XTalks

DECEMBER 20, 2023

As we step into 2024, the life sciences continue to evolve at an unprecedented pace, driven by technological innovation, a deeper understanding of human biology and the application of new technologies in areas like drug development and health wearables. These companies are at various stages of research and clinical trials.

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XTalks

JANUARY 16, 2025

BlueRock Therapeutics, a subsidiary of Bayer AG, is making waves in the treatment of Parkinsons disease by advancing its investigational cell therapy, bemdaneprocel, to a Phase III clinical trial. In the Phase I trial, 12 participants received the therapy and were observed for two years. As of 2023, there were approximately 2.7

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XTalks

FEBRUARY 4, 2025

The company plans to use these funds to advance its groundbreaking research in small molecule precision medicines, targeting renal, cardiovascular and metabolic diseases, including obesity.

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XTalks

JUNE 14, 2023

Courtney Silverthorn who is an Associate Vice President at the Foundation for the National Institutes of Health (FNIH) and the Director of the Accelerating Medicines Partnership (AMP) program including the Bespoke Gene Therapy Consortium. Xtalks spoke with Dr. Silverthorm about the consortium’s new rare disease clinical trial portfolio.

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Gene Therapy Life Science Gene Clinical Trials 98

XTalks

APRIL 3, 2024

Before beginning his career in industry in 2007, Dr. Culleton was a Clinical Associate Professor in the Department of Medicine at the University of Calgary. The candidate is currently being evaluated in Phase II and Phase III clinical trials. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

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XTalks

FEBRUARY 14, 2024

OncoImmune was founded in 2000 based on the scientific discoveries of the company’s founders who moved their lead product from a basic concept into clinical trials for multiple indications. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

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XTalks

JANUARY 8, 2024

Whether it’s for a treatment for a chronic ambulatory condition, precision medicine or cell and gene therapy, there is a massive uptick in clinical trial complexity. It’s important to make sure that with this increase in clinical trial complexity, we don’t make our trials overly burdensome to sites or patients,” says Markham.

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Clinical Trials Clinical Trials Trials Gene Therapy 105

XTalks

AUGUST 23, 2023

BriaCell is developing cell therapies for the treatment of advanced breast cancer and has promising compounds, including Bria-IMT, that are currently being evaluated in clinical trials. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

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Pharmaceutical Technology

APRIL 10, 2023

The HALOS platform is built using an invention from the research team led by Professor Chris Scott, who is the scientific co-founder and chief scientific officer of Aviceda and interim dean of research, faculty of medicine, health, and life sciences, at Queen’s.

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Development Life Science Clinical Trials Clinical Trials 259

pharmaphorum

OCTOBER 28, 2022

In June, NHSE and NICE published details on the Innovative Medicines Fund, which will help improve patient access to cutting-edge medicines, with a particular focus on rare diseases, and ensure global pharmaceutical and biotech organisations continue to prioritise the UK as a launch destination. Angela McFarlane ?,

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pharmaphorum

JULY 8, 2022

The COVID-19 pandemic has catalysed significant changes in the way pharma develops drugs, particularly in the clinical trial space. Hybrid or decentralised clinical trials (DCTs) have gained traction as technology, infrastructure and knowledge have evolved to support their use. Source: Izmailova et al, 2017.

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XTalks

JANUARY 17, 2024

They discussed the top new trends in oncology trial design that sponsors are either incorporating into clinical trials or need to start planning to include. Evolution in Oncology Clinical Trial Design Recent discussions at ESMO highlight a shift in how clinical trials are designed and conducted.

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XTalks

MAY 17, 2023

The Foundation for the National Institutes of Health (FNIH) announced this week that the Accelerating Medicines Partnership Bespoke Gene Therapy Consortium (AMP BGTC) has selected eight rare diseases for its clinical trial portfolio.

