XTalks

MARCH 25, 2021

Xtalks is proud to announce the launch of the Xtalks Life Science podcast. Subscribe to the Xtalks Life Science Podcast to never miss a new episode. Fresh Conversations About Life Science Topics. Sarah is passionate about science communication and journalistic integrity.

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Life Science HR Clinical Trials Clinical Trials 105

XTalks

MAY 17, 2023

The Foundation for the National Institutes of Health (FNIH) announced this week that the Accelerating Medicines Partnership Bespoke Gene Therapy Consortium (AMP BGTC) has selected eight rare diseases for its clinical trial portfolio. Of the more than 10,000 rare diseases, more than 80 percent are caused by genetic defects.

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Gene Therapy Clinical Trials Clinical Trials Gene 82

XTalks

FEBRUARY 21, 2024

Black participation in clinical trials, and the underrepresentation of minority groups in general in trials, remains low. It is therefore important to work towards increasing Black participation in clinical trials, which begins with understanding the barriers to participation and taking steps to address them.

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Clinical Trials Clinical Trials Trials Life Science 59

XTalks

JULY 29, 2024

Orphan drug development poses many challenges that are unique to rare diseases, including recruitment in small patient populations, variable progression with heterogenous clinical manifestations and limited understanding of disease progression and natural history. Read on to learn key lessons in rare disease drug development.

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Clinical Trials Clinical Trials Trials Research 92

XTalks

DECEMBER 29, 2022

The life sciences and healthcare are among the biggest industries globally, and their significance was particularly highlighted during the past couple of years by the COVID-19 pandemic. Given the hyperfocus on the life sciences thanks to COVID, consumers appear to be more autonomous and vocal about their medical demands and choices.

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XTalks

AUGUST 16, 2024

The effectiveness of clinical trials often depends on the quality and depth of the data utilized. This rich data resource has significant potential to innovate clinical trials, providing real-world, timely insights that can enhance success and streamline trial processes.

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Clinical Trials Clinical Trials Trials Clinical Research 59

XTalks

MAY 16, 2023

Clinical trials for pulmonary fibrosis are being conducted to evaluate the effectiveness of novel therapies and interventions, providing hope for improved outcomes in the future. Pulmonary fibrosis is a serious condition that can significantly impact life expectancy.

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Clinical Trials Clinical Trials Trials Research 96

XTalks

SEPTEMBER 16, 2024

Lung-MAP is a pioneering clinical trial designed to simultaneously test multiple treatments for non-small cell lung cancer (NSCLC) under a single, comprehensive “umbrella” protocol. Could you give us an overview of the Lung-MAP trial and its significance in the treatment of NSCLC?

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Clinical Trials Clinical Trials Trials Clinical Research 52

XTalks

FEBRUARY 28, 2024

Advancements in rare disease research are leading to innovative new treatments for various rare conditions, including genetic disorders, which make up just over 70 percent of all rare diseases. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

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Life Science Research Genetics Drugs 52

XTalks

DECEMBER 14, 2023

In an insightful interview with Xtalks , Cassadie Moravek, the Senior Director of Clinical Trial Portfolio and Program Management at the Pancreatic Cancer Action Network (PanCAN) , shares her perspective on the organization’s efforts in advancing pancreatic cancer research and patient care. Read on to learn more from Moravek.

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Clinical Trials Clinical Trials Trials Doctors 52

XTalks

SEPTEMBER 14, 2022

In this episode, Ayesha discussed the FDA approval of Sanofi’s enzyme replacement therapy Xenpozyme for the treatment of non-central nervous system (non-CNS) manifestations of acid sphingomyelinase deficiency (ASMD), a rare genetic lysosomal storage disease, in adults and pediatric patients.

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XTalks

DECEMBER 22, 2021

If the past year is anything to go by, then 2022 will also be a year marked by continued innovations in the life sciences. Here is a look at some life science trends to expect in the coming year, including key themes and topics in the pharmaceutical, biotechnology and medical device industries to keep an eye out for in 2022.

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XTalks

MAY 23, 2024

One of the more intriguing developments in cancer research in recent years is the growing understanding of clonal hematopoiesis, a phenomenon where blood cells expand from a single clone due to genetic mutations. Clonal hematopoiesis increases in prevalence with age and can precede hematologic malignancies.

