Scientists to rewrite DNA in search for heart disease cure
Pharma Times
JULY 28, 2022
The British Heart Foundation’s ‘Big Beat Challenge’ grant of £30m for research into cardiovascular medicine was given to CureHeart
DNA Medicine Scientist 
Nobel Prize in medicine awarded for research into the evolutionary history of humankind
STAT News
OCTOBER 3, 2022
A Swedish scientist won the 2022 Nobel Prize in medicine or physiology on Monday for his groundbreaking research into the evolutionary history of humankind. Pääbo unlocked scientists’ understanding of how genes from these extinct relatives have been passed down to present-day humans. Read the rest…
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The pangenome is making personalised medicine more equitable
Pharmaceutical Technology
JUNE 14, 2023
Basic human traits such as eye and hair colour are determined by our DNA. metres of supercoiled DNA contained within its nucleus. If you were to uncoil all the DNA in your body into a single continuous strand it would be 54 trillion metres in length, enough to stretch from the Earth to the Sun and back 180 times.
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Long telomeres, the endcaps on DNA, not the fountain of youth once thought, and scientists may now know why
Medical Xpress
MAY 4, 2023
In a study of 17 people from five families, Johns Hopkins Medicine researchers say they found that ultra-lengthy DNA endcaps called telomeres fail to provide the longevity presumed for such people.
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The future of genomic medicine: can it fulfil its promises?
pharmaphorum
SEPTEMBER 14, 2020
Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. At that time, we thought this would be the holy grail for medicine. Now, however, the field is changing with respect to genomic medicine. This allows for much lengthier reads.
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STAT+: Liquid biopsy study suggests a better way to decide which colorectal cancer patients need chemo
STAT News
JANUARY 16, 2023
But bits of tumor DNA adrift in a patient’s blood are an important bellwether for whether cancer will return — and, as a new study shows, can predict which treatments are likely to work. They’re far too small to be seen by even the most sophisticated medical imaging device.
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USC researchers discover better way to identify DNA variants
Scienmag
JULY 12, 2021
USC researchers have achieved a better way to identify elusive DNA variants responsible for genetic changes affecting cell functions and diseases. Using computational biology tools, scientists at the university’s Dornsife College of Letters, Arts and Sciences studied “variable-number tandem repeats” (VNTR) in DNA.
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How brain cells repair their DNA reveals “hot spots” of aging and disease
Scienmag
APRIL 1, 2021
Salk scientists reveal new insights into neurodegenerative disorders and potential for genetic therapies Credit: Salk Institute/Waitt Advanced Biophotonics Center LA JOLLA–(April 1, 2021) Neurons lack the ability to replicate their DNA, so they’re constantly working to repair damage to their genome.
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Fastest DNA sequencing technique helps undiagnosed patients find answers in mere hours
Scienmag
JANUARY 12, 2022
Pacific time to coincide with the study’s publication in The New England Journal of Medicine Media contact: Hanae Armitage at (650) 725-5376 (harmitag@stanford.edu) Fastest DNA sequencing technique helps undiagnosed patients find answers in mere hours A new ultra-rapid genome sequencing approach developed by Stanford Medicine scientists and their collaborators (..)
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Japanese-European research team discovers novel genetic mitochondrial disorder
Scienmag
APRIL 15, 2021
Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.
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Researchers speed identification of DNA regions that regulate gene expression
Scienmag
MAY 6, 2021
Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Credit: St. Jude Children’s Research Hospital St.
Human neurons implanted in a rodent’s brain lead a rat to water — and make it drink
STAT News
OCTOBER 12, 2022
The scientist flicked on a laser, filling the rat’s brain with blue light. From the outside, this would appear to be a pretty run-of-the-mill neuroscience experiment, except for the fact that the neurons directing the rat to its thirst-quenching reward didn’t contain any rat DNA.
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Scientists put CRISPR on safer path to patient treatments with new process for evaluating impacts of gene edits that alter rather than “knock out” DNA code
Scienmag
MARCH 21, 2022
Wilmington, DE, (MARCH 21, 2022) – A new study from scientists at ChristianaCare’s Gene Editing Institute is advancing the safety and efficacy of using CRISPR gene editing in patient treatments by demonstrating how to identify and evaluate the broad-based biological impact of gene editing on targeted tissues, where the edits are designed to fully disable (..)
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Gene editing DNA deletion sizes reduced with new fusion method developed at WFIRM
Scienmag
MAY 2, 2022
WINSTON-SALEM, NC – May 2, 2022 — Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.
