Worldwide Clinical Trials

DECEMBER 19, 2024

At the recent World Orphan Drug Congresses (WODC) in Europe and the United States, Worldwide Clinical Trials Derek Ansel , Vice President, Therapeutic Strategy Lead, Rare Disease, facilitated roundtable discussions to explore the operational challenges and ethical barriers surrounding genetic testing.

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Genetics In-Vitro Drugs Clinical Trials 130

pharmaphorum

OCTOBER 31, 2022

Verge Genomics has joined a select group of biotechs who have taken a drug discovered and developed using artificial intelligence into human testing. The post Verge Genomics takes AI-sourced drug for ALS into clinic appeared first on.

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Genome Genomics Drugs RNA 136

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 30, 2024

Silently tucked away in our genomes, some of these bits of foreign DNA can get passed down through the generations. When viruses pay us a visit, they sometimes leave parts of themselves behind. They were long thought inactive, but we’ve since learned these stowaway sequences can be turned back on to wreak all sorts of […]

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DNA Gene Genome Genomics 243

pharmaphorum

SEPTEMBER 12, 2022

Alongside drugs and therapeutics, data collection and technology enhancements have redefined the traditional healthcare experience, especially within oncology, and genomic profiling has become a significant factor in allowing for personalised care. Tailored oncology. Navigating barriers to access.

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Genome Genomics Clinical Trials Clinical Trials 106

pharmaphorum

NOVEMBER 27, 2022

A group representing pharma companies selling precision therapies for cancer has called for a change to the way genomic testing is done in Scotland, to make sure patients get access to targeted drugs. The post Genomic testing ‘should be offered to all cancer patients in Scotland’ appeared first on. Why not lead?”

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Genome Genomics Genetics Medicine 104

Worldwide Clinical Trials

JANUARY 24, 2024

Much of what we discuss I covered in my presentation, “Leveraging Genetics to Support Rare Disease Clinical Trials,” at last year’s World Orphan Drug Congress (WODC) EU. In my capstone, I focused on how, if, and when genetic counselors discuss clinical trials with their patients in the context of a counseling session.

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Genetics Trials Clinical Trials Clinical Trials 189

BioSpace

OCTOBER 24, 2021

C2i Genomics plans to make sophisticated AI-informed cancer diagnostics and tumor monitoring available throughout the world, regardless of where patients or clinical trials are located.

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Genomics Genome Clinical Trials Clinical Trials 83

Worldwide Clinical Trials

DECEMBER 12, 2022

Genetic testing provides patients with a diagnosis for their illness, helps patients and family members to understand risks of developing new diseases, and can be used to support clinical trial advancement. However, genetic tests can be expensive and may not be covered by insurance.

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Clinical Trials Clinical Trials Genetics Trials 130

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 1, 2022

As drug companies have embarked on an initiative to launch affordable medicines for rare diseases in India, experts have called for using pharmacogenetics to develop treatments and whole genome sequencing to identify etiologies.

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Development Genome Genomics Medicine 189

AuroBlog - Aurous Healthcare Clinical Trials blog

OCTOBER 3, 2023

Also companies like the healthtech startup HaystackAnalytics are engaged in developing India’s first Universal Infectious Disease (UID) genomic test, which highlights the need to put in place preventive health strategies. On the occasion of the […]

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Production Genome Genomics Development 189

BioSpace

JULY 19, 2022

CAMP4 Therapeutics raised another $100 million in financing to advance its approach into the “dark side of the genome” and drive two therapeutics into clinical trials next year.

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Genomics Genome Clinical Trials Clinical Trials 75

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 11, 2023

The drug regulator, in a drug alert issued, said that a batch of Typbar, manufactured by Bharat Biotech International Ltd in Genome Valley in Hyderabad, Telangana, failed […]

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Vaccination Vaccine Genome Genomics 180

Rethinking Clinical Trials

AUGUST 17, 2023

When research and clinical care are deliberately integrated in an embedded pragmatic clinical trial, the nature and extent of investigators’ obligations to patient-subjects are blurred, as is the clinician’s duty to participate is such research. More-Than-Partial Entrustment in Pragmatic Clinical Trials Henry S.

