World of DTC Marketing

DECEMBER 29, 2020

Both the Pfizer and Moderna vaccines copied RNA sequence from the virus genome and found a way to manufacture it at scale with high-level processes and quality control. These vaccines were developed using different “platform technologies” that involve slotting genetic material from the virus into a tried and tested delivery package.

Vaccine 307

Vaccine Vaccination Development Clinical Trials 307

Pharmaceutical Technology

FEBRUARY 13, 2023

SOPHiA GENETICS is expanding its collaboration with AstraZeneca to include multimodal approaches for developing cancer drugs. This collaboration aims to use the global SOPHiA DDM platform, a cloud-native platform of SOPHiA GENETICS, and multimodal algorithmic capabilities for AstraZeneca’s oncology portfolio.

Genetics 130

Genetics Development Drugs Genomics 130

XTalks

APRIL 21, 2023

The application of whole genome sequencing (WGS) to derive a more complete understanding of cancer has been a central goal of cancer researchers even before the first human genome was decoded in 2003. Ultima Genomics has already partnered with other leading biotech startups.

Genomics 97

Genomics Genome Bioinformatics Genetics 97

pharmaphorum

SEPTEMBER 12, 2022

Alongside drugs and therapeutics, data collection and technology enhancements have redefined the traditional healthcare experience, especially within oncology, and genomic profiling has become a significant factor in allowing for personalised care. In other words, every person’s cancer has its own genetic construct. Tailored oncology.

Genomics 105

Genomics Genome Clinical Trials Clinical Trials 105

XTalks

MAY 23, 2024

One of the more intriguing developments in cancer research in recent years is the growing understanding of clonal hematopoiesis, a phenomenon where blood cells expand from a single clone due to genetic mutations. Clonal hematopoiesis increases in prevalence with age and can precede hematologic malignancies.

Genetics 114

Genetics Research Genome Genomics 114

pharmaphorum

NOVEMBER 27, 2022

A group representing pharma companies selling precision therapies for cancer has called for a change to the way genomic testing is done in Scotland, to make sure patients get access to targeted drugs. “It would have saved me and the NHS a lot of money. .” Why do we always have to follow? Why not lead?”

Genomics 104

Genomics Genome Genetics Medicine 104

Pharmaceutical Technology

JULY 29, 2022

CAMP4’s CSO David Bumcrot PhD tells Pharmaceutical Technology that the company plans to see clinical trials go forward for their urea cycle disorder programs late next year. However, in patients with urea cycle disorders, genetic defects result in inadequate amounts of the enzymes needed to convert nitrogen into urea.

RNA 245

RNA Gene Expression Gene Gene Therapy 245

Pharmaceutical Technology

JUNE 20, 2023

The Department of Health Abu Dhabi (DoH) has signed a memorandum of understanding with integrated healthcare company M42 and AbbVie Biopharmaceuticals to advance personalised medicine and genomics in the city. M42 was created through the combination of Mubadala Health and G42 Healthcare.

Medicine 130

Medicine Genome Genomics Clinical Trials 130

XTalks

FEBRUARY 21, 2025

This capital will accelerate the companys clinical programs and support its pipeline of investigational drugs aimed at treatments for metabolic diseases like Prader-Willi syndrome (PWS). Current Share Price: PWS is a complex, genetically determined neurodevelopmental disorder that affects multiple organ systems.

Genetics 59

Genetics Hormones Gene Expression Gene 59

XTalks

DECEMBER 1, 2020

Fortunately, technological advances — such as those pioneered by Menarini Silicon Biosystems — have allowed researchers and healthcare practitioners to decipher these issues, drilling down to single-cell genomic levels to uncover variations that may account for reduced drug efficacy or biochemical resistance. billion in 2019.

Clinical Trials 96

Clinical Trials Clinical Trials Trials Clinical Research 96

pharmaphorum

MARCH 24, 2022

LifeMine has developed an industrialised, genomics-based discovery engine that it hopes will take a broad, systematic approach to identifying new compounds from fungi and screening them for activity against disease targets. Greg Verdine – LifeMine. Image by jggrz from Pixabay .

Medicine 105

Medicine Genomics Genome Engineer 105

Pharmaceutical Technology

DECEMBER 14, 2022

GSK has entered a strategic partnership with Wave Life Sciences to progress the discovery and development of oligonucleotide therapies for new genetic targets. The alliance will merge the PRISM oligonucleotide platform of Wave and the capabilities of GSK in genetics and genomics.