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Scientists implicate non-cardiac genes in congenital heart disease
Scienmag
APRIL 27, 2022
CHAPEL HILL, NC – Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Then, organs develop and hopefully function properly.
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Study identifies two genes linked to microcephaly
Medical Xpress
DECEMBER 15, 2022
Northwestern Medicine scientists have identified disease-causing DNA variants in two genes linked to neurodevelopmental deficits including microcephaly in children, according to findings published in Nature Communications.
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New gene implicated in cancer, cellular stress response
Medical Xpress
FEBRUARY 21, 2023
Northwestern Medicine scientists have identified a gene that plays a role in cellular responses to molecular stressors, such as DNA damage and nutrient scarcity, according to findings published in Nature Communications.
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STAT+: Mice with two fathers and base-edited baby monkeys highlight potential — and limitations — of hereditable gene editing
STAT News
MARCH 9, 2023
LONDON — Scientists at this year’s genome editing summit spent Tuesday showing the world just how far CRISPR -based medicines for treating human diseases have come in a decade. Continue to STAT+ to read the full story…
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DNA in fringe-lipped bat poop reveals unexpected eating habits
Scienmag
OCTOBER 22, 2020
For scientists, digging into feces provides insights into animal diets and is particularly useful for understanding nocturnal or rare species. When animals eat, prey DNA travels all the way through animal digestive tracts and comes out again. Credit: Illustration by Amy Koehler Poop is full of secrets.
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Blood test detects childhood tumors based on their epigenetic profiles
Scienmag
MAY 28, 2021
The scientists analyzed short fragments of tumor DNA that are circulating in the blood. Credit: Tatjana Hirschmugl A new study exploits the characteristic epigenetic signatures of childhood tumors to detect, classify and monitor the disease.
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Researchers revive abandoned technique in effort to make artificial human eggs in a test tube
STAT News
JULY 28, 2022
In a little-noticed study published earlier this year, scientists from Oregon Health & Science University reported the birth of three mouse pups that had been created with a never-before-used recipe for reproduction.
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Salk scientists reveal most commonly mutated gene in all cancers
Scienmag
OCTOBER 13, 2021
LA JOLLA—(October 13, 2021) For the past fifteen years, cancer researchers have been using DNA sequencing technology to identify the gene mutations that cause the different forms of cancer.
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Protein may protect healthy cells during cancer treatment
Scienmag
DECEMBER 8, 2020
Credit: Kim Ratliff, Production Coordinator, Augusta University A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.
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Lilly Announces the Institute for Genetic Medicine and $700 Million investment in Boston Seaport Site
The Pharma Data
FEBRUARY 22, 2022
State-of-the-art facility will headquarter research efforts in Boston and New York to accelerate the development of RNA and DNA-based medicines. Adams, vice president of genetic medicine at Lilly and co-director of the Institute. ” The Institute will be headquartered in 334,000 sq.
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CRISPR pioneers Doudna and Charpentier claim Nobel chemistry prize
pharmaphorum
OCTOBER 7, 2020
Originally discovered in bacteria as a defense mechanism against pathogens, CRISP/Cas9 has made it possible to make exquisitely detailed and precise alterations to DNA sequences on demand, and as a tool for molecular biology has already transformed research into diseases and drug discovery. million) Nobel Prize award. “In
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Scientists at IRB Barcelona identify a potential target to treat lung cancer
Scienmag
APRIL 8, 2021
Credit: IRB Barcelona In cancer, personalised medicine takes advantage of the unique genetic changes in an individual tumour to find its vulnerabilities and fight it. Many tumours have a higher number of mutations due to a antiviral defence mechanism, the APOBEC system, which can accidentally damage DNA and cause mutations.
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Scientists identify new types of a blood cancer and potential targeted treatments
The Pharma Data
NOVEMBER 17, 2021
Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood cancer called multiple myeloma.
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UCLA scientists develop high-throughput mitochondria transfer device
Scienmag
DECEMBER 29, 2020
Method will help researchers better understand mitochondrial DNA diseases LOS ANGELES — Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells.
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Affordable CRISPR app reveals unintended mutations at site of CRISPR gene repair
Scienmag
FEBRUARY 11, 2021
11, 2020 -Scientists have developed an affordable, downloadable app that scans for potential unintended mistakes when CRISPR is used to repair mutations that cause disease. The app reveals potentially risky DNA […].
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New method helps pocket-sized DNA sequencer achieve near-perfect accuracy
Scienmag
JANUARY 12, 2021
Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer, potentially enabling scientists working outside the lab to study and track microorganisms like the SARS-CoV-2 virus more efficiently.
