XTalks

APRIL 21, 2023

The application of whole genome sequencing (WGS) to derive a more complete understanding of cancer has been a central goal of cancer researchers even before the first human genome was decoded in 2003. Ultima Genomics has already partnered with other leading biotech startups.

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Genomics Genome Bioinformatics Genetics 97

Scienmag

MARCH 10, 2022

Scientists have developed a powerful, inclusive new tool for genomic research that boosts efforts to develop more precise treatments for many diseases by leveraging a better representation of the genetic diversity of people around the world.

Genomics 84

Genomics Genome Research Scientist 84

Pharmaceutical Technology

SEPTEMBER 29, 2022

Scribe Therapeutics and Sanofi have signed a strategic partnership to expedite the development of breakthrough clustered regularly interspaced short palindromic repeats (CRISPR)-based cell therapies for cancer. Scribe is also entitled to receive potential payments worth over $1bn on meeting development and commercial milestones.

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Development In-Vivo Genomics Genome 130

XTalks

MAY 20, 2022

If you enjoy working with biological samples and are enthusiastic about healthcare, a career as a clinical scientist might be just right for you. To start applying to clinical scientist jobs today, head over to the Xtalks Job Search platform. Who is a Clinical Scientist? What is it Like to Work as a Clinical Scientist?

Scientist 105

Scientist Life Science Clinical Research Doctors 105

STAT News

OCTOBER 3, 2022

A Swedish scientist won the 2022 Nobel Prize in medicine or physiology on Monday for his groundbreaking research into the evolutionary history of humankind. Pääbo unlocked scientists’ understanding of how genes from these extinct relatives have been passed down to present-day humans.

Medicine 142

Medicine Research Contamination DNA 142

pharmaphorum

NOVEMBER 23, 2021

Genomics England, the Department of Health and Social Care’s genome-sequencing hub, has this year announced that support for whole genome sequencing (WGS) has reached a level at which its national rollout on the NHS may someday become a reality. Only when genomic databases are diverse can we ensure that we all benefit equally.

Genomics 116

Genomics Genome Genetics Doctors 116

Scienmag

MARCH 11, 2021

The CRISPR-based gene editor, C-to-G Base Editor (CGBE), opens up treatment avenues for up to 40 per cent of genetic disorders caused by single-nucleotide mutations Credit: Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS) A team of researchers from the Agency for Science, Technology and Research’s (A*STAR) (..)

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Gene Scientist Genome Genomics 74

XTalks

NOVEMBER 10, 2020

For more information on tackling this “genomic analysis bottleneck,” watch this on-demand webinar. HS: Due to the heterogeneity of the rare disease population, there are many relevant gene lists, and the genomic data analysis of these patients covers almost 2,000 different genetic targets. ” or “Why is my child different?”

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Genomics Genome Medicine Genetic Disease 98

XTalks

OCTOBER 19, 2023

An assay development scientist combines deep biological and biochemical expertise with practical laboratory skills to develop tests that can answer specific biological questions or drive the drug discovery process. Related: Pharmaceutical Scientist Jobs: What to Know Before Applying What Does an Assay Development Scientist Do?

Scientist 59

Scientist Development Research Compliance 59

STAT News

FEBRUARY 22, 2023

The Cambridge biotech company announced Wednesday that it will partner with Life Edit Therapeutics to develop potentially permanent treatments for rare genetic diseases and other conditions. Moderna is aiming to build a gene editing franchise powered by some of the same technologies used in its COVID-19 vaccines.

Gene Editing 126

Gene Editing Gene Genetic Disease Research 126

Worldwide Clinical Trials

JANUARY 24, 2024

Why Partnering with Genetic Counselors May Benefit Your Clinical Program The American College of Medical Genetics (ACMG) has issued a statement that geneticists should be involved in the development of genetic therapies. As of July 2023, the American Society of Cell + Gene Therapy stated there were 3,905 therapies in development.

Genetics 189

Genetics Trials Clinical Trials Clinical Trials 189

pharmaphorum

OCTOBER 19, 2022

million ($40 million) first-round financing that will be used to explore so-called ‘dark’ regions of the human genome. M Ventures’ Dr Bauke Anninga said that that the startup has a “differentiated platform technology has the potential to fundamentally shift the way we discover and develop precision medicines.

