pharmaphorum

OCTOBER 19, 2022

million ($40 million) first-round financing that will be used to explore so-called ‘dark’ regions of the human genome. Nucleome’s platform adds 3D genomic information to a wealth of available genomic data, uncovering a new dimension of information that is disease as well as cell type-specific.

Genomics 59

Genomics Genome Gene Gene Expression 59

Medical Xpress

NOVEMBER 23, 2022

Consequently, an enormous amount of genomic and transcriptomic data has been generated. However, these eliminated data contain relevant information. Aiming to test this hypothesis, researchers acquired genomic and transcriptomic data from public datasets.

Research 78

Research Genomics Genome Containment 78

Scienmag

NOVEMBER 20, 2020

It contains the information for the production of 27 proteins. Scientists at Goethe University within the international consortium COVID19-NMR refine previous 2D models The genetic code of the SARS-CoV2 virus is exactly 29,902 characters long, strung through a long RNA molecule.

Genome 70

Genome Genomics RNA Protein 70

Scienmag

AUGUST 13, 2020

Researchers from the Garvan Institute of Medical Research have uncovered four new subtypes of cells within triple negative breast cancer, which contain promising new therapeutic targets for the aggressive disease.

Genome 74

Genome Genomics Containment Research 74

Scienmag

MAY 7, 2021

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […]. (..)

DNA 62

DNA Regulation Genome Genomics 62

Scienmag

FEBRUARY 8, 2022

Scientists at the University of Cambridge have shown that it is possible to modify the mitochondrial genome in live mice, paving the way for new treatments for incurable mitochondrial disorders. Our cells contain mitochondria, […].

Gene Editing 67

Gene Editing Gene Genomics Genome 67

Pharmaceutical Technology

OCTOBER 26, 2022

New doors were opened in the 2000s with the development of genome editing, such as CRISPR-Cas9, which introduces molecular tools to change existing DNA. ILC Dover is a leader in the innovative design and production of containment solutions for biopharmaceutical and pharmaceutical markets, including its single-use liquid bags.

Gene Therapy 130

Gene Therapy Gene Marketing Manufacturing 130

Camargo

NOVEMBER 11, 2020

In November 2017, Foundation Medicine received approval for FoundationOne CDx , a genomic profiling test for solid state tumors, which paved the way for partnerships with pharma companies’ therapeutics. Approval of the Month: Companion Diagnostic for Bayer’s Vitrakvi Should Lead to Improved Patient Outcomes.

Development 242

Development Bioequivalency Generic Drugs Production 242

Pharmaceutical Technology

FEBRUARY 26, 2023

The idea behind these treatments relies on altering the gut microbiome by designing therapeutics that contain bacteria derived from donated stool samples. Although research here is about 20 years old, it remains new compared to other areas like genomics, says Gilbert.

Bacteria 278

Bacteria Trials Research Medicine 278

Scienmag

JUNE 7, 2021

Travellers abroad may pick up bacteria and other vectors containing genes conferring antimicrobial resistance which remain in the gut when returning to their home country, according to a study published in Genome Medicine.

Gene 40

Gene Bacteria Genome Genomics 40

WCG Clinical

NOVEMBER 17, 2023

Although the NIH Guidelines were originally written with non-clinical laboratory research in mind, they also apply to human gene transfer (HGT) research, wherein rsNA or rsNA-containing products are administered to research participants. Since then, however, certain genetic engineering technologies (e.g.,

Genome 52

Genome Genomics Gene Editing Genetic Engineering 52

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Genuity Science focuses on population genomics as a tool to derive novel biological insights through partnerships with industry-leading pharmaceutical and biotech companies.

Research 98

Research Biobanking Drugs Genome 98

The Pharma Data

JANUARY 14, 2021

We leverage advances in machine learning, genomics, and artificial intelligence by using a proprietary A.I. We believe that the use of machine learning, genomics and computational methods can help accelerate the revitalization, refocusing and development of small molecule-based therapies.

Containment 52

Containment Genome Genomics Sales 52

Worldwide Clinical Trials

JUNE 15, 2022

There have been a few cases lately where patients receiving gene therapy had a severe adverse effect because of their immune response to the mechanism of the AAV viral vector, based on their own genomic markers. Institutional Biosafety Committees (IBC) assess the risk of gene therapies to public health or the environment.

