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Using analytics and bioassays to de-risk your mRNA LNP drug development programme

Pharmaceutical Technology

“At the small scale, manufacturing between 1 ml and 10 ml is typically not problematic , but it’s not straightforward to replicate processes and technologies once you want to produce tens of litres of formulations,” says Dr Crowe, who manages a team that develop novel analytical assays related to LNPs and nanomaterials for drug delivery.

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mRNA Synthesis: ManufacturingProcess of Modern Revolutionary Molecule

Roots Analysis

Further, the biggest challenge in this domain is the purification which involve the use of hazardous solvents / materials and stability of drug products ( thereby, requiring specialized facilities and cold chain transportation).

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Transitioning Between Academia and Industry: Advice from Leading Scientists That Made the Switch

XTalks

Xtalks spoke with WeiQi Lin, MD, PhD, executive vice president, research & development, and principal scientist at DURECT Corporation — a company focused on developing drugs and drug delivery methods in therapeutic areas with significant unmet need — about her transition from academia to industry.