Genomics 59

Genomics Genome Gene Gene Expression 59

Scienmag

OCTOBER 7, 2020

Credit: UC Berkeley Biochemist Jennifer Doudna, a professor at UC Berkeley and faculty scientist at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), is co-winner of the 2020 Nobel Prize in Chemistry for “the development of a method for genome editing.”

Genome 89

Genome Genomics Scientist Development 89

Scienmag

DECEMBER 15, 2020

An international team of Swedish, Norwegian, Danish and Irish scientists has used whole genome sequencing to characterise 53 herring populations from the Atlantic Ocean and the Baltic Sea. They have developed genetic markers that make it possible to better monitor herring populations and avoid overfishing.

Genomics 52

Genomics Genome Genetics Scientist 52

BioTech 365

SEPTEMBER 14, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists can now assemble entire genomes on their personal computers in minutes.Scientists at the Massachusetts Institute of Technology (MIT) and the Institut Pasteur in France have developed … Continue reading → (..)

Genomics 40

Genomics Genome Scientist Development 40

Medical Xpress

JANUARY 12, 2023

Twenty years ago, after the human genome was first sequenced, geneticists began conducting large genome-wide association studies to identify genomic regions linked to human disease. For more than a decade, scientists have studied these epigenetic modifications to test associations with disease.

Genome 74

Genome Genomics DNA Scientist 74

Scienmag

DECEMBER 8, 2021

Researchers at the University of Missouri, led by Praveen Rao, are developing a free, online resource that could help scientists accelerate their discoveries for various human diseases — such as sickle cell disease, cystic fibrosis, and even COVID-19 — by analyzing human genomes three times faster than currently available methods.

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DNA Genome Genomics Scientist 80

BioTech 365

MARCH 11, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists develop novel gene editor to correct disease-causing mutations.A

Scientist 40

Scientist Gene Development Genome 40

pharmaphorum

JANUARY 18, 2023

In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. First, start co-development with participants early on in the process.

Genetic Disease 97

Genetic Disease Genetics Research Genomics 97

Scienmag

MAY 28, 2021

New study used whole genome sequencing to gain further understanding of why some children develop secondary leukaemia after neuroblastoma treatment Scientists from the Wellcome Sanger Institute and the University of Cambridge found that in children with neuroblastoma – a cancer of immature nerve cells – treatment with platinum chemotherapy (..)

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Development Genome Genomics Scientist 49

Scienmag

DECEMBER 7, 2020

Credit: CSHL Cold Spring Harbor Laboratory (CSHL) scientists developed the world’s first mobile genome sequence analyzer, a new iPhone app called iGenomics. By pairing an iPhone with a handheld DNA sequencer, users can create a mobile genetics laboratory, reminiscent of the “tricorder” featured in Star Trek.

DNA 74

DNA Genome Genomics Genetics 74

Medical Xpress

DECEMBER 13, 2022

It was a good year for medical research as Swedish scientist Svante Paabo won the Nobel Prize in medicine for discoveries he made regarding human evolution—he spearheaded the development of new techniques that will allow researchers to compare the genomes of modern humans and that of other hominins such as Neanderthals and Denisovans.

Genome 72

Genome Genomics Scientist Medicine 72

Scienmag

APRIL 4, 2021

Test for rare genomic condition measures disease severity and success of liver transplantation for patients Credit: Ernesto del Aguila III, NHGRI Researchers at the National Institutes of Health have developed a breath test that measures how well patients with methylmalonic acidemia (MMA) respond to receiving liver or combined liver and kidney transplantation. (..)

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Development Scientist Genome Genomics 41

The Pharma Data

OCTOBER 26, 2021

The AVENIO Tumor Tissue Comprehensive Genomic Profiling (CGP) Kit is the first jointly-developed product that brings together the expertise and reach of Roche with Foundation Medicine’s pioneering leadership in genomic science. Cancer is a disease of the genome and treatment no longer depends solely on the tissue of origin.

Genomics 52

Genomics Genome Research Medicine 52

pharmaphorum

SEPTEMBER 9, 2020

Geneticist Dr Charles Steward has spent his career studying the human genome – but his work became much more personal when his children were diagnosed with severe neurological diseases. Charlie told pharmaphorum how his search for a genetic cause has led him to straddle the divide between scientist and patient advocate.

