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New CRISPR-Based Rapid COVID-19 Test Can Detect SARS-CoV-2 Variants

XTalks

A porous membrane was engineered to capture RNA on its surface. A CRISPR-based reaction generates a fluorescent signal in the presence of SARS-CoV-2 viral RNA in a saliva sample. Image source: Wyss Institute at Harvard University. One of the great things about miSHERLOCK is that it’s entirely modular.

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Silence Tx uses game to raise thalassaemia awareness

pharmaphorum

Thalassaemia is a severe genetic disease that is characterised by significantly reduced production of functional beta-globin, a component of haemoglobin, the oxygen-carrying protein in the blood. It has a candidate in development that targets TMPRSS6, an enzyme that reduces levels of a protein (hepcidin) that controls iron levels in the body.

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Moderna and BioNTech – who are they?

pharmaphorum

Their technology is based on synthetic messenger RNA – short for ribose nucleic acid – which is a short transcript of a longer DNA code. As it’s just a messenger molecule, it does not affect the body’s own genetic code when it is injected as a vaccine – but what it does do is instruct cells to code for copies of a certain protein.

Vaccine 111
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Personalized Blood Test Detecting ctDNA Can Help Predict Lung Cancer Relapse

XTalks

XTALKS WEBINAR: Using CRISPR interference (CRISPRi) Viability Screens to Map Long Noncoding RNA Dependencies in Tumor Cells. Register for this webinar to get an overview of the role of long non-protein coding RNAs (lncRNAs) in gene regulations. Live and On-Demand: Thursday, April 21, 2022, at 11am EDT (4pm BST/UK).

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Race to the finish: pharma edges closer to approval with RSV vaccines

Pharmaceutical Technology

A major breakthrough from the National Institutes of Health (NIH), in mapping the structure of the RSV protein significantly changed the landscape, allowing companies to leap into RSV drug research with better efficacy results. However, subsequent RSV drugs, like Medimmune’s motavizumab, failed in clinical trials.

Vaccine 162
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Long COVID but short on treatment options

pharmaphorum

With no specific medication available, doctors are likely to recommend exercise and self-management of the condition, through rest and reduced workload. Anyone living with Long COVID would likely be interested in knowing why the same urgency is not being shown to develop a treatment for this condition.

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STAT+: Foundation charges cancer patients $83,000 for unproven but promising experimental drug

STAT News

Still, when doctors told her last year that the cancer was growing despite two operations, radiation therapy, and a fifth regimen of chemotherapy, the retired business-meeting facilitator decided to do something unorthodox: spend $83,000 out of pocket on an unproven experimental cancer vaccine.

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