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New discovery shows human cells can write RNA sequences into DNA

Scienmag

In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells PHILADELPHIA – Cells contain machinery that duplicates DNA into a new set that goes into a newly formed cell.

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Why Proviral DNA Drug Resistance Testing is Useful in Guiding Treatment Decisions for HIV-1 Patients

XTalks

Compared to standard plasma HIV-1 RNA drug resistance profiling, which requires a viral load of at least 500 copies per mL, proviral HIV-1 testing can be performed on samples with much lower virion counts of <50 copies per mL (below the detectable limit in RNA testing). Proviral DNA Genotyping. HIV Drug Resistance Testing.

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Moderna’s founder launches Laronde, promising new ‘Endless RNA’ drug class

pharmaphorum

Flagship Pioneering, the VC fund run by Moderna’s co-founder Noubar Afeyan has launched a new biotech Laronde , with an ambitious plan to create a new class of drugs based on Endless RNA. The post Moderna’s founder launches Laronde, promising new ‘Endless RNA’ drug class appeared first on.

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Deep learning takes on synthetic biology

Scienmag

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications DNA and RNA have been compared to “instruction manuals” containing the information needed for living “machines” to operate.

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New CRISPR-Based Rapid COVID-19 Test Can Detect SARS-CoV-2 Variants

XTalks

Moreover, studies show that saliva samples can contain a marginally higher SARS-CoV-2 viral load compared with nasopharyngeal samples (shown in a study involving hospitalized patients), and that the virus can be detected in saliva for a greater number of days post-infection. A porous membrane was engineered to capture RNA on its surface.

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Top 30 New Medical Devices of 2024

XTalks

The liquid portion of the blood (serum or plasma) containing antibodies is separated and tested using the Liason Biotrin parvovirus B19 IgG plus test on a Liason XL analyzer. The Shield test provides a non-invasive approach to colorectal cancer screening by analyzing blood for key DNA changes linked to cancer. Photo courtesy of BD.

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Rome Therapeutics raises $77m for junk DNA-targeting drugs

pharmaphorum

Startup Rome Therapeutics has raised $77 million in second-round financing to help mine sequences of DNA – which were dismissed for years as ‘junk’ – for hidden treasure. Much of this repeatome is thought to derive from viruses that embedded in our DNA millions of years ago.

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