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During this period, Nobel prize-winning German scientist Paul Ehrlich developed his lock-key hypothesis of molecules that specifically bind to cell receptors. Building on the success of cytokine-based immunotherapies, scientists continued to seek other areas where the immune system could be leveraged against tumours.
But scientists at the University of California (UC), Santa Barbara, believe fluoride may offer hope in the fight against antibiotic-resistant bacteria. “Essentially, what Justin did was to create a series of DNA instructions you can give to cells that will enable them to survive when fluoride is around,” said O’Malley.
These resistance genes are commonly found on small circles of DNA called plasmids. As scientists look for new strategies to combat antibiotic resistance, the idea of taking advantage of bacteria’s natural pathogens has become resurgent. Many argue we need a different approach. Phages already exist as bacteria’s natural pathogen.
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