Remove Development Remove Gene Editing Remove Gene Expression Remove Protein
article thumbnail

Gene editing: beyond the hype

pharmaphorum

Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome. That would just slow the whole field down.

article thumbnail

Gene Therapy and Pharmacokinetics

Camargo

How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19. Gene Expression Considerations.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

This week in drug discovery (2-6 October)  

Drug Discovery World

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

Drugs 52
article thumbnail

AI-designed protein awakens silenced genes, one by one

The Pharma Data

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. These methyl groups must be refreshed so if PRC2 is blocked the genes it has silenced. it can be reawakened.

Protein 52
article thumbnail

Why Women with Alzheimer’s Live Longer and Do Better Than Men with the Disease

XTalks

It helps explain why women with the disease survive longer with less severe symptoms than men during the early stages of the Alzheimer’s, despite having the same levels of toxic amyloid beta and tau proteins in their brains. The gene, called KDM6A , is a histone demethylase that is believed to function as a tumor suppressor.

Gene 89
article thumbnail

Women in Science Who Have Paved the Way Forward in Genetics

XTalks

After several such Nobel Prize snubs for female scientists, 2020 saw the Nobel Prize in Chemistry go to a female scientist duo for the first time for their revolutionary discovery of the CRISPR-Cas9 gene editing system. However, World War II developments led to a change in plans, leading her to serve as a London air raid warden.

Genetics 119
article thumbnail

The Dose: DDW’s drug discovery highlights

Drug Discovery World

DDW highlights the most interesting global news and comments within the drug discovery and development sector this month. . Everyone enjoys a good news story and the drug discovery and development sector is no exception. Those cells can then be safely set loose in the body to find and destroy their target. . “It And finally… .

Drugs 52