The Pharma Data

MARCH 7, 2022

Decision Regarding Slick-Haired Cattle is Agency’s First Enforcement Discretion Decision for an Intentional Genomic Alteration in an Animal for Food Use. The IGA results in the equivalent genotype (genetic make-up) and short-hair coat trait seen in some conventionally bred cattle, known as a “slick” coat. Today, the U.S.

Genomics 52

Genomics Genome Production Marketing 52

pharmaphorum

JANUARY 29, 2019

How the shift towards cancer as a phenotype/genotype is being applied in clinical trials and how they are run •What are co-clinical trials and why could they hold the key to answering unmet need in cancer treatment and beyond into broader drug development? What are the implications from these changes for clinical trials?

Genomics 52

Genomics Genome Medicine Clinical Trials 52

Bioengineer

JANUARY 16, 2024

Often, the loss of T790M is associated with the development of alternative competitive resistance mechanisms. not reached) in genomic analysis of post-progression samples from patients receiving second-line osimertinib. T790M loss has been linked to earlier resistance and poorer survival in other cohorts. months, 95% CI 1.3,

Genomics 119

Genomics Genome Protein In-Vitro 119

XTalks

JANUARY 21, 2025

TriClip G4 System Manufacturer/developer : Abbott Medical Date of FDA approval : April 1, 2024 Approved for : Tricuspid regurgitation (TR). Abbott Spinal Cord Stimulation (SCS) Systems Manufacturer/developer : Abbott Medical Date of FDA approval : May 30, 2024 Approved for : Chronic, hard-to-manage pain in the torso, arms and legs.

FDA Approval 105

FDA Approval Manufacturing Development RNA 105

Worldwide Clinical Trials

DECEMBER 12, 2022

Genetic testing provides patients with a diagnosis for their illness, helps patients and family members to understand risks of developing new diseases, and can be used to support clinical trial advancement. Why is the turnaround time for whole-genome sequencing and whole-exome sequencing (WES/WGS) longer than a single-gene or panel test?

Clinical Trials 130

Clinical Trials Clinical Trials Genetics Trials 130

pharmaphorum

JANUARY 24, 2023

Drug development has long been an issue for the pharma industry, due to the expense and the high failure rate of potential treatments. Ben Hargreaves finds that the vast amount of genetic data that exists today could help provide a faster, more targeted way of developing new drug candidates.

Genetics 98

Genetics Drugs Genome Project Biobanking 98

pharmaphorum

AUGUST 11, 2022

There have been great strides made in genomics to refine tools that determine the safest, most effective course of treatments for patients across a number of disease states. First, members who opt-in to the program receive a saliva collection kit, which is analysed using newly developed pharmacogenomics technologies.

Genomics 98

Genomics Genome Drugs Genetics 98

pharmaphorum

NOVEMBER 10, 2021

It recommends the National Library of Medicine, which has already published “considerable information” on resistance genes, genome sequences, antimicrobial susceptibility data, and bacterial genomes, establish an open-source, unified AMR database. New agents: Development and accessibility.

Medicine 105

Medicine Genomics Genome Genotype 105

XTalks

APRIL 29, 2021

While ARV-based treatments work well to keep the virus suppressed and patients healthy — some for many years — resistance to one or more drugs in a treatment regimen can develop in some patients. HIV drug resistance occurs when virions develop mutations that make them less susceptible to given drugs. Proviral DNA Genotyping.

DNA 98

DNA Drugs RNA Genotype 98

The Pharma Data

NOVEMBER 18, 2020

18, 2020 — Genetic variants in some patients with inflammatory bowel disease (IBD) are associated with a significantly increased risk for developing thromboembolic disease (TED), according to a study published online Oct. WEDNESDAY, Nov. 21 in Gastroenterology. Takeo Naito, Ph.D.,

Genetics 52

Genetics Genotype Genomics Genome 52

Delveinsight

DECEMBER 13, 2020

Due to hepatitis C, most people develop cirrhosis, or scarring of the liver, before liver cancer; about 5–25% of patients with chronic hepatitis C develop cirrhosis over 10–20 years. Research and development in Hepatitis. 2b) was developed to maintain a steady level of an active drug and reduce the frequency of administration.

Genotype 52

Genotype FDA Approval DNA Drugs 52

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. Nutrigenomics is the science studying the relationship between human genome, nutrition and health.

Genomics 40

Genomics Genome Genetics Gene 40

Advarra

FEBRUARY 28, 2023

For example, the Genomic Data Sharing Policy applies to NIH-funded research generating large-scale human or non-human genomic data. IRBs may be asked to assist the institution in developing general guidelines for DMS plans, or to participate in pre-review of proposed DMS plans prior to NIH funding application.

Research 52

Research Genomics Genome Genotype 52

Roots Analysis

AUGUST 12, 2024

Molecular diagnostic tests are advanced techniques and tools used to analyze biological markers in the genome and proteome. Molecular diagnostic tests refer to tests intended to detect specific sequences in human genomic samples, such as DNA or RNA, in order to diagnose a particular disease. What are Molecular Diagnostic Tests?

Genetics 40

Genetics Gene Expression RNA DNA 40

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Biobanking will continue to play an integral role in accelerating drug discovery and development, which will necessitate access to a larger array of biological samples.

Research 98

Research Biobanking Drugs Genomics 98

The Pharma Data

SEPTEMBER 2, 2021

in the US and Canada) to develop and commercialise Lynparza; with Daiichi Sankyo Company, Limited (Daiichi Sankyo) to develop and commercialise Enhertu and Dato-DXd, and with HUTCHMED to develop and commercialise savolitinib. AstraZeneca is collaborating with MSD (Merck & Co., Lead author. Abstract title. Garassino, MC.

Trials 52

Trials Medicine Antibody Clinical Trials 52

XTalks

APRIL 24, 2023

To achieve this, Medpace works in multi-disciplinary teams of experts to jointly develop and execute advanced therapy protocols. For rare disease studies where there is little or no clinical trial experience, outcome assessments would have to be validated within a clinical development program.

Gene Therapy 95

Gene Therapy Gene Trials Clinical Trials 95

pharmaphorum

FEBRUARY 17, 2022

Identified as the “VB variant,” the virus has proved to be highly virulent and to speed up the progression of a patient developing AIDS faster. Therefore, the risk of developing AIDS more rapidly was higher. ” Researchers used whole-genome data, providing the 17 whole genomes available for the variant.

Genomics 98

Genomics Genome Genetics Genotype 98