Development - Clinical Research Informer

Digital transformation expected to shorten drug development timelines

Pharmaceutical Technology

NOVEMBER 27, 2024

Pharmaceutical professionals expect digital solutions to solve drug development headaches, with AI already proving disruptive.

Development

Development Drugs

India’s Tata Institute develops tablet for cancer recurrence prevention

Pharmaceutical Technology

FEBRUARY 29, 2024

India’s Tata Institute has developed a tablet combining resveratrol and copper that has the potential to prevent the recurrence of cancer.

Development

Lilly and ProQR to expand genetic medicine development agreement

Pharmaceutical Technology

DECEMBER 23, 2022

Eli Lilly and Company has expanded a licencing and partnership agreement with ProQR Therapeutics to discover, develop and market new genetic medicines. The post Lilly and ProQR to expand genetic medicine development agreement appeared first on Pharmaceutical Technology.

Genetics

Genetics Medicine Development Gene Therapy

AbbVie and Umoja to develop new CAR-T therapies for cancer

Pharmaceutical Technology

JANUARY 5, 2024

AbbVie and Umoja Biopharma partnered for the development of in-situ CAR-T cell therapy candidates for oncology targets.

Development

Roles and Responsibilities of Specialized Clinical Supply Experts

However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

Clinical Supply

Citryll gains Series B funds to develop NET-targeting antibody

Pharmaceutical Technology

DECEMBER 9, 2024

Citryll has secured an oversubscribed Series B funding round, raising 85m ($89.8m) to advance the clinical development of CIT-013.

Development

Development Antibody Clinical Development

Into the unknown: How quickly can vaccines be developed for Disease X

Pharmaceutical Technology

SEPTEMBER 13, 2024

R&D frameworks are in place for the next pandemic-causing pathogen, but ways to derisk development are unclear.

Development

Development Vaccination Vaccine

Aptose Biosciences secures funds for AML treatment development

Pharmaceutical Technology

SEPTEMBER 2, 2024

Aptose Biosciences has secured a loan of $10m through a facility agreement with Hanmi Pharmaceutical to develop tuspetinib.

Development

Ovid partners with Waksal startup to develop drugs for rare brain disorders

Bio Pharma Dive

MAY 1, 2023

Founded by Sam Waksal, Graviton Biosciences is developing drugs that block an enzyme called ROCK2, which drew the interest of neurology-focused Ovid.

Development

Development Drugs

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies.

Clinical Trials

Moderna leads the development of mRNA vaccines in infectious diseases

Pharmaceutical Technology

JANUARY 29, 2024

The rapid sequencing of the SARS-CoV-2 and the subsequent development of mRNA vaccines led to the authorisation of the first of these vaccines in late 2020.

Vaccination

Vaccination Vaccine Development

Angle signs AstraZeneca deal to develop prostate cancer assay

Pharmaceutical Technology

MAY 3, 2024

UK liquid biopsy company, Angle, has agreed a supplier agreement with AstraZeneca to develop a Parsotix-based Androgen Receptor (AR) assay for use in prostate cancer studies.

Development

Pelage secures funds to develop regenerative medicine for hair loss

Pharmaceutical Technology

FEBRUARY 28, 2024

Pelage Pharmaceuticals has secured $16.75m in a Series A financing round to further the development of PP405 for hair loss.

Development

Development Medicine

Valneva and LimmaTech partner for shigellosis vaccine development

Pharmaceutical Technology

AUGUST 1, 2024

Valneva and LimmaTech have signed a deal to potentially develop the first marketed shigellosis vaccine.

Vaccination

Vaccination Vaccine Development Marketing

Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials.

Clinical Supply

ArriVent partners Alphamab to develop ADCs for cancer

Pharmaceutical Technology

JUNE 6, 2024

ArriVent BioPharma has entered a partnership with Jiangsu Alphamab Biopharmaceuticals for developing new ADCs to treat cancer.

Development

Eisai and Bristol Myers Squibb terminate ADC development deal

Pharmaceutical Technology

JULY 2, 2024

Eisai has announced the termination of a deal with Bristol Myers Squibb to jointly develop and commercialise farletuzumab ecteribulin (FZEC).

Development

Abingworth raises $356M to invest in late-stage drug development

Bio Pharma Dive

OCTOBER 30, 2023

The venture firm has supported a number of approved medicines with its co-development strategy, including Pfizer’s Besponsa and Apellis’ Empaveli.

Development

Development Medicine Drugs

Northwestern and Case Western Reserve universities develop Huntington’s therapy

Pharmaceutical Technology

NOVEMBER 4, 2024

Researchers from Northwestern and Case Western Reserve universities have developed a polymer therapeutic to treat Huntington's disease.

Development

Development Research

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management.

