Drug Discovery World

NOVEMBER 17, 2022

Researchers have identified 35 genes associated with long-term Lyme disease that could potentially be used as biomarkers to diagnose patients with the condition. . As part of the study, RNA sequencing was conducted using blood samples from 152 patients with symptoms of post-treatment Lyme disease to measure their immune response. .

Genetics 52

Genetics RNA Immune Response Bioinformatics 52

Camargo

JULY 27, 2021

How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Similarly, DNA molecules can be genetically modified and introduced into human cells, or individual patient cells can be genetically modified and reintroduced to the body. PK Planning for Gene Therapy Development Programs.

Gene Therapy 238

Gene Therapy Gene Gene Editing Genetics 238

Worldwide Clinical Trials

JUNE 21, 2024

The 2024 ASCO Annual Meeting from the American Society of Clinical Oncology is a fantastic platform for clinical researchers to discuss the latest advancements and challenges in oncology research. Currently, there are 12 approved ADC drugs, and several hundred more are in the development pipeline.

Antibody 162

Antibody Clinical Trials Clinical Trials In-Vitro 162

Drug Discovery World

AUGUST 7, 2023

Evox Therapeutics has agreed a research collaboration and option agreement with the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) in New York, NY, US. The collaboration will work on developing exosome-encapsulated AAV (exoAAV) vectors as a novel gene delivery technology aimed at improving treatments for heart disease.

Gene Therapy 52

Gene Therapy Gene Research In-Vivo 52

Drug Discovery World

OCTOBER 4, 2023

By analysing gene interactions in mice subjected to behavioural tests, the researchers from Korea University Anam Hospital, Konkuk University, and Sahmyook University identified 141 genes primarily linked to immune responses correlating with depressive behaviours.

Research 52

Research Gene DNA Gene Expression 52

Drug Discovery World

JULY 5, 2023

Global Cancer Segment Market Manager at Agilent Technologies, recently sat down with DDW Editor Reece Armstrong to tell us about the developments in the ‘golden age’ of cancer research. MG: I am responsible for Agilent’s cancer segment. RA: What is the current state of the cancer research industry? Mark Garner, PhD.,

Research 98

Research Protein Scientist Immune Response 98

Drug Discovery World

MAY 9, 2023

Jantzen Sperry , PhD, Director of Scientific Operations at Certis Oncology looks at how the adoption of orthotopic PDX models can elevate the impact of cancer research and improve translation in oncology drug development. Mice have long been heroes of preclinical cancer research.

Development 52

Development Drugs In-Vivo Clinical Trials 52

Drug Discovery World

MAY 23, 2024

A team of scientists in the US and the UK are combining a genetically modified cold sore virus with a cancer vaccine to treat an aggressive type of brain cancer in children. The researchers will use a genetically engineered herpes simplex virus type 1 to eliminate cancer cells. million of funding for this research project.

Genetic Engineering 59

Genetic Engineering Engineer Immune Response Vaccination 59

pharmaphorum

OCTOBER 12, 2022

Now, he leads Whitelab Genomics as its artificial intelligence (AI) platform powers the development of genomic therapies – an emerging field in which genetic sequences are injected into cells to target and repair damaged genes. We have been very impressed by their vision and the relevance of their platform.”.

Genome 90

Genome Genomics Medicine Development 90

Scienmag

JUNE 27, 2021

A new vaccine to protect against deadly cholera has been made by grinding up genetically modified grains of rice. The first human trial has shown no obvious side effects and a good immune response. Researchers based […].

Vaccination 72

Vaccination Vaccine Immune Response Trials 72

Scienmag

JUNE 2, 2021

When pigs get hit with significant illnesses during key stages of pregnancy, their immune response may negatively affect developing piglets, making them less productive on the farm. Credit: University of Illinois URBANA, Ill.

Immune Response 98

Immune Response Production Development Research 98

Scienmag

OCTOBER 9, 2020

Findings could lay the foundation for the development of effective therapeutic and malaria vaccine strategies, which has largely been hindered by a lack of understanding of the host immune response Credit: Aissatou Diawara Abu Dhabi, UAE, October 9, 2020: The Plasmodium parasite, which transmits malaria to humans through infected mosquitos, triggers (..)

