Bio Pharma Dive

SEPTEMBER 28, 2020

The FDA has suspended the planned start of a late-stage trial of Inovio's experimental shot, dealing another setback to one of the most advanced DNA-based vaccine programs in development.

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Vaccine Vaccination DNA Trials 265

BioPharma Reporter

AUGUST 2, 2021

With Scancell taking its DNA-based COVID-19 vaccine tech into clinical trials this year, it is already focusing its attention on the techâs potential to be used as a needle-free booster shot to address Variants of Concern.

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DNA Vaccine Vaccination Clinical Trials 137

Worldwide Clinical Trials

JUNE 13, 2024

Pharmacogenomics (PGx), the study of how genes affect a person’s response to drugs, has brought significant changes to the clinical trial industry. At Worldwide, our recent study delved into the intricacies of PGx, comparing two common methods of DNA sample collection: buccal swabs and blood samples. for buccal swabs and 93.2%

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Medicine DNA Compliance Clinical Trials 182

AuroBlog - Aurous Healthcare Clinical Trials blog

DECEMBER 24, 2024

It all started with research on a sugar that naturally occurs in the body and helps form DNA: the ‘deoxyribose‘ part of deoxyribonucleic acid. Earlier this year, scientists stumbled upon a potential new treatment for hereditary-patterned baldness, the most common cause of hair loss in both men and women worldwide.

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DNA Scientist Research Clinical Trials 246

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 30, 2024

Silently tucked away in our genomes, some of these bits of foreign DNA can get passed down through the generations. When viruses pay us a visit, they sometimes leave parts of themselves behind. They were long thought inactive, but we’ve since learned these stowaway sequences can be turned back on to wreak all sorts of […]

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DNA Gene Genome Genomics 243

Pharmaceutical Technology

JULY 19, 2023

The Phase I trial evaluates the combination Telix’s targeted radiation therapy with Merck’s peposertib, a DNA-PK Inhibitor.

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Trials DNA Development 130

Pharmaceutical Technology

APRIL 3, 2023

The deal will see Polyplus join the German life science group’s portfolio allowing the latter to leverage expertise in transfection reagents and plasmid DNA for gene therapy. to complete an in-house plasmid DNA facility in Marburg, Germany. “In In February 2023, the mRNA specialist BioNTech invested $43.8m

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Gene Therapy Gene DNA Reagent 246

pharmaphorum

JANUARY 6, 2021

Pharma companies are always talking about moving ‘beyond the pill’, and Pfizer’s new brand identity embodies that – it’s decades old pill-like logo has been replaced with a DNA double helix that it says reflects its commitment to breakthrough science. Encoded within a successful emblem is a company’s DNA – its history, its future.

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DNA Branding Vaccination Vaccine 116

pharmaphorum

JULY 2, 2021

Zydus Cadila has filed for emergency use approval (EUA) in India of its plasmid DNA-based vaccine for COVID-19, which if given a green light could become the first shot of its type to be cleared for widespread use in humans. . The post Zydus Cadila nears world-first human plasmid DNA vaccine approval appeared first on.

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DNA Vaccination Vaccine Clinical Trials 98

Scienmag

MAY 26, 2022

A team of researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), have shown that they can use methylation patterns in cell-free DNA (cfDNA) extracted from blood samples to predict which patients with muscle-invasive bladder cancer are likely to benefit from chemotherapy before their (..)

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DNA Clinical Trials Clinical Trials Trials 86

Pharmaceutical Technology

MARCH 28, 2024

Boundless has two assets in clinical trials targeting extrachromosomal DNA in cancer patients.

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DNA Clinical Trials Clinical Trials Marketing 147

BioPharma Reporter

FEBRUARY 17, 2022

Start-up biotech Alvea has started pre-clinical testing for its DNA vaccine: with clinical trials set to begin as soon as March.

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DNA Vaccine Vaccination Clinical Trials 75

Medical Xpress

APRIL 18, 2023

A combination of the PARP inhibitor olaparib (Lynparza) and the investigational ATR inhibitor ceralasertib showed clinical benefit in pediatric patients with solid tumors exhibiting DNA replication stress and/or DNA repair deficiencies, according to results from the phase I portion of the phase I/II AcSé-ESMART trial presented at the AACR Annual Meeting (..)