Clinical Trials

Myricx Bio gains $114m in Series A round to develop NMTi-ADCs

Pharmaceutical Technology

JULY 8, 2024

Myricx Bio has secured £90m ($114m) in its Series A financing round to propel its NMTi-ADC therapeutics into the clinical development stage.

Development

Development Clinical Development

Narcan developer to be acquired by Indivior

Bio Pharma Dive

NOVEMBER 14, 2022

The deal, which could carry a total value of roughly $145 million, is in large part focused on a nasal formulation of the opioid overdose drug nalmefene.

Development

Development Drugs

Editas and Genevant team up to develop gene editing therapies

Pharmaceutical Technology

OCTOBER 22, 2024

Editas is partnering its CRISPR platform with Genevant’s LNP technology to develop novel gene editing medicines in a deal worth $283m.

Gene Editing

Gene Editing Gene Development Medicine

Xyphos and Poseida to develop allogeneic cell therapies for cancer

Pharmaceutical Technology

MAY 2, 2024

Xyphos Biosciences and Poseida Therapeutics have signed a deal to develop new allogeneic cell therapies for treating cancer.

Development

What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

Learning Objectives: Dose-response curves and patient treatment: How do pharmacologic and toxicologic principles apply to the dosing of drugs in clinical development? Ben Locwin will discuss the potential effects of this draft, along with the pharmacological and toxicological considerations for optimizing doses of prescription drugs.

Clinical Research

Brain drug developer Alto Neuroscience prices $129M IPO

Bio Pharma Dive

FEBRUARY 2, 2024

The California biotech is the third this year to go public, following stock offerings from CG Oncology and Arrivent Biopharma.

Development

Development Drugs

Real-world evidence in pharmaceutical drug development – faster, safer and more relevant?

Bio Pharma Dive

NOVEMBER 13, 2023

How can these increase the probability of success or efficiency in a pre-clinical and clinical drug development program? Regulatory agencies have set the framework and use cases for RWE.

Development

Development Drugs

Dr Reddy’s, Aurigene and Kainomyx to co-develop anti-malarials

Pharmaceutical Technology

AUGUST 21, 2024

Dr Reddy's Laboratories, Aurigene Pharmaceutical and Kainomyx signed an MoU to co-develop and co-commercialise an anti-malarial drug.

Development

Development Drugs

Biogen quits Aduhelm, handing back rights to original developer

Bio Pharma Dive

JANUARY 31, 2024

The decision to discontinue the controversial drug closes a tumultuous three-year saga that brought significant upheaval to the company.

Development

Development Drugs

Lundbeck to buy brain drug developer Longboard for $2.6B

Bio Pharma Dive

OCTOBER 14, 2024

The deal would hand Lundbeck a treatment for a series of rare brain disorders that could, by the company's estimates, become a blockbuster product.

Development

Development Drugs Production

Moderna gets US funding for bird flu vaccine development

Bio Pharma Dive

JULY 2, 2024

BARDA will provide Moderna with $176 million to advance late-stage testing of an H5 influenza shot, as health officials monitor animal outbreaks.

Development

Development Vaccination Vaccine

ADC developed by Daiichi, Merck outperforms chemo in lung cancer trial

Bio Pharma Dive

SEPTEMBER 17, 2024

The FDA previously rejected patritumab deruxtecan over manufacturing issues. Tuesday's study data should boost the companies' case, however.

Development

Development Manufacturing Trials

Pfizer, BioNTech stumble in effort to develop combination flu, COVID shot

Bio Pharma Dive

AUGUST 16, 2024

The vaccine didn’t spur a strong enough immune response against a particular flu strain in a Phase 3 trial, leading the companies to ponder adjustments.

Immune Response

Immune Response Development Vaccination Vaccine

A Single Drop of Blood Could Soon Reveal Your Risk of Developing MS

AuroBlog - Aurous Healthcare Clinical Trials blog

MAY 13, 2024

With nothing more than a drop of blood, medical specialists could soon have years of advance warning that the disease is developing. As treatments for multiple sclerosis (MS) continue to improve, scientists are looking for ways to spot the condition before symptoms set in. MS affects nearly a million people in the US alone, whose […]

Development

Development Scientist Clinical Trials Clinical Trials

Viking joins obesity drug development race with early study data

Bio Pharma Dive

MARCH 28, 2023

The biotech is working on a dual-acting weight loss treatment that could compete with medicines from Novo Nordisk, Eli Lilly and others.

Development

Development Medicine Drugs

Bayer partners with RNA drugmaker to develop new cancer therapies

Bio Pharma Dive

AUGUST 28, 2024

Under a collaboration with NextRNA Therapeutics, Bayer will access the biotech’s platform to target long, non-coding RNA interactions with small molecule drugs.

RNA

RNA Development Drugs

Thermo Fisher, Bayer partner to develop companion diagnostics

Bio Pharma Dive

MARCH 21, 2024

The companies aim to identify potential patients for Bayer’s precision cancer therapies and increase access to the treatments.

