Development and Research - Clinical Research Informer

Biopharma & medical devices cos view advanced infrastructure to propel manufacturing & new drug development

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 21, 2024

Critical infrastructure in biopharma and medical devices plays a vital role in enabling innovation, bolstering research and development, and ensuring the production of novel drugs and products. It ensures scalability, quality control, and regulatory compliance.

Manufacturing

Manufacturing Development Compliance Drugs

Researchers develop new DNA test for personalized treatment of bacterial vaginosis

Medical Xpress

MARCH 29, 2025

Roughly one out of three women ages 14-49 in the United States develop a vaginal bacterial imbalance known as bacterial vaginosis (BV) during their lifetime. BV is characterized by unpleasant odors, and potentially painful side effects, as well as the risk of associated health issues later in life.

DNA

DNA Development Research Genetics

Innovation in Autoimmune and Bone Health Research: Driving Progress for Better Patient Outcomes

Worldwide Clinical Trials

OCTOBER 14, 2024

Fortunately, advances in clinical research are providing hope for better treatments and outcomes. With the support of global networks like ours at Worldwide Clinical Trials (Worldwide), autoimmune and bone health research is accelerating, providing new solutions to patients around the world.

Research

Research Clinical Trials Clinical Trials Immune Response

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

Panel recommends developing comprehensive long-term strategic plan for mental healthcare and research

AuroBlog - Aurous Healthcare Clinical Trials blog

FEBRUARY 13, 2025

The measures should also include […]

Development

Development Research Clinical Trials Clinical Trials

What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? This new guidance will clearly impact the clinical research field, but how? Learning Objectives: Dose-response curves and patient treatment: How do pharmacologic and toxicologic principles apply to the dosing of drugs in clinical development?

Clinical Research

March 4, 2025: PRIM-ER Team Develops Innovative Statistical Techniques for Stepped-Wedge Trials

Rethinking Clinical Trials

MARCH 4, 2025

Researchers with PRIM-ER, an NIH Collaboratory Trial, published 2 innovative statistical techniques for evaluating intervention effects in stepped-wedge, cluster randomized trials. The PRIM-ER researchers tested 2 new Bayesian hierarchical penalized spline models to improve the estimation of intervention effects in stepped-wedge trials.

Trials

Trials Development Contamination Clinical Trials

Innovating in Autoimmune and Bone Health Research: Driving Progress for Better Patient Outcomes

Worldwide Clinical Trials

OCTOBER 14, 2024

Fortunately, advances in clinical research are providing hope for better treatments and outcomes. With the support of global networks like ours at Worldwide Clinical Trials (Worldwide), autoimmune and bone health research is accelerating, providing new solutions to patients around the world.

Research

Research Clinical Trials Clinical Trials Immune Response

March 10, 2025: Developing Monitoring Plans Warrants Special Attention in Pragmatic Clinical Trials

Rethinking Clinical Trials

MARCH 10, 2025

The post March 10, 2025: Developing Monitoring Plans Warrants Special Attention in Pragmatic Clinical Trials appeared first on Rethinking Clinical Trials. By attempting to reflect real-world conditions, pragmatic trials are conducted in settings that cannot be closely controlled. The article was published in Contemporary Clinical Trials.

Clinical Trials

Clinical Trials Clinical Trials Trials Development

Researchers develop CRISPR-based drug candidate for microbiome targeting

Pharmaceutical Technology

MAY 12, 2023

The Technical University of Denmark (DTU) has announced that an international scientific team has developed a CRISPR-based drug candidate that targets E coli directly and leaves the microbiome intact. The research team has designed four bacterial viruses which use CRISPR technology to kill the unwanted bacteria precisely.

Development

Development Bacteria Research Gene Editing

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management.

Clinical Trials

November 4, 2024: Update to Living Textbook Offers Tips for Developing a Compelling PCORI Grant Application

Rethinking Clinical Trials

NOVEMBER 4, 2024

The NIH and the Patient-Centered Outcomes Research Institute (PCORI) are major funders of pragmatic clinical trials embedded in healthcare systems. An existing chapter of the Living Textbook of Pragmatic Clinical Trials provided guidance on how to Develop a Compelling Grant Application for the NIH.

