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Genetic analysis uncovers shared evolutionary history of fish fins and vertebrate limbs

Scienmag

Those appendages vary greatly in size, shape, and function, of course — from fins to wings, arms, and legs — but a new genetic analysis shows that genes that control development at the ends of the appendages share a deep evolutionary history. All vertebrates have the same basic body plan: head, spine, four appendages.

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International Women’s Day 2024: A Spotlight on 5 Women’s Health Webinars with Xtalks

XTalks

Research at SRI International has highlighted the relationship between hormonal changes and sleep disruptions and developed systems to manage hot flashes. Addressing women’s health issues on this day also underscores the critical link between women’s health and broader socio-economic development.

Genetics 115
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Hope in sight with Apellis’ pegcetacoplan OAKS/DERBY results for GA

pharmaphorum

It’s one of the most common causes of blindness across Europe and across the United States, and many developed countries around the world. That’s why there’s a lot of interest around this particular molecule and around this development programme.”. When we do that, we call it a perilesional analysis. About the interviewee.

Genetics 105
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What Do Patients Have to Say about Gene Therapy Trials? An Upcoming FDA Public Meeting to Hear from Patients and Caregivers

FDA Law Blog

Valentine — Incorporating patient and caregiver experiences into every phase of drug development has become increasingly prioritized during both development and review ( see, e.g. , previous coverage here ). At least some (if not all) of the panelists will have had experience participating in gene therapy trials. By Larry J.

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Genes Help Explain Role of Race in Prostate Cancer Risk

The Pharma Data

In doing so, dozens more risk factors that could better help pinpoint the odds of developing prostate cancer have been uncovered. The study — described as the most diverse genetic analysis for prostate cancer ever — included men of African, Asian, Hispanic and European ancestry. Known variations now number 269.

Gene 52
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Immunotherapies could target aggressive pancreatic cancer, research indicates

The Pharma Data

Comparing four separate forms of the disease, they found that samples of the most aggressive form, known as metastases-like primary tumours, saw changes in activity of 74 immune-related genes, compared with changes in only 12 in the more benign insulinoma-like tumours.

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Beam makes USD 120M bet; GRAIL and Quest announce the collaboration; Brain organoids mimic infant’s brains; Improvement in T cells to kill cancer

Delveinsight

Beam Therapeutics has taken over a startup whose technology could proffer the biotech’s genetic medicines to more tissues in the body, widening the potential to approach more diseases. The gene-editing technologies, which have reached the clinic, CRISPR, zinc finger nucleases, and TALENs, make their edits by nicking DNA at the target site.

DNA 52