this rare disease will steal my child.

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Clinical Trials Clinical Trials DNA Trials 98

XTalks

JANUARY 15, 2025

XTALKS WEBINAR: Transforming Lung Health and Disease using AI-based Registries Live and On-Demand: Thursday, February 20, 2025, at 1pm EST (10am PST) Register for this free webinar to gain insights into the power of AI-driven data analysis to identify at-risk patients, optimize clinical trials and accelerate innovation in pulmonary disease care.

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DNA Clinical Trials Clinical Trials Genetics 105

Pharmaceutical Technology

MARCH 28, 2023

On March 27, researchers presented new interim results from the Phase III RUBY clinical trial that could indicate a new standard of care for endometrial cancer treatment. GSK’s trial evaluated the programmed death receptor-1 (PD-1)-blocking antibody Jemperli (dostarlimab).

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Scienmag

APRIL 10, 2022

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers — ATR inhibitor elimusertib and PARP inhibitor AZD5305 — are safe and clinically beneficial in treating patients with advanced solid tumors. NEW ORLEANS ? Principal investigator Timothy Yap, M.B.B.S.,

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DNA Clinical Trials Clinical Trials Trials 57

Pharmaceutical Technology

MAY 17, 2023

Precision oncology company Boundless Bio has raised $100m in a Series C financing round for advancing extrachromosomal DNA (ecDNA)-directed therapies for oncogene-amplified cancer patients. The funds will also support the advancement of Boundless Bio’s ECHO (ecDNA Harboring Oncogenes), an ecDNA diagnostic clinical trial assay.

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Clinical Trials Clinical Trials DNA Genetics 147

BioTech 365

JULY 27, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Artios raises $153M to fund DNA damage repair clinical trials.Artios raises $153M to fund DNA damage repair clinical trials ntaylor Tue, 07/27/2021 – 07:43 from FierceBiotech: Biotech … Continue reading →

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BioPharma Reporter

FEBRUARY 13, 2023

Scancell has reported preliminary immunogenicity data from its Phase 1 COVIDITY clinical trial: with the plasmid DNA based COVID-19 vaccine candidates inducing immune responses when delivered via needle-free tech.

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Immune Response Vaccine Vaccination DNA 96

Outsourcing Pharma

MAY 25, 2023

A company developing small molecule therapeutics targeting DNA Damage Response (DDR) in order to treat patients with a broad range of cancers has its first assay development customer.

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DNA Clinical Trials Clinical Trials Development 52

Camargo

JULY 27, 2021

It is a comprehensive term which encompasses a large variety of therapy products including viral and bacterial vectors, plasmid DNA, human gene editing technology, and patient-specific cellular gene therapy. Additionally, gene editing allows us either to remove or to modify harmful genes. Formulation Considerations.

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Gene Therapy Gene Gene Editing Genetics 238

BioSpace

APRIL 29, 2024

The FDA has cleared a clinical trial of an ex vivo prime editing candidate in patients with a rare disease, Prime Medicine announced Monday. The technique taps CRISPR technology to rewrite defective genes without breaking DNA double helix strands.

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Worldwide Clinical Trials

JUNE 21, 2024

The 2024 ASCO Annual Meeting from the American Society of Clinical Oncology is a fantastic platform for clinical researchers to discuss the latest advancements and challenges in oncology research. Check out this webinar on navigating the landscape of oncology clinical trials. Interested in hearing more insights from Matt?

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Scienmag

MAY 25, 2021

These Oncotarget data reveal a new class of mibefradil-based DNA repair inhibitors which can be further advanced into pre-clinical testing and eventually clinical trials, as potential GBM radiosensitizers Credit: Correspondence to – Yulia V. Surovtseva – yulia.surovtseva@yale.edu and Ranjit S.

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DNA Clinical Trials Clinical Trials Trials 97

BioTech 365

APRIL 12, 2021

Applied DNA and Evvivax Announce Positive Preliminary Results of Phase I Clinical Trial for LinearDNA™ COVID-19 Vaccine Candidate in Felines Applied DNA and Evvivax Announce Positive Preliminary Results of Phase I Clinical Trial for LinearDNA™ COVID-19 Vaccine Candidate in Felines … Continue reading →

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Scienmag

JANUARY 20, 2021

Study supports launch of Phase I clinical trial to test a designer DNA agent — an antisense oligonucleotide that targets a gene called IRF4 — in patients with multiple myeloma Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another.

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DNA Clinical Trials Clinical Trials Gene 56

Scienmag

SEPTEMBER 28, 2020

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial – highlighting the potential of a new class of drugs known as ATR inhibitors.

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Pharmaceutical Technology

DECEMBER 21, 2022

The latest development is based on the findings from the multinational, single-arm Phase II LOTIS-2 clinical trial of Zynlonta to treat r/r DLBCL in adults who have received two or more lines of systemic treatment previously. It is subsequently internalised by the cell, where enzymes then release a pyrrolobenzodiazepine payload.

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DNA Clinical Trials Clinical Trials Medicine 130

Pharmaceutical Technology

NOVEMBER 3, 2022

The latest approval is backed by 24-week findings from a Phase II clinical trial (Trial 1092) that analysed 25mg Vemlidy versus placebo in 70 paediatric patients who are treatment-naïve and treatment-experienced.

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XTalks

AUGUST 29, 2022

Viral vectors have traditionally been used in gene editing where the shells of viruses carry the template DNA into cells, but this method has its disadvantages. It is difficult to control where the viral vectors insert genes in the genome, and it is difficult to manufacture large quantities of clinical-grade viral vectors.

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pharmaphorum

SEPTEMBER 14, 2021

Startup Rome Therapeutics has raised $77 million in second-round financing to help mine sequences of DNA – which were dismissed for years as ‘junk’ – for hidden treasure. Much of this repeatome is thought to derive from viruses that embedded in our DNA millions of years ago.

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DNA Immune Response Genomics Genome 52

ACRP blog

MAY 15, 2023

Looking ahead to Clinical Trials Day on May 20, I am excited by the opportunity to work across the industry to address ways we can put patients at the center of the drug development process. Modern trial designs: Earlier this month, the FDA announced it is taking additional steps to support using decentralized clinical trials.

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Clinical Trials Clinical Trials Trials Pharmacy 52

STAT News

NOVEMBER 3, 2022

in the shadow of an 11-foot-tall granite Stonehenge replica built by Jonathan Rothberg, a biotech entrepreneur, as he talked up his newest gadget, a tabletop DNA sequencer. I was standing by the Long Island Sound in Sachem’s Head, Conn., It was 2010. Read the rest…

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DNA Sales Clinical Trials Clinical Trials 137

pharmaphorum

NOVEMBER 22, 2021

This forum will specifically focus on targeting mitochondrial dysfunction to develop therapies for chronic diseases caused by mitochondrial DNA mutation/nuclear DNA mutations, muscle dystrophy diseases/muscle loss, metabolic disorders, neurodegenerative disease, and conditions linked to oxidative damage.

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Development DNA Drugs Gene Therapy 98

Worldwide Clinical Trials

JUNE 15, 2022

Further, some patients are still hesitant to go into the clinic, and the prevalence of misinformation from the pandemic has led to greater concerns about therapies like gene therapies and the impact they fear it will have on their RNA/DNA. Working with a centralized IBC/IRB provider can speed up your process. .

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