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Clinical Trials Clinical Trials Trials Research 130

World of DTC Marketing

DECEMBER 29, 2020

Both the Pfizer and Moderna vaccines copied RNA sequence from the virus genome and found a way to manufacture it at scale with high-level processes and quality control. Another consideration is that while in traditional vaccine development, clinical trials are carried out in sequence. Then there are the finances.

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Vaccine Vaccination Development Clinical Trials 307

Scienmag

MARCH 16, 2022

Bottom Line: Genomic sequencing of tumors from pediatric cancer patients experiencing a relapse enabled 107 patients to receive an appropriate matched therapy that is not the standard of care, according to data from the international clinical trial MAPPYACTS.

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Scienmag

OCTOBER 13, 2020

NCI-MATCH precision medicine trial makes major contributions to the use of tumor gene testing to select treatment for patients; new data has broad relevance in medicine and provides a roadmap for future precision medicine trials Credit: ECOG-ACRIN Cancer Research Group Five years ago, the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) and National Cancer (..)

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Clinical Trials Clinical Trials Trials Genomics 88

Pharmaceutical Technology

JUNE 20, 2023

The Department of Health Abu Dhabi (DoH) has signed a memorandum of understanding with integrated healthcare company M42 and AbbVie Biopharmaceuticals to advance personalised medicine and genomics in the city. M42 was created through the combination of Mubadala Health and G42 Healthcare.

Medicine 130

Medicine Genome Genomics Clinical Trials 130

Scienmag

JANUARY 19, 2021

Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, January 19, 2021–Gene editing therapies, including CRISPR-Cas systems, offer the potential to correct mutations causing inherited retinal degenerations, a leading cause of blindness.

Gene Editing 101

Gene Editing Genomics Genome Gene Therapy 101

BioTech 365

OCTOBER 14, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Large genomics study points the way to future cancer clinical trials.Large genomics study points the way to future cancer clinical trials aliu Wed, 10/14/2020 – 04:56 from … Continue reading →

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Worldwide Clinical Trials

FEBRUARY 6, 2023

When using genetic screening to identify clinical trial volunteers, a sponsor’s obligations for further testing and disclosure of results to patients and families are unclear, especially when the results have no impact on medical management. Guidance in this area is much needed. Read the full article!

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Genetics Clinical Trials Clinical Trials Genotype 130

The Pharma Data

OCTOBER 26, 2021

The AVENIO Tumor Tissue Comprehensive Genomic Profiling (CGP) Kit is the first jointly-developed product that brings together the expertise and reach of Roche with Foundation Medicine’s pioneering leadership in genomic science. Cancer is a disease of the genome and treatment no longer depends solely on the tissue of origin.

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Genome Genomics Research Medicine 52

BioSpace

NOVEMBER 16, 2020

There are many examples of how biopharma is leveraging AI and forging partnerships with companies focused on AI for drug development and clinical trials. There have been a few recent AI-based partnerships as well.

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Genomics Genome Clinical Trials Clinical Trials 77

BioSpace

OCTOBER 18, 2021

On Monday, LogicBio Therapeutics unveiled clinical trial results demonstrating the first-ever in vivo, nuclease-free genome editing in little humans.

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In-Vivo Gene Genome Genomics 82

STAT News

JANUARY 30, 2023

The human genome was sequenced in 2003. New ways of conducting clinical trials have also emerged. That said, a lot has changed in science and drug development since 1983. Read the rest…

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RNA Gene Therapy Drugs Gene 111

pharmaphorum

MARCH 24, 2022

LifeMine has developed an industrialised, genomics-based discovery engine that it hopes will take a broad, systematic approach to identifying new compounds from fungi and screening them for activity against disease targets. Greg Verdine – LifeMine. Image by jggrz from Pixabay .

