pharmaphorum

JANUARY 13, 2022

AstraZeneca has expanded its efforts to develop new therapies targeting transcription factors – proteins that regulate processes in the cell that have become a hot topic for drug discovery in cancer and other diseases. It’s not the big pharma’s first foray into the transcription factor area.

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Protein Gene Expression Gene Regulation 59

The Pharma Data

FEBRUARY 24, 2022

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme.

Scientist 52

Scientist Gene Expression Gene Genomics 52

XTalks

NOVEMBER 6, 2020

Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The gene therapy-based vaccine targets mucosal tissues in the gastrointestinal tract, allowing for greater selectivity and targeted delivery compared to traditional vaccines.

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Clinical Trials Clinical Trials Vaccination Vaccine 75

XTalks

MARCH 13, 2024

Biomarker testing is being pursued to identify biological signs of the disease and provide an approach to develop personalized treatment plans for each patient. As this technology continues to evolve, it is expected to help identify glaucoma in its nascent stages of development.

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Gene Therapy Gene Life Science DNA 111

XTalks

MARCH 7, 2024

Research at SRI International has highlighted the relationship between hormonal changes and sleep disruptions and developed systems to manage hot flashes. Addressing women’s health issues on this day also underscores the critical link between women’s health and broader socio-economic development.

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Genetics Hormones Genomics Genome 115

pharmaphorum

MARCH 10, 2021

Philip Gregory, chief scientific officer at bluebird, said the latest analysis showed that the integration site of the vector was in a gene called VAMP4. VAMP4 has no known association with development of AML or with processes such as cellular proliferation or genome stability that could be linked with cancer.

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Gene Therapy Gene Trials Gene Expression 59

Delveinsight

JANUARY 18, 2021

The first sign of a child suffering from Angelman syndrome is a delay in development, such as the inability to sit without support or making incoherent babbling sounds. Angelman syndrome is a result of the missing or dysfunctional gene known as UBE3A. GeneTx and Ultragenyx are co-developing the therapy.

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Marketing Gene Drugs Protein 52

Roots Analysis

AUGUST 12, 2024

Hybridization Tests – These tests utilize complementary DNA or RNA probes to detect and quantify specific genetic targets, enabling the identification of pathogens, genetic variations, and gene expression patterns. Such test can be used for gene expression profiling, genotyping and detecting chromosomal abnormalities.

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Genetics Gene Expression RNA DNA 40

pharmaphorum

NOVEMBER 22, 2022

The company focuses on so-called ‘undruggable’ targets – those that have defied the efforts of drug developers using conventional treatment approaches.

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Gene Expression Packaging Packaging Medicine 52

The Pharma Data

SEPTEMBER 2, 2021

This process is often described as a ‘seed’ (circulating tumor cell) that must fall on fertile ‘soil’ (metastatic niche) for a new tumor to develop at the distant site. In this way, the scientists were able to observe the development of metastases in the absence of the primary tumor.

Scientist 52

Scientist Gene Expression Antibody Research 52

The Pharma Data

JUNE 14, 2023

Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch. By measuring bacterial gene expression in human tissue samples, the researchers identified a biomarker for the transition. aeruginosa infections.

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RNA Regulation Scientist Bacteria 40

The Pharma Data

OCTOBER 19, 2020

The Submission is the output of five years’ work including extensive dialogue with FDA, and the development of over 400 technical reports and documents, which have been submitted to FDA. This is important because cancer develops and changes over time and there is a clear medical need for up-to-date information on the status.

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Protein Gene Expression RNA DNA 40

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly.

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Genomics Genome Genetics Gene 40

Camargo

JULY 27, 2021

How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19. Gene Expression Considerations.

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Gene Therapy Gene Gene Editing Genetics 238

Pharmaceutical Technology

JUNE 4, 2023

Innovation S-curve for the pharmaceutical industry Transcription factors for genetically modified cells is a key innovation area in the pharmaceutical industry Transcription factors are proteins which control gene expression by controlling the rate of transcription of genetic information from DNA to RNA.

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Genetics Gene Expression DNA Antibody 130

The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. These methyl groups must be refreshed so if PRC2 is blocked the genes it has silenced. it can be reawakened.

Protein 52

Protein Gene Genomics Genome 52

pharmaphorum

JANUARY 29, 2021

“Maybe in 50 years’ time we’ll be using gene editing to lower cholesterol, but it won’t replace statins in anyone but those with life threatening mutations for a long time”. They wanted someone who had lots of experience in drug development, was a molecular biologist, and was stubborn enough to take on CRISPR!” billion in funding.

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Gene Editing Gene Gene Therapy In-Vivo 145

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. It’s a great tool for controlling gene expression.”.