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DNA Trials 75

BioSpace

APRIL 29, 2024

The FDA has cleared a clinical trial of an ex vivo prime editing candidate in patients with a rare disease, Prime Medicine announced Monday. The technique taps CRISPR technology to rewrite defective genes without breaking DNA double helix strands.

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Gene Editing Gene Medicine In-Vivo 88

Worldwide Clinical Trials

DECEMBER 12, 2022

Genetic testing provides patients with a diagnosis for their illness, helps patients and family members to understand risks of developing new diseases, and can be used to support clinical trial advancement. Can prior genetic testing results be utilized in a trial, or should a new genetic sample be taken before participating?

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Clinical Trials Clinical Trials Genetics Trials 130

pharmaphorum

NOVEMBER 20, 2020

Just over a year after its first phase 3 trial of its Engensis gene therapy for painful diabetic peripheral neuropathy (DPN) bombed, Helixmith has started dosing patients in a new study. The South Korean biotech says the DNA plasmid-based therapy has been administered to a patient at Innovative Research of West Florida.

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Gene Therapy Gene Trials DNA 98

Pharmaceutical Technology

FEBRUARY 3, 2023

Only a few weeks into the new year, the prospect of getting a successful advanced HIV vaccine shrank after the discontinuation of yet another late-stage trial. This marks the second time one of Janssen’s HIV vaccines failed after another showed disappointing results in the Phase IIb Imbokodo trial in August 2021.

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Vaccine Vaccination Antibody Trials 293

Pharmaceutical Technology

MARCH 28, 2023

On March 27, researchers presented new interim results from the Phase III RUBY clinical trial that could indicate a new standard of care for endometrial cancer treatment. GSK’s trial evaluated the programmed death receptor-1 (PD-1)-blocking antibody Jemperli (dostarlimab). GlobalData is the parent company of Pharmaceutical Technology.

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DNA Clinical Trials Clinical Trials Trials 130

XTalks

JANUARY 8, 2024

Whether it’s for a treatment for a chronic ambulatory condition, precision medicine or cell and gene therapy, there is a massive uptick in clinical trial complexity. It’s important to make sure that with this increase in clinical trial complexity, we don’t make our trials overly burdensome to sites or patients,” says Markham.

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Clinical Trials Clinical Trials Trials Gene Therapy 105

Scienmag

APRIL 10, 2022

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers — ATR inhibitor elimusertib and PARP inhibitor AZD5305 — are safe and clinically beneficial in treating patients with advanced solid tumors. NEW ORLEANS ? Principal investigator Timothy Yap, M.B.B.S.,

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DNA Clinical Trials Clinical Trials Trials 57

XTalks

JANUARY 15, 2025

XTALKS WEBINAR: Transforming Lung Health and Disease using AI-based Registries Live and On-Demand: Thursday, February 20, 2025, at 1pm EST (10am PST) Register for this free webinar to gain insights into the power of AI-driven data analysis to identify at-risk patients, optimize clinical trials and accelerate innovation in pulmonary disease care.

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DNA Clinical Trials Clinical Trials Genetics 105

pharmaphorum

JULY 13, 2022

Verve Therapeutics has started dosing patients in a phase 1b trial of its in vivo gene-editing drug for high cholesterol, designed to permanently switch off the PCSK9 gene with a one-shot treatment. Through base editing, drugs replace single nucleotide in the DNA strand with another, without making double-strand breaks (DSBs) in the gene.

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Gene Editing Trials Drugs In-Vivo 98

Camargo

JULY 27, 2021

It is a comprehensive term which encompasses a large variety of therapy products including viral and bacterial vectors, plasmid DNA, human gene editing technology, and patient-specific cellular gene therapy. Additionally, gene editing allows us either to remove or to modify harmful genes. Formulation Considerations.

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Gene Therapy Gene Gene Editing Genetics 238

XTalks

NOVEMBER 6, 2020

Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The first healthy volunteer was dosed with the vaccine in Australia as part of the bacTRL-Spike COVID-19 Phase I clinical trial. COVID-19 Clinical Trials.