Life Science 162

Life Science Development Gene Therapy Genetics 162

XTalks

MARCH 7, 2024

Experts discuss the therapeutic landscape, treatment gaps, regulatory considerations and clinical trial strategies. Breast Cancer Multiomics: Unified Insights in Tumor Heterogeneity This on-demand webinar introduces a cutting-edge single-cell multiomics method designed for garnering detailed genetic insights into breast cancer.

Genetics 115

Genetics Hormones Genomics Genome 115

Pharmaceutical Technology

JULY 5, 2022

HAV usually hijacks TENT4 and utilises it for the replication of its own genome. They also noted how the oral treatment could lower the ability of the virus to cause liver injury in mice genetically modified to develop HAV infection and disease.

Protein 130

Protein RNA Genomics Genome 130

XTalks

SEPTEMBER 16, 2024

Lung-MAP is a pioneering clinical trial designed to simultaneously test multiple treatments for non-small cell lung cancer (NSCLC) under a single, comprehensive “umbrella” protocol. Could you give us an overview of the Lung-MAP trial and its significance in the treatment of NSCLC?

Clinical Trials 52

Clinical Trials Clinical Trials Trials Clinical Research 52

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. It is difficult to control where the viral vectors insert genes in the genome, and it is difficult to manufacture large quantities of clinical-grade viral vectors.

Gene Editing 98

Gene Editing DNA Gene Genome 98

Cloudbyz

JUNE 26, 2023

Clinical Trial Design and Optimization: Generative AI can aid in the design and optimization of clinical trials. By simulating patient populations, generating synthetic trial data, and optimizing trial protocols, generative models can enhance the efficiency and effectiveness of clinical trials.

Clinical Research 97

Clinical Research Research Clinical Trials Clinical Trials 97

Camargo

DECEMBER 10, 2021

Voxzogo’s approval was based on an intermediate clinical endpoint (though accelerated approvals can also come from surrogate endpoints ). This means that full approval can only come from a clinical trial that assesses adult height. Voxzogo also received a priority review voucher.

Development 176

Development Genetics Production Clinical Trials 176

XTalks

DECEMBER 20, 2023

This includes analyzing how drug combinations may impact individual patients or groups of patients before even entering a clinical trial. With a staggering 90 percent of drugs failing in clinical trials, AI has the potential to help improve these statistics.

Life Science 119

Life Science Gene Editing Development Clinical Trials 119

pharmaphorum

JUNE 23, 2022

The deal comes a year after Intellia and partner Regeneron reported promising results from the first clinical trial of a drug used to edit the genomes of cells within the body, in patients with rare disease ATTR amyloidosis. billion in potential milestones if the project advances through development and onto the market.

Gene Editing 97

Gene Editing In-Vivo Gene Sequencing Gene 97

Scienmag

OCTOBER 28, 2020

The COVID-19 Host Genetics Initiative was created to study the relationship between variation in the human genome and SARS-CoV-2 infection. Insights into why some people develop more severe symptoms than others and how to better treat the disease are desperately needed. This is an […].

Genetics 40

Genetics Genome Genomics Development 40

Bioengineer

JANUARY 16, 2024

not reached) in genomic analysis of post-progression samples from patients receiving second-line osimertinib. Another genetic change at the C797 residue in the ATP binding region of EGFR’s exon 20 has emerged as a key mechanism of resistance to osimertinib. months, 95% CI 1.3,

Genomics 119

Genomics Genome Protein In-Vitro 119

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Genuity Science focuses on population genomics as a tool to derive novel biological insights through partnerships with industry-leading pharmaceutical and biotech companies.

Research 98

Research Biobanking Drugs Genome 98

pharmaphorum

OCTOBER 18, 2022

US-based Tempus has built a precision medicine platform – powered by artificial intelligence and machine learning – that sifts through a large library of anonymised patient data, including results of clinical, molecular, and genomic testing.

Production 52

Production Clinical Trials Clinical Trials Genome 52

The Pharma Data

SEPTEMBER 28, 2020

Accenture Applied Intelligence announced a new data and analytics approach to manage and derive insights from paediatric acute myeloid leukaemia (AML) genomic data, with the potential to improve precision medicine. Insights from project could potentially improve precision medicine use for paediatric AML.

