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Robert Langer was part of the first cohort of researchers to begin nanoparticle research , as his lab at Cornell University developed tiny particles to deliver large molecules for angiogenesis. The next wave came from early research into liposomes and lipid nanoparticles, both of which are used for drugdelivery.
In the 20 th century, major research went into discovery of a therapeutic class with the primary purpose of interfering with the RNA expression linked to disease causing proteins, nowadays classified as oligonucleotides. Till date, 14 oligonucleotide-based therapies have been approved. Our Social Media Platform. Web: [link].
Clinical research experts from the CRO Medpace shared insights about the operational and regulatory considerations for neuroscience trials with direct CNS administration. In a recent webinar, Dr. Vornov described the history and current progress in targeted CNS therapeutic delivery. Viral Vectors for Gene Delivery to the CNS.
Application of Synthetic mRNA Several studies conducted by healthcare companies and research institutions have demonstrated the potential of mRNA. Additionally, they also require appropriate drugdeliverysystems to efficiently administer the intervention (in a manner that they can avoid degradation by cellular endonucleases).
Amidst the ongoing initiatives to develop therapeutic interventions with improved bioavailability, lipid nanoparticle (LNPs) have specifically attracted the attention of researchers and drug developers. The LNPs can be monitored using various imaging modalities to confirm the delivery of siRNA to the target cells.
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