Development

Development Clinical Trials Clinical Trials Trials

ICMR invites researchers to develop evidence-based guidelines for empirical use of antibiotics

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 22, 2024

The Indian Council of Medical Research (ICMR) has announced a Request for Expressions of Interest (EoI) aimed at inviting researchers, academicians, and scientists to participate in the formulation of evidence-based guidelines for the empirical use of antibiotics in the management of sepsis, dental infections, and vaginal discharge.

Research

Research Development Scientist Clinical Trials

Light-activated ink developed to remotely control cardiac tissue to repair the heart

Medical Xpress

JANUARY 24, 2025

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart.

Development

Development Research Cardiology

As ALS research booms, one treatment center finds itself in the spotlight

Bio Pharma Dive

DECEMBER 20, 2023

The Healey center is at the front of ALS research and care, earning acclaim from patients, doctors and scientists. Still, the complexities of the disease and of drug development have brought hard-felt losses.

Research

Research Doctor Doctors Scientist

Sickle cell pipeline narrows as gene therapy developers rethink research plans

Bio Pharma Dive

FEBRUARY 23, 2023

Graphite Bio and Sangamo are stopping work on their respective sickle cell gene therapies, while Intellia revealed partner Novartis ended development of its genetic treatment for the blood disease.

Gene Therapy

Gene Therapy Gene Development Genetics

Cyagen and Neurophth partner to develop gene therapy vectors

Pharmaceutical Technology

NOVEMBER 8, 2022

Cyagen and Neurophth Therapeutics have entered a strategic partnership to jointly develop next-generation AAV gene therapy vectors for specific kinds of genetic ophthalmic ailments. Additionally, Neurophth will oversee the clinical trials and marketing of gene therapy products developed leveraging the new AAV capsids of Cyagen.

Gene Therapy

Gene Therapy Gene Development Genetics

Cloud robotics labs are accelerating drug discovery and development

Pharmaceutical Technology

OCTOBER 28, 2022

Drug discovery and development is an incredibly expensive and time-consuming process, taking between 12 and 18 years, and costing on average between $2 billion and $3 billion. Robots can improve drug discovery and development. Lab-specific industrial co-bots can carry out both complex and repetitive tasks such as liquid handling.

Development

Development Drugs Pharma Companies Life Science

Editas to cut jobs, narrow research focus in restructuring

Bio Pharma Dive

JANUARY 9, 2023

The CRISPR-focused biotech will lay off 20% of its workforce, stop development of two eye disease treatments and end some early-stage cell therapy research.

Research

Research Development

Lilly and ProQR to expand genetic medicine development agreement

Pharmaceutical Technology

DECEMBER 23, 2022

Eli Lilly and Company has expanded a licencing and partnership agreement with ProQR Therapeutics to discover, develop and market new genetic medicines. The post Lilly and ProQR to expand genetic medicine development agreement appeared first on Pharmaceutical Technology.

Genetics

Genetics Medicine Development Gene Therapy

Psylo signs research deal with Daiichi Sankyo for psychiatric therapies

Pharmaceutical Technology

JUNE 23, 2023

Psylo and Daiichi Sankyo have signed a sponsored research deal to advance the development of non-hallucinogenic psychiatric therapies.

Research

Research Development

Northwestern and Case Western Reserve universities develop Huntington’s therapy

Pharmaceutical Technology

NOVEMBER 4, 2024

Researchers from Northwestern and Case Western Reserve universities have developed a polymer therapeutic to treat Huntington's disease.

Development

Development Research

Hookipa partners with Roche for cancer immunotherapy development

Pharmaceutical Technology

OCTOBER 21, 2022

Hookipa Pharma and Roche have signed a strategic partnership and licence agreement for developing HB-700 and another undisclosed arenaviral immunotherapy. Under the deal, Hookipa will carry out research and initial clinical development through Phase Ib for HB-700 to treat KRAS-mutated cancers.