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pharmaphorum

FEBRUARY 1, 2022

Across the industry, pharma companies are turning to AI and real-world data to address many of the challenges of running clinical trials. Can the combined potential of new AI technologies and real-world patient data hold the key to overcoming the challenges in clinical trial design that have historically led to trial failure?

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XTalks

AUGUST 22, 2023

Recruiting participants is perhaps the most challenging aspect of any clinical trial, regardless of the therapeutic area. Yet this one piece is also the most vital, with a trial’s ability to enroll and retain participants being a key predictor of a study’s future success. What is Clinical Trials For All?

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Clinical Trials Clinical Trials Trials Clinical Research 97

XTalks

JULY 28, 2022

July is Disability Pride Month in the US and Bristol Myers Squibb has teamed up with the non-profit Disability Solutions to improve disability diversity in clinical trials. This initiative can pave the way for better accessibility and inclusion of people with disabilities in clinical trials.

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Pharmaceutical Technology

MARCH 10, 2023

Personalised medicines will also be developed at the centre. In an email to Pharmaceutical Technology , an NHSBT spokesperson said the centre will “support early phase clinical trials and preclinical work, providing a route to eventual commercial scale production”.

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XTalks

JANUARY 19, 2022

The way in which clinical trials are conducted is entering a new dimension as clinical trial operations are becoming more adaptable. The COVID-19 pandemic certainly has pushed to the forefront of clinical trials, the digital evolution in clinical research. MRI scan, endoscopy, etc.)

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Clinical Trials Clinical Trials Trials Clinical Research 98

Pharmaceutical Technology

MAY 16, 2023

The Foundation’s Accelerating Medicines Partnership (AMP) Bespoke Gene Therapy Consortium (BGTC) will study these eight conditions by focusing on gene therapies using adeno-associated vectors (AAV). These organisations include 12 life science companies, 11 NIH institutes and centres, and ten non-profit organisations.

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Gene Therapy Gene Research Clinical Trials 227

Pharmaceutical Technology

FEBRUARY 15, 2023

JSR Life Sciences’ business unit Similis Bio is planning to collaborate with Novel351k for the development of three biosimilar programmes targeting cancer and autoimmune diseases. This will lead to pharmacokinetics/pharmacodynamic clinical trials. This will lead to pharmacokinetics/pharmacodynamic clinical trials.

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XTalks

MAY 16, 2022

The partnership between Abbott and non-profit Women as One will train female and underrepresented physicians to help improve diversity in clinical trials. In a study that analyzed the demographics of clinical trial participants of the 102 new drugs approved between 2013 to 2015 by the FDA’s CDER, only 40.4

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Clinical Trials Clinical Trials Trials Research 98

XTalks

NOVEMBER 27, 2024

In this episode, Ayesha spoke with Thomas Heineman, MD, PhD, Chief Medical Officer at Oncolytics Biotech , a company developing an oncolytic virus cancer therapeutic that is currently in clinical trials for indications including metastatic breast cancer and pancreatic cancer.

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XTalks

DECEMBER 4, 2024

Proceeds from the IPO will propel key initiatives, including the Phase II clinical trial of Jotrol in Parkinson’s disease. In the Asia-Pacific market, Jupiter has negotiated partnerships with companies such as Sichuan Kelun and Tianjin Pharmaceuticals, focusing on Jotrol’s integration into traditional Chinese medicine frameworks.

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Bioavailability Genetic Disease Marketing RNA 111

XTalks

OCTOBER 12, 2022

Hear more about Neuromod’s Lenire device, including clinical and real-world data showing its effectiveness in improving symptoms of tinnitus. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

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XTalks

FEBRUARY 25, 2025

With a singular mission to end childhood cancer, the partnership will merge the unique strengths of both institutions combining clinical expertise, cutting-edge research and an expansive network of clinical trials to accelerate improved outcomes for young patients.

