This site uses cookies to improve your experience. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country, we will assume you are from the United States. Select your Cookie Settings or view our Privacy Policy and Terms of Use.
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Used for the proper function of the website
Used for monitoring website traffic and interactions
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Strictly Necessary: Used for the proper function of the website
Performance/Analytics: Used for monitoring website traffic and interactions
The study included 754 adolescents, comparing immuneresponses and safety profiles between vaccine and placebo groups. Chikungunya, a mosquito-borne viral disease, causes severe joint pain, fever and rash, with symptoms that can linger for months or even years.
Additionally, a collaboration with NurExone is creating an intranasal delivery system for exosome-based therapies targeting spinal cord injuries, with potential expansion into other neurological uses. Polyrizon’s focus on intranasal protection aligns with a rapidly expanding market in drugdelivery innovation.
With early nanoparticle studies, researchers often found the human body’s innate immuneresponse to drugs and the short-lasting effects of drugs challenging, as they can also reduce a drug’s efficacy. Liposomes have the same function as lipid nanoparticles in drugdelivery but have a simpler formulation.
An intranasal formulation of AstraZeneca’s widely-used COVID-19 vaccine Vaxzevria has failed at the first hurdle, after results from a phase 1 trial found it was unable to stimulate a strong immuneresponse to the virus. “The authors acknowledge certain limitations of the study, including small numbers of participants.
In addition, NLCs offer benefits such as high drug loading capacity, improved drug retention and avoidance of drug expulsion. Advantages of Lipid Nanoparticle LNPs are gaining significant attention of formulation scientists in drugdelivery due to the various advantages offered by them.
Just a few months after starting clinical trials of its nasal spray vaccine for COVID-19, US biotech Altimmune is abandoning the project, saying that it generated weaker than expected immuneresponses in a phase 1 trial. . We believe that prior immunity in humans may be important for a robust immuneresponse to intranasal dosing.”
Linker Stability : The stability of the linker, which attaches the chemotherapy agent to the antibody, is essential for efficient and precise drug-delivery. Researchers are actively looking for ways to solve these problems with the goal of finding the optimal balance between efficacy and toxicity for many of these drugs.
For instance, oral vaccines could allow repeat dosing without a treatment-limiting anti-vector response – where the body generates an immuneresponse against the harmless, non-replicating viruses used to deliver the COVID-19 antigens. There are other theoretical advantages as well.
Approved by the US Food and Drug Administration (FDA) in May 2023, Arexvy is designed to prevent lower respiratory tract disease (LRTD) caused by RSV in older adults. The trial assessed vaccine efficacy using RSV-LRTD cases, which refer to lower respiratory tract infections caused by RSV, leading to complications like pneumonia.
The companies allege Moderna’s vaccine uses their technology for a drug-delivery system without permission. Citing The early-stage study, which is being sponsored by BioNTech, aims to evaluate safety, tolerability, and immunogenicity, or the ability to generate an immuneresponse.
The authorization was based on trial data that showed the vaccine was safe, well-tolerated and induced robust immuneresponses among children in this age group; side effects were generally mild to moderate. Genentech’s New Ocular Implant DrugDelivery System for Macular Degeneration Could Be a Game Changer.
Over time, many research studies have shown that myeloid cells can interact with the immune system and aid in generating an appropriate anti-tumor immuneresponse. Our Social Media Platform. Web: [link]. LinkedIn: [link]. Twitter: [link]. Medium: [link]. Pinterest: [link]. Quora: [link].
In the context of asthma, this means potentially restoring the immuneresponse in the respiratory tract to better protect against viral infections that often trigger severe asthma symptoms. These aggregates can trigger unwanted immuneresponses and reduce transfection efficiency.
After dosing, the LNPs deliver the mRNA sequence into cells, which is then used by cellular machinery to manufacture the viral protein and stimulate an immuneresponse. .” Both Pfizer’s BioNTech-partnered Comirnaty and Moderna’s SpikeVax vaccines use LNPs to carry mRNA coding for the SARS-CoV-2 spike protein.
The complement-targeted therapeutics inhibit complement activation, thereby reducing tissue inflammation and dampening the adaptive immuneresponse to foreign and tissue antigens. Next Generation Complement Therapeutics – Current Market Landscape. Our Social Media Platform. Web: [link]. LinkedIn: [link]. Twitter: [link].
The Company will share a Spotlight Theater Presentation: The Orchestrated ImmuneResponse: Dynamic Forces Guiding Cancer Immunity , introducing a novel framework for understanding the role of the immune system in cancer, with the potential to reshape the way scientists develop medicines to counteract tumour growth.
Kala’s proprietary AMPPLIFY drugdelivery technology is what gets EYSUVIS its backstage pass to penetrate the mucus barrier and delivering the loteprednol etabonate (LE) to the ocular tissue. The corticosteroid then works to relieve swelling, redness and itching by targeting the immuneresponse that drives dry eye disease flares. .
Dr. Bryan began his career at Schering-Plough, engaging in formulation and drugdelivery. Unlike traditional therapies that act on the immune cascade after it has been initiated, Revolo’s treatments act at the very beginning of the immuneresponse.
Albeit, in the past two decades, a lot has been learnt and understood about the etiology of the pathogenesis of Drug-Induced Thrombocytopenia, the knowledge of the molecular nature of the drugs, immune-response to the drugs and the production of antibodies in the body is far from complete.
CIDP is a rare autoimmune disorder where the body’s immune system mistakenly attacks its own tissues. The exact cause of this immuneresponse is unknown, and there appears to be no identifiable genetic predisposition to CIDP. Researchers estimate that the incidence of CIDP in the US ranges from 0.8
In order to help circumvent these disadvantages, several drugdelivery devices, which enable patients to self-administer drugs through subcutaneous route are now being developed. Moreover, protein-based drugs are also well tolerated inside the body, thereby reducing the chances of causing any immuneresponse in the body.
We organize all of the trending information in your field so you don't have to. Join 21,000+ users and stay up to date on the latest articles your peers are reading.
You know about us, now we want to get to know you!
Let's personalize your content
Let's get even more personalized
We recognize your account from another site in our network, please click 'Send Email' below to continue with verifying your account and setting a password.
Let's personalize your content