Drug Discovery World

OCTOBER 6, 2023

The top stories: mRNA pioneers Katalin Karikó and Drew Weissman receive Nobel prize The Nobel Assembly at Karolinska Institutet has awarded the 2023 Nobel Prize in Physiology or Medicine jointly to Katalin Karikó and Drew Weissman for their discoveries that enabled the development of mRNA vaccines against Covid-19.

Drugs 52

Drugs Gene Editing Genome Genomics 52

Pharmaceutical Technology

JUNE 4, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely.

Genetics 130

Genetics Gene Expression DNA Antibody 130

Drug Discovery World

AUGUST 16, 2023

For example, women whose primary tumours have a higher presence of immune cell genes, and genes linked to their activity, are more likely to respond to docetaxel than carboplatin. The presence of these biomarkers could be used to accelerate the development of more personalised treatments for triple negative breast cancers.

Genetics 52

Genetics Gene Hormones RNA 52

XTalks

NOVEMBER 6, 2020

Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The gene therapy-based vaccine targets mucosal tissues in the gastrointestinal tract, allowing for greater selectivity and targeted delivery compared to traditional vaccines.

Clinical Trials 75

Clinical Trials Clinical Trials Vaccination Vaccine 75

XTalks

MARCH 13, 2024

Biomarker testing is being pursued to identify biological signs of the disease and provide an approach to develop personalized treatment plans for each patient. As this technology continues to evolve, it is expected to help identify glaucoma in its nascent stages of development.

Gene Therapy 111

Gene Therapy Gene Life Science DNA 111

Roots Analysis

JANUARY 14, 2024

With the increased interest and gradual shift of investment from small molecule drugs to biologics and the establishment of several biologics manufacturing companies / biologics CMOs, more than 250 biologic therapies and vaccines have been developed, globally. Mammalian cell cultures offer stability and are preferred for long term usage.

Contract Manufacturing 40

Contract Manufacturing Manufacturing Protein Bacteria 40

pharmaphorum

MARCH 10, 2021

The US biotech said the suspected serious adverse reaction reported in the phase 1/2 study of LentiGlobin gene therapy for sickle cell disease was unlikely to be related to the virus vector used in the therapy, used to deliver the genetic material to the body. bluebird bio’s Philip Gregory.

Gene Therapy 53

Gene Therapy Gene Trials Gene Expression 53

pharmaphorum

JANUARY 29, 2021

‘Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome. billion in funding. About the author.

Gene Editing 144

Gene Editing Gene Gene Therapy In-Vivo 144

XTalks

AUGUST 12, 2020

The identification of T cells that essentially ‘hide’ the virus has significant implications for developing therapeutic strategies to improve the treatment and long-term management of HIV. Fucosylation is the attachment of a specific sugar molecule called fucose to proteins on the surface of cells. T Cell Glycomic Signatures in HIV.

RNA 52

RNA Protein DNA In-Vivo 52

Roots Analysis

AUGUST 31, 2023

Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. There are various regulatory proteins or transcription factors that are responsible for affecting the transcription rate.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40

Drug Discovery World

NOVEMBER 15, 2022

Known for its ability to offer precision and flexibility while expanding the experimental scale, synthetic biology tools can reduce development timelines and costs, and lend a competitive advantage over traditional methods. . Rapid and accurate DNA synthesis .

DNA 98

DNA Drugs Antibody Engineer 98

Drug Discovery World

JULY 8, 2024

For decades, the life sciences community held the belief that RNA was merely the intermediary messenger (mRNA) between DNA and protein, a dogma that has been the foundation of biology. The most developed RNAi is small interfering ribonucleic acid (siRNA)-based therapies.

RNA 59

RNA Protein Gene Expression Vaccination 59

Drug Discovery World

APRIL 30, 2024

Messenger RNA (mRNA) has come into focus within the drug discovery and development as an exciting tool to deliver genetic information. This is essential to its use as a therapeutic agent and gives the technology a vast versatility making it suitable to treating a wide range of diseases – especially those that have high protein expression.

RNA 52

RNA Protein Vaccination Vaccine 52

XTalks

FEBRUARY 11, 2021

For example, British scientist Rosalind Franklin gained recognition for her work after her death, which is not unheard of, but with it came the revelation that her work, which helped demonstrate the double helical structure of DNA, went largely uncredited by famed DNA duo James Watson and Francis Crick.