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DNA Gene Gene Silencing Genomics 98

XTalks

MARCH 22, 2021

And as big pharma works on developing and growing their oncology portfolios, the rising trend of such mergers and acquisitions won’t be slowing down any time soon. Resolution has been a leader in the development of NGS-based companion diagnostics (CDx) test development and registration services for precision oncology.

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Life Science Development Marketing Gene Expression 110

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. ASOs are short single-stranded nucleotides that bind to specific messenger RNAs and prevent the production of a particular protein.

RNA 40

RNA Protein Genetics Gene Expression 40

XTalks

OCTOBER 8, 2024

Their breakthrough revealed a previously unknown mechanism by which genes are controlled that is essential for the development and function of multicellular organisms, including humans. A gene contains instructions within our DNA. This control plays a critical role in development and cellular function.

Regulation 52

Regulation Genetics Scientist RNA 52

Roots Analysis

AUGUST 31, 2023

Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. There are various regulatory proteins or transcription factors that are responsible for affecting the transcription rate.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40

XTalks

JUNE 18, 2024

In a field quickly gaining attention for its role in vaccine development and personalized medicine, Elixirgen Therapeutics stands out through its pursuit of innovation and safety. Founded in Baltimore, Maryland, a vibrant science hub, Elixirgen Therapeutics emerged from a vision to harness the untapped potential of mRNA technology.

Protein 52

Protein RNA Genetics Gene Expression 52

XTalks

AUGUST 12, 2020

The identification of T cells that essentially ‘hide’ the virus has significant implications for developing therapeutic strategies to improve the treatment and long-term management of HIV. Fucosylation is the attachment of a specific sugar molecule called fucose to proteins on the surface of cells. T Cell Glycomic Signatures in HIV.

RNA 52

RNA Protein DNA In-Vivo 52

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. These modifications regulate gene expression without altering the sequence or structure of DNA.

DNA 52

DNA Gene Gene Silencing Genomics 52

Roots Analysis

JANUARY 14, 2024

With the increased interest and gradual shift of investment from small molecule drugs to biologics and the establishment of several biologics manufacturing companies / biologics CMOs, more than 250 biologic therapies and vaccines have been developed, globally. Mammalian cell cultures offer stability and are preferred for long term usage.

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Contract Manufacturing Protein Manufacturing Production 40

The Pharma Data

AUGUST 3, 2021

senior vice president, Hematology Development, Bristol Myers Squibb. “As As always, our efforts across blood cancer research and development remain centered on delivering better outcomes for patients in need.”. HDACs also deacetylate non-histone proteins, such as transcription factors.

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In-Vitro Nurses Gene Expression Medicine 52

XTalks

FEBRUARY 11, 2021

However, World War II developments led to a change in plans, leading her to serve as a London air raid warden. She developed expertise in X-ray crystallography, which came to serve as the foundation of her revolutionary DNA work. Franklin studied physical chemistry at Newnham College, University of Cambridge, graduating in 1941.

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Genetics DNA Genomics Genome 119

XTalks

SEPTEMBER 21, 2020

It helps explain why women with the disease survive longer with less severe symptoms than men during the early stages of the Alzheimer’s, despite having the same levels of toxic amyloid beta and tau proteins in their brains. The gene, called KDM6A , is a histone demethylase that is believed to function as a tumor suppressor.

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Gene Protein Gene Expression Scientist 89

Delveinsight

JULY 30, 2020

The Swiss pharma, Roche, is handing over USD 120 million upfront for the right of UCB’s anti-tau antibody development. The drug, UCB0107, is designed to impede or decrease the buildup of tau proteins in the brain, which leads to nerve cell damage and death. Omega Therapeutics is getting a USD 85 million cash boost.

Genomics 52

Genomics Genome Antibody Gene 52

The Pharma Data

DECEMBER 27, 2020

The drug is a humanized IgG4 monoclonal antibody that blocks CCR5 and is being developed for COVID-19, HIV and metastatic triple-negative breast cancer. The drug is a topical ointment applied to the lower lid to address the build-up and shedding of proteins at the opening of the Meibomian gland. Non-COVID-19-Related.

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Trials Antibody Gene Therapy Gene 52

XTalks

DECEMBER 24, 2020

Focusing on biologics, vaccine development and policy platforms in anticipation of an eventual outbreak is why we’re where we are today in terms of the positive side [of the pandemic].”. The spike protein is critical for binding to ACE2 receptors on host cells — this interaction mediates the entry of the virus into cells.

Life Science 111

Life Science Vaccination Vaccine Gene 111

The Pharma Data

MAY 13, 2021

Fructose as a key player in the development of fatty liver disease. How does brain insulin resistance develop in Alzheimer’s disease? Effect of Glucocorticoid-Induced Insulin Resistance on Follicle Development and Ovulation. Dietary Fructose and Metabolic Syndrome and Diabetes. The Journal of Nutrition. 2009;139(6):1263S-1268S.

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Insulin Production Hormones Medicine 52