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Genetics Research Genome Genomics 95

XTalks

MARCH 20, 2024

When it comes to leadership in clinical trials today, what qualities are necessary to navigate the evolving landscape of clinical research effectively? Continue reading to explore effective leadership in clinical trials. Can you begin by telling us about your experience in clinical research?

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Clinical Trials Clinical Trials Trials Clinical Research 52

pharmaphorum

SEPTEMBER 7, 2022

Pharma has a great opportunity ahead of it when it comes to conducting representative clinical trials. The processes used are now seeing huge infrastructure commitments, in order to cement their place in the development of future products and trials. The same is true for Asian and Hispanic populations. About the author.

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Clinical Trials Clinical Trials Trials Genetics 98

XTalks

SEPTEMBER 11, 2020

Expanding minority Americans’ access to care and clinical trials isn’t just the right thing to do. Clinical Trials Don’t Reflect Demographics. Why, then, are clinical trials so stubbornly homogeneous? Why, then, are clinical trials so stubbornly homogeneous? What Clinicians Are Struggling With.

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Clinical Trials Clinical Trials Trials Drugs 98

pharmaphorum

JUNE 11, 2021

Abel Archundia discusses how COVID-19 has highlighted the importance of securing clinical trials against cyber threats. However, data-intensive, decentralised clinical trials also present a major risk to healthcare participants through cybercrime and data privacy vulnerability. About the author.

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Clinical Trials Clinical Trials Trials Compliance 111

XTalks

APRIL 13, 2022

Pediatric rare disease clinical trials are vital to determining the safety and efficacy of medications for children living with a rare disease. About 80 percent of rare diseases have a genetic basis. Most rare diseases are chronic conditions, and many are clinically progressive and potentially fatal. adults).

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Clinical Trials Clinical Trials Clinical Research Trials 92

XTalks

NOVEMBER 7, 2022

Gleich, MD, FACS, Senior Vice President, Medical Department, and Dr. Christopher Huth, PhD, Senior Clinical Trial Manager, Clinical Trial Management. Liquid Biopsy Use in Oncology Clinical Trials. percent show less reliability). Optimal methods for bioinformatic analysis are still needed.

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Clinical Trials Clinical Trials Trials FDA Approval 92

XTalks

NOVEMBER 6, 2020

Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The first healthy volunteer was dosed with the vaccine in Australia as part of the bacTRL-Spike COVID-19 Phase I clinical trial. COVID-19 Clinical Trials.

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Clinical Trials Clinical Trials Vaccination Vaccine 73

XTalks

FEBRUARY 25, 2022

There has been increasing awareness around the need for improving inclusion and diversity in clinical trials. As such, there has been a growing emphasis on efforts to achieve better and more accurate representations of minority and underrepresented populations like Black people in clinical studies. Personalized Medicine.

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Clinical Trials Clinical Trials Trials Research 52

XTalks

FEBRUARY 24, 2023

When life sciences industry partners with patients and their advocacy communities, the patient voice becomes integrated into the drug development process. It’s an increasingly common and evolving practice that has brought about meaningful change in the clinical trial process.

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Development Clinical Trials Clinical Trials Gene Therapy 85

XTalks

MARCH 13, 2023

The US Food and Drug Administration’s (FDA) Office of Tissues and Advanced Therapies (OTAT) held a recent town hall where three experts from the regulator provided guidance on how to design and conduct gene therapy clinical trials for rare diseases. There are around 300 million people worldwide living with a rare disease.

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The Pharma Data

AUGUST 7, 2020

As the pharma industry stands firm in its commitment to advance the sector to fight Covid-19, news has emerged from the European Commission who intend to streamline the development of therapies using genetically modified organisms to treat Covid-19. CluePoints provides clinical studies with risk management support package during Covid-19.

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Clinical Trials Clinical Trials Gene Trials 52

XTalks

NOVEMBER 14, 2024

This therapy, the first of its kind to be administered directly into the brain, addresses a rare genetic disorder that severely affects motor function and dopamine production. Kebilidi has a known safety profile from clinical trials. for this purpose.

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Gene Therapy FDA Approval Gene Clinical Trials 90

XTalks

DECEMBER 1, 2020

As the research and medical community learns more about population variances in disease outcomes, whether as a result of regional genetic profiles, socioeconomic factors, or environmental inputs, it’s become necessary to ensure that clinical research trials include broad swaths of global participants. billion in 2019.

