pharmaphorum

MAY 16, 2022

GLP-1 and GIP are hormones involved in blood sugar control and Mounjaro, a first-in-class medicine that activates both GLP-1 and GIP receptors, demonstrated improved blood sugar control. The findings were made via Lilly’s SURPASS phase 3 global clinical development programme, which comprised studies ranging from 40 to 52 weeks.

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The Pharma Data

AUGUST 17, 2021

approval of pump use for Lilly’s novel insulin is latest development designed to help people with diabetes manage blood sugar levels. Lyumjev, a novel formulation of insulin lispro developed to speed the absorption of insulin into the bloodstream and reduce A1C levels, was approved by the FDA in June 2020.

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XTalks

FEBRUARY 9, 2021

While diabetes is associated with an increased risk of developing severe COVID-19, it appears that the opposite may also be true in that the infection itself may lead to the onset of diabetes. Perhaps an even more perplexing aspect of this diabetogenic effect is the finding that some of the patients developed type 1 diabetes.

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XTalks

MARCH 8, 2021

Lilly and Novo are longtime competitors in the diabetes drug arena, particularly in the development of glucagon-like peptide-1 (GLP-1) receptor agonist drugs. GLP-1 receptor agonists lower blood glucose levels by increasing the production of insulin. GLP-1 acts on GLP-1 receptors on insulin-producing pancreatic ?

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XTalks

JANUARY 16, 2025

It is a complication of Graves disease, an immune system condition that causes the thyroid gland to make excess amounts of thyroid hormone. Linsitinib, an oral small molecule that targets the insulin-like growth factor-1 receptor (IGF-1R), is designed to address the underlying mechanisms driving thyroid eye disease.

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Trials Clinical Trials Clinical Trials Insulin 59

XTalks

SEPTEMBER 15, 2020

A vaccine developed by Swedish company Diamyd Medical has demonstrated significant treatment efficacy in a predefined genetic subgroup of individuals with type 1 diabetes in a Phase IIb clinical trial. Diamyd Medical is a clinical-stage biopharmaceutical company that develops therapies for type 1 diabetes. cells (see video above).

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pharmaphorum

NOVEMBER 9, 2020

billion, as it continues its quest to develop diabetes medicines that can be taken as pills. But the company has tried and failed to produce insulin that can be taken orally – this proved unfeasible due to the high doses of the hormone that were needed for absorption through the gut.

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XTalks

JULY 17, 2024

Sweden-based biotech Camurus shared positive Phase III trial data for CAM2029, one of its lead candidates, in patients with the rare hormonal disorder acromegaly. Octreotide is a synthetic analog of somatostatin, a hormone in the body that inhibits the release of several other hormones, including growth hormone (GH), glucagon and insulin.

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Scienmag

SEPTEMBER 13, 2021

Philadelphia, September 13, 2021—Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin.

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The Pharma Data

FEBRUARY 25, 2021

and Eli Lilly and Company (NYSE: LLY) announced today a collaboration and licensing agreement to integrate Welldoc’s software into Lilly’s connected insulin solutions, currently in development. Lilly will commercialize the pen platform, which will include the new app and Lilly’s connected insulin pen solutions.

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The Pharma Data

MAY 6, 2021

These companies offer unique diabetes management platforms that will be compatible with Lilly ‘s Tempo Pen (approved in several global markets) and Tempo Smart Button (currently in late-stage development) to support people with diabetes and healthcare professionals. About DexCom Inc. DexCom, Inc.

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The Pharma Data

DECEMBER 15, 2020

The Phase III trial evaluated the use of the diabetes vaccine Diamyd ® , an antigen-specific immunotherapy based on the auto-antigen GAD (glutamic acid decarboxylase), to induce immunological tolerance and stop the autoimmune destruction of insulin producing cells.

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The Pharma Data

DECEMBER 17, 2020

7, 2020 — After starting a drug that’s officially approved to treat a type of blood cancer, a young man with type 1 diabetes was able to stop using insulin. He’s been off insulin since August 2018 — more than two years. WEDNESDAY, Oct. He started the drug nine months after being diagnosed with type 1 diabetes.