Immune Response 52

Immune Response Gene Research Vaccination 52

Drug Discovery World

JULY 5, 2023

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. Join DDW for this exclusive free event, Comparing immune-humanized platforms: Which one is best for my application?

Immune Response 52

Immune Response Genetics Regulation Development 52

Drug Discovery World

JUNE 28, 2023

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. Join DDW for this exclusive free event, Comparing immune-humanized platforms: Which one is best for my application?

Immune Response 52

Immune Response Genetics Regulation Development 52

Drug Discovery World

JUNE 21, 2023

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. Join DDW for this exclusive free event, Comparing immune-humanized platforms: Which one is best for my application?

Immune Response 52

Immune Response Genetics Regulation Development 52

XTalks

MAY 30, 2023

Established by the Multiple Sclerosis International Federation (MSIF) in 2009, World MS Day has quickly grown to be an influential movement that brings together various stakeholders that include patients and caregivers, researchers and healthcare professionals across more than 90 countries.

Genetics 98

Genetics Research Immune Response Drugs 98

Drug Discovery World

JUNE 14, 2023

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. Join DDW for this exclusive free event, Comparing immune-humanized platforms: Which one is best for my application?

Immune Response 52

Immune Response Genetics Regulation Development 52

Drug Discovery World

JUNE 8, 2023

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. Join DDW for this exclusive free event, Comparing immune-humanized platforms: Which one is best for my application?

Immune Response 52

Immune Response Genetics Regulation Development 52

XTalks

FEBRUARY 19, 2024

In a recent study published by Weill Cornell Medicine in the Journal of Infectious Diseases , researchers have reported the potential of Moderna’s experimental mRNA vaccine in protecting adults against CMV, which could potentially also stop the transmission of the virus from mothers to their infants during pregnancy.

Vaccination 59

Vaccination Vaccine Trials Clinical Trials 59

Pharmaceutical Technology

FEBRUARY 15, 2023

The key component in all vaccines is one or more active ingredients made from viruses or bacteria, also called antigens, which generates an immune response. The active component of the Pfizer-BioNTech vaccine tozinameran, contains the genetic code for the coronavirus spike protein, inside a lipid (fat) capsule.

Vaccination 130

Vaccination Vaccine Containment Immune Response 130

XTalks

NOVEMBER 6, 2020

Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The bacterium then secretes pDNA-protein complexes, triggering an immune response to treat and prevent infection associated with the delivered genes.

Clinical Trials 75

Clinical Trials Clinical Trials Vaccination Vaccine 75

Cloudbyz

MARCH 6, 2024

For example, monoclonal antibodies, a type of biologic, can selectively bind to specific targets such as proteins or cells involved in disease processes, thereby modulating immune responses or inhibiting disease progression. Challenges and Future Directions: Despite their immense promise, biologics are not without challenges.

Gene 83

Gene Immune Response Manufacturing Gene Therapy 83

The Pharma Data

NOVEMBER 30, 2020

Nasdaq: NVAX), a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, today provided an update on its COVID-19 vaccine program. Vaccines Taskforce and National Institute for Health Research played pivotal roles in the rapid recruitment and enrollment of volunteers. GAITHERSBURG, Md.,

Clinical Development 52

Clinical Development Vaccination Vaccine Development 52

The Pharma Data

APRIL 8, 2022

The mere motions of breathing are known to influence vital functions of the lungs, including their development in babies, the production of air-exchange-enhancing fluid on their inner surfaces, and maintenance of healthy tissue structure. a Wyss Technology Development Fellow at the Institute. During his Ph.D.

Immune Response 52

Immune Response In-Vivo Genetic Analysis Research 52

The Pharma Data

MARCH 8, 2022

SARS-CoV-2 viruses can hide from recognition by the immune system. However, the antiviral immune receptor RIG-I can be stimulated, which improves protection against lethal SARS-CoV-2 infections. Researchers led by Prof. Its absence is associated with disease progression and the development of severe COVID-19,” Prof.

Immune Response 52

Immune Response RNA Protein Genetics 52

Drug Discovery World

JULY 26, 2022

ahin and will provide an overview on the scientific groundwork, key discoveries, inventions, and technological solutions that have paved the development and clinical application of highly potent, personalised mRNA cancer vaccines. . Lecture – Project Lightspeed – The discovery of the first Covid-19 mRNA Vaccine 11:30AM (BST) .

