Pharmaceutical Technology

APRIL 27, 2023

Every stage of development should result in a reproducible, safe drug product with no cross contamination from one batch to another. The risk of contamination is particularly important for genomic medicines in which trace amounts of nucleic acids would impact the quality of the drug product.

Manufacturing 130

Manufacturing RNA Contamination Vaccination 130

XTalks

NOVEMBER 18, 2021

The brand’s products are packed with 14 grams of protein, prebiotics and 21 different organic ingredients, including kale and mushrooms. Related: Better Bagel: The Low-Carb, High-Protein Bagel That’s “Changing the Grain”. To catch the eyes of young adult consumers, the boxes feature bright colors and minimal typefaces.

Branding 98

Branding Protein Contamination Marketing 98

XTalks

SEPTEMBER 20, 2023

Plant-based meats, on the other hand, are often derived from pea or soy proteins and mimic the taste and texture of conventional meats. The mixture uses the mass-produced plant proteins with the essential ingredients needed for cultivated meat production. Despite their environmental advantages, some challenges remain.

Contamination 64

Contamination Protein Production FDA Approval 64

Pharmaceutical Technology

APRIL 4, 2023

There are 13 sites in the region that offer API biologic services and 12 of these are based in Telangana, all offering protein and peptide manufacturing, and one – Loka Biosciences (Hyderabad, Telangana, India) – also offers gene therapy production. Source: GlobalData, Pharma Intelligence Center Drug Database (Accessed March 20, 2023).

Manufacturing 130

Manufacturing Generic Drugs Contract Manufacturing Production 130

Pharmaceutical Technology

APRIL 16, 2023

Yet PFSs also come with a challenge such as presenting difficulties in maintaining the stability of protein-based molecules or complex monoclonal antibodies. Protein aggregation and particle formation 5 can occur due to silicone oil-water and air-water interfaces, making the siliconisation of the primary container crucial.

Protein 130

Protein Containment Drug Delivery Drugs 130

XTalks

AUGUST 25, 2023

The FDA established the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA), which requires that food labels clearly identify the food source names of any ingredients that contain any protein derived from the nine most common food allergens.

Allergies 98

Allergies Manufacturing Contamination Production 98

XTalks

JULY 25, 2023

While there is no evidence of person-to-person transmission, anthrax skin lesions may be contagious through direct contact or contaminated objects. The bacteria usually enter the body through wounds, but infection can also occur through contaminated meat or inhalation of spores.

FDA Approval 98

FDA Approval Vaccination Vaccine Antibody 98

Pharmaceutical Technology

MAY 17, 2023

In addition to revolutionising diabetes care, insulin has become an essential component of biopharmaceutical manufacturing, where its growth-supplementing ­­­properties are relied on to enhance commercially available cell culture media and achieve higher yields of target therapeutic proteins. One big challenge is contamination.

Insulin 130

Insulin Production Manufacturing Contamination 130

pharmaphorum

JULY 21, 2022

If businesses have received a notice of inspection, they should focus on two key things: Adulteration: proof there is no chemical, microbial, viral, or other type of contamination in products. However, we understand that this is not always possible. Implementing Pharmaceutical Quality systems.

Compliance 98

Compliance Regulation Manufacturing Contamination 98

Pharmaceutical Technology

JULY 22, 2022

Schistosomiasis, also called the snail fever, is caused by parasitic flatworms that enter the human skin when individuals come in contact with contaminated water, the article noted. Long-term infections can cause damage to the liver and kidneys, and can cause infertility and bladder cancer.

Vaccination 130

Vaccination Vaccine Life Science Immune Response 130

Roots Analysis

OCTOBER 16, 2023

Biopharmaceutical filtration is a critical step in the production of biopharmaceuticals, including proteins, antibodies, and vaccines. It involves the separation of unwanted particles from biological materials to obtain contaminant free products. For example, ultrafiltration retains proteins, allowing other molecules to pass through.

Bacteria 40

Bacteria Production Protein Contamination 40

XTalks

JUNE 22, 2023

The factsheet also brings attention to the issues of paper packaging, asserting that it can have a significant toll on forest resources and is not always recyclable due to contamination by food or coatings of plastic and aluminum. The success of The Better Bagel reflects the growing market demand for low-carb and keto-friendly products.