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Medicine Genome Genomics Engineer 105

Scienmag

MAY 19, 2021

Proprietary bioinformatics, paired with comprehensive clinical curation results in reporting that defines clinically actionable, FDA-approved, and clinical trial drug options for the management of the patient’s cancer.

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Genomics Genome Bioinformatics FDA Approval 41

Crucial Data Soutions

AUGUST 6, 2020

In this blog post, we recap the top three tips our panelists provided throughout the presentation to confront the hurdles in today’s clinical trial landscape and achieve efficient study execution. For a number of years, the clinical trials industry relied on case report forms (CRFs) and a select few non-CRF sources (i.e.,

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Clinical Trials Clinical Trials Trials Genome 71

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 15, 2023

Some of the medical advances with the technology are genomics and epigenetics, Big Data, AI and ML which are allowing molecular […] Technology adoptions like artificial intelligence and machine learning are bringing in major transformation in the way a primary physician will extend treatment protocols.

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Big Data Genome Genomics Clinical Trials 100

XTalks

DECEMBER 1, 2020

Fortunately, technological advances — such as those pioneered by Menarini Silicon Biosystems — have allowed researchers and healthcare practitioners to decipher these issues, drilling down to single-cell genomic levels to uncover variations that may account for reduced drug efficacy or biochemical resistance. billion in 2019.

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Clinical Trials Clinical Trials Trials Clinical Research 96

pharmaphorum

JANUARY 29, 2019

What are the implications from these changes for clinical trials? How the shift towards cancer as a phenotype/genotype is being applied in clinical trials and how they are run •What are co-clinical trials and why could they hold the key to answering unmet need in cancer treatment and beyond into broader drug development?

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Genomics Genome Medicine Clinical Trials 52

Pharmaceutical Technology

JULY 29, 2022

CAMP4’s CSO David Bumcrot PhD tells Pharmaceutical Technology that the company plans to see clinical trials go forward for their urea cycle disorder programs late next year. According to Bumcrot, regRNAs are “RNAs that arise out of the non-coding genome”.

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RNA Gene Expression Gene Gene Therapy 245

Roots Analysis

FEBRUARY 27, 2024

The global genome editing market is anticipated to grow at a CAGR of 12.6% The global genome editing market is anticipated to grow at a CAGR of 12.6% Recently, in July 2019, a first in vivo clinical trial for a CRISPR-based therapy was initiated. during the forecast period 2023-2035. during the forecast period 2023-2035.

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Genome Genomics Gene In-Vivo 40

XTalks

MAY 23, 2024

Eterovic brings much knowledge and experience to the table, having led the development of a new Oncology Diagnostic program at Eurofins Viracor that integrates the latest genomic profiling techniques. Eterovic highlights that the financial and logistical barriers to comprehensive genomic profiling are high but not impossible to overcome.

Genetics 114

Genetics Research Genome Genomics 114

Medical Xpress

APRIL 13, 2023

These themes include genomic alterations, metabolism, the tumor microenvironment, immunotherapy and innovative clinical trial design. Their new study presents several crucial themes in the biology of pancreatic cancer that can serve as hallmarks for pancreatic cancer therapy. The study appears in the journal Cell.

Research 75

Research Genome Genomics Clinical Trials 75

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. It is difficult to control where the viral vectors insert genes in the genome, and it is difficult to manufacture large quantities of clinical-grade viral vectors.

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Gene Editing DNA Gene Genome 98

Pharmaceutical Technology

JUNE 29, 2022

Apart from financial uncertainty, inherent scientific risks also hinder rare disease research since the lack of understanding about the underlying pathophysiology of rare diseases and the fact that a small patient population makes designing clinical trials complicated.

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Drugs FDA Approval Development Marketing 246

Pharmaceutical Technology

NOVEMBER 8, 2022

With the takeover, Fulgent Genetics intends to transform into a completely integrated precision medicine firm focusing on oncology from a genomic diagnostic business. According to the deal, the purchase price, contingent on adjustments, has to be paid by Fulgent Genetics as a combination of cash on hand and its shares of common stock.

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