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Genomics Genome Genetics Genome Project 102

Pharmaceutical Technology

JULY 5, 2022

The team also found that the oral compound, RG7834, developed by Hoffmann-La Roche, hindered replication at a crucial step, preventing the virus from infecting liver cells. In addition, the scientists later found that the HAV needs TENT4A/B for its replication.

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Protein RNA Genomics Genome 130

Scienmag

JULY 19, 2022

Scientists have found that non-coding ‘junk’ DNA, far from being harmless and inert, could potentially contribute to the development of cancer. Their study has shown how non-coding DNA can get in the way of the replication and repair of our genome, potentially allowing mutations to accumulate.

DNA 68

DNA Genome Genomics Scientist 68

pharmaphorum

FEBRUARY 25, 2022

A new stem cell model, discovered by researchers exploring the human genome, will help scientists to map out the key genomic changes during early development. Prior to this latest development, research into the human ZGA was limited to human embryos at a later stage of growth, under stringent UK regulations.

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Research Genome Genomics Protein 69

The Pharma Data

NOVEMBER 25, 2021

The International Cancer Genome Consortium (ICGC) is further enabling cancer research worldwide by making a massive collection of cancer data available for analysis via Microsoft’s Azure cloud computing platform. ” ICGC has now moved into its next phase called ICGC ARGO (Accelerating Research in Genomic Oncology).

Genomics 52

Genomics Genome Research Scientist 52

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. It is difficult to control where the viral vectors insert genes in the genome, and it is difficult to manufacture large quantities of clinical-grade viral vectors.

Gene Editing 98

Gene Editing DNA Gene Genomics 98

Scienmag

JUNE 23, 2021

Multiple acquired resistance mechanisms discovered for cancers with KRASG12C mutation after treatment with KRASG12C inhibitors; Results point to need for new drugs targeting KRAS and new combination therapies A new study by Dana-Farber Cancer Institute researchers has given scientists their first look at the genomic landscape of tumors that have grown (..)

Research 53

Research Genome Genomics Drugs 53

pharmaphorum

SEPTEMBER 26, 2022

As the field strives to strike a delicate balance between safety and efficacy, in the context of increased regulatory scrutiny and safety challenges, attending the 4 th Annual Gene Therapy Analytical Development as an analytical scientist has never been so important. Download the full event guide to find out more.

Gene Therapy 52

Gene Therapy Gene Development Bioassay 52

Scienmag

JANUARY 24, 2021

A group of scientists is calling on governments to consider the continued use of strict control measures as the only way to reduce the evolution and spread of new COVID-19 variants.

Genome 74

Genome Genomics Scientist Vaccine 74

Scienmag

NOVEMBER 16, 2020

Singapore scientists uncover potential role of long non-coding RNAs in pancreatic cancer Credit: From Figure 4 in Liu, S., Genome Med 12, 89 (2020). Harmston, N., Glaser, T.L. Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation.

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In-Vivo RNA DNA Genome 53

Scienmag

JANUARY 12, 2022

Pacific time to coincide with the study’s publication in The New England Journal of Medicine Media contact: Hanae Armitage at (650) 725-5376 (harmitag@stanford.edu) Fastest DNA sequencing technique helps undiagnosed patients find answers in mere hours A new ultra-rapid genome sequencing approach developed by Stanford Medicine scientists and their collaborators (..)

DNA 62

DNA Genome Genomics Scientist 62

pharmaphorum

DECEMBER 14, 2020

As the first microbiome-based therapeutic steps closer to market approval, the scientific community continue to demonstrate the functional role of the human microbiome as a novel source of therapeutic, biomarker and diagnostic development. The post 5th Microbiome Movement – Drug Development Summit Europe 2021 appeared first on.

Development 52

Development Drugs Big Data Genomics 52

pharmaphorum

DECEMBER 20, 2022

Genomic profiling has made it possible to diagnose and treat patients with far greater precision. Often, the initial focus is on participating in the data revolution by expanding genomic sequencing capacity, implementing electronic health records (EHRs), and so on.

Genomics 105

Genomics Genome Trials Doctors 105