Gene Therapy 130

Gene Therapy Gene Clinical Trials Clinical Trials 130

XTalks

JANUARY 21, 2025

The liquid portion of the blood (serum or plasma) containing antibodies is separated and tested using the Liason Biotrin parvovirus B19 IgG plus test on a Liason XL analyzer. The test collection kit includes a container for stool collection and a separate sampler for hemoglobin testing, requiring only a single stool sample to collect both.

FDA Approval 105

FDA Approval Manufacturing Development RNA 105

XTalks

JANUARY 2, 2024

Filsuvez topical gel is a sterile botanical drug product designed for topical use, containing birch triterpenes within an oil base. Upon Vyjuvek’s entry into cells, the vector genome is integrated into the nucleus, initiating the transcription of the encoded human COL7A1.

FDA Approval 111

FDA Approval Gene Therapy Gene Trials 111

The Pharma Data

JANUARY 19, 2021

Based on its unique ability to elucidate regulatory regions of the genome, Syros aims to develop medicines that provide a profound benefit for patients with diseases that have eluded other genomics-based approaches. Syros is redefining the power of small molecules to control the expression of genes.

Containment 52

Containment Genome Genomics Sales 52

The Pharma Data

MARCH 30, 2021

In Europe, KEYTRUDA is approved for the treatment of adult patients with advanced or metastatic urothelial carcinoma (bladder cancer) who are not eligible for cisplatin-containing chemotherapy and whose tumors express PD-L1 with a Combined Positive Score (CPS) ?10. Head and Neck Squamous Cell Cancer. 1] as determined by an FDA-approved test.

FDA Approval 52

FDA Approval Containment Trials Genome 52

Camargo

DECEMBER 10, 2021

In October 2017, the European Commission (EC) and the European Medicines Agency (EMA) collaborated with the Member States’ authorities to launch a plan to reduce discrepancies across the EU in applying certain legislation to advanced therapy medicinal products (ATMPs) containing or consisting of genetically modified organisms (GMOs).

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Development Genetics Production Clinical Trials 176

The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase.

Protein 52

Protein Genome Genomics Research 52

Advarra

JULY 5, 2022

Aggregate results do not contain reference to individually identifiable data. blood labs and genomic sequencing) to be processed in a Clinical Laboratory Improvement Amendment of 1988 (CLIA)-certified lab before being returned to patients or participants.

Research 97

Research FDA Approval Packaging Packaging 97

Roots Analysis

AUGUST 31, 2023

Nutrigenomics is the science studying the relationship between human genome, nutrition and health. In part, the success of the Human Genome Project has also paved a path for the novel concept of nutrigenomics. For example, people affected by phenylketonuria must avoid consuming food containing phenylalanine amino acid.

Genome 40

Genome Genomics Genetics Gene 40

The Pharma Data

DECEMBER 1, 2020

NASDAQ:NTLA), a leading genome editing company focused on developing curative therapeutics using CRISPR/Cas9 technology both in vivo and ex vivo , announced today the pricing of an underwritten public offering of 4,794,521 shares of its common stock at a public offering price of $36.50 CAMBRIDGE, Mass., About Intellia Therapeutics.

In-Vivo 40

In-Vivo Containment Genome Genomics 40

Roots Analysis

MARCH 16, 2023

Genome Engineering: mRNA therapeutics have been demonstrated to be capable of editing genomic DNA sequences in an efficient and precise manner, thereby, making them potential candidates for the treatment of genetic disorders.

Vaccine 52

Vaccine Vaccination DNA Protein 52

XTalks

AUGUST 20, 2020

The wearable device giant partnered with Scripps Research and Stanford Medicine to study the role of wearables to detect, track and contain infectious diseases like COVID-19 before the onset of symptoms. The collaboration was announced by Fitbit in April and the company has now announced preliminary results from the study after 90 days.

Research 98

Research Medicine Development Genome 98

The Pharma Data

DECEMBER 14, 2020

engine along with algorithms tuned to predict BBB permeability played an important role in helping determine which CNS cancers and which genomically-defined subtypes of CNS cancer should be prioritized for development. . We leverage advances in machine learning, genomics, and artificial intelligence by using a proprietary A.I.