Vaccination 52

Vaccination Vaccine Immune Response Antibody 52

Olympian Clinical Research

NOVEMBER 30, 2023

Vitiligo, characterized by the loss of skin pigment and the formation of white patches, has been a subject of medical intrigue and research for decades. It occurs when melanocytes, the cells responsible for skin pigmentation, are destroyed or stop functioning.

Clinical Research 52

Clinical Research Clinical Trials Clinical Trials Immune Response 52

Drug Discovery World

FEBRUARY 6, 2023

WM : Infinimmune is an early-stage antibody biotechnology company, focused on reinventing antibody drug discovery by developing human-derived antibody drugs. We couldn’t walk away from the opportunity to apply our skills to impactful problems in drug development! We do this by studying B cells from human blood and tissue.

Antibody 52

Antibody Immune Response Genome Genomics 52

pharmaphorum

FEBRUARY 23, 2022

The Japanese drugmaker will get access to Code Bio’s 3DNA non-viral genetic medicine delivery platform, initially for a liver-directed programme, and is also interested in deploying the technology for central nervous system disorders.

Gene Therapy 95

Gene Therapy Gene Gene Sequencing Immune Response 95

Drug Discovery World

JULY 17, 2023

Paul Denslow , CEO, Intus Bio, discusses how a new approach to tracking gut bacteria can revolutionse our understanding of the microbiome and bring about new discoveries for therapeutics. It’s a long-held doctrine that there’s no effective method to track the microbiome during drug research and development.

Bacteria 52

Bacteria Drugs Gene Immune Response 52

XTalks

MAY 1, 2023

This makes Qalsody the first approved treatment to target a genetic cause of ALS. Tofersen was discovered by Ionis Pharmaceuticals, and Biogen licensed tofersen from Ionis under a collaborative development and license agreement. To date, over 200 mutations in the SOD1 gene have been associated with the development of ALS.

FDA Approval 89

FDA Approval Gene Genetics Protein 89

The Pharma Data

JULY 6, 2021

But HIV’s ability to mutate isn’t unique among RNA viruses – most viruses develop mutations, or changes in their genetic code, over time. Half of the recovered COVID-19 patients studied had T cell responses to highly networked epitopes identified by the research team. 1.351 Beta, P1 Gamma, and B.1.617.2

Vaccination 52

Vaccination Vaccine Research Immune Response 52

pharmaphorum

FEBRUARY 18, 2021

Researchers from the University of Texas Medical Branch based their findings on lab tests using SARS-CoV-2 coronaviruses that were genetically engineered to have the same mutations as those in the strain that is causing scientists so much concern.

Immune Response 52

Immune Response Genetic Engineering Vaccination Vaccine 52

The Pharma Data

NOVEMBER 16, 2020

16, 2020 — Scientists are reporting early success with an experimental herpes vaccine that uses a genetically modified version of the virus. The gene edit prevents the virus from performing its normal evasive maneuver: hiding out in nervous system cells in order to elude the immune system. The researchers are working on that.

Vaccination 52

Vaccination Vaccine Immune Response Genetics 52

XTalks

JUNE 15, 2022

The Novavax candidate NVX-CoV2373 is a protein-based vaccine developed using recombinant nanoparticle technology. protein that triggers the immune system to generate antibodies against the virus. protein that triggers the immune system to generate antibodies against the virus. Novavax Vaccine Research.

Vaccination 59

Vaccination Vaccine Immune Response Protein 59

XTalks

NOVEMBER 30, 2023

Over the last 35 years, substantial strides have been made in tackling HIV/AIDS, propelled by advancements in medical research, enhanced accessibility to treatment and prevention and a more comprehensive understanding of the virus. World AIDS Day offers an occasion for reflection on the strides achieved thus far.

FDA Approval 111

FDA Approval Gene Therapy Clinical Trials Clinical Trials 111

Drug Discovery World

JULY 25, 2023

Background Lymphocyte-activation gene 3, or LAG-3, is a gene that provides the genetic information to make a cell surface molecule with biologic effects on T-cell function. Triebel founded Immutep SA in 2001 to develop the clinical potential of LAG-3 and stayed with this company through to its acquisition by Prima BioMed in 2014.

Immune Response 98

Immune Response Gene Protein Antibody 98