Medical Xpress

DECEMBER 13, 2024

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA.

DNA 52

DNA Genetics Life Science Protein 52

Pharmaceutical Technology

FEBRUARY 16, 2023

The biology of ageing Ageing is an intensely complex syndrome influenced by environmental, genetic, and epigenetic factors. These primarily include oxidative stress caused by the accumulation of reactive oxygen species, telomere shortening, and deoxyribonucleic acid (DNA)/histone methylation patterns. Can we extend human life?

Insulin 130

Insulin DNA Genetics Life Science 130

pharmaphorum

OCTOBER 7, 2020

Originally discovered in bacteria as a defense mechanism against pathogens, CRISP/Cas9 has made it possible to make exquisitely detailed and precise alterations to DNA sequences on demand, and as a tool for molecular biology has already transformed research into diseases and drug discovery. What started as a curiosity?

Gene Editing 105

Gene Editing Bacteria DNA Gene 105

pharmaphorum

OCTOBER 2, 2020

Swiss medical data specialist Sophia Genetics has raised $110 million in an oversubscribed funding round that will be used to boost its headcount and international presence and prepare to take its shares public. The post $110m financing sets up US, Asia expansion for Sophia Genetics appeared first on.

Genetics 59

Genetics Genomics Genome Life Science 59

XTalks

MARCH 17, 2025

In the broader cancer detection space, Grail, in partnership with Quest Diagnostics , recently rolled out its Galleri multi-cancer early detection (MCED) test, which screens for over 50 cancers through a simple blood draw by analyzing circulating tumor DNA (ctDNA).

Production 71

Production Manufacturing DNA Genetics 71

XTalks

JUNE 20, 2022

XTALKS WEBINAR: Liquid Biopsy Workflow Optimization for Improved Assay Sensitivity and Multianalyte Applications of Cell-Free RNA, DNA and CTCs. The featured speaker will discuss the need of standardized workflows as well as the need for blood stabilization for circulating cell-free DNA (ccfDNA) analysis and impact on assay sensitivity.

FDA Approval 98

FDA Approval Protein Genetics RNA 98

XTalks

AUGUST 29, 2022

Viral vectors have traditionally been used in gene editing where the shells of viruses carry the template DNA into cells, but this method has its disadvantages. The CRISPR-Cas9 system works by having “spacer” sequences transcribed into short RNA sequences that can guide the system to the matching target in the DNA sequence of a cell.

Gene Editing 98

Gene Editing DNA Gene Genomics 98

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. Epigenetic Editing with CRISPR. pyogenes dCas9.

DNA 98

DNA Gene Gene Silencing Genomics 98

The Pharma Data

JANUARY 31, 2021

Illumina , the world’s leading DNA sequencing and array-based technologies company, is partnering with Sequoia Capital China, an investment firm, to launch a life sciences incubator in China. The focus will be on building life science startups specializing in genomics.

Life Science 52

Life Science Genome Genomics Reagent 52

Pharmaceutical Technology

FEBRUARY 3, 2023

With scientists fervently developing mRNA vaccines, nucleic acid therapeutics, and viral vector-based gene therapies, clinicians are set to have a growing number of tools available to treat a wide range of conditions, from infectious diseases to genetic disorders and more. or an affiliate doing business as Cytiva.

Genome 244

Genome Genomics Medicine Gene Therapy 244

Pharmaceutical Technology

MAY 8, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely. The company's lead asset involving this technology is isaralgagene civaparvovec (ST 920).

Genetics 130

Genetics DNA Genetic Engineering Antibody 130

XTalks

MARCH 24, 2021

Among the findings, researchers found that different shades of brown eye color found among Asians are genetically similar to eye color variations in Europeans that range from dark brown to light blue. The research findings further underscore the complexity of the genetic determination of human eye color.

Genetics 59

Genetics Gene Genomics Genome 59

XTalks

SEPTEMBER 28, 2020

The leading global life science company is set to introduce Resolution Bio’s ctDx Lung assay , a non-invasive liquid biopsy test for patients with non-small cell lung cancer (NSCLC). Based on the genetic biomarker(s) identified, the most effective therapy targeting the specific molecular marker can be selected.

Gene 105

Gene DNA Life Science Genotype 105

XTalks

OCTOBER 8, 2024

A gene contains instructions within our DNA. Today, it’s known that the human genome encodes over a thousand microRNAs, which play vital roles in how organisms grow, differentiate and operate, uncovering a new layer of complexity in genetic regulation. However, microRNAs can bind to this mRNA, preventing it from functioning.

