XTalks

APRIL 13, 2021

Now, thanks to a study funded by the National Institutes of Health Intramural Research Program, scientists have discovered that ?-synuclein, synuclein, a protein involved in the formation of amyloid deposits in the brain characteristic of Parkinson’s disease and other neurodegenerative disorders, is also implicated in melanoma.

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The Pharma Data

AUGUST 15, 2021

Even as several safe and effective COVID-19 vaccines are being administered to people worldwide, scientists are still hard at work developing different vaccine strategies that could provide even stronger or longer-lasting immunity against SARS-CoV-2 and its variants. bioRxiv [Preprint]. 2021 Apr 8:2021.04.08.438884. Source link: [link].

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Protein Vaccination Vaccine Antibody 52

XTalks

JULY 28, 2020

For decades, formulation scientists have relied on the assumption that common pharmaceutical excipients are biologically inert. For example, Advil tablets contain 18 inactive ingredients alongside ibuprofen, the drug’s active pharmaceutical ingredient (API). But just how inert are these excipients?

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Protein Drugs In-Vitro Scientist 103

XTalks

MAY 5, 2021

Plant-based meat has come a long way since food tech got involved, but will any chef, scientist or a hybrid of the two be able to create the perfect plant-based marbled steak? Certain cuts of meat also contain more marbling than others. But for the time being, the product is sold out with no estimated restocking date.

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XTalks

JULY 8, 2021

Along with a team of scientists, Kozubel fermented the microbe into a protein-rich substance and dubbed it “Fy.” While many faux meats tend to use soy, pea and other plant-based proteins, Fy is the foundation of Nature’s Fynd products. But is it safe to eat? The US Food and Drug Administration (FDA) says yes.

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Protein Production Branding Marketing 98

XTalks

NOVEMBER 8, 2021

Beans, soy, tofu, mushrooms and pea protein are some of the most common ingredients in meat analogues, but kelp could soon be added to that list. Each 43-gram bag contains between 150 and 160 calories, 8 grams of fat and boasts a slew of vitamins and minerals, like iron, thiamine and riboflavin.

Containment 98

Containment Protein Marketing Production 98

pharmaphorum

SEPTEMBER 14, 2020

We will back our scientists to deliver an effective vaccine as soon as safely possible [link]. It uses a weakened, non-replicating, version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 coronavirus spike protein.

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Vaccination Vaccine Trials Protein 102

XTalks

MAY 13, 2022

A container closure system consists of all the packaging components that contain and protect a pharmaceutical product. Container Closure Systems. A container closure system protects the product from environmental conditions, safeguarding a product’s purity, strength, safety and efficacy.

Packaging 98

Packaging Packaging Containment Production 98

Pharmaceutical Technology

AUGUST 24, 2022

More than three decades ago, scientists at the National Cancer Institute began exploring ways to fight cancer using the patient’s immune system. Their work formed the basis of what is now a promising cancer treatment that doesn’t require surgery or radiation. CAGR between 2020 and 2028.

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Clinical Trials Clinical Trials Trials Development 130

pharmaphorum

SEPTEMBER 14, 2020

While there may be just under 20,000 confirmed protein coding genes, it turns out that much of the genome outside of these genes is also important in regulating how the genome is controlled. To address these issues, scientists and clinicians are starting to look at ‘long-read’ sequencing.

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Genome Genomics Medicine Gene 119

XTalks

SEPTEMBER 8, 2020

“Positive results from preclinical research led by the National Institute of Allergy and Infectious Diseases (NIH) scientists supported the rapid development of this vaccine candidate, which has also showed promise in early-stage clinical trials.”. The genetic material contains SARS-CoV-2 spike protein.

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Manufacturing Vaccination Vaccine Allergies 83

XTalks

MAY 5, 2021

Plant-based meat has come a long way since food tech got involved, but will any chef, scientist or a hybrid of the two be able to create the perfect plant-based marbled steak? Certain cuts of meat also contain more marbling than others. But for the time being, the product is sold out with no estimated restocking date.

Containment 52

Containment Production Protein Branding 52

The Pharma Data

DECEMBER 10, 2020

Through its Genome5000 program, Lexicon scientists studied the role and function of nearly 5,000 genes and identified more than 100 protein targets with significant therapeutic potential in a range of diseases. Lexicon is a biopharmaceutical company with a mission of pioneering medicines that transform patients’ lives.

