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metres of supercoiled DNA contained within its nucleus. All that DNA is organised into hereditary units called genes, with humans having about 25,000 genes collectively known as the genome. The Human GenomeProject was completed in April 2003 when the human reference genome was made public to the world.
Charlie has spent more than 26 years working on the human genome – 22 of which were spent at the Wellcome Sanger Institute, helping to assemble the human genome and trying to understand the function of the genes contained within it. Everything the 100,000 GenomesProject does has to be rubber-stamped by the patients”.
Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. As mentioned, this accounts for roughly 1-2% of the genome, so there’s 98% that we’re not actually looking at yet because we don’t know what it does. “It’s
Charlie has spent more than 26 years working on the human genome – 22 of which were spent at the Wellcome Sanger Institute, helping to assemble the human genome and trying to understand the function of the genes contained within it. Everything the 100,000 GenomesProject does has to be rubber-stamped by the patients”.
Nutrigenomics is the science studying the relationship between human genome, nutrition and health. In part, the success of the Human GenomeProject has also paved a path for the novel concept of nutrigenomics. For example, people affected by phenylketonuria must avoid consuming food containing phenylalanine amino acid.
The Human GenomeProject recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two.
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