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1 This is an important requirement, as the NIH Guidelines were originally created partly in response to public concerns surrounding recombinant DNA and geneticengineering. Many of those original concerns of the 1970s and 1980s surrounding geneticengineering have lessened over time.
This change expanded the definition of HGT research to include research using nucleic acids that are able to replicate, be transcribed, translated into protein, and/or integrate into the host genome. Since then, however, certain geneticengineering technologies (e.g.,
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