XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. These modifications regulate gene expression without altering the sequence or structure of DNA.

DNA 52

DNA Gene Gene Silencing Genome 52

pharmaphorum

MARCH 10, 2021

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy. Shares in bluebird ticked up following the announcement.

Gene Therapy 59

Gene Therapy Gene Trials Gene Expression 59

pharmaphorum

OCTOBER 19, 2022

The dark genome – a loose term that covers non-coding regions of the genome that are capable of regulating the expression of genes, previously rather inaccurately referred to as junk DNA – is increasingly being explored by biopharma companies for new drug targets.

Genome 59

Genome Genomics Gene Gene Expression 59

XTalks

MARCH 13, 2024

Secondly, other funded research is exploring differential gene expression regulated by DNA methylation. By identifying genes affected by DNA methylation in glaucoma, researchers hope to uncover new insights into the disease’s molecular mechanisms.

Gene Therapy 111

Gene Therapy Gene Life Science DNA 111

The Pharma Data

MARCH 7, 2022

The new technique controls gene activity without altering the DNA sequence of the genome by targeting chemical modifications that help package genes in our chromosomes and regulate their activity. The chemical modifications that regulate gene activity are called epigenetic markers.

Protein 52

Protein Gene Genome Genomics 52

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. RNA interference (RNAi) Therapeutics : Fundamentally, RNAi is a natural process of post-transcriptional gene silencing, involving short strands of nucleic acids.

RNA 40

RNA Protein Genetics Gene Expression 40

XTalks

AUGUST 12, 2020

Unique and diverse patterns of cell surface protein glycosylation (the addition of sugar molecules to proteins) make up specific glycoimmune profiles that have key functional roles in regulating cellular processes and immune functions.

RNA 52

RNA Protein DNA In-Vivo 52

Roots Analysis

JANUARY 14, 2024

Like all drugs, biologics are regulated by the FDA. Usually, the desired gene, such as human insulin gene, when inserted into the plasmid of the host cell uses transcriptional and translational machinery of the host to express itself. They are different from small molecules in terms of their size and complexity.

Contract Manufacturing 40

Contract Manufacturing Protein Manufacturing Production 40

XTalks

DECEMBER 24, 2020

BioNTech/Pfizer’s vaccine became the world’s first approved COVID-19 vaccine, with UK regulators becoming the first to authorize it for emergency use, followed by Health Canada, which fully approved it. The system can be used to precisely edit out portions of DNA flanked by CRISPR sequences. Vaccine Considerations.

Life Science 111

Life Science Vaccination Vaccine Gene 111