Drugs 52

Drugs Genome Genomics DNA 52

Pharmaceutical Technology

JUNE 5, 2023

This latest release features data from 135 patients in the first cohort of the Phase II study, (NCT04736823), which enrolled those who are treatment-naïve with advanced or metastatic NSCLC whose tumours do not have actionable genomic alterations. months for the overall cohort. Two further cohorts were also studied in the Phase II trial.

Genome 130

Genome Genomics Clinical Trials Clinical Trials 130

The Pharma Data

SEPTEMBER 11, 2021

Twist Bioscience is a leading and rapidly growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. This press release contains forward-looking statements. About Twist Bioscience Corporation. Legal Notice Regarding Forward-Looking Statements.

Antibody 52

Antibody DNA Containment Manufacturing 52

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. SALT LAKE CITY–( BUSINESS WIRE )– Spectrum Solutions, LLC today announced its SDNA-1000 saliva collection device has secured U.S.

RNA 52

RNA DNA Engineer Packaging 52

The Pharma Data

NOVEMBER 3, 2020

LogicBio’s proprietary genome editing technology platform, GeneRide, enables the site-specific integration of a therapeutic transgene without nucleases or exogenous promoters by harnessing the native process of homologous recombination. LogicBio is headquartered in Lexington, Mass. For more information, please visit www.logicbio.com.

Clinical Trials 40

Clinical Trials Clinical Trials Gene Editing Genome 40

The Pharma Data

DECEMBER 5, 2020

Based on its unique ability to elucidate regulatory regions of the genome, Syros aims to develop medicines that provide a profound benefit for patients with diseases that have eluded other genomics-based approaches. About Syros Pharmaceuticals Syros is redefining the power of small molecules to control the expression of genes.

Clinical Trials 52

Clinical Trials Clinical Trials Trials HR 52

XTalks

APRIL 29, 2021

However, the variant viral genomes will still persist in the latent reservoir as provirus and can be detected with proviral DNA testing. Importantly, ARV treatment does not affect the proviral DNA genome that persists in latently infected cells. Proviral DNA Genotyping.

DNA 98

DNA Drugs RNA Genotype 98

The Pharma Data

DECEMBER 12, 2020

AstraZeneca has developed a broad range of technologies, initially focused on small molecules and biologics and with a growing focus in precision medicine, genomics, oligonucleotides and epigenetics. More recently, AstraZeneca has increased its efforts in immunology research and the development of medicines for immune-mediated diseases.

Development 75

Development Regulation Medicine Containment 75

Delveinsight

DECEMBER 7, 2020

In May 2020, Freenome initiated AI-EMERGE, a clinical study for the AI-Genomics blood test has been completed, which collected samples from up to 3,000 patients in the US and Canada. The device is worn on the patients’ body, which contains a biharmonic cartridge in it that carries insulin and glucagon.

Protein 56

Protein Insulin Development Hormones 56

The Pharma Data

JANUARY 17, 2021

We are pleased to announce this partnership with VHIO which will bring liquid biopsy comprehensive genomic testing to more cancer patients in Spain and beyond,” said Helmy Eltoukhy, Guardant Health CEO. Guardant Health has achieved CE mark approval as well as U.S. Forward-Looking Statements.

Genome 40

Genome Genomics Clinical Trials Clinical Trials 40

The Pharma Data

DECEMBER 16, 2020

” ABOUT PANOMICS/PANHUNTER PanOmics involves the innovative use of genomics, transcriptomics, proteomics, and phenotypic data in an integrated fashion. FORWARD-LOOKING STATEMENTS Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties.

Protein 40

Protein Bioinformatics Containment Drugs 40

The Pharma Data

OCTOBER 14, 2021

It is also approved in combination with bendamustine, followed by Gazyva/Gazyvaro maintenance for the treatment of FL patients who did not respond to a MabThera®/Rituxan® (rituximab)-containing regimen, or whose FL returned after such treatment and in combination with chemotherapy for previously untreated advanced FL. Source link: [link].

Medicine 52

Medicine In-Vitro Antibody Genome 52