Genome 52

Genome Genomics Clinical Trials Clinical Trials 52

pharmaphorum

FEBRUARY 11, 2022

.” Hopes were high that a drug developed by Sangamo based on its zinc finger nuclease (ZFN) genome-editing technology could lead to the first therapy that could correct the genetic defect n MPS I, but that candidate – called SB-318 – flunked out in a clinical trial reported in 2019 and was discontinued.

Gene Therapy 111

Gene Therapy Gene Trials FDA Approval 111

ACRP blog

JUNE 7, 2023

At the same time, thought leaders in the field are endeavoring to ensure that real people—the ultimate beneficiaries of these rapidly evolving capabilities for clinical trial design and management—are not getting lost in the shuffle. Undoubtedly, the expectations for precision medicine are high,” Olsen adds.

Big Data 59

Big Data Clinical Research Research Clinical Trials 59

WCG Clinical

NOVEMBER 17, 2023

This change expanded the definition of HGT research to include research using nucleic acids that are able to replicate, be transcribed, translated into protein, and/or integrate into the host genome. Since then, however, certain genetic engineering technologies (e.g., Since then, however, certain genetic engineering technologies (e.g.,

Genome 52

Genome Genomics Gene Editing Genetic Engineering 52

Bioengineer

JULY 22, 2021

Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and – in lab studies working with model cell types – successfully reverse its effects to slow cancer cell growth with a targeted drug.

Genetics 52

Genetics Drugs Clinical Trials Clinical Trials 52

XTalks

JANUARY 21, 2025

In a clinical trial, participants demonstrated a 98% success rate after six months post implantation, with arteries widened successfully and no stent fractures observed. There, plasma is separated, and tumor DNA is identified by detecting genetic mutations, methylation patterns and fragmentation signals.

FDA Approval 105

FDA Approval Manufacturing Development RNA 105

Cloudbyz

MARCH 12, 2023

Data Cleaning One of the most time-consuming tasks in CDM is data cleaning, which involves identifying and correcting errors and inconsistencies in the data collected during a clinical trial. Data Validation AI can also be used to validate data collected during a clinical trial.

Clinical Trials 52

Clinical Trials Clinical Trials Genetics Trials 52

pharmaphorum

JULY 20, 2022

Armed with a $100 million second-round financing, CAMP4 Therapeutics is preparing to start the first clinical trial of a drug targeting regulatory RNA (regRNA) molecules that can be used to fine-tune the expression of genes. ” The post CAMP4 raises $100m to take lead RNA drugs into clinic appeared first on. .

RNA 52

RNA Genetic Disease Drugs Protein 52

pharmaphorum

MARCH 25, 2021

The COSMIC (Catalogue of Somatic Mutations in Cancer) database, operated by the Wellcome Sanger Institute, grew out of the work of the Cancer Genome Project and has been gathering data on mutations associated with specific cancers for almost 17 years. The post COSMIC database matches drugs to cancer mutations appeared first on.

Drugs 59

Drugs Genome Project Genomics Genome 59

XTalks

SEPTEMBER 6, 2024

As the co-founder of Blueprint Genetics, a proud member of the Quest Diagnostics family, I’ve witnessed firsthand the complexities and nuances involved in rare disease diagnostics and the development of orphan drugs. At Blueprint Genetics, we are committed to making sense of this complexity.

Genetics 52

Genetics Drugs Development FDA Approval 52

The Pharma Data

NOVEMBER 17, 2021

Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood cancer called multiple myeloma. doi: 10.1126/sciadv.abg9551. Source link: [link].

Scientist 52

Scientist RNA DNA Genetics 52

XTalks

JULY 24, 2024

They also address diversity in clinical trials by supporting efforts to improve the representation of underrepresented patient populations. AI-driven models also help in identifying the most effective treatment regimens based on patient-specific factors, including genetic makeup and treatment history. Nanostics Inc.

Big Data 52

Big Data Clinical Trials Clinical Trials Life Science 52

XTalks

JANUARY 2, 2024

The clinical study also highlighted the favorable tolerability profile of Filsuvez. The most commonly reported adverse reactions in the clinical trial were pruritus (itching) and pain at the wound application site, occurring in 7.3 Specifically, 41.3 percent observed in the control gel arm. percent of cases.

FDA Approval 111

FDA Approval Gene Therapy Gene Trials 111