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Clinical Trials Clinical Trials Trials Research 82

pharmaphorum

APRIL 11, 2022

Dudley Tabakin, CEO of VivoSense, describes how this financing is set to accelerate the development of novel digital biomarkers and improve digital clinical outcome assessments. How can this data be incorporated into clinical trials?”. How can this data be incorporated into clinical trials?”. Tabakin agrees. “In

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Clinical Trials Clinical Trials Trials Development 111

XTalks

APRIL 13, 2022

Pediatric rare disease clinical trials are vital to determining the safety and efficacy of medications for children living with a rare disease. Therefore, pediatric rare disease clinical trials are vital to determining the safety and efficacy of medications for children living with a rare disease.

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Clinical Trials Clinical Trials Clinical Research Trials 98

pharmaphorum

JULY 27, 2022

Latest UK Life Sciences Competitive Indicators “ought to ring alarm bells across Government,” says ABPI. Despite the UK’s potential as an international life sciences leader, it lags many competitors in a number of key metrics, including access to new medicines and global share of clinical trial recruitment.

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XTalks

DECEMBER 4, 2024

Dr. Yu has also led numerous clinical trials. Subscribe to the Xtalks Life Science Podcast to never miss a new episode. He has developed numerous immunotherapies and nanotechnologies from his National Institutes of Health (NIH) funded laboratory. Yu is leading at Kairos Pharma to address cancer drug resistance.

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Drugs Life Science Clinical Trials Clinical Trials 59

XTalks

MAY 21, 2024

Yesterday, on International Clinical Trials Day 2024, the global healthcare community came together to commemorate the significant advancements in clinical research and the vital role clinical trials play in improving patient care and outcomes.

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Clinical Trials Clinical Trials Trials Clinical Research 64

XTalks

DECEMBER 12, 2023

Plasma medicine is a critical and specialized field within healthcare, centering on the use of human plasma for the development and administration of life-saving treatments. When people think about innovation drivers in global healthcare, they often think of “big pharma,” and not necessarily companies in the plasma medicines space.

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Pharmaceutical Technology

OCTOBER 12, 2022

Neumora Therapeutics has raised $112m in a Series B financing round to advance its new precision medicine candidates pipeline for neuropsychiatric disorders and neurodegenerative diseases. Neumora has raised nearly $650m in capital to date. The company also intends to use the funding to develop its precision neuroscience platform.

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Development Life Science Clinical Trials Clinical Trials 147

XTalks

JUNE 14, 2024

Ontario, Canada’s largest province by population, is stepping up its commitment to the life sciences sector with an investment of $40 million. The $40 million will come from the Venture Ontario Fund, which is dedicated to helping Ontario life sciences companies and biomanufacturers innovate, grow and compete in global markets.

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XTalks

JANUARY 21, 2025

The approval makes Datroway AstraZenecas eighth new medicine since 2020, the first US approval for Daiichi Sankyo and AstraZenecas TROP2-directed ADC and the second based on their proprietary DXd technology. The FDA approval sent Daiichi Sankyos shares soaring by 8.7% to 4,437 yen, reflecting investor confidence.

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Antibody FDA Approval HR Trials 105

XTalks

MAY 11, 2023

Clinical trials are essential for the development of new treatments for rare diseases, but they can be complex and challenging to execute. Patient input is a crucial component of rare disease clinical trials, as it can provide valuable insights into the patient experience and inform decisions about study design and implementation.

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Clinical Trials Clinical Trials Trials Development 97

XTalks

APRIL 2, 2025

Fordyce previously worked in clinical development leadership roles at Gilead Sciences in the 2010s, driving innovation in treatments for HIV and hepatitis. Dr. Fordyce received his BA from Harvard University and MD from Harvard Medical School, trained in Internal Medicine and served as Chief Resident at NYU Bellevue.

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XTalks

NOVEMBER 1, 2023

Basadonna, MD, Chief Medical Officer, Head of Global Medical Strategy, and Annabel de Maria, Chief Patient Officer, recently spoke on a webinar where they shared insights on how to increase patient engagement in clinical trials. The webinar was moderated by their colleague Giulia Pierini, Patient Engagement Principal at Alira Health.

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