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Containment Clinical Development Development Protein 52

XTalks

JANUARY 28, 2021

Not only are the egg bites free of meat and dairy, but they are also GMO-free, cholesterol-free and contain a similar amount of protein as their animal-based counterparts at nine to 13 grams of protein, depending on the flavor.

Production 59

Production Protein Manufacturing Containment 59

XTalks

APRIL 14, 2021

Scientists used synthetic biology and computational protein design tools to develop an enzymatic process to transform red cabbage anthocyanins into their desired color. The color cyan blue is not easy to find in nature, making this discovery significant for the industry’s innovation and developments.

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Regulation Production Branding Research 94

The Pharma Data

APRIL 7, 2023

One of the greatest challenges in modern drug design is to find compounds that satisfy somewhat contradictory requirements – they need to be small enough to permeate human cell membranes, while being large enough to target various protein surfaces and protein–protein interactions.

Drugs 40

Drugs Protein Bioavailability Research 40

The Pharma Data

OCTOBER 18, 2020

Dyskeratosis congenita (DC) is a disease of pre-mature aging, which occurs due to a deficiency of telomere maintenance proteins. In this recently published study, scientists examined connective tissue cells from DC patients and found that, not only were their telomeres significantly damaged, but they were also depleted in NAD +.

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DNA Scientist Genetic Disease Research 52

The Pharma Data

DECEMBER 21, 2020

Targeted protein degradation (TPD) is an approach whereby the body’s natural process for degrading proteins is diverted using small molecule drugs to eliminate disease-causing proteins. However, there has so far been limited progress in applying this exciting approach to membrane-associated proteins such as GPCRs.

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Protein Drugs Development Production 40

The Pharma Data

DECEMBER 30, 2020

It is a tribute to the incredible UK scientists at Oxford University and AstraZeneca whose breakthrough will help to save lives around the world. After vaccination, the surface spike protein is produced, priming the immune system to attack the SARS-CoV-2 virus if it later infects the body.

Vaccination 52

Vaccination Vaccine Clinical Trials Clinical Trials 52

The Pharma Data

JANUARY 25, 2021

Fernström Prize for Junior Scientists and the Inga Sandeborg Prize for Research on Alzheimer’s Disease. NervGen’s platform technology targets protein tyrosine phosphatase sigma (“PTP?”), The forward-looking statements contained in this news release are expressly qualified by this cautionary statement.

Clinical Development 40

Clinical Development Containment Development Research 40

The Pharma Data

OCTOBER 30, 2020

To develop REGN-COV2, Regeneron scientists evaluated thousands of fully-human antibodies produced by the company’s VelocImmune ® mice, which have been genetically modified to have a human immune system, as well as antibodies identified from humans who have recovered from COVID-19.

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Production Antibody Manufacturing Trials 52

The Pharma Data

JANUARY 18, 2021

About Chemerin and its receptor: The chemerin receptor (“CMKLR1”, also known as ChemR23) is a chemokine like G protein-coupled receptor (“GPCR”) expressed on select populations of cells, including inflammatory mediators (including macrophages, monocytes, plasmacytoid/myeloid dendritic cells and natural killer cells), as well as epithelial cells.

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Life Science Development Sales Drugs 40

Roots Analysis

AUGUST 31, 2023

For example, people affected by phenylketonuria must avoid consuming food containing phenylalanine amino acid. Challenges Associated with Nutrigenomics Although scientists have conducted extensive research on interaction of genes and nutrition, the science of nutrigenomics is still in its infancy stage.

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Genome Genomics Genetics Gene 40

The Pharma Data

DECEMBER 5, 2020

BCMA (B-cell maturation antigen) is a protein that is typically over-expressed on multiple myeloma cells. (NASDAQ: REGN) today announced updated data for REGN5458, a BCMAxCD3 bispecific antibody, from the Phase 1 portion of a Phase 1/2 trial in patients with relapsed or refractory (R/R) multiple myeloma. and the world, respectively, in 2020.

Antibody 40

Antibody Production Trials Medicine 40

The Pharma Data

DECEMBER 17, 2020

To develop this novel medicine, Regeneron scientists evaluated thousands of fully-human antibodies produced by the company’s VelocImmune ® mice, which have been genetically modified to have a human immune system, as well as antibodies identified from humans who have recovered from COVID-19.