Development

Pharma earnings outline drug law’s looming impact on sales, development

Bio Pharma Dive

NOVEMBER 9, 2022

While many companies are still unsure of the Inflation Reduction Act's effects, some have begun to warn investors about the likelihood of lower sales and reduced profitability.

Sales

Sales Development Drugs

Prevail, Capsida partner to develop gene therapies for nervous system diseases

Bio Pharma Dive

JANUARY 4, 2023

The Lilly-owned subsidiary will pay $55 million to gain access to Capsida’s AAV gene therapy technology in a deal aimed at central nervous system disorders.

Gene Therapy

Gene Therapy Gene Development

Convergent raises $90M to develop its radiopharmaceutical for prostate cancer

Bio Pharma Dive

MAY 5, 2023

The biotech is the latest startup to capitalize on rising investor interest in targeted drugs that use radioisotopes to destroy tumors.

Development

Development Drugs

Forbion-backed biotech raises $138M to develop ALS drug

Bio Pharma Dive

NOVEMBER 14, 2023

The Series A round for three-year-old startup VectorY is one of the largest private financings in Europe this year, Forbion said.

Development

Development Drugs

ALS drug approved by FDA in closely watched decision, marking win for patients, developer

Bio Pharma Dive

SEPTEMBER 30, 2022

The drug, which will be sold as Relyvrio, showed modest benefits in function and survival in testing. It also became the latest test of the FDA's flexibility toward new therapies for neurological disorders.

Drugs

Drugs Development

FDA, NIH initiative aims to speed development of drugs for ALS, other brain diseases

Bio Pharma Dive

SEPTEMBER 16, 2022

The public-private partnership plans to bring together scientific experts, private entities and patient groups to better understand certain neurodegenerative disorders and find new treatments.

Development

Development Drugs

Pharma companies must adapt to keep pace with AI developments, say experts

Pharmaceutical Technology

OCTOBER 25, 2024

At the Outsourcing in Clinical Trials Conference, key opinion leaders shared predictions for workflow changes due to AI.

Pharma Companies

Pharma Companies Clinical Trials Clinical Trials Development

Digital transformation expected to shorten drug development timelines

India’s Tata Institute develops tablet for cancer recurrence prevention

Trending Sources

Lilly and ProQR to expand genetic medicine development agreement

AbbVie and Umoja to develop new CAR-T therapies for cancer

Roles and Responsibilities of Specialized Clinical Supply Experts

Citryll gains Series B funds to develop NET-targeting antibody

Into the unknown: How quickly can vaccines be developed for Disease X

Aptose Biosciences secures funds for AML treatment development

Ovid partners with Waksal startup to develop drugs for rare brain disorders

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Moderna leads the development of mRNA vaccines in infectious diseases

Angle signs AstraZeneca deal to develop prostate cancer assay

Pelage secures funds to develop regenerative medicine for hair loss

Valneva and LimmaTech partner for shigellosis vaccine development

Accelerating Clinical Supply Through Integrated Drug Development

ArriVent partners Alphamab to develop ADCs for cancer

Eisai and Bristol Myers Squibb terminate ADC development deal

Abingworth raises $356M to invest in late-stage drug development

Northwestern and Case Western Reserve universities develop Huntington’s therapy

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Myricx Bio gains $114m in Series A round to develop NMTi-ADCs

Narcan developer to be acquired by Indivior

Editas and Genevant team up to develop gene editing therapies

Xyphos and Poseida to develop allogeneic cell therapies for cancer

What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Brain drug developer Alto Neuroscience prices $129M IPO

Real-world evidence in pharmaceutical drug development – faster, safer and more relevant?

Dr Reddy’s, Aurigene and Kainomyx to co-develop anti-malarials

Biogen quits Aduhelm, handing back rights to original developer

Lundbeck to buy brain drug developer Longboard for $2.6B

Moderna gets US funding for bird flu vaccine development

ADC developed by Daiichi, Merck outperforms chemo in lung cancer trial

Pfizer, BioNTech stumble in effort to develop combination flu, COVID shot

A Single Drop of Blood Could Soon Reveal Your Risk of Developing MS

Viking joins obesity drug development race with early study data

Bayer partners with RNA drugmaker to develop new cancer therapies

Thermo Fisher, Bayer partner to develop companion diagnostics

Pharma earnings outline drug law’s looming impact on sales, development

Prevail, Capsida partner to develop gene therapies for nervous system diseases

Convergent raises $90M to develop its radiopharmaceutical for prostate cancer

Forbion-backed biotech raises $138M to develop ALS drug

ALS drug approved by FDA in closely watched decision, marking win for patients, developer

FDA, NIH initiative aims to speed development of drugs for ALS, other brain diseases

Pharma companies must adapt to keep pace with AI developments, say experts

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