Development

Development Production Licensing Licensing

Aviceda, QUB to develop next-generation glyco-immune therapeutics

Pharmaceutical Technology

APRIL 10, 2023

Aviceda Therapeutics (Aviceda) has entered into a strategic partnership with the Patrick G Johnston Centre for Cancer Research at Queen’s University Belfast (QUB) for the development of next-generation glyco-immune therapeutics. The company strengthens the translational research collaboration between the US and Ireland.

Development

Development Life Science Clinical Trials Clinical Trials

Cancer Research UK and CRIS fund lung cancer vaccine research

Pharmaceutical Technology

MARCH 25, 2024

Cancer Research UK and the CRIS Cancer Foundation have awarded a £1.7m ($2.1m) grant for developing the lung cancer vaccine LungVax.

Vaccination

Vaccination Vaccine Research Development

Biotechs reveal layoffs, research revamps in third quarter earnings

Bio Pharma Dive

NOVEMBER 16, 2022

Tricida, Harpoon, Freeline and three other small drug developers have this week announced plans to cut staff or to reprioritize their drug development.

Research

Research Development Drugs

InvisiShield and Gladstone partner to develop intranasal preventatives

Pharmaceutical Technology

MARCH 21, 2023

Pre-clinical-stage biotechnology firm InvisiShield Technologies has partnered with Gladstone Institutes to develop intranasal preventatives against airborne viral infections including influenza, respiratory syncytial virus (RSV) and SARS-CoV-2.

Development

Development Scientist Vaccine Vaccination

Hospital Universitario and Josep Carreras develop cell therapy for leukaemia

Pharmaceutical Technology

JANUARY 17, 2023

Spain’s Hospital Universitario 12 de Octubre researchers, along with the Josep Carreras Leukaemia Research Institute, have developed a new cell therapy based on STAb cells to treat a type of leukaemia. The Spanish Association Against Cancer (AECC) provided funding for the new STAb therapy development.

Development

Development Gene Therapy Antibody Gene

Ginkgo and Boehringer partner to develop hard-to-treat disease therapies

Pharmaceutical Technology

MAY 9, 2023

Ginkgo Bioworks and Boehringer Ingelheim have collaborated to develop breakthrough therapies for hard-to-treat diseases. The companies will use the natural product discovery capabilities of Ginkgo Bioworks to expedite the discovery and development of new therapeutic molecules to address diseases with high unmet patient needs.

Development

Development Protein Sales Production

Merck and Moderna partner to develop and sell cancer vaccine

Pharmaceutical Technology

OCTOBER 14, 2022

German pharmaceutical firm Merck has extended its partnership with Moderna to jointly develop and sell mRNA-4157/V940, an investigational personalised cancer vaccine (PCV). In 2016, the companies entered a strategic partnership to develop novel messenger RNA (mRNA) based PCVs.

Vaccination

Vaccination Vaccine Development Immune Response

Magazine: Left in limbo: when pharma halts rare disease research

Pharmaceutical Technology

JULY 31, 2024

Gene therapy research is expensive. Biotechs invest millions of dollars in early research to develop therapies for conditions that might be rare. But when funds are limited and the market potential is dim, such programs are often abandoned by companies, leaving patients and investigators in a bind.

Gene Therapy

Gene Therapy Research Gene Marketing

Lilly agrees to acquire gene therapy developer Akouos for $610m

Pharmaceutical Technology

OCTOBER 19, 2022

Akouos focuses on developing adeno-associated viral gene therapies to treat inner ear conditions, including sensorineural hearing loss. The post Lilly agrees to acquire gene therapy developer Akouos for $610m appeared first on Pharmaceutical Technology. The deal comprises an acquisition value of $12.50

Gene Therapy

Gene Therapy Gene Development Genetics

The Benefits of Integrated CDMO Services: Streamlining Drug Development and Manufacturing

