Scienmag

JULY 4, 2021

These Oncotarget results suggest that GBM might induce epigenetic alterations in tumor infiltrating CD4 T-cells Credit: Correspondence to – Mahua Dey – dey@neurosurgery.wisc.edu Oncotarget published “Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cells” (..)

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Genome Genomics DNA Medicine 73

pharmaphorum

JULY 20, 2022

It has suspected for many years that some diseases may be linked to non-coding or ‘junk’ DNA, but the mechanism behind the pathology hasn’t been worked out. Junk DNA is a term used to describe the 97% of the genetic sequence in human cells found between the 3% coding for our 20,000 genes, once thought to be inert.

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DNA Scientist Genomics Genome 115

STAT News

JULY 27, 2022

As the cost of DNA sequencing plummets, we’re fast approaching a point when decoding a human genome could cost $100 — about as much as the average American’s weekly grocery store run. Health systems are preparing to test programs that could lead to the use of whole-genome screening in millions of newborns.

Genome 105

Genome Genomics DNA Genetics 105

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 30, 2024

Silently tucked away in our genomes, some of these bits of foreign DNA can get passed down through the generations. When viruses pay us a visit, they sometimes leave parts of themselves behind.

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DNA Gene Genome Genomics 190

Medical Xpress

FEBRUARY 22, 2023

A new research paper was published in Aging, titled "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity."

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DNA Genome Genomics Research 98

STAT News

JANUARY 11, 2023

But genomics startup Element Biosciences on Wednesday announced it can now read a whole human genome for as little as $200 — the cost of a couple trips to the grocery store. SAN FRANCISCO — Decoding the billions of chemical letters that help shape who we are once cost a fortune.

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Genome Genomics DNA Genetics 98

Scienmag

NOVEMBER 20, 2021

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.

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DNA Gene Expression Genome Genomics 96

Bio Pharma Dive

OCTOBER 25, 2022

“Every struggle that I've had has woven a sense of persistence into my DNA,” said Zhang, in a wide-ranging interview about leading a biotech startup as a young CEO.

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Genome Genomics DNA Drugs 271

Outsourcing Pharma

DECEMBER 23, 2020

The analytical tool, developed via Bionano Genomics, maps structural variations in DNA that are known to cause disease and are tied to symptom severity.

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DNA Genome Genomics Development 143

Scienmag

DECEMBER 17, 2021

The first genome-wide ancient human DNA data from Sudan reveals new insights into the ancestry and social organization of people who lived more than 1,000 years ago in the Nile Valley, an important genetic and cultural crossroads.

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DNA Genome Genomics Genetics 60

Pharmaceutical Technology

JUNE 30, 2022

Analysing almost eight thousand tumours across 33 different cancers, researchers say this marks the first time that a framework was created to understand the role of internal factors in driving such genomic alterations. Genomic research have greatly expanded our understanding of disease pathophysiology over the years.

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Genome Project Genome Genomics DNA 130

Scienmag

JULY 19, 2022

Scientists have found that non-coding ‘junk’ DNA, far from being harmless and inert, could potentially contribute to the development of cancer. Their study has shown how non-coding DNA can get in the way of the replication and repair of our genome, potentially allowing mutations to accumulate.

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DNA Genome Genomics Scientist 68

STAT News

SEPTEMBER 30, 2022

SAN DIEGO — After a steep drop in its stock price and with mounting competition from rivals, genomics giant Illumina on Thursday launched a new line of high-powered DNA sequencers, ratcheting up the race to read genetic information accurately and cheaply. Continue to STAT+ to read the full story…

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DNA Genome Genomics Genetics 105

STAT News

FEBRUARY 9, 2023

Researchers who believe genomics can transform human health love to recount success stories. Or the baby girl who could have had a life-threatening reaction to anesthesia had researchers not sequenced her DNA ahead of time.

Genetic Disease 119

Genetic Disease DNA Genetics Genome 119

STAT News

OCTOBER 25, 2022

firm best known for its niche approach to DNA sequencing, on Tuesday announced plans to launch a new product that will put the company in direct competition with genomics juggernaut Illumina. The new DNA sequencer, dubbed Onso, reads the genome in small pieces and uses software to stitch that information together.

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DNA Production Genome Genomics 98

STAT News

AUGUST 17, 2022

When the Smithsonian National Museum of Natural History opened its genomics exhibit in 2013, the field was just celebrating the 10th anniversary of the completed Human Genome Project. Sequencing that first genome cost over $500 million. The genomes since cost $10,000. The development of CRISPR-Cas9 landed a Nobel Prize.

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Genome Genomics Genome Project DNA 98

Scienmag

JUNE 16, 2022

In 2014, Professor Anton Henssen discovered something unusual in the cells of pediatric cancer patients: small rings of DNA, which meant that part of the genetic information was no longer packaged in the chromosomes as normal. It was very clear that the rings disturbed the rest of the genome so much that the children’s cells […].

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DNA Packaging Packaging Genome 83

pharmaphorum

JANUARY 26, 2023

2022 was a banner year for genomics. In March, the collaborative T2T consortium published the first complete telomere-to-telomere sequence of the human genome, filling in the last 8% of the 3 billion base pairs that make up our DNA.