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XTalks

APRIL 29, 2022

Tirzepatide is a novel investigational obesity treatment that contains mimetics of two hormones that are involved in regulating appetite in a single peptide: a GIP (glucose-dependent insulinotropic polypeptide) receptor agonist and a GLP-1 (glucagon-like peptide-1) receptor agonist. GLP-1 agonists were first developed as diabetes treatments.

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The Pharma Data

NOVEMBER 2, 2020

That’s one finding from an early study that tested the injection drug, which mimics the effects of a natural hormone called fibroblast growth factor 21 (FGF21). FGF21 is a hormone that helps control metabolism by stimulating certain receptors in fat tissue, the liver, the pancreas and the central nervous system. MONDAY, Nov.

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XTalks

FEBRUARY 8, 2024

Ozempic (Semaglutide) Ozempic sales in 2022: $8.713 billion Company/Developer: Novo Nordisk Date of first FDA approval: December 5, 2017 Indications Ozempic is FDA-approved for: Type 2 diabetes Price of Ozempic: $1,029 for 1.5 Trulicity (Dulaglutide) Trulicity sales in 2022: $7.439 billion Company/Developer: Eli Lilly & Co.

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XTalks

SEPTEMBER 2, 2020

Viking Therapeutics is a clinical-stage biopharmaceutical company that develops novel therapies for metabolic and endocrine disorders. VK2809 is a novel, oral small molecule thyroid hormone receptor beta agonist that has selectivity for liver tissue. Related: Six of the Latest NASH/NAFLD Webinars. VK2809 and the VOYAGE Trial.

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Roots Analysis

JANUARY 23, 2024

The peptide therapeutics market has undergone substantial evolution since the inception of insulin. They also play important roles in antibiotics , toxins, hormones, and enzymes. As a result, many small drug developers and occasionally larger pharmaceutical companies prefer to outsource manufacturing to contract service providers.

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The Pharma Data

DECEMBER 15, 2020

The study, which pooled the results of 26 previous ones, revealed a clear pattern: The younger people were when they developed type 2 diabetes, the greater their risk of complications like heart disease and stroke. He noted, though, that older adults who develop diabetes are not off the hook. TUESDAY, Dec. © 2020 HealthDay.

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XTalks

JUNE 10, 2024

Efruxifermin is a novel Fc-FGF21 fusion protein designed to emulate the activity of native FGF21, an endogenous hormone that regulates metabolism and alleviates cellular stress. It not only reduces liver fat and inflammation but can also reverse fibrosis, enhance insulin sensitivity and improve lipid profiles.

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XTalks

SEPTEMBER 28, 2023

Parabens, which are also prevalent in cosmetics, can interfere with the regular operation of human hormonal systems, affecting both male and female reproductive health, development, fertility and birth results. There’s been varied research regarding the synthetic hormone’s association with breast cancer.

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XTalks

SEPTEMBER 17, 2020

While the table lists acceptable surrogate endpoints for trials of more common conditions, such as asthma, type 2 diabetes and various cancer types, the document also provides key information to developers of certain rare disease therapies. The tumor secretes adrenocorticotropic hormone (ACTH), which stimulates cortisol production.

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The Pharma Data

MAY 15, 2021

Did you know that if you intentionally avoid your favorite carbs all the time because you think they’re unhealthy or you believe they’re the root cause of your belly fat, it can be disastrous for your hormone levels and wreak havoc on your metabolism? Yes, believe it or not, things like insulin aren’t always evil!

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XTalks

FEBRUARY 21, 2024

Tirzepatide’s mechanism of action involves activating two naturally produced hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Liraglutide: This is another GLP-1 receptor agonist developed by Novo Nordisk, which has similarities with tirzepatide in its mechanism of action.