Antibody 52

Antibody Medicine Production Trials 52

The Pharma Data

OCTOBER 28, 2020

To develop REGN-COV2, Regeneron scientists evaluated thousands of fully-human antibodies produced by the company’s VelocImmune ® mice, which have been genetically modified to have a human immune system, as well as antibodies identified from humans who have recovered from COVID-19.

Antibody 40

Antibody Trials Production Clinical Trials 40

XTalks

OCTOBER 21, 2020

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. The researchers focused on the spike proteins that protrude from the surface of the coronavirus, which are responsible for viral attachment and entry into host cells.

RNA 98

RNA Protein Genome Genomics 98

The Pharma Data

JULY 8, 2021

Today, access to the world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease was launched through a genetic exome sequence analysis collaboration between AbbVie (NYSE: ABBV), Biogen Inc. PFIZER DISCLOSURE NOTICE: The information contained in this release is as of July 8, 2021.

Genetics 52

Genetics Biobanking Protein Containment 52

XTalks

OCTOBER 8, 2024

The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. A gene contains instructions within our DNA.

Regulation 52

Regulation Genetics Scientist RNA 52

XTalks

MAY 4, 2021

To develop CRISPRoff, the researchers generated a single “dead” Cas9 fusion protein capable of mediating DNA methylation and repressive histone modifications, but devoid of any DNA cleavage function. Epigenetic Editing with CRISPR. It’s a great tool for controlling gene expression.”. pyogenes dCas9.

DNA 98

DNA Gene Gene Silencing Genome 98

pharmaphorum

FEBRUARY 24, 2022

Viral or bacterial infections, or airway irritants can damage lung cells, causing them to release damage associated molecular pattern (DAMP) molecules that attach to and activate the receptor for advanced glycation endproducts (RAGE) protein found on a cell’s membrane. said Cantex CEO Stephen Marcus.

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Licensing Licensing Development Drugs 64

The Pharma Data

DECEMBER 7, 2020

7, 2020 — Another study has confirmed what scientists have long known — eating a lot of red meat may be bad for your heart. On the other hand, opting for plant-based proteins instead of ordering a steak may boost your cardiovascular health. MONDAY, Dec. Chan School of Public Health, in Boston. 2 in the BMJ. . 2 in the BMJ.

Protein 52

Protein Scientist Research Containment 52

The Pharma Data

JULY 15, 2021

The access to the world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease was launched through a genetic exome sequence analysis collaboration between AbbVie (NYSE: ABBV), Biogen Inc. Nasdaq: BIIB) and Pfizer (NYSE: PFE). About the UK Biobank.

Biobanking 52

Biobanking Genetics Protein Research 52

pharmaphorum

SEPTEMBER 9, 2020

Charlie told pharmaphorum how his search for a genetic cause has led him to straddle the divide between scientist and patient advocate. Platform’s like Congenica’s help clinicians to do this by filtering out the many millions of harmless variants, through computer algorithms and input from highly trained clinical scientists.

Genome 99

Genome Genomics Genetics Genome Project 99

XTalks

SEPTEMBER 30, 2024

Gold Nanocrystals — Insights into Nanomedicine Central to Clene’s efforts is CNM-Au8 , an oral suspension containing gold nanocrystals. CNM-Au8 works by improving the health of mitochondria — the energy producers in our cells — while also reducing harmful oxidative stress and lowering levels of misfolded proteins.

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Research Clinical Trials Clinical Trials Drugs 59

Pharmaceutical Technology

OCTOBER 28, 2022

They inform industrial scientists what is necessary to ensure that their product meets the safety and efficacy requirements to get a product approved in humans. For companies in the US, if the results show bioequivalence, an abbreviated new drug application (ANDA) containing the results is sent to the FDA to review and potentially approve.

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Advarra

MARCH 10, 2023

Red blood cells contain hemoglobin, a protein that carries oxygen. Understanding SCD According to the Centers for Disease Control and Prevention (CDC) , SCD, also known as sickle cell anemia, is “a group of inherited red blood cell disorders. While the exact number is unknown, SCD affects approximately 100,000 Americans.

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Clinical Trials Clinical Trials Trials Doctors 98