pharmaphorum

DECEMBER 3, 2020

Germany’s Merck KGaA has joined with UK-based Artios Pharma in a potential multi-billion dollar deal to investigate novel DNA damage response targets in cancer. The principle of DNA damage response is already being exploited by AstraZeneca and other companies with their poly (ADP-ribose) polymerase (PARP) inhibitor drugs.

DNA 94

DNA Research Genetics Sales 94

Scienmag

JULY 19, 2022

Scientists have found that non-coding ‘junk’ DNA, far from being harmless and inert, could potentially contribute to the development of cancer. Their study has shown how non-coding DNA can get in the way of the replication and repair of our genome, potentially allowing mutations to accumulate.

DNA 68

DNA Genome Genomics Scientist 68

XTalks

DECEMBER 14, 2022

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

Gene Editing 98

Gene Editing DNA Gene Gene Sequencing 98

Scienmag

SEPTEMBER 13, 2021

DNA is the instruction manual for every living organism, guiding the development and functioning of all biological processes. In essence, it is a molecule with a double helix structure with each unit of a helix containing what are known as “DNA bases”.

DNA 62

DNA Scientist Containment Development 62

STAT News

NOVEMBER 30, 2022

The scientists sent the blood 950 miles east to Massachusetts General Hospital in Boston, to a tiny lab (recently converted from a storeroom) where a 28-year-old postdoc named James Gusella and his 23-year-old research technician, Rudolph Tanzi, got to work.

Genetics 111

Genetics Scientist DNA Gene 111

Scienmag

DECEMBER 7, 2020

Credit: CSHL Cold Spring Harbor Laboratory (CSHL) scientists developed the world’s first mobile genome sequence analyzer, a new iPhone app called iGenomics. By pairing an iPhone with a handheld DNA sequencer, users can create a mobile genetics laboratory, reminiscent of the “tricorder” featured in Star Trek.

DNA 74

DNA Genome Genomics Genetics 74

STAT News

OCTOBER 3, 2022

A Swedish scientist won the 2022 Nobel Prize in medicine or physiology on Monday for his groundbreaking research into the evolutionary history of humankind. Pääbo unlocked scientists’ understanding of how genes from these extinct relatives have been passed down to present-day humans.

Medicine 142

Medicine Research Contamination DNA 142

Scienmag

MAY 6, 2021

Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Credit: St. Jude Children’s Research Hospital St.

Gene Expression 97

Gene Expression Regulation Gene DNA 97

XTalks

APRIL 29, 2021

While ARV-based treatments work well to keep the virus suppressed and patients healthy — some for many years — resistance to one or more drugs in a treatment regimen can develop in some patients. HIV drug resistance occurs when virions develop mutations that make them less susceptible to given drugs. HIV Drug Resistance Testing.

DNA 98

DNA Drugs RNA Genotype 98

Scienmag

MAY 2, 2022

WINSTON-SALEM, NC – May 2, 2022 — Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.

Gene Editing 58

Gene Editing DNA Gene Development 58

Scienmag

JANUARY 11, 2022

Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Scientists at St. Jude Children’s Research Hospital studied the Vsx2 super-enhancer and its role in the development of the retina. Their assessment showed the super-enhancer has four […].

Development 80

Development DNA Gene Protein 80

Scienmag

MAY 17, 2022

These small, circular DNA molecules are used by scientists to introduce new genes into a target organism. Plasmids have extensive use in basic and applied biology. Well known for their applications in the production of therapeutic proteins like insulin, plasmids are broadly used in the large-scale production of many bioproducts.

Production 90

Production Insulin Development DNA 90

Pharma Mirror

APRIL 21, 2024

With the rapid development of biotechnology and molecular medicine, the introduction of mRNA as a vaccine or therapeutic agent enables the production of almost any desired functional protein/peptide within the human body.

In-Vitro 130

In-Vitro Drugs Genetic Disease RNA 130

Scienmag

FEBRUARY 23, 2021

CRISPR gene editing has transformed research, but it is not perfect, and can sometimes target unintended genes; to watch CRISPR enzymes respond to different genes, Leipzig University researchers developed a new method using DNA origami and were able to me Credit: Image courtesy of Julene Madariaga Marcos.

DNA 56

DNA Gene Gene Editing Scientist 56

Scienmag

APRIL 27, 2022

CHAPEL HILL, NC – Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Then, organs develop and hopefully function properly.

Scientist 83

Scientist Gene RNA Protein 83

Scienmag

DECEMBER 8, 2021

Researchers at the University of Missouri, led by Praveen Rao, are developing a free, online resource that could help scientists accelerate their discoveries for various human diseases — such as sickle cell disease, cystic fibrosis, and even COVID-19 — by analyzing human genomes three times faster than currently available methods.

DNA 80

DNA Genome Genomics Scientist 80

Scienmag

JANUARY 12, 2022

Pacific time to coincide with the study’s publication in The New England Journal of Medicine Media contact: Hanae Armitage at (650) 725-5376 (harmitag@stanford.edu) Fastest DNA sequencing technique helps undiagnosed patients find answers in mere hours A new ultra-rapid genome sequencing approach developed by Stanford Medicine scientists and their collaborators (..)

DNA 62

DNA Genome Genomics Scientist 62

STAT News

FEBRUARY 7, 2023

From the color of our eyes to our odds of developing cancer, we’re all shaped by the genetic legacy of our ancestors. Both these modifications and their metabolic effects were shown to have passed down for at least three to six generations — something scientists once assumed was impossible. Read the rest…

Gene 105

Gene DNA Genetics Scientist 105

Scienmag

MAY 11, 2021

Scientists investigate the evolution of Mimivirus, one of the world’s largest viruses, through how they replicate DNA Credit: Indian Institute of Technology Bombay 2003 was a big year for virologists.

