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A team of scientists from the universities of Glasgow and Tel Aviv has developed a groundbreaking method to transform the brain parasite Toxoplasma gondii into a potential vehicle for delivering therapeutic treatments directly to brain cells.
In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Key innovation: Leading companies in nanoparticles for drugdelivery. Bristol-Myers Squibb is the leading patent filer in nanoparticles for drugdelivery.
Genentech’s ocular implant drugdeliverysystem for treatment of macular degeneration has received approval from the US Food and Drug Administration (FDA). Susvimo delivers ranibizumab via a port deliverysystem into a surgically placed implant in the eye, allowing for continuous delivery of the drug.
at Northwestern University—has developed novel technology with the potential to change the future of drugdelivery. A team of scientists—led by Yamin Zhang, Ph.D., and Colin Franz, MD, Ph.D., at Shirley Ryan AbilityLab and John Rogers, Ph.D.,
The purpose of writing this review on floating drugdeliverysystems (FDDS) was to The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail.
Interestingly, over the past few years, drugdevelopers focused on non-respiratory diseases have also shifted their attention towards intranasal drug formulations. This can be attributed to ease of delivery, increased bioavailability and by-pass of first-pass metabolism offered by this type of route of administration.
Programmable Oligonucleotide DeliverySystem (PODS), developed by Sixfold Bioscience, is a versatile system which delivers short interfering RNA (siRNA) gene silencing cargo to specific cancer cells.
Furthermore, a wide variety of drugs and macromolecules, including DNA , proteins, and imaging agents, can be encapsulated in liposomal vesicles due to their unique ability to entrap both lipophilic and hydrophilic substances. The various therapeutic applications of liposomes in drugdelivery have been highlighted in the figure.
Ceapro has extended a partnership underway to carry out a further research project with McMaster University for developing an inhalable immuno-therapeutic/-prophylactic for Covid-19-induced lung fibrosis. This project is intended to develop therapies for people suffering from Covid-19’s long-term effects.
Liposomes are concentric bilayer vesicles, which were first developed by Bangham and his colleagues in 1961. They are highly efficient having high drug entrapment capacity. Due to their size, hydrophobic and lipophilic character they are most widely used vehicles for drugdelivery.
Hence, a precision therapy or we can say a target therapy (involving intracellular drugdelivery) is much needed to all the patients suffering from cancer. Here is how the intracellular drugdelivery comes into action for majority of the fatal diseases that requires target therapy. The answer is yes.
In a promising advancement, scientists from the University of North Carolina at Chapel Hill and Emory University have developed a novel drugdeliverysystem using synthetic amyloid beta (AÎ) peptides.
Over the last two decades, the pharmaceutical industry has observed a paradigm shift from conventional drugdelivery strategies to the long-acting drugdelivery (LADD) of products to treat several disease indications, such as ophthalmic disorders, oncological disorders, neurological disorders and infectious diseases.
Elyxyb is a prescription nonsteroidal anti-inflammatory drug (NSAID) used for acute migraine treatment in adult patients with or without aura. It is formulated using a self-micro-emulsifying drugdeliverysystem that improves the drug’s bioavailability and solubility.
CPhI Worldwide will see Gerresheimer showcase its latest developments in primary packaging, drugdeliverysystems for newly developed biologics along with medical and diagnostic products.
Hydrocortisone is under clinical development by Antares Pharma and currently in Phase I for Adrenal Insufficiency. According to GlobalData, Phase I drugs for Adrenal Insufficiency have a 67% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. It is administered by parenteral route.
Scientists have established a new method to image proteins that could lead to new discoveries in disease through biological tissue and cell analysis and the development of new biomaterials that can be used for the next generation of drugdeliverysystems and medical devices.
Decoy-20 is under clinical development by Indaptus Therapeutics and currently in Phase I for Hepatocellular Carcinoma. According to GlobalData, Phase I drugs for Hepatocellular Carcinoma have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. it is administered through intravenous route.
The information contained within the download document is intended for pharmaceutical manufacturers, wholesalers, retailers and distributors, pharmaceutical executives, medical representatives, business development managers, retail salesmen, sales managers, pharmacy executives, and any other individual involved in pharmaceutical marketing.
Amidst the ongoing initiatives to develop therapeutic interventions with improved bioavailability, lipid nanoparticle (LNPs) have specifically attracted the attention of researchers and drugdevelopers. In addition, NLCs offer benefits such as high drug loading capacity, improved drug retention and avoidance of drug expulsion.
Synairgen’s SNG001 among the many potential treatments and vaccines to be delivered via Aerogen’s aerosol drugdeliverysystem Adds to the thousands of COVID-19 patients already safely and effectively treated with Aerogen’s Solo aerosol drugdeliverysystem in the intensive … Continue reading →
However, several drugdelivery devices that enable patients to self-administer their respective medications are now available. Biologics have emerged as a direct consequence of the rapid development that has taken place in the field of life sciences, particularly in cell and molecular biology, over the past few decades.
