Clinical Trials Immune Response Manufacturing 
XTalks
JANUARY 22, 2025
The VLA1553-321 trial, conducted in Brazil, was the first to assess the vaccine in an endemic region. The study included 754 adolescents, comparing immune responses and safety profiles between vaccine and placebo groups. These sustained responses build on earlier data showing 99.1% efficacy at six months and 98.8%
Drug Patent Watch
DECEMBER 9, 2024
These large, complex molecules are made inside living cells, which can lead to small variations in the manufacturing methods that can have a significant impact on the final product. Robust Clinical Trial Design : Clinical trials for biosimilars should be designed to demonstrate equivalence or non-inferiority to the reference product.
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World of DTC Marketing
DECEMBER 29, 2020
Both the Pfizer and Moderna vaccines copied RNA sequence from the virus genome and found a way to manufacture it at scale with high-level processes and quality control. Another consideration is that while in traditional vaccine development, clinical trials are carried out in sequence. Then there are the finances.
Pharmaceutical Technology
AUGUST 15, 2022
The latest MHRA decision is based on findings from the Phase II/III clinical trial, where the mRNA-1273.214 vaccine met all primary endpoints. In baseline seronegative subjects, the updated vaccine offered a superior neutralising antibody response against Omicron (BA.1) 1) versus the 50µg mRNA-1273 booster dose.
XTalks
NOVEMBER 6, 2020
Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The first healthy volunteer was dosed with the vaccine in Australia as part of the bacTRL-Spike COVID-19 Phase I clinical trial.
Pharmaceutical Technology
OCTOBER 6, 2022
Intended for intranasal administration, NGoXIM was demonstrated to be effective in animal models and elicited a durable and cross-protective immune response in proof-of-concept (PoC) studies. . This trial will evaluate the safety of the vaccine and generate efficacy data.
Pharmaceutical Technology
JANUARY 19, 2023
The expanded manufacturing and marketing approval was based on the data obtained from the Phase II trial, conducted in Australia and the US; a separate Phase II trial held in South Africa; and the UK-sponsored COV-BOOST trial. It has been developed using the company’s recombinant nanoparticle technology.
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