Drug Patent Watch

DECEMBER 10, 2024

The pharmaceutical industry has undergone significant changes over the past decade, with a growing trend towards outsourcing key aspects of research, development, and manufacturing to third-party vendors. The Rise of Integrated CDMOs The global biotechnology and pharmaceutical services outsourcing market size was valued at $70.48

Manufacturing

Manufacturing Development Drugs Compliance

Umoja and IASO partner to develop therapies for haematological malignancies

Pharmaceutical Technology

NOVEMBER 22, 2022

Umoja Biopharma has signed a research agreement with IASO Biotherapeutics (IASO Bio) to develop off-the-shelf therapies for haematological malignancies. The post Umoja and IASO partner to develop therapies for haematological malignancies appeared first on Pharmaceutical Technology.

Development

Development In-Vivo Engineer Clinical Trials

IPC and CSIR-IMTech forge strategic partnership to advance research in microbiology

AuroBlog - Aurous Healthcare Clinical Trials blog

MAY 6, 2024

Aimed at driving innovation and progress in the field of microbiology, the Indian Pharmacopoeia Commission (IPC) and the CSIR-Institute of Microbial Technology (IMTech), Chandigarh, have joined forces towards advancing microbiological research and development for the betterment of public health.

Research

Research Development Clinical Trials Clinical Trials

Forge Biologics and Labcorp partner for gene therapies development

Pharmaceutical Technology

MAY 4, 2023

Forge Biologics and global life sciences company Labcorp have announced a strategic adeno-associated virus (AAV) gene therapy development and manufacturing collaboration. This will improve accessibility to services for AAV-mediated gene therapy programmes. This will improve accessibility to services for AAV-mediated gene therapy programmes.

Gene Therapy

Gene Therapy Gene Development Manufacturing

NIH funds research for three experimental ALS drugs

Bio Pharma Dive

OCTOBER 6, 2023

The funding, which is part of ACT for ALS, will support expanded access studies of drugs developed by Prilenia Therapeutics, Clene Nanomedicine and Rapa Therapeutics.

Drugs

Drugs Research Development

Foundery, a new biotech venture firm, sets out to speed early immune drug research

Bio Pharma Dive

AUGUST 22, 2023

Billing itself as both a scientific and investment partner, Foundery aims to provide research grants and drug development support to researchers developing new immunotherapies.

Research

Research Drugs Development

November 14, 2024: Interagency Pain Research Coordinating Committee is Accepting Nominations for New Members

Rethinking Clinical Trials

NOVEMBER 14, 2024

The Interagency Pain Research Coordinating Committee (IPRCC) is accepting nominati ons for new members to help advance the diagnosis, prevention, and treatment of pain and diseases and disorders associated with pain. View the IPRCC Member Nomination Form. For more information, contact Leah Pogorzala leah.pogorzala@nih.gov.

Research

Research Clinical Trials Clinical Trials Scientist

Vertex, Verve team up to develop a gene editing drug for liver disease

Bio Pharma Dive

JULY 20, 2022

The deal, which is worth $60 million upfront, broadens Vertex’s reach into gene editing and expands Verve’s research beyond heart disease.

Gene Editing

Gene Editing Gene Development Drugs

Startup Abdera raises $110M to fuel radiopharmaceutical research

Bio Pharma Dive

APRIL 20, 2023

The company, which previously raised $32 million in Series A funding, joins a growing list of new startups working to develop targeted radiation treatments.

Research

Research Development

Upstream Bio, a richly funded startup, reveals its lead drug and research plans

Bio Pharma Dive

JUNE 2, 2022

Backed by $200 million in funding and led by biotech veteran Samantha Truex, Upstream is developing a clinical-stage inflammatory disease drug acquired from Astellas last year.

Drugs

Drugs Research Development

Feinstein Institutes researchers discover new protein for sepsis treatment

Pharmaceutical Technology

FEBRUARY 6, 2023

Researchers at the Feinstein Institutes for Medical Research have discovered a new protein that can be a potential therapeutic target for lethal sepsis. Led by Feinstein Institutes researcher Haichao Wang, the new study focuses on detecting protein mediators that might contribute to uncontrolled immune responses to lethal infections.