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Clinical Trials Clinical Trials Trials Clinical Research 75

XTalks

JULY 24, 2024

XTALKS WEBINAR: Digital Health Tools That Will Transform Cancer Treatment Live and On-Demand: Thursday, August 22, 2024, at 1pm EDT (10am PDT) Register for this webinar today to learn how pharmaceutical and life science technology companies are collaborating to harness digital health tools in oncology care delivery.

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Big Data Clinical Trials Clinical Trials Life Science 52

XTalks

SEPTEMBER 13, 2024

Diverse clinical trials are a matter of equity and essential for the validity and reliability of research outcomes. Historically, racial and ethnically minoritized groups or populations have been excluded from clinical trials, leading to a lack of data on how different demographic subgroups respond to treatments.

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Trials Clinical Trials Clinical Trials Clinical Research 52

XTalks

JULY 29, 2024

This blog will discuss new US Food and Drug Administration(FDA)-approved treatments, promising clinical trials and the latest advancements in lung cancer research, providing hope for better patient outcomes. Here are some promising treatments currently in Phase II/III trials. billion in 2022 and is projected to reach $299.13

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Research Clinical Trials Clinical Trials FDA Approval 59

XTalks

FEBRUARY 19, 2024

The team used the data and patient samples from a gB/MF59 Phase II trial in adolescent girls as a benchmark to assess the new mRNA-based vaccine. The comparison is particularly important as gB/MF59 demonstrated promise in Phase II clinical trials but did not advance to Phase III.

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Vaccination Vaccine Trials Clinical Trials 59

XTalks

OCTOBER 16, 2024

This is Pfizer’s second FDA-approved treatment for a rare genetic blood disorder this year. Related: World Thrombosis Day 2024: Move Against Thrombosis This approval stems from the results of the Phase III BASIS trial, which evaluated the efficacy and safety of Hympavzi in patients with hemophilia A or B.

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FDA Approval Trials Clinical Trials Clinical Trials 90

XTalks

OCTOBER 15, 2024

The cancer link for the gene therapy was already known at the time of its approval as its label included a boxed warning for hematologic malignancies, including “life-threatening cases” of MDS. Prior to its approval, the FDA placed a clinical hold on Skysona’s development program in 2021 after a patient developed MDS following treatment.

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Gene Therapy Gene Clinical Trials Clinical Trials 92

XTalks

NOVEMBER 7, 2024

With pediatric trials underway and growing access through 45 global authorized treatment centers (ATCs), Casgevy presents a new option for many previously limited by traditional treatments. Clinical trials show promising response durations of 9.7 months, with median survival extending to 15.2 million Americans.

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Gene Therapy Gene Editing Gene FDA Approval 87

pharmaphorum

SEPTEMBER 12, 2022

Everyone’s genetic makeup differs, and each person’s cancer experience is unique to them – how cancer develops, how fast it spreads, which drugs it responds to, and more. Furthermore, each cancer has various gene changes – also referred to as the genetic makeup of cancer. Tailored oncology. Navigating barriers to access.

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Genome Genomics Clinical Trials Clinical Trials 105

XTalks

SEPTEMBER 9, 2024

Building DEI within life science organizations, particularly in the area of clinical research, is not just a social imperative but also a scientific one, ensuring that drugs developed are both safe and effective for the populations they are intended to serve. This dual focus can, however, introduce challenges.

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Clinical Research Research Clinical Trials Clinical Trials 76

XTalks

MARCH 28, 2024

For CRC, treatment options that are targeting genetic mutations such as BRAF , KRAS and HER2 have been developed. Building Cancer Awareness and Empowering Métis Youth: Featuring Jordyn Playne, President, Métis Nation of Ontario Youth Council – Xtalks Life Science Podcast Ep.

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Gene Editing Life Science Clinical Trials Clinical Trials 59

XTalks

DECEMBER 12, 2023

The world of neuroscience trials is rapidly evolving, presenting new challenges and opportunities for researchers and clinicians. The worldwide market for neurology clinical trials stood at a valuation of $5.24 There is currently a heightened emphasis on imaging and liquid biomarkers in neuroscience clinical trials.

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Trials Clinical Trials Clinical Trials Genetics 98