DNA 52

DNA Scientist Gene Engineer 52

BioTech 365

MAY 14, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists reveal unprecedentedly versatile new DNA staining probe.A

DNA 40

DNA Scientist Development Research 40

Medical Xpress

FEBRUARY 2, 2023

A new microfluidic device developed by scientists in Switzerland can detect the SARS-CoV-2 virus with high accuracy and speed, using a unique DNA/RNA duplex technology. The device could prove to be a game-changer in the fight against the ongoing COVID-19 pandemic.

RNA 87

RNA DNA Scientist Development 87

BioTech 365

FEBRUARY 17, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: First videos to show the helix of ‘dancing DNA’ developed by scientists.Videos allowing us to see for the first time how small circles of DNA adopt dance-like … Continue reading →

DNA 40

DNA Development Scientist Research 40

STAT News

OCTOBER 5, 2022

Scientists rely on gene synthesis technologies as a research tool for everything from basic research to vaccine development and drug target identification. Ever since the inception of gene synthesis, there have been concerns about possible misuse of synthetic genes.

Gene 98

Gene DNA Engineer Scientist 98

Pharmaceutical Technology

FEBRUARY 3, 2023

With scientists fervently developing mRNA vaccines, nucleic acid therapeutics, and viral vector-based gene therapies, clinicians are set to have a growing number of tools available to treat a wide range of conditions, from infectious diseases to genetic disorders and more. The field of genomic medicine has reached a true turning point.

Genome 244

Genome Genomics Medicine Gene Therapy 244

Scienmag

DECEMBER 29, 2020

Method will help researchers better understand mitochondrial DNA diseases LOS ANGELES — Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells.

Scientist 40

Scientist Development DNA Genetics 40

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. Viral vectors have traditionally been used in gene editing where the shells of viruses carry the template DNA into cells, but this method has its disadvantages.

Gene Editing 98

Gene Editing DNA Gene Genome 98

Pharmaceutical Technology

FEBRUARY 16, 2023

Rather than viewing ageing as an inevitability, scientists are beginning to perceive it as a disease, one that could be treated, halted, or even reversed. These primarily include oxidative stress caused by the accumulation of reactive oxygen species, telomere shortening, and deoxyribonucleic acid (DNA)/histone methylation patterns.

Insulin 130

Insulin DNA Genetics Life Science 130

Scienmag

SEPTEMBER 23, 2021

Scientists at the University of East Anglia (UEA) have identified a way of determining the age of a lobster based on its DNA. Credit: Dr Martin Taylor – University of East Anglia Scientists at the University of East Anglia (UEA) have identified a way of determining the age of a lobster based on its DNA. […].

DNA 52

DNA Development Scientist Research 52

Scienmag

FEBRUARY 11, 2021

Study in The CRISPR Journal reports the app advances CRISPR gene therapy R&D; 18-year-old software savant helped lead the app’s development Wilmington, DE, Feb. 11, 2020 -Scientists have developed an affordable, downloadable app that scans for potential unintended mistakes when CRISPR is used to repair mutations that cause disease.

Gene 73

Gene Gene Therapy DNA Scientist 73

Scienmag

SEPTEMBER 22, 2020

Chemists make cellular forces visible at the molecular scale Credit: Microscopy photos by Alisina Bazrafshan Scientists have developed a new technique using tools made of luminescent DNA, lit up like fireflies, to visualize the mechanical forces of cells at the molecular level.

DNA 74

DNA Scientist Development 74

BioTech 365

AUGUST 7, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists use CRISPR to knock down gene messages early in development.Since its discovery, scientists have been using the much-lauded gene editing tool CRISPR to alter the DNA … Continue reading →

Scientist 40

Scientist Gene Gene Editing DNA 40

Pharmaceutical Technology

JUNE 30, 2022

Earlier this month, scientists from Cambridge University and the Madrid-based National Cancer Research Center described a novel framework tracking chromosomal instability and copy number changes in particularly deadly cancers. Studying point mutations gives valuable insight into the development of mutations in cancer.

Genome Project 130

Genome Project Genome Genomics DNA 130

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. Epigenetic Editing with CRISPR. pyogenes dCas9.

DNA 98

DNA Gene Gene Silencing Genome 98

Pharmaceutical Technology

JULY 6, 2022

Scientists at the National Institutes of Health (NIH) unit National Institute of Neurological Disorders and Stroke (NINDS) have found that Covid-19-induced immune response could damage the blood vessels of the brain and may lead to short and long-term neurological symptoms. .

Immune Response 162

Immune Response Antibody Gene DNA 162

Medical Xpress

JANUARY 12, 2023

In addition to DNA sequence, another stable level of molecular information—epigenetic modifications established during development—can affect one's risk of disease. For more than a decade, scientists have studied these epigenetic modifications to test associations with disease.

Genome 74

Genome Genomics DNA Scientist 74

BioTech 365

DECEMBER 7, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: The world’s first DNA ‘tricorder’ in your pocket.Cold Spring Harbor Laboratory (CSHL) scientists developed the world’s first mobile genome sequence analyzer, a new iPhone app called iGenomics.

DNA 40

DNA Genome Genomics Scientist 40

Medical Xpress

MAY 1, 2023

A decade after scientists developed the ability to edit DNA using the CRISPR sequence, the first drugs using the technique are approaching the market, with the potential to transform the lives of people with certain genetic illnesses. But questions of ethics, access, and pricing remain.

DNA 65

DNA Genetics Scientist Marketing 65