pharmaphorum

SEPTEMBER 14, 2020

Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. I saw this, in particular, with the finishing of the human genome,” says Charlie. “At In reality, finishing the human genome was the first step of what is a long journey.”.

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Genomics Genome Medicine Gene 119

pharmaphorum

JANUARY 26, 2023

2022 was a banner year for genomics. In March, the collaborative T2T consortium published the first complete telomere-to-telomere sequence of the human genome, filling in the last 8% of the 3 billion base pairs that make up our DNA.

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Genomics Genome Genome Project Genetics 129

Pharmaceutical Technology

JUNE 30, 2022

Analysing almost eight thousand tumours across 33 different cancers, researchers say this marks the first time that a framework was created to understand the role of internal factors in driving such genomic alterations. Genomic research have greatly expanded our understanding of disease pathophysiology over the years.

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Genome Project Genomics Genome DNA 130

STAT News

JULY 27, 2022

As the cost of DNA sequencing plummets, we’re fast approaching a point when decoding a human genome could cost $100 — about as much as the average American’s weekly grocery store run. Health systems are preparing to test programs that could lead to the use of whole-genome screening in millions of newborns.

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Outsourcing Pharma

DECEMBER 23, 2020

The analytical tool, developed via Bionano Genomics, maps structural variations in DNA that are known to cause disease and are tied to symptom severity.

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DNA Genomics Genome Development 139

pharmaphorum

OCTOBER 12, 2022

David Del Bourgo (CEO and co-founder, Whitelab Genomics) has always been passionate about introducing disruptive, innovative technologies to markets. We founded Whitelab Genomics after realising the potential to use data, data science, and AI in a more systematic way to develop genomic therapies,” Del Bourgo says.

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Genomics Genome Medicine Development 105

STAT News

FEBRUARY 7, 2023

Complete Genomics, a U.S. firm affiliated with Chinese sequencing giant BGI, on Tuesday announced plans to launch a new line of sequencers it says can decode DNA in larger amounts — and at lower costs — than any instrument on the market.

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Genomics Genome DNA Marketing 98

pharmaphorum

OCTOBER 31, 2022

Verge Genomics has joined a select group of biotechs who have taken a drug discovered and developed using artificial intelligence into human testing. The post Verge Genomics takes AI-sourced drug for ALS into clinic appeared first on.

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Genomics Genome Drugs RNA 136

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 30, 2024

Silently tucked away in our genomes, some of these bits of foreign DNA can get passed down through the generations. When viruses pay us a visit, they sometimes leave parts of themselves behind.

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DNA Gene Genomics Genome 191

STAT News

JANUARY 11, 2023

But genomics startup Element Biosciences on Wednesday announced it can now read a whole human genome for as little as $200 — the cost of a couple trips to the grocery store. SAN FRANCISCO — Decoding the billions of chemical letters that help shape who we are once cost a fortune.

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Genomics Genome DNA Genetics 98

STAT News

AUGUST 17, 2022

When the Smithsonian National Museum of Natural History opened its genomics exhibit in 2013, the field was just celebrating the 10th anniversary of the completed Human Genome Project. Sequencing that first genome cost over $500 million. The genomes since cost $10,000. The development of CRISPR-Cas9 landed a Nobel Prize.

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Genomics Genome Genome Project DNA 98

Scienmag

JULY 4, 2021

These Oncotarget results suggest that GBM might induce epigenetic alterations in tumor infiltrating CD4 T-cells Credit: Correspondence to – Mahua Dey – dey@neurosurgery.wisc.edu Oncotarget published “Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cells” (..)

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Genomics Genome DNA Medicine 73

Medical Xpress

MAY 14, 2023

For two decades, scientists have been comparing every person's full set of DNA they study to a template that relies mostly on genetic material from one man affectionately known as "the guy from Buffalo."

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DNA Scientist Genomics Genome 98

STAT News

MARCH 3, 2023

Next week, hundreds of scientists from around the world will convene in London for an international summit on genome editing. That technology, which enables scientists to easily excise, alter, or replace specific sections of DNA, was awarded the 2020 Nobel Prize for Chemistry.

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Genomics Genome Gene Editing Genetic Disease 111

Scienmag

FEBRUARY 12, 2021

— An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the “guardian of the genome” for its ability to repair DNA damage or destroy cancerous cells. Research offers new lead for cancer drug discovery Credit: Rensselaer Polytechnic Institute TROY, N.Y.

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Genomics Genome DNA Protein 98

Scienmag

NOVEMBER 20, 2021

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.

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DNA Gene Expression Genomics Genome 96

STAT News

DECEMBER 12, 2022

LONDON — England is launching a pilot program sequencing the genomes of up to 100,000 newborns to see if such a strategy can speed up the detection of genetic illnesses. The Newborn Genomes Programme will scan DNA for mutations that can cause some 200 conditions.

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Genomics Genome Genetic Disease Genetics 98

pharmaphorum

JULY 20, 2022

It has suspected for many years that some diseases may be linked to non-coding or ‘junk’ DNA, but the mechanism behind the pathology hasn’t been worked out. Junk DNA is a term used to describe the 97% of the genetic sequence in human cells found between the 3% coding for our 20,000 genes, once thought to be inert.