Packaging 52

Packaging Packaging Containment Contamination 52

XTalks

AUGUST 7, 2023

Transmission of the molluscum contagiosum virus occurs through direct person-to-person contact or via contaminated objects known as fomites. It then activates enzymes known as neutral serine proteases, which are responsible for protein degradation.

FDA Approval 98

FDA Approval Dermatology Trials Clinical Trials 98

Roots Analysis

OCTOBER 24, 2023

The ADCs bind to specific proteins or peptides in cancer cells with very high specificity and efficacy influencing the biological functions. A molecule having 2-50 amino acids is considered as peptide whereas, group of peptides are responsible for forming a protein.

Manufacturing 40

Manufacturing Hormones Contamination Containment 40

Roots Analysis

APRIL 15, 2024

These complex entities, such as antibodies, antibody drug conjugates, cell therapies, gene therapies, and therapeutic proteins, are highly specific molecules that are designed to precisely target biomarkers associated with a particular disease pathway.

Manufacturing 40

Manufacturing Production Contract Manufacturing Contamination 40

Roots Analysis

MAY 24, 2024

These autoinjectors offer several advantages, including simplified drug administration process, safer injection, reduced risk of contamination and minimized maintenance ( due to elimination of cleaning and sterilization steps ). This is extremely important for injectable medications.

Drug Delivery 40

Drug Delivery Containment Contamination Production 40

Roots Analysis

OCTOBER 24, 2023

The limitations of stainless-steel bioreactors such as high risk of contamination, process related challenges and high operational cost have prompted innovators to develop more advanced single use bioreactor in order to meet the rising demand for safe and efficacious biotherapeutics.

Manufacturing 40

Manufacturing Contamination Marketing Production 40

XTalks

NOVEMBER 7, 2022

However, Dr. Bahassi reported that the selection of CTCs using this method is often not very efficient and the CTC population is usually highly contaminated with leukocytes. Exosomes are extracellular vesicles that contain molecular cargoes (such as various proteins, RNAs and DNAs) specific to the origin cell.

Clinical Trials 98

Clinical Trials Clinical Trials Trials FDA Approval 98

XTalks

MAY 13, 2022

This highly sensitive method even works to detect package defects clogged by product formulation proteins or salts, explains Liss. E&L testing is performed to substantiate that packaging materials will not contaminate the drug product over a product’s shelf life. These compounds thus become a part of the drug matrix.

Packaging 98

Packaging Packaging Containment Production 98

XTalks

FEBRUARY 8, 2024

for a one-month supply Why it did so well: Jardiance belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, inhibiting the SGLT2 protein in the kidneys to lead to the excretion of excess glucose through the urine. Jardiance brought in $2.06 billion for Eli Lilly and $6.23 billion for Boehringer Ingelheim.

Sales 52

Sales Insulin FDA Approval Drugs 52

The Pharma Data

MAY 4, 2021

In February 2021, Pfizer and BioNTech announced results from an in vitro study published in NEJM that demonstrated sera from individuals immunized with BNT162b2 neutralize SARS-CoV-2 with the South African variant spike protein. The study investigated the full set of South African variant (also known as B.1.351

Vaccination 40

Vaccination Vaccine Production Sales 40

XTalks

JANUARY 6, 2025

RNA-Based Therapeutics RNA molecules have emerged as promising therapeutic agents due to their ability to precisely target undruggable proteins or molecules, often with minimal side effects. This reduces human error and contamination risks, ensuring higher-quality production outcomes.

Gene Therapy 111

Gene Therapy RNA Gene Editing Gene 111

XTalks

MARCH 11, 2025

While RT-PCR methods can handle some level of multiplexing, they do require specialized, contamination-free environments. Additionally, manufacturers often use proprietary codon optimization schemes, meaning that even mRNA constructs for the same protein may differ significantly at the nucleotide level.

Vaccination 64

Vaccination Vaccine Development Manufacturing 64

XTalks

SEPTEMBER 14, 2020

The company’s candidate vaccine, mRNA-1273, is a synthetic messenger RNA that encodes the stabilized SARS-CoV-2 spike protein. The University of Oxford/AstraZeneca partnership, in turn, is testing a viral-vectored coronavirus vaccine that again expresses the spike protein of SARS-CoV-2 virus.

Vaccination 92

Vaccination Vaccine Antibody Life Science 92