Genetics 119

Genetics DNA Genome Genomics 119

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. It’s a great tool for controlling gene expression.”.

DNA 98

DNA Gene Gene Silencing Genome 98

Drug Discovery World

APRIL 14, 2023

DDW Editor Reece Armstrong speaks to Nautilus Co-Founder and Chief Scientist Parag Mallick , about the company’s recent collaboration which aims to uncover the proteins that could be behind a rare and fatal childhood cancer. To do this, Nautilus will useits protein analysis platform to provide TGen with data on the proteins involved in DPIG.

Protein 52

Protein Genome Genomics DNA 52

Drug Discovery World

JULY 15, 2022

The remaining 8% of the genome was often referred to as the dark matter of the genome or sometimes even ‘Junk DNA’ 2. The Telomere-to-Telomere (T2T) Consortium successfully sequenced about 200 million remaining base pairs to approach 100% of the human genome by using the newly developed long read sequencing (LRS) technology 3,4,5.

Genome 52

Genome Genomics DNA Containment 52

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. Years of development and fast-paced research have continued to unlock its potential, expanding how CRISPR can be used to treat, detect, and prevent common diseases such as cancer and Covid-19.

DNA 98

DNA Genome Genomics RNA 98

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. These modifications regulate gene expression without altering the sequence or structure of DNA.

DNA 52

DNA Gene Gene Silencing Genome 52

Drug Discovery World

OCTOBER 17, 2023

BN : Our bodies consist of an incredibly complex network of about 35 trillion cells divided into as many as 300 cell types that fulfil distinct roles in development, homeostasis, and disease. This limits its efficacy in later stages of drug development or in the discovery and characterisation of biomarkers.

Gene Expression 52

Gene Expression Drugs Protein Gene 52

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly.

Genome 40

Genome Genomics Genetics Gene 40

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. ASOs are short single-stranded nucleotides that bind to specific messenger RNAs and prevent the production of a particular protein.

RNA 40

RNA Protein Genetics Gene Expression 40

Delveinsight

JULY 30, 2020

The Swiss pharma, Roche, is handing over USD 120 million upfront for the right of UCB’s anti-tau antibody development. The drug, UCB0107, is designed to impede or decrease the buildup of tau proteins in the brain, which leads to nerve cell damage and death. Omega Therapeutics is getting a USD 85 million cash boost.

Genome 52

Genome Genomics Antibody Gene 52

Drug Discovery World

DECEMBER 15, 2022

Gene editing tools such as zinc finger nucleases, transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeat (CRISPR) nucleases have been heralded for their enormous potential to treat diseases and genetic disorders. In one example, Choi et al.

Gene Editing 52

Gene Editing Gene In-Vivo Genome 52

Drug Discovery World

JANUARY 23, 2023

Kevin Hemphill, R&D Manager at PerkinElmer’s Horizon Discovery explores how base editing has emerged as an attractive gene editing option for researchers wanting to develop stem cell-based therapies. Adult fibroblasts were cultured in a cocktail of transcription factors to reactivate embryonic gene expression patterns 2.

Gene Editing 52

Gene Editing Gene Engineer DNA 52

The Pharma Data

OCTOBER 19, 2020

The Submission is the output of five years’ work including extensive dialogue with FDA, and the development of over 400 technical reports and documents, which have been submitted to FDA. This is important because cancer develops and changes over time and there is a clear medical need for up-to-date information on the status.

Protein 40

Protein Gene Expression RNA DNA 40

The Pharma Data

DECEMBER 27, 2020

The drug is a humanized IgG4 monoclonal antibody that blocks CCR5 and is being developed for COVID-19, HIV and metastatic triple-negative breast cancer. The drug is a topical ointment applied to the lower lid to address the build-up and shedding of proteins at the opening of the Meibomian gland. Non-COVID-19-Related.

Trials 52

Trials Antibody Gene Therapy Clinical Trials 52

XTalks

DECEMBER 24, 2020

Focusing on biologics, vaccine development and policy platforms in anticipation of an eventual outbreak is why we’re where we are today in terms of the positive side [of the pandemic].”. The spike protein is critical for binding to ACE2 receptors on host cells — this interaction mediates the entry of the virus into cells.

Life Science 111

Life Science Vaccination Vaccine Gene 111