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Genome Genomics Genome Project Genetics 127

pharmaphorum

OCTOBER 12, 2022

David Del Bourgo (CEO and co-founder, Whitelab Genomics) has always been passionate about introducing disruptive, innovative technologies to markets. We founded Whitelab Genomics after realising the potential to use data, data science, and AI in a more systematic way to develop genomic therapies,” Del Bourgo says.

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Genome Genomics Medicine Development 102

BioPharma Reporter

SEPTEMBER 19, 2023

The UK startup Broken String Biosciences has raised a $15 million Series A round to fund the development of a DNA sequencing platform that maps off-target DNA breaks resulting from genome editing technology.

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Genome Genomics DNA Development 52

Medical Xpress

APRIL 4, 2023

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

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Genome Genomics DNA Gene 95

Scienmag

MARCH 22, 2021

Credit: WEHI, Australia Melbourne researchers have revealed how melanoma cells are flooded with DNA changes as this skin cancer progresses from early, treatable stages through to fatal end-stage disease.

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DNA Genome Genomics Research 96

XTalks

DECEMBER 14, 2022

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

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Gene Editing DNA Gene Gene Sequencing 92

Scienmag

JUNE 13, 2022

For many years, the human genome was viewed as a book of life in which sections of great eloquence and economy of expression were interspersed with vast stretches of gibberish.

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Genomics Genome DNA Containment 77

STAT News

DECEMBER 12, 2022

LONDON — England is launching a pilot program sequencing the genomes of up to 100,000 newborns to see if such a strategy can speed up the detection of genetic illnesses. The Newborn Genomes Programme will scan DNA for mutations that can cause some 200 conditions.

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Genome Genomics Genetic Disease Genetics 98

STAT News

MARCH 3, 2023

Next week, hundreds of scientists from around the world will convene in London for an international summit on genome editing. That technology, which enables scientists to easily excise, alter, or replace specific sections of DNA, was awarded the 2020 Nobel Prize for Chemistry.

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Genome Genomics Gene Editing Genetic Disease 111

Pharmaceutical Technology

JUNE 14, 2023

Basic human traits such as eye and hair colour are determined by our DNA. metres of supercoiled DNA contained within its nucleus. If you were to uncoil all the DNA in your body into a single continuous strand it would be 54 trillion metres in length, enough to stretch from the Earth to the Sun and back 180 times.

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Genome Project Medicine Genome Genomics 130

BioPharma Reporter

JANUARY 5, 2023

mRNA specialist Moderna will acquire OriCiro Genomics K.K, a pioneer in cell-free DNA synthesis and amplification technologies, for $85m.

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Genome Genomics DNA Development 52

Pharmaceutical Technology

FEBRUARY 3, 2023

The field of genomic medicine has reached a true turning point. The established method for this process is a triple transfection using three different DNA plasmids. More efficient, suspension-based cell culture processes are urgently needed in the now fast-developing genomic medicine space.

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Genome Genomics Medicine Gene Therapy 244

Scienmag

OCTOBER 20, 2021

The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all.

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DNA Gene Editing Genome Genomics 75

Roots Analysis

FEBRUARY 15, 2022

Gene engineering based on recombination was pioneered in the mid-1990s; Currently, development of gene editing technologies has opened up the possibility of modifying genomic sequences in both eukaryotic and prokaryotic organisms. Genome Editing is a way of making changes in the DNA. Type of Genome Editing: Zinc-Finger Nuclease.

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Genome Genomics Gene Editing DNA 52

Pharmaceutical Technology

SEPTEMBER 29, 2023

HitGen and the Structural Genomics Consortium entered a collaboration to discover drugs based on a DNA-encoded library (DEL).

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DNA Genome Genomics Drugs 130

pharmaphorum

SEPTEMBER 14, 2020

Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. I saw this, in particular, with the finishing of the human genome,” says Charlie. “At In reality, finishing the human genome was the first step of what is a long journey.”.

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Genome Genomics Medicine Gene 118

STAT News

APRIL 17, 2023

But with the advent of genetic engineering, genes encoding favorable traits in one species (say, that hornless cow) could be spliced into the genomes of other animals. Read the rest…

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Genome Genomics Genetic Engineering Production 98

Scienmag

MAY 11, 2022

TORONTO – Researchers at The Hospital for Sick Children (SickKids) and Centre for Addiction and Mental Health (CAMH) have found that repeated DNA sequences in the genome may contribute to an individual’s risk of developing schizophrenia.

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DNA Genetics Genome Genomics 54

STAT News

SEPTEMBER 20, 2022

A new CRISPR startup — backed by some big names in venture capital — is planning to develop gene-editing treatments that can insert a genetic sequence of any length, at any location in the DNA strand, according to industry insiders and documents.

DNA 98

DNA Gene Editing Genome Genomics 98

BioTech 365

DECEMBER 23, 2021

Codex DNA Expands Catalog of COVID-19 Tools with Release of Full-Length Synthetic Genome for SARS-CoV-2 Omicron Variant Codex DNA Expands Catalog of COVID-19 Tools with Release of Full-Length Synthetic Genome for SARS-CoV-2 Omicron Variant Researchers around the world can utilize … Continue reading →

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DNA Genome Genomics Research 40