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Bringing science and medicine together to help patients with cancer
The Pharma Data
SEPTEMBER 14, 2020
One of the biggest game-changing advancements in cancer care came about 20 years ago when researchers learned that they could create medicines that selectively jam up cancer’s growth machinery without damaging the rest of the body. Today these medicines, called targeted therapies, are available for treating many forms of cancer.
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Gladstone investigators receive 4D Nucleome award from the NIH
Scienmag
OCTOBER 15, 2020
Benoit Bruneau and Katie Pollard study DNA folding to identify the genetic causes of congenital heart disease Credit: Photo: Gladstone Institutes SAN FRANCISCO, CA–October 15, 2020–The National Institutes of Health (NIH) has granted a 4D Nucleome award to support research by a group of scientists at Gladstone Institutes led by Benoit Bruneau, (..)
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“Nuclear speckle” structures inside cells enhance gene activity, may help block cancers
Scienmag
APRIL 5, 2021
Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in (..)
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Common HIV drugs may prevent leading cause of vision loss, study finds
Scienmag
FEBRUARY 1, 2021
Credit: UVA Health Scientists have identified a group of drugs that may help stop a leading cause of vision loss after making an unexpected discovery that overturns a fundamental belief about DNA. The drugs, known as Nucleoside Reverse Transcriptase Inhibitors, or NRTIs, are commonly used to treat HIV.
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Mitochondria destruction for Cancer Treatment; Atsena raises USD 55 Million financings; Novartis and Cadent Therapeutics collaboration; Neuron23’s strategy to tackle CNS disorders
Delveinsight
DECEMBER 17, 2020
Following that hypothesis, scientists designed oral inhibitors, which could target mitochondrial DNA (mtDNA). Instead of directly targeting existing mitochondria, the team went after mitochondrial DNA transcription that is vital to the formation of new mitochondria and the production of energy. Neuron23 reveals with USD 113.5
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Shining a light on the role of the genome’s ‘dark matter’ in cancer development
Scienmag
NOVEMBER 16, 2020
Singapore scientists uncover potential role of long non-coding RNAs in pancreatic cancer Credit: From Figure 4 in Liu, S., doi:10.1186/s13073-020-00788-5… SINGAPORE, 3 Nov 2020 – Long RNA molecules carrying DNA codes that […]. Harmston, N., Glaser, T.L. Genome Med 12, 89 (2020). Genome Med 12, 89 (2020).
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WCG’s Philosophy of Biosafety
WCG Clinical
JUNE 24, 2024
In 1953, Watson and Crick formulated the current description of DNA as a double helix 1 and soon thereafter experiments with restriction endonucleases gave scientists the ability to modify and manipulate DNA 2. 2008) Discovery of DNA structure and function: Watson and Crick. Institute of Medicine. Loenen, David T.
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NHS England starts largest ever trial of Galleri cancer blood test
pharmaphorum
SEPTEMBER 13, 2021
The test – which works by finding chemical changes in fragments of cell-free DNA (cfDNA) that leak from tumours into the bloodstream – is already available in the US at a cost of around $950, but so far hasn’t been covered there by health insurance. ” She added.
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Transitioning Between Academia and Industry: Advice from Leading Scientists That Made the Switch
XTalks
OCTOBER 1, 2020
Leaving academia for industry is a route that academic scientists and professors did not traditionally pursue in the past due to perceived differences in skillsets, experiences and even associated stigmas. WeiQi Lin, MD, PhD, executive vice president of research & development and principal scientist, DURECT Corporation.
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CRISPR Cas-9 System Doubles Life Expectancy in Mice with Aggressive Cancers
The Pharma Data
NOVEMBER 22, 2020
Scientists in Israel have used the CRISPR Cas-9 gene editing system to destroy cancerous cells in mice without damaging other cells. To conduct the research, the scientists used hundreds of mice with two of the most aggressive forms of cancer: glioblastoma and metastatic ovarian cancer. Photo courtesy of Science Advances.
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Research identifies sperm biomarker associated with couples’ pregnancy probability
Scienmag
OCTOBER 6, 2020
UMass Amherst scientists say discovery could lead to better diagnosis of male infertility Researchers at the University of Massachusetts Amherst have identified a single-measure biomarker in sperm mitochondrial DNA that may predict male reproductive health and pregnancy success.
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New CRISPR technology offers unrivaled control of epigenetic inheritance
Scienmag
APRIL 16, 2021
Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome — proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.
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Discovery about how cancer cells evade immune defenses inspires new treatment approach
Scienmag
DECEMBER 28, 2020
As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer’s aggressiveness. Cancer cells are known for spreading genetic chaos.
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