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With $82 million in hand, Flare Therapeutics is looking to create precision cancer drugs by going after a type of protein called transcription factors.
It has suspected for many years that some diseases may be linked to non-coding or ‘junk’ DNA, but the mechanism behind the pathology hasn’t been worked out. Junk DNA is a term used to describe the 97% of the genetic sequence in human cells found between the 3% coding for our 20,000 genes, once thought to be inert.
Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Credit: St. Jude Children’s Research Hospital St.
Of these various macromolecules that form droplets, DNA is quite interesting because it is predictable and programmable, which are qualities useful in nanotechnology. Recently, the programmability of DNA was used to construct and regulateDNA droplets […].
For example, once considered incurable and terminal, patients with sickle cell disease may reach new summits in their lives with gene editing technologies such as CRISPR to repair affected DNA and, in some cases, functionally cure the condition. Operationalizing these trials requires proactive and flawless management at every stage.
A benchtop DNA sequencer developed by the U.S. DNA sequencing company Element Biosciences, Inc., has seen sales grow by triple digits and has received more than 100 orders since its launch in March 2022.
The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […]. (..)
While financier Carl Icahn and regulators want the DNA-sequencing company to divest liquid biopsy company Grail, Illumina’s board isn’t budging yet. Analysts say they may be waiting for the best moment.
coli enzyme synthesizing ribosomal RNA that shift it between turbo- and slow-modes depending on the bacteria’s growth rate Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the […].
This needs to be owned by the C-Suite and at every turn communicated to employees, so it is part of the DNA of the transformation: consider the ethical and legal implications when data is handled, and tasks are automated. The post Why intelligent automation is the future for regulation appeared first on.
One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off. Researchers have found that in bacteria DNA methylation plays a role in regulating virulence, reproduction and gene […].
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: DNA methylation regulator QSER1 identified.A has identified a DNA methylation regulator called QSER1. team of researchers from a number of institutions in the U.S.
Regulating what kinds of cargo can pass through the borderlands formed by the cell’s two-layer membrane is essential […]. Just as countries import a vast array of consumer goods across national borders, so living cells are engaged in a lively import-export business.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: How does a cell regulate the repair of its damaged DNA? Human DNA can be modified or damaged in a variety of ways that can alter its sequence … Continue reading →
Federal Trade Commission on Monday ordered DNA sequencing giant Illumina to divest Grail, a cancer diagnostics firm it purchased without regulatory approval, saying the $7.1 billion acquisition “would stifle competition and innovation in the U.S. market for life-saving cancer tests.”
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Researchers discover that protein switches functions to regulateDNA replication.One protein. One mechanism of action. Two biologically opposite effects. from Biotechnology News – Biology News [link].
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Regulator proteins or symphonies of genes: Statistical modeling points way toward unified theory for DNA folding.At more than 2 meters long, the human DNA molecule uses intricate … Continue reading →
A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study from researchers at Weill Cornell Medicine. organizes the spool-like structures around which DNA […].
Polyplus, a provider of transfection reagents, has acquired e-Zyvec, a France-based provider of DNA design and production services for tailor-made DNA vectors to expand expertise in plasmid DNA vector engineering.
A collaboration between Touchlight and Lonza expands the Swiss CDMOâs end-to-end offering for mRNA manufacturing with an additional, differentiated source of DNA raw material, the UK biotechâs doggybone DNA (dbDNA).
Study suggests the impact of non-coding microRNAs on circadian rhythms is tissue specific and may reveal new insights into disease processes If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function.
The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. A gene contains instructions within our DNA.
In August 2021, Zydus secured emergency use authorisation (EUA) from the Drugs Controller General of India for its Covid-19 deoxyribonucleic acid (DNA) plasmid vaccine, ZyCoV-D. It carries out operations in the regulated markets of the US and Europe, as well as in Latin America and South Africa.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: DNA methylation from bacteria and microbiome using nanopore technology.Bacterial DNA methylation occurs in diverse sequence contexts and plays important functional roles in cellular defense and gene regulation.
Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Super-enhancers are clusters of enhancers that together regulate genes with important roles in cell identity. Scientists at St. Jude Children’s Research Hospital studied the Vsx2 super-enhancer and its role in the development of the retina.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Regulating the ribosomal RNA production line.The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the most abundant … Continue reading →
DNA cloning refers to the process of generating multiple copies of a particular DNA segment. DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study uncovers structural features regulating mRNA processing.RNA is the central tenet of molecular biology, the stepping-stone between DNA and proteins. from Biotechnology News – Biology News [link].
The regulator has set 13 February 2024 as a Prescription Drug User Fee Act goal date for the review of Ipsen’s sNDA. Onivyde works by blocking an enzyme called topoisomerase I, which is involved in copying cell DNA.
The investigational DNA medicine candidate INO-3107 has been designed for eliciting a targeted T cell response against HPV[human papillomavirus]-6 and HPV-11, the types of HPV that cause RRP and other related diseases. This makes INO-3107 the first RRP product candidate to receive designations from both the EU and the US regulatory agencies.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Regulation of the genome affects its 3D structure.All the cells of an organism share the same DNA sequence, but their functions, shapes or even lifespans vary greatly. … Continue reading →
A company developing small molecule therapeutics targeting DNA Damage Response (DDR) in order to treat patients with a broad range of cancers has its first assay development customer.
The use of CRISPR, the genetic scissors that allow scientists to edit the instruction manual of life, DNA, has drawn massive global attention over the last several years.
The tool targets the epigenome, the collection of DNA modifications in a cell such as methylation and post-translational histone modifications. These modifications regulate gene expression without changing the sequence or structure of DNA. DNA methylation occurs endogenously in all mammalian cells in response to various stimuli.
Andelyn Biosciences says the FDA's acceptance of its GMP plasmid DNA drug master file (DMF) enables the CDMO to vertically integrate its clientsâ manufacturing process, condensing timelines for developers to begin manufacturing to just three months.
4basebio AG / Key word(s): Strategic Company Decision 4basebio AG announces process for spin-off and separate stock market listing for its DNA business 17-Aug-2020 / 11:32 CET/CEST Disclosure of an inside information acc. to Article 17 MAR of the Regulation … Continue reading →
Element Biosciences, Inc., will share news of its sequencing methodology and host a workshop on higher accuracy sequencing for improved variant detection in Washington DC from today.
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