Are you meeting safety standards for residual host cell DNA?
Bio Pharma Dive
JULY 1, 2024
Ensure the safety of gene therapies with accurate HEK293 DNA measurement using Vericheck ddPCR kits.
Synplogen and Ginkgo Bioworks sign MoU for DNA manufacture
Pharmaceutical Technology
DECEMBER 7, 2023
Synplogen and Ginkgo Bioworks have signed an MOU to expedite DNA manufacturing and gene therapy platform services in Japan.
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Sartorius upscales gene therapy prowess with $2.6bn Polyplus acquisition
Pharmaceutical Technology
APRIL 3, 2023
The deal will see Polyplus join the German life science group’s portfolio allowing the latter to leverage expertise in transfection reagents and plasmid DNA for gene therapy. Polyplus, based in Strasbourg, France, produces key components in the production of viral vectors used in cell and gene therapies.
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A new startup from Feng Zhang and an ex-Illumina executive zeroes in on the epigenome
Bio Pharma Dive
JANUARY 4, 2024
Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.
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New CRISPR-Based Tool Called PASTE Gene Editing Inserts Large DNA Sequences at Desired Sites
XTalks
DECEMBER 14, 2022
Expanding upon the CRISPR-Cas9 gene editing system, researchers at MIT have designed a new technique called PASTE gene editing that can cut out defective genes and replace them with new genes in a safer and more efficient way. The PASTE gene editing technique was recently published in Nature Biotechnology.
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Rising Demand for DNA and Gene Cloning Service Providers
Roots Analysis
OCTOBER 16, 2023
DNA cloning refers to the process of generating multiple copies of a particular DNA segment. DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence.
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Gene Therapy and Pharmacokinetics
Camargo
JULY 27, 2021
How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19. Gene Therapy Definition.
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CDMO Bionova branches into plasmid DNA to serve cell and gene therapy developers
Fierce Pharma
JUNE 3, 2024
subsidiary Bionova Scientific is launching a new business line to provide services around plasmid DNA (pDNA), the companies announced Monday. As part of the pDNA pivot, Bionova is setting up a new facility in The Woodlands, Texas.
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Ancient Genes of Zombie Viruses Revealed as Hidden Drivers of Cancer
AuroBlog - Aurous Healthcare Clinical Trials blog
JULY 30, 2024
Silently tucked away in our genomes, some of these bits of foreign DNA can get passed down through the generations. When viruses pay us a visit, they sometimes leave parts of themselves behind. They were long thought inactive, but we’ve since learned these stowaway sequences can be turned back on to wreak all sorts of […]
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Asklepios partners with ReCode on gene-editing platform
Pharmaceutical Technology
JANUARY 10, 2023
Asklepios BioPharmaceutical has entered a research partnership and option agreement with ReCode Therapeutics for exploring its single-vector gene-editing platform. The new solution will enable complete gene insertion by delivering the gene-editing tool and DNA as mixed cargo to desired targets in one LNP.
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Blocking DNA production in cancer therapy by targeting the POLtheta enzyme
Medical Xpress
NOVEMBER 17, 2022
BRCA1 (BReast CAncer Gene 1), a key gene that becomes faulty in some instances, leading to breast and ovarian cancer, plays an important role in the body's DNA repair mechanisms. BRCA1, once mutated, can cause cancer to develop.
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Leading innovators in gene splicing using nucleases for the pharmaceutical industry
Pharmaceutical Technology
FEBRUARY 15, 2023
In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Gene splicing using nucleases. Nucleases are enzymes that hydrolytically cleave the phosphodiester backbone of DNA.
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Researchers discover key role of DNA methylation in Alzheimer's disease
Medical Xpress
FEBRUARY 22, 2023
Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).
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UK scientists say they have found cancer driver in junk DNA
pharmaphorum
JULY 20, 2022
It has suspected for many years that some diseases may be linked to non-coding or ‘junk’ DNA, but the mechanism behind the pathology hasn’t been worked out. Junk DNA is a term used to describe the 97% of the genetic sequence in human cells found between the 3% coding for our 20,000 genes, once thought to be inert.
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New facility boosts UK’s cell and gene therapy manufacturing capacity
Pharmaceutical Technology
MARCH 10, 2023
On 10 March, the National Health Service Blood and Transplant (NHSBT) opened a new Clinical Biotechnology Centre (CBC) with the aim of improving the UK’s ability to develop and manufacture cell and gene therapies. The strategy , underlines one of the government’s goals of increasing the UK’s manufacturing capacity for DNA-based therapeutics.