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DNA Scientist Genomics Genome 116

Medical Xpress

APRIL 4, 2023

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

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Genomics Genome DNA Gene 88

STAT News

AUGUST 11, 2022

The company would begin sequencing and analyzing the DNA of 150,000 people from Mexico City, thanks to a research collaboration with the University of Oxford. As the only Mexican geneticist at Regeneron, Gonzaga saw this as a unique opportunity.

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Genomics Genome Research DNA 105

BioPharma Reporter

FEBRUARY 4, 2021

Illumina, a DNA sequencing and array-based technology specialist, is supporting the Belgian Society of Medical Oncology (BSMO) in a pilot study examining the use of comprehensive genomic profiling (CGP) in 864 patients with advanced metastatic cancer.

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Genomics Genome DNA Trials 90

STAT News

APRIL 17, 2023

But with the advent of genetic engineering, genes encoding favorable traits in one species (say, that hornless cow) could be spliced into the genomes of other animals. Read the rest…

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Genomics Genome Genetic Engineering Production 98

Scienmag

JUNE 13, 2022

For many years, the human genome was viewed as a book of life in which sections of great eloquence and economy of expression were interspersed with vast stretches of gibberish.

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Genomics Genome DNA Containment 77

STAT News

FEBRUARY 9, 2023

Researchers who believe genomics can transform human health love to recount success stories. Or the baby girl who could have had a life-threatening reaction to anesthesia had researchers not sequenced her DNA ahead of time.

Genetic Disease 119

Genetic Disease DNA Genetics Genomics 119

Pharmaceutical Technology

JUNE 14, 2023

Basic human traits such as eye and hair colour are determined by our DNA. metres of supercoiled DNA contained within its nucleus. If you were to uncoil all the DNA in your body into a single continuous strand it would be 54 trillion metres in length, enough to stretch from the Earth to the Sun and back 180 times.

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Genome Project Medicine Genomics Genome 130

STAT News

SEPTEMBER 30, 2022

SAN DIEGO — After a steep drop in its stock price and with mounting competition from rivals, genomics giant Illumina on Thursday launched a new line of high-powered DNA sequencers, ratcheting up the race to read genetic information accurately and cheaply. Continue to STAT+ to read the full story…

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DNA Genomics Genome Genetics 105

Medical Xpress

FEBRUARY 22, 2023

A new research paper was published in Aging, titled "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity."

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DNA Genomics Genome Research 97

Scienmag

MARCH 22, 2021

Credit: WEHI, Australia Melbourne researchers have revealed how melanoma cells are flooded with DNA changes as this skin cancer progresses from early, treatable stages through to fatal end-stage disease.

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DNA Genomics Genome Research 96

Pharmaceutical Technology

APRIL 12, 2023

With advances in DNA sequencing, such as the technology developed by Foundation Medicine, the genetic profiles of lung cancer patients could be annotated to then select appropriate treatment options. Individuals that develop lung cancer with no smoking history are genetically distinct from those who develop the cancer with a smoking history.

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Genomics Genome In-Vitro Gene 130

STAT News

OCTOBER 25, 2022

firm best known for its niche approach to DNA sequencing, on Tuesday announced plans to launch a new product that will put the company in direct competition with genomics juggernaut Illumina. The new DNA sequencer, dubbed Onso, reads the genome in small pieces and uses software to stitch that information together.

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DNA Production Genomics Genome 98

Pharmaceutical Technology

SEPTEMBER 29, 2023

HitGen and the Structural Genomics Consortium entered a collaboration to discover drugs based on a DNA-encoded library (DEL).

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DNA Genomics Genome Drugs 130

Scienmag

DECEMBER 17, 2021

The first genome-wide ancient human DNA data from Sudan reveals new insights into the ancestry and social organization of people who lived more than 1,000 years ago in the Nile Valley, an important genetic and cultural crossroads.

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DNA Genomics Genome Genetics 60

Scienmag

JUNE 16, 2022

In 2014, Professor Anton Henssen discovered something unusual in the cells of pediatric cancer patients: small rings of DNA, which meant that part of the genetic information was no longer packaged in the chromosomes as normal. It was very clear that the rings disturbed the rest of the genome so much that the children’s cells […].

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DNA Packaging Packaging Genomics 83

STAT News

SEPTEMBER 20, 2022

A new CRISPR startup — backed by some big names in venture capital — is planning to develop gene-editing treatments that can insert a genetic sequence of any length, at any location in the DNA strand, according to industry insiders and documents.

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DNA Gene Editing Genomics Genome 98

Scienmag

OCTOBER 20, 2021

The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all.

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DNA Gene Editing Genomics Genome 75

Scienmag

DECEMBER 22, 2021

of our entire DNA Very little is known about the function of regions of DNA outside our genes – termed the ‘dark genome’ A Cambridge-led team recently discovered that proteins are produced by over […]. Genes code for proteins – the building blocks of life.

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Genomics Genome DNA Gene 63

STAT News

FEBRUARY 16, 2023

Since helping to discover CRISPR-Cas9 — often referred to as molecular scissors that can cut into the genome and edit DNA — Zhang has founded at least six companies, worth around $4.6 billion combined. Continue to STAT+ to read the full story…

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Genetics DNA Genomics Genome 142