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Clinical Trials Clinical Trials Vaccination Vaccine 75

BioPharma Reporter

FEBRUARY 4, 2021

Illumina, a DNA sequencing and array-based technology specialist, is supporting the Belgian Society of Medical Oncology (BSMO) in a pilot study examining the use of comprehensive genomic profiling (CGP) in 864 patients with advanced metastatic cancer.

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Genome Genomics DNA Trials 98

Pharmaceutical Technology

NOVEMBER 3, 2022

The latest approval is backed by 24-week findings from a Phase II clinical trial (Trial 1092) that analysed 25mg Vemlidy versus placebo in 70 paediatric patients who are treatment-naïve and treatment-experienced.

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DNA FDA Approval Clinical Trials Clinical Trials 130

Pharmaceutical Technology

MARCH 10, 2023

In an email to Pharmaceutical Technology , an NHSBT spokesperson said the centre will “support early phase clinical trials and preclinical work, providing a route to eventual commercial scale production”. In the past, researchers have often had to seek help from outside the UK, thus delaying clinical trials and patient access.

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Gene Therapy Manufacturing Gene Clinical Trials 264

STAT News

FEBRUARY 28, 2023

Wheeler is missing the DNA needed to recycle a waste product called lipofuscin that his cells naturally produce. My toddler, Wheeler, will probably not live to adulthood. Juvenile Batten disease — he has the type known as CLN3 — is stealing his childhood. And then this rare disease will steal my child.

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Clinical Trials Clinical Trials DNA Trials 98

Outsourcing Pharma

MAY 25, 2023

A company developing small molecule therapeutics targeting DNA Damage Response (DDR) in order to treat patients with a broad range of cancers has its first assay development customer.

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DNA Clinical Trials Clinical Trials Development 52

Scienmag

MARCH 15, 2021

The first vaccine has been administered in a comparative adjuvant trial of DNA prime/protein boost HIV vaccine regimens in Kericho, Kenya Credit: U.S. Military HIV Research Program SILVER SPRING, Md.

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Vaccination Vaccine Trials DNA 68

Scienmag

JANUARY 20, 2021

Study supports launch of Phase I clinical trial to test a designer DNA agent — an antisense oligonucleotide that targets a gene called IRF4 — in patients with multiple myeloma Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another.

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DNA Clinical Trials Clinical Trials Gene 56

BioPharma Reporter

FEBRUARY 13, 2023

Scancell has reported preliminary immunogenicity data from its Phase 1 COVIDITY clinical trial: with the plasmid DNA based COVID-19 vaccine candidates inducing immune responses when delivered via needle-free tech.

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Immune Response Vaccine Vaccination DNA 96

BioTech 365

JULY 27, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Artios raises $153M to fund DNA damage repair clinical trials.Artios raises $153M to fund DNA damage repair clinical trials ntaylor Tue, 07/27/2021 – 07:43 from FierceBiotech: Biotech … Continue reading →

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DNA Clinical Trials Clinical Trials Trials 40

Pharmaceutical Technology

MAY 17, 2023

Precision oncology company Boundless Bio has raised $100m in a Series C financing round for advancing extrachromosomal DNA (ecDNA)-directed therapies for oncogene-amplified cancer patients. The funds will also support the advancement of Boundless Bio’s ECHO (ecDNA Harboring Oncogenes), an ecDNA diagnostic clinical trial assay.

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Clinical Trials Clinical Trials DNA Genetics 147

pharmaphorum

FEBRUARY 22, 2021

In December interim phase 1/2 trial results showed the vaccine produced a lower immune response in older adults. The new phase 2 trial will involve 720 volunteers aged 18 and over to select the most appropriate antigen dosage for the next stage of development.

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Vaccine Vaccination Recombinant DNA Technology Trials 89

pharmaphorum

SEPTEMBER 14, 2021

Startup Rome Therapeutics has raised $77 million in second-round financing to help mine sequences of DNA – which were dismissed for years as ‘junk’ – for hidden treasure. Much of this repeatome is thought to derive from viruses that embedded in our DNA millions of years ago.

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DNA Immune Response Genome Genomics 52

Scienmag

SEPTEMBER 28, 2020

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial – highlighting the potential of a new class of drugs known as ATR inhibitors. The drug candidate, tested in humans for the first time, was shown to be well tolerated and stopped the growth of tumours […].

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DNA Clinical Trials Clinical Trials Drugs 51