Regulation 52

Regulation Genetics Scientist RNA 52

XTalks

DECEMBER 13, 2023

3) Fulgent Genetics Compound annual growth rate: 260 percent Fulgent Genetics, headquartered in California, is a technology-driven company with a strong presence in clinical diagnostics and therapeutic development. The company achieved core revenues of $67 million, reflecting a remarkable 48 perecent year-over-year growth.

Genetics 111

Genetics Vaccination Vaccine DNA 111

XTalks

NOVEMBER 6, 2020

The Burnaby, BC-based company developed the oral DNA-based vaccine using its proprietary bacTRL Gene Therapy Platform, which uses genetically modified bifidobacteria as carriers of genetic vaccine elements on a DNA plasmid. Related: Red Meat Allergy Test Gets FDA Clearance. “We

Clinical Trials 75

Clinical Trials Clinical Trials Vaccine Vaccination 75

XTalks

FEBRUARY 4, 2021

Bernard, executive vice president for research and chief research officer at Vanderbilt University Medical Center, shared his experience in helping set up a DNA and clinical data resource called BioVU. The project began in 2004, in the early days of biobanking for DNA, says Dr. Bernard, and has grown tremendously since.

Research 98

Research Biobanking Drugs Genomics 98

XTalks

MARCH 13, 2024

Related: Transforming Eye Care: Innovating New Glaucoma and Dry Eye Disease Treatments — Featuring Pierre Simon, VP Marketing, Sight Sciences – Xtalks Life Science Podcast Ep. There are also studies examining gene therapy-based techniques to repair or replace genetic defects contributing to this disease.

Gene Therapy 111

Gene Therapy Gene Life Science DNA 111

XTalks

JANUARY 26, 2024

This technology, which allows for precise editing of DNA at specific locations, has been a major focus in the field due to its potential to directly target and modify cancer-causing genes. By tailoring treatments based on an individual’s genetic makeup, it may allow for more effective and targeted therapies.

Research 118

Research Gene Editing Gene Genetics 118

pharmaphorum

OCTOBER 12, 2022

Now, he leads Whitelab Genomics as its artificial intelligence (AI) platform powers the development of genomic therapies – an emerging field in which genetic sequences are injected into cells to target and repair damaged genes. The payload, Del Bourgo tell us, is the therapeutic DNA or RNA sequence that will cure or fix damaged cells.

Genome 105

Genome Genomics Medicine Development 105

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. These modifications regulate gene expression without altering the sequence or structure of DNA.

DNA 52

DNA Gene Gene Silencing Genomics 52

pharmaphorum

AUGUST 31, 2022

The key to why this technology could become central to gene editing is due to the specificity with which it can edit DNA and that it is also a relatively cheap process, compared with existing technologies. Tessera emerged from Flagship Pioneering, a venture capital company responsible for launching life science companies.

Gene Therapy 98

Gene Therapy Gene Gene Editing DNA 98

pharmaphorum

FEBRUARY 5, 2021

DNA testing company 23andMe has signed a deal to merge with a ‘blank cheque’ company set up by Virgin billionaire Sir Richard Branson as a shortcut to a public listing. That’s been achieved thanks to a group of 10 million people worldwide who have agreed to allow their genetic data to be used for research.

Genetics 52

Genetics DNA Life Science Clinical Trials 52

XTalks

JUNE 16, 2023

The test utilizes circulating cell-free DNA (cfDNA) isolated from plasma derived from the anti-coagulated peripheral whole blood of advanced cancer patients. Additionally, advancements in genetic testing and the development of personalized medicine therapies have driven market growth. billion in 2021 and is projected to grow from $7.67

FDA Approval 97

FDA Approval Genomics Genome DNA 97

XTalks

DECEMBER 28, 2023

Utilizing BillionToOne’s unique molecular counting technology, Quantitative Counting Templates (QCTs), the test employs next-generation sequencing (NGS) to detect genetic variants linked to the relevant fetal antigens. This test can be performed as early as the tenth week of pregnancy.

Trials 97

Trials Clinical Trials Clinical Trials Antibody 97

The Pharma Data

OCTOBER 19, 2020

20, 2020 /PRNewswire/ — Caris Life Sciences® , a leading innovator in molecular science focused on fulfilling the promise of precision medicine, announced today that Winship Cancer Institute of Emory University (Winship) has joined Caris’ Precision Oncology Alliance (The Alliance/POA). .

