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A new intracellular drugdelivery centre will be established in the UK to support potential ribonucleic acid (RNA) vaccines and therapeutics , as well as the development of innovative drugdelivery technologies. Another key focus area will be the creation of a framework to develop advanced nano-delivery systems.
Akouos focuses on developing adeno-associated viral gene therapies to treat inner ear conditions, including sensorineural hearing loss. It has combined expertise in otology, gene therapy and inner ear drugdelivery to meet the requirements of individuals with disabling hearing loss globally.
We have put in our best effort to make it easily graspable what are the intracellular drugdelivery technologies and how it can ensure effective treatment for fatal disease. Below are the highlights that we feel would be helpful to understand about the intracellular drugdelivery / intracellular non-viral drugdelivery approach.
Sixfold Bioscience in partnership with Medicines Discovery Catapult, has been given the green light, through the award of an Innovate UK Smart Grant to test a pioneering system designed to deliver drugs directly to cancerous cells, without impacting the healthy cells around it.
Furthermore, a wide variety of drugs and macromolecules, including DNA , proteins, and imaging agents, can be encapsulated in liposomal vesicles due to their unique ability to entrap both lipophilic and hydrophilic substances. The various therapeutic applications of liposomes in drugdelivery have been highlighted in the figure.
In addition, NLCs offer benefits such as high drug loading capacity, improved drug retention and avoidance of drug expulsion. Advantages of Lipid Nanoparticle LNPs are gaining significant attention of formulation scientists in drugdelivery due to the various advantages offered by them.
The company will undertake a technology transfer and feasibility study for a drug product focused on the treatment of IPF at its centre of cell and gene expertise in Milan, Italy. Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.
When combined with mRNA therapeutic molecules developed by LG Chem, the pre-made drugdelivery formulation helps to simplify and improve the combination process. This is expected to shorten the development time of new drugs and to support personalised treatments.
Additionally, the wide-ranging expertise of RVAC in mRNA, vaccine and drugdelivery technologies, and its capabilities in research and development (R&D), biopharmaceutical manufacturing, clinical development and marketing is leveraged under the partnership. “We
Owing to their unique size and physicochemical properties ( surface roughness, surface area, surface energy, crystal structure and shape ), nanoparticles can be widely used as a contrasting agent in medical imaging, a vesicle to cross the blood-brain barrier and a carrier for targeted delivery of genes / drugs, proteins, vaccines and antibiotics.
XTALKS WEBINAR: DrugDelivery — Evaluating Off-The-Shelf and Novel DrugDelivery Solutions Live and On-Demand: Tuesday, July 11, 2023, at 1pm EDT (10am PDT) Register for this free webinar to learn about important tradeoffs when considering an off-the-shelf (OTS) drugdelivery platform vs. novel development.
CPhI North America 2022 host city Philadelphia is set to become one of the worldâs biggest cell and gene therapy manufacturing hubs. But itâs just one of many centers of innovation that are helping drive the US pharma and biopharma industry.
One of the biggest challenges with developing therapies to treat CNS disorders is the delivery of systemically administered investigational products (IPs) to the brain, which is limited by the blood-brain barrier. Some methods of direct CNS administration include intrathecal, intraparenchymal and intracerebroventricular (ICV) delivery.
Bayer strengthens gene therapy portfolio with lipid nanoparticle technology from Acuitas Therapeutics Bayer AG is joining forces with Acuitas Therapeutics, Inc., a biotechnology company specializing in the development of lipid nanoparticle (LNP) delivery systems for molecular therapeutics. Financial details were not disclosed.
The rankings are based on each companys ability to tackle critical challenges from drugdelivery and diagnostics to personalized therapies using cutting-edge science. Here we spotlight the top 20 most innovative pharma and biotech companies of 2025 from their 2025 list that are transforming health care.
SAE Media Group’s 5th Annual Ophthalmic Drugs Conference will explore advancements in ophthalmic treatments and variety of novel drugs, which are showing good clinical trial data. Drugdelivery will also be an important aspect of the agenda, with advancements in novel technologies. And many more!
The research answers a long-standing biological question and could have implications for the timing of drugdelivery, biotechnology, and […]. Now research reveals that bacteria too have internal clocks that align with the 24-hour cycle of life on Earth.
HitGen & UPPTHERA Collaborate for DrugDelivery Research. HitGen has entered into a collaboration for drug discovery research with UPPTHERA to identify small molecule Hits against previous known-to-be undruggable targets and novel E3 ligase.
Uncover advances in CNS gene therapy , new generation vectors for intravenous delivery, and the challenges of scaling up for CNS delivery beyond highly specialized centers. The high concentration of scientists who face similar challenges makes this Summit so essential to the development of the field.
Harness Safe & Efficacious Lipid-Based Delivery for Novel Therapeutics Beyond RNA & Hepatic Tissue. The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drugdelivery.