–(BUSINESS WIRE)–Inflammasome Therapeutics, a private, science-based company developing therapies for prevalent, degenerative diseases as well as sustained-release drugdeliverysystems, announced it has been awarded a $1.0-million million grant to develop a long-term bioerodible birth control implant.
Presently, outsourcing of liposomes development and manufacturing related services has become a popular practice. Drugdevelopers are actively outsourcing their operations to specialized repurposed-based service providers, which are known to have the required capabilities and expertise.
The companies allege Moderna’s vaccine uses their technology for a drug-deliverysystem without permission. Citing The single-dose vaccine candidate is a combination of Pfizer’s mRNA-based flu shot and the Omicron-tailored Covid-19 booster shot developed by both companies.
SHL Medical is a world-leading solutions provider for advanced drugdeliverysystems with a unified purpose to further enable patient independence. The Charleston Regional Development Alliance (CRDA) is supporting SHL Medical by facilitating valuable connections to best-in-class service providers in the area.
In order to promote the use of exosomes in various therapeutic applications including targeted drugdelivery vehicles, engineered exosomes and many more, there are a number of companies that offer services related to the isolation, purification, characterization or quantification of exosomes. Want additional details on the pipeline?
Interestingly, recent advances in this domain have led to the development of several treatment strategies that, according to developers, exhibit the necessary capabilities to overcome challenges posed by traditional oral protein formulations and peptide-based therapies. Oral Protein / Peptide-based Drugs. Web: [link].
CNS drugs treat a range of neurologic and psychiatric disorders, such as psychosis, depression, Parkinson’s disease, multiple sclerosis and epilepsy. Direct CNS administration techniques facilitate drugdelivery to the brain to treat neurological disorders and these approaches are vital for CNS targets. Intrathecal Chemotherapy.
However, research related to metabolites is essential to increase the understanding of molecular level interactions, functions, modifications and regulations in cells, therefore, the field of metabolomics plays a vital role in biomarker discovery for early disease diagnosis and prognosis as well as for drug discovery and development processes.
Healthcare Technology commonly known as ‘Healthtech’ is the usage of technology developed to aid all healthcare related activities or any software or tool specifically designed to provide assistance to healthcare professionals, administrators, managers in the most effortless way possible. DrugDevelopment. Diagnostics.
Register for this free webinar to learn the best practices to successfully incorporate 2022 ISO 11608 methodology to mitigate risk and accelerate time to market in combination product development. The FDA’s Innovation Challenge 2 is centered on developing strategies to lower EtO emissions.
However, certain biological targets have long eluded drugdevelopment efforts. Advances in drug discovery and development technologies / platforms have increased the likelihood of targeting a number of the aforementioned types of biological targets.
Conjugation with a Variety of Molecular Conjugates and Labels The combination of the conjugates / labels with molecules ( proteins, peptides, antibodies and small molecules ) is being used abundantly for several applications, ranging from therapeutics and diagnostics to isolation and characterization of drugdeliverysystems.
Outsourcing offers several benefits to the developers including cost saving opportunities, increased operational efficiencies, expedited time-to-market, access to advanced capabilities and technologies, validated quality control setup, flexibility, risk sharing and, in several cases, regulatory support. Our Social Media Platform. Web: [link].
For instance, if the trial involves a novel drug-deliverysystem, the DSMB might include a pharmaceutical scientist. The Role of DSMB in the COVID-19 Pandemic The importance of DSMBs was highlighted during the COVID-19 pandemic when several vaccines were developed and tested in clinical trials at record speed.
The integration of the blue ocean strategy in healthcare landscape, often known as blue ocean therapy, and its application in medical product development, such as blue ocean medical products, is the silver lining that can revolutionize the industry. This strategy is not a silver bullet; it’s a calculated voyage into uncharted waters.
Furthermore, excipients play a critical role in biologics development by enhancing the solubility and bioavailability, controlling pH and tonicity of the active pharmaceutical ingredients (APIs). The market is dominated by the companies based in developed regions, which account for nearly 75% of biopharmaceutical excipient manufacturers.
Presently, more than 195 mRNA therapeutics / mRNA vaccines are under development or commercialized for the treatment of a variety of indications. Additionally, they also require appropriate drugdeliverysystems to efficiently administer the intervention (in a manner that they can avoid degradation by cellular endonucleases).
The key focus of these studies is on the development of anti-tumor therapeutics. You may also be interested in the following titles: Live Biotherapeutic Products and Microbiome Manufacturing Marke t Next Generation Complement Therapeutics Market Intranasal Therapeutics and DrugDeliverySystems Market. Web: [link].
The company developingdrug product through such an intense process, use to consider container closure system only for packaging of the product. [1] In earlier times, container closure integrity testing was not regarded as an essential step in the process of manufacturing. Our Social Media Platform. Web: [link]. Twitter: [link].
Since the approval of Soliris® in 2007, an anti-C5 antibody, the field of complement drug discovery has gained significant attention. Currently, nine complement therapeutics are commercially available, while around 190 molecules are under development for various disease indications. Next Generation Complement Therapeutics. Web: [link].
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