Protein

Protein Research Antibody Immune Response

Psychiatry Clinical Trials: Inclusive, Patient-Centric Approaches for Mental Health Research

XTalks

DECEMBER 19, 2024

Especially as we exited the blockbuster drug period of psychiatric development and trials were failing with huge placebo effects, I think we started realizing that the patients going into trials were not the real-world patients that were getting treated with drugs in the clinic.

Clinical Trials

Clinical Trials Clinical Trials Trials Research

A brain drug developer joins a growing list of biotech layoffs

Bio Pharma Dive

MARCH 30, 2023

California-based Alector plans to reduce its headcount by around 30 as part of a larger effort to reprioritize research programs.

Development

Development Drugs Research

Biopharma & medical devices cos view advanced infrastructure to propel manufacturing & new drug development

Researchers develop new DNA test for personalized treatment of bacterial vaginosis

Webinars

Trending Sources

Innovation in Autoimmune and Bone Health Research: Driving Progress for Better Patient Outcomes

Webinars

Panel recommends developing comprehensive long-term strategic plan for mental healthcare and research

What the FDA's New Dosage Guidance Means for the Future of Clinical Research

March 4, 2025: PRIM-ER Team Develops Innovative Statistical Techniques for Stepped-Wedge Trials

Innovating in Autoimmune and Bone Health Research: Driving Progress for Better Patient Outcomes

March 10, 2025: Developing Monitoring Plans Warrants Special Attention in Pragmatic Clinical Trials

Researchers develop CRISPR-based drug candidate for microbiome targeting

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

November 4, 2024: Update to Living Textbook Offers Tips for Developing a Compelling PCORI Grant Application

ICMR invites researchers to develop evidence-based guidelines for empirical use of antibiotics

Light-activated ink developed to remotely control cardiac tissue to repair the heart

As ALS research booms, one treatment center finds itself in the spotlight

Sickle cell pipeline narrows as gene therapy developers rethink research plans

Cyagen and Neurophth partner to develop gene therapy vectors

Cloud robotics labs are accelerating drug discovery and development

Editas to cut jobs, narrow research focus in restructuring

Lilly and ProQR to expand genetic medicine development agreement

Psylo signs research deal with Daiichi Sankyo for psychiatric therapies

Northwestern and Case Western Reserve universities develop Huntington’s therapy

Hookipa partners with Roche for cancer immunotherapy development

Aviceda, QUB to develop next-generation glyco-immune therapeutics

Cancer Research UK and CRIS fund lung cancer vaccine research

Biotechs reveal layoffs, research revamps in third quarter earnings

InvisiShield and Gladstone partner to develop intranasal preventatives

Hospital Universitario and Josep Carreras develop cell therapy for leukaemia

Ginkgo and Boehringer partner to develop hard-to-treat disease therapies

Merck and Moderna partner to develop and sell cancer vaccine

Magazine: Left in limbo: when pharma halts rare disease research

Lilly agrees to acquire gene therapy developer Akouos for $610m

The Benefits of Integrated CDMO Services: Streamlining Drug Development and Manufacturing

Umoja and IASO partner to develop therapies for haematological malignancies

IPC and CSIR-IMTech forge strategic partnership to advance research in microbiology

Forge Biologics and Labcorp partner for gene therapies development

NIH funds research for three experimental ALS drugs

Foundery, a new biotech venture firm, sets out to speed early immune drug research

November 14, 2024: Interagency Pain Research Coordinating Committee is Accepting Nominations for New Members

Vertex, Verve team up to develop a gene editing drug for liver disease

Startup Abdera raises $110M to fuel radiopharmaceutical research

Upstream Bio, a richly funded startup, reveals its lead drug and research plans

Feinstein Institutes researchers discover new protein for sepsis treatment

Psychiatry Clinical Trials: Inclusive, Patient-Centric Approaches for Mental Health Research

A brain drug developer joins a growing list of biotech layoffs

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