pharmaphorum

OCTOBER 19, 2022

The dark genome – a loose term that covers non-coding regions of the genome that are capable of regulating the expression of genes, previously rather inaccurately referred to as junk DNA – is increasingly being explored by biopharma companies for new drug targets.

Genome 59

Genome Genomics Gene Gene Expression 59

Roots Analysis

AUGUST 31, 2023

At present, extensive studies are being conducted to understand the interaction between nutrients and gene expression at the molecular level, to determine the effect of a specific nutrient and dietary regime on human health. For example, people affected by phenylketonuria must avoid consuming food containing phenylalanine amino acid.

Genome 40

Genome Genomics Genetics Gene 40

XTalks

MAY 4, 2021

These modifications regulate gene expression without changing the sequence or structure of DNA. In the paper, the scientists also describe the CRISPRon “antidote,” which removes methylation marks placed by CRISPRoff, making the process fully reversible. It’s a great tool for controlling gene expression.”.

DNA 98

DNA Gene Gene Silencing Genome 98

XTalks

OCTOBER 8, 2024

The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. A gene contains instructions within our DNA.

Regulation 52

Regulation Genetics Scientist RNA 52

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. In the paper, the scientists also describe the CRISPRon “antidote,” which removes methylation marks placed by CRISPRoff, making the process fully reversible. It’s a great tool for controlling gene expression.”.

DNA 52

DNA Gene Gene Silencing Genome 52

XTalks

FEBRUARY 11, 2021

Much of the fundamental groundwork for genetics and genomic research was laid in the 20 th century, with significant contributions from women scientists, some of whom worked during times when acceptance of female researchers was not widespread. The marriage ended in divorce after a few short years.

Genetics 119

Genetics DNA Genome Genomics 119

The Pharma Data

MAY 15, 2021

It’s because certain genes act one way on some people… and another way on other people. Putting this in medical jargon, the gene ‘expresses’ one way with Bob, for example, and a completely different way with Mary. How a gene expresses – that is, how the gene affects you – goes on to determine whether you get ill or not.

Bacteria 52

Bacteria Gene Gene Therapy Gene Expression 52