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Prime Medicine Gets FDA Okay for First Trial of Gene Editing Technique
BioSpace
APRIL 29, 2024
The technique taps CRISPR technology to rewrite defective genes without breaking DNA double helix strands. The FDA has cleared a clinical trial of an ex vivo prime editing candidate in patients with a rare disease, Prime Medicine announced Monday.
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Gene editing DNA deletion sizes reduced with new fusion method developed at WFIRM
Scienmag
MAY 2, 2022
WINSTON-SALEM, NC – May 2, 2022 — Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.
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Scientists use DNA origami to monitor CRISPR gene targeting
Scienmag
FEBRUARY 23, 2021
CRISPR gene editing has transformed research, but it is not perfect, and can sometimes target unintended genes; to watch CRISPR enzymes respond to different genes, Leipzig University researchers developed a new method using DNA origami and were able to me Credit: Image courtesy of Julene Madariaga Marcos.
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The future of the gene therapy market: driving innovations in biotherapeutics
Pharmaceutical Technology
OCTOBER 26, 2022
The biotherapeutics market is rapidly growing, with 2021 seeing the highest-ever cell and gene therapy approval number. Gene therapy uses DNA to manipulate cells and correct defective genes, whereas cell therapy is the infusion or transplantation of cells into a patient. The future of cell and gene therapies.
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A startup emerges with $125M and plans to edit the epigenome
Bio Pharma Dive
NOVEMBER 17, 2021
Chroma Medicine's launch is the latest step in a decadeslong quest by drugmakers to capitalize on research into epigenetics, a way of controlling gene expression without altering DNA.
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Researchers speed identification of DNA regions that regulate gene expression
Scienmag
MAY 6, 2021
Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Credit: St. Jude Children’s Research Hospital St.
Charles River and Captain T Cell sign vector production agreement
Pharmaceutical Technology
JUNE 18, 2024
Charles River and Captain T Cell have signed a deal to produce plasmid DNA and retrovirus vectors for gene-modified cell therapy.
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Mitochondrial drugs, with a twist: Pretzel Therapeutics launches with $72.5M in funding
Bio Pharma Dive
SEPTEMBER 12, 2022
Scientists at Pretzel believe fixing mutated mitochondrial DNA with a mix of small molecule therapies and gene editing could be key to solving a number of hard-to-treat diseases.
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STAT+: After early wins, CRISPR gene editing is about to get a lot harder
STAT News
SEPTEMBER 21, 2022
The short history of CRISPR gene editing in humans has, with rare exception, been a history of triumphant progress: A patient apparently cured of sickle cell in 2019, six patients with toxic DNA knocked out of their liver last year, another six patients with a different strand of toxic liver DNA knocked out last week.
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A Reversal on Sequencing? Proposed Legislation Would Allow Patenting of Naturally Occurring Genes
FDA Law Blog
OCTOBER 24, 2024
Rather, developers of diagnostic tests and, indeed of any product that relies on free access to gene sequence and other biomarker information, should pay also close attention, as PERA would overturn longstanding judicial precedent. By 2010, about 2000 isolated human genes had been patented in the U.S. Supporters of AMP v.
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Opinion: Needed: stricter screening of gene synthesis orders, customers
STAT News
OCTOBER 5, 2022
Scientists rely on gene synthesis technologies as a research tool for everything from basic research to vaccine development and drug target identification. Ever since the inception of gene synthesis, there have been concerns about possible misuse of synthetic genes.
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Novel artificial genomic DNA can replicate and evolve outside the cell
Scienmag
NOVEMBER 20, 2021
Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.
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Moderna partners with Life Edit for mRNA gene editing therapies
Pharmaceutical Technology
FEBRUARY 23, 2023
Moderna has entered a strategic research and development partnership with ElevateBio’s Life Edit Therapeutics to discover and develop new in-vivo mRNA gene editing therapies. The company’s nuclease collection includes several Protospacer Adjacent Motifs (PAMs), short sequences that help determine the genome’s DNA segments.
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STAT+: Intellia says CRISPR treatment safely corrects DNA of six patients with rare disease
STAT News
SEPTEMBER 16, 2022
Intellia Therapeutics said Friday the first six patients to receive its CRISPR-based treatment for a genetic swelling disorder have safely had small, corrective changes made to dysfunctional DNA inside their liver cells.