Editas Medicine is pausing its ocular gene therapy program after demonstrating a favorable safety profile and seeking a potential partner to develop EDIT-101, the company announced Thursday.
Messenger ribonucleic acid (mRNA) is a single-stranded molecule that is complementary to a gene’s DNA. In the last few years, researchers have become interested in using in vitro transcribed (IVT) mRNA as a drugdelivery agent.
. “Doctors often treat patients who have rheumatoid arthritis with injections or infusions of anti-inflammatory biologic drugs, but those drugs can cause significant side effects when delivered long enough and at high enough doses to have beneficial effects,” said senior investigator Farshid Guilak, PhD, the Mildred B.
The conference will explore advancements in ophthalmic treatments and variety of novel drugs, which are showing great clinical trial data. There will also be a specific focus on drugdelivery along with advancements in novel technologies. The conference is co-chaired by Mitchell A.
The new master agreement, covering another five years, will foster research on genetic medicines, intrathecal delivery of therapeutics into the spinal canal or subarachnoid space of the brain, and the use of nanoparticles to improve drugdelivery.
However, certain biological targets have long eluded drug development efforts. Scientific literature suggests that the RAS gene is mutated across about 30% of cancer types. One such target is Ras family, which has been identified to play a critical role in oncogenesis.
In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines and gene therapies), by the US FDA, have steadily risen. Over the years, the rising popularity of biologics has led to a paradigm shift in the healthcare industry. Our Social Media Platform.
Beam adds to drugdelivery stable with USD 120 Million GuideTx buy. The gene-editing technologies, which have reached the clinic, CRISPR, zinc finger nucleases, and TALENs, make their edits by nicking DNA at the target site.
Therapies such as dexamethasone drugdelivery system and vascular endothelial growth factor inhibitors have already pierced deeper into the market. Looking at the potential of the pipeline therapies they hold once approved, pharmaceutical companies are charting out a seemingly exciting course in the market.
These innovative instruments combine precision, convenience, and patient-centered design to revolutionize drugdelivery. These devices are equipped with advanced features like programmable dosing, connectivity to mobile apps, and safety mechanisms to ensure accurate and controlled drugdelivery.
Driven by the increasing need for safe and efficient medical devices and drugdelivery systems, the pharmaceutical polymers / medical grade polymers domain is advancing significantly. There has been a rise in the development of polymers for biopharma with improved biocompatibility, biodegradability and functionality.
In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines, and gene therapies), by the US FDA, have steadily risen. Over the years, the rising popularity of biologics has led to a paradigm shift in the healthcare industry.
Advances in DrugDelivery (Session #ADT08), with a discussion on the advances and innovations fueling the development of the next generation of antibody drug conjugates. Data identifying a novel immunosuppressive myeloid gene signature for clinical biomarker development.
Through our innovation in the scientific discovery of new potential drug targets, personalised healthcare, molecular engineering, biomarkers and continuous drugdelivery, we strive to design the right therapies for the right patients.
Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. In the last few years, researchers have become interested in using in vitro transcribed (IVT) mRNA as a drugdelivery agent. RNA therapeutics offer several advantages over small molecules.
Genomics is the study of genetic material within a cell, and transcriptomics is the study of gene activity in different cells. Scientific fields involved in high throughput measurement of biological molecules are referred with the suffix- omics including, transcriptomics, genomics, proteomics and metabolomics. Our Social Media Platform.
“This marks another significant milestone as we continue to leverage our polypeptide nano-particle technology for siRNA drugdelivery to advance our pipeline of oncology therapeutic candidates,” said Patrick Lu , Ph.D., 1 and COX-2 gene expression. the founder, President and CEO of Sirnaomics. Chief Medical Officer.
Over the last two decades the pharmaceutical industry has observed a paradigm shift from conventional drugdelivery strategies to more enhanced, potent, and targeted therapeutics. This led the researchers to find alternative pathways and drugdelivery strategies to enhance the potent delivery of the drug to the site of action.
Among launches resilient for these reasons were Tepezza, an orphan thyroid eye disease medication in the US, Zolgensma, a gene therapy for Spinal Muscular atrophy in Germany, and more recently Evrysdi, an oral agent for the same condition. Orphan drugs launch challenges. the impact of the pandemic on medicines markets and Rx launch.
The health regulatory agencies all over have issued several guidelines, released strategies, and amended regulations to expedite the drugdelivery process in the rare disease market landscape.
Relying on independent research and development, the Company has formed gene recombination and fermentation engineering technology, and developed a number of core technologies, such as recombinant collagen, enzymatic and genetic engineering synthesis of bioactive peptides. For additional information, please visit [link].
Through our innovation in the scientific discovery of new potential drug targets, personalised healthcare, molecular engineering, biomarkers and continuous drugdelivery, we strive to design the right therapies for the right patients.
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