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Clinical Trials Clinical Trials Trials Insulin 59

pharmaphorum

JULY 28, 2022

Alnylam Pharma has made a name for itself, developing gene-silencing therapies for rare disorders, but its latest discovery could take it into a much larger category – metabolic and cardiovascular disease. Transgenic mice in which the gene has been deleted have improved control of blood glucose and insulin sensitivity.

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Delveinsight

DECEMBER 7, 2020

For instance, the shortage of healthcare professionals can be tackled by creating better diagnostic and treatment procedures, integrating solutions developed by physicians worldwide, and providing them seamlessly over a platform accessed by all practicing physicians. In May 2018, Ava raised about $30 million in a Series B round.

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Delveinsight

DECEMBER 29, 2020

Myovant Sciences have decided to put their forces and efforts together to advance the Prostate cancer market as they announced their partnership deal to develop and market relugolix for prostate cancer and women’s health. . Relugolix is a once-daily, oral gonadotropin-release hormone (GnRH) receptor antagonist.

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Roots Analysis

MARCH 21, 2022

Biologics have emerged as a direct consequence of the rapid development that has taken place in the field of life sciences, particularly in cell and molecular biology, over the past few decades. There are a variety of biologically derived therapeutics that are presently available / being developed.

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XTalks

AUGUST 2, 2023

is a global pharmaceutical company, working across both developed and emerging markets. They are committed to capitalizing on growth opportunities primarily through the advancement of their own product pipeline and constantly improving their existing products, as well as through business development activities. Pfizer Inc.

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pharmaphorum

JANUARY 10, 2023

It was approved by the FDA as Sotyktu last September; 5) Foscarbidopa/foslevodopa ( ABBV-951 ): Developed by AbbVie, the drug is a reformulation of a standard Parkinson’s treatment (carbidopa/levodopa) delivered by subcutaneous pump for hard-to-treat patients with advanced disease, and is in the latter stages of FDA review.

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The Pharma Data

NOVEMBER 11, 2021

Moment Eli Lilly and Company (NYSE LLY) blazoned the five winners of the initial Leonard Award, which commemorates the 100th anniversary of the discovery of insulin by feting different titleholders devoted to advancing diabetes operation. The 2021 Leonard Award winners and their orders are.

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pharmaphorum

APRIL 1, 2022

Semglee (insulin glargine-yfgn) is the first biosimilar available at the retail pharmacy counter, and it obtained interchangeable status. As such, manufacturers—some we have seen before and some new to biosimilars—will likely look to enter into existing and new therapeutic areas, including ophthalmology and the growth hormone space.

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The Pharma Data

JUNE 28, 2021

GIP is a hormone that may complement the effects of GLP-1. Tirzepatide is in phase 3 development for blood glucose management in adults with type 2 diabetes and for chronic weight management. Diabetes is a chronic disease that occurs when the body does not properly produce or use the hormone insulin.

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Roots Analysis

SEPTEMBER 9, 2024

However, this is still a nascent protein expression technology and is relatively less developed than other host systems. Hormones (includes recombinant insulin, erythropoietin and growth hormones) Enzyme replacement therapies used in treatment of rare genetic disorders such as Gaucher disease.

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The Pharma Data

MAY 15, 2021

Physique developers around the world are amazed that… …using natural food and training techniques, you can increase your body’s normal production of growth producing hormone! Going back to the drawing board and looking for ways to restart my body’s natural hormone output, I came across an amazing discovery.

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The Pharma Data

MARCH 5, 2021

GIP is a hormone that may complement the effects of GLP-1 receptor agonists. Tirzepatide is in phase 3 development for blood glucose management in adults with type 2 diabetes and for chronic weight management. Diabetes is a chronic disease that occurs when the body does not properly produce or use the hormone insulin.

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Clinical Trials Clinical Trials Trials Hormones 52

The Pharma Data

AUGUST 17, 2021

GSK is responsible for the ongoing research, development, commercialization, and manufacture of each of these Products under the Agreement. For Grade 2 or higher adrenal insufficiency, initiate symptomatic treatment per institutional guidelines, including hormone replacement as clinically indicated.

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