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Princeton-led study of DNA repair boosts prospects for gene editing technology
Scienmag
OCTOBER 20, 2021
The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all.
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Forge adds plasmid DNA manufacturing to integrate gene therapy production service
BioPharma Reporter
OCTOBER 20, 2022
Forge Biologics has added plasmid DNA manufacturing to its roster of services, enabling it to vertically integrate its production process.
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Faulty DNA repair may lead to BRCA-linked cancers
Medical Xpress
NOVEMBER 15, 2022
Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators. The discovery has potential implications for preventing the development of cancer in patients with these mutations.
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Ionis teams with Metagenomi and dives into gene editing
Bio Pharma Dive
NOVEMBER 14, 2022
The RNA drug developer is paying the richly-funded startup $80 million in a wide-ranging alliance that marks its first foray into DNA editing medicines.
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Intellia cleared to start key CRISPR drug study in UK
Bio Pharma Dive
OCTOBER 19, 2020
The trial would be the first test of a systemically administered gene editing treatment that uses the Nobel Prize-winning technology to alter DNA.
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Gene p16, which drives colorectal cancer, is emerging as a target for potential therapies
Medical Xpress
MAY 10, 2023
How colorectal cancer develops is not well understood, but a team led by researchers at Baylor College of Medicine reports in the Journal of Experimental & Clinical Cancer Research that silencing the gene p16, even though the DNA itself does not change, can drive colorectal cancer progression in animal models.
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GenScript ProBio and CCS partner for cell and gene therapies development
Pharmaceutical Technology
JUNE 8, 2023
GenScript ProBio has collaborated with the New York Blood Center Enterprises’ business unit, called Comprehensive Cell Solutions (CCS), to accelerate the development and manufacture of cell and gene therapies. Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.
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#news #biotech Fluorescence lifetime imaging for studying DNA compaction and gene activities
BioTech 365
DECEMBER 27, 2021
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Fluorescence lifetime imaging for studying DNA compaction and gene activities.Studies of the genomic DNA compaction in the cell nucleus and dynamic reorganization during physiologic processes or disease … Continue reading (..)
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Epigenic joins wave of startups raising cash to edit the epigenome
Bio Pharma Dive
AUGUST 30, 2023
The China-based company is one of at least four young biotechs in a competitive race to use CRISPR tools to alter gene expression without changing DNA.
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Unlocking the Future of Personalized Medicine: Blood vs. Buccal Swab in Pharmacogenomics Testing
Worldwide Clinical Trials
JUNE 13, 2024
Pharmacogenomics (PGx), the study of how genes affect a person’s response to drugs, has brought significant changes to the clinical trial industry. At Worldwide, our recent study delved into the intricacies of PGx, comparing two common methods of DNA sample collection: buccal swabs and blood samples. for buccal swabs and 93.2%
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Study identifies two genes linked to microcephaly
Medical Xpress
DECEMBER 15, 2022
Northwestern Medicine scientists have identified disease-causing DNA variants in two genes linked to neurodevelopmental deficits including microcephaly in children, according to findings published in Nature Communications.
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DNA Cloning Market: A Step Towards Future of Genetics Science
Roots Analysis
JUNE 1, 2022
DNA cloning is the field of synthetic biology which can be helpful to understand the effect of mutation on a particular gene. Many diseases that can be treated using DNA cloning, such as leukemia and sickle cell anemia, involving the replacement of defected gene. DNA Cloning Kit Providers – Current Market Landscape.
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New gene implicated in cancer, cellular stress response
Medical Xpress
FEBRUARY 21, 2023
Northwestern Medicine scientists have identified a gene that plays a role in cellular responses to molecular stressors, such as DNA damage and nutrient scarcity, according to findings published in Nature Communications.
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Huge U.S. study starts sharing gene findings with volunteers
STAT News
DECEMBER 13, 2022
More than 155,000 Americans who shared their DNA for science are about to learn something in return: Do they have some particularly worrisome genes? It’s part of a massive project to unravel how people’s genetics, environments, and habits interact to determine their overall health.
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STAT+: New CRISPR startup, drawing big-name backers, seeks to fix diseases caused by large DNA errors
STAT News
SEPTEMBER 20, 2022
A new CRISPR startup — backed by some big names in venture capital — is planning to develop gene-editing treatments that can insert a genetic sequence of any length, at any location in the DNA strand, according to industry insiders and documents.
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