Life Science 52

Life Science Clinical Trials Clinical Trials RNA 52

XTalks

NOVEMBER 30, 2023

This candidate, derived from a person’s own genetically modified cells, aims to restore the Gag-specific CD4+ T cell response in those receiving antiretroviral therapy. The noteworthy candidate, EBT-101, is designed to eliminate HIV proviral DNA using CRISPR-Cas9 along with two guide RNAs (gRNAs).

FDA Approval 111

FDA Approval Gene Therapy Gene Clinical Trials 111

The Pharma Data

DECEMBER 22, 2020

This assay enables clinical geneticists to detect genetic aberrations associated with developmental delay, intellectual disabilities, congenital anomalies, and unexplained dysmorphic features. “We are truly excited and humbled to bring the power of diagnostic microarray testing to the Japanese market. About Agilent Technologies.

Genomics 40

Genomics Genome Genetics In-Vitro 40

Delveinsight

JANUARY 14, 2021

The study’s primary result will be the proportion of patients attaining a functional treatment, defined as an off-therapy loss of hepatitis B surface antigen (HBsAg) and HBV DNA from the serum. Verve Therapeutics unveils its lead program for treating genetically high cholesterol. The round was led by Alaska Permanent Fund Corp.,

Gene Editing 40

Gene Editing Gene Genetics DNA 40

XTalks

NOVEMBER 7, 2022

Liquid biopsy tests in oncology involve isolating entities such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and tumor-derived exosomes. The cfDNA that originates from tumors is called circulating tumor DNA (ctDNA). These tumor-derived entities are used to derive genomic and proteomic data.

Clinical Trials 98

Clinical Trials Clinical Trials Trials FDA Approval 98

XTalks

OCTOBER 26, 2023

The Flu versus COVID-19: Virology and Vaccines SARS-CoV-2 versus Influenza Virology Viruses contain genetic material that can either be RNA or DNA. Both influenza and SARS-CoV-2 have RNA as their genetic material. An RNA genome enables the genetic material to mutate more rapidly. remains the dominant variant.

Vaccine 105

Vaccine Vaccination RNA Manufacturing 105

XTalks

DECEMBER 4, 2023

CAR T-cell therapies, which have been transformative in several blood cancers, involve extracting a patient’s own T cells, genetically modifying them with a chimeric antigen receptor (CAR) targeting specific proteins on cancer cells and then reinfusing them into the body.

Gene Therapy 69

Gene Therapy Gene Clinical Trials Clinical Trials 69

XTalks

DECEMBER 13, 2023

The CRISPR system is dubbed to be molecular “scissors” that can cut out parts of genes that are abnormal, deactivating or replacing them with new strands of normal DNA. This has tremendous potential for curing diseases that are caused by faulty/mutated genes.

Gene Therapy 98

Gene Therapy Gene FDA Approval In-Vivo 98

XTalks

APRIL 5, 2021

Specific skills are required to succeed in this job; these include advanced writing skills for scientific literature, developing software tools, working on genome sequencing projects, and designing DNA sequencing libraries. Having a strong background in biochemistry or genetics is necessary for the problem-solving element of the job.

Bioinformatics 59

Bioinformatics Engineer Scientist Genomics 59

XTalks

FEBRUARY 5, 2024

In the dynamic landscape of oncology therapeutics, understanding the trends and performances of leading drugs is crucial for stakeholders across the healthcare and life sciences sectors. The top 40 best-selling oncology drugs in 2023, informed by 2022 sales statistics, mark significant milestones in cancer treatment and research.

FDA Approval 101

FDA Approval Drugs Sales Development 101

Intouch Solutions

SEPTEMBER 27, 2024

Our industry is making great strides toward individualized therapies that tailor treatment plans to the unique genetic makeup of each patient’s tumor. ctDNA: New data was presented demonstrating major advances in the understanding of circulating tumor DNA (ctDNA). This is Pharmaphorum web editor Nicole Raleigh.

DNA 59

DNA Trials Antibody Marketing 59

XTalks

DECEMBER 24, 2020

The pandemic propelled the life science and healthcare sectors onto center stage, and they rose to the occasion against the most unprecedented health challenge in recent times. While COVID-19 has undoubtedly been the biggest story in the life science industry in 2020, it was a busy and positive year in many other areas.

Life Science 111

Life Science Vaccine Vaccination Gene 111