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Since then, the field of nanomedicine has steadily progressed to reach high points such as the successful use of nanotechnology to deliver messenger RNA (mRNA)-based Covid-19 vaccines. In the case of most mRNA vaccines, a lipid nanoparticle-based approach was chosen due to its ability to protect the mRNA in the body and prevent degradation.
Valneva SE, who developed the worlds first FDA-approved chikungunya vaccine , has now unveiled promising Phase III data for its single-shot chikungunya vaccine, IXCHIQ, in adolescents aged 12 to 17. IXCHIQ is the only licensed chikungunya vaccine in the US for adults aged 18 and older at increased risk of exposure to the virus.
When it comes to vaccines and other high-value biologics, it is essential that effective formulations go hand in hand with safe delivery. By having the drug already dosed inside the chamber and no need to draw it from a vial into a syringe, the process is streamlined and the risk of a potential dosing error is eliminated.
An intranasal formulation of AstraZeneca’s widely-used COVID-19 vaccine Vaxzevria has failed at the first hurdle, after results from a phase 1 trial found it was unable to stimulate a strong immune response to the virus. Other efforts to develop a nasally-delivered COVID-19 vaccine have met with greater success.
ImmunityBio has licensed technology underpinning a COVID-19 vaccine that could be administered orally rather than by injection from UK biotech iosBio. Non-injectables remove the need for health professional-led immunisation programmes, making widespread vaccine roll-outs quicker and easier and more affordable,” Channon told pharmaphorum.
Just a few months after starting clinical trials of its nasal spray vaccine for COVID-19, US biotech Altimmune is abandoning the project, saying that it generated weaker than expected immune responses in a phase 1 trial. . The post Altimmune ditches nasal COVID vaccine on weak trial data appeared first on.
Sorrento Reports Promising Results With mRNA Vaccine For COVID-19 Delivered With The MuVaxx Lymphatic DrugDelivery Device Sorrento Reports Promising Results With mRNA Vaccine For COVID-19 Delivered With The MuVaxx Lymphatic DrugDelivery Device Sorrento’s mRNA vaccine (“STI-mRNA”) delivered with … Continue reading →
… A Delaware federal court refused to throw out patent infringement claims brought by Arbutus Biopharma and Genevant Sciences against Moderna over its sale of Covid-19 vaccine doses to the U.S. Genevant and Arbutus sued Moderna in February, seeking royalties from Moderna’s sale of its Covid-19 vaccine.
In this episode, Ayesha discusses the FDA’s authorization of Pfizer/BioNTech’s COVID-19 vaccine for children between five and 11 years of age. The editorial team discussed the positive trial data, the importance of vaccinating kids amid rising infections among younger children, as well as vaccine hesitancy among parents.
In the last few years, researchers have become interested in using in vitro transcribed (IVT) mRNA as a drugdelivery agent. It is worth noting that several companies have begun to develop mRNA-based cancer immunotherapies and vaccines for infectious diseases.
Alnylam claims it is owed a slice of the massive revenues booked by Pfizer and Moderna for their mRNA-based COVID-19 vaccines, because they are both infringing patents its holds on a delivery technology. The post Alnylam sues Pfizer, Moderna over COVID-19 vaccines appeared first on.
Gelteq centers its technology on a proprietary, customizable gel platform designed for precise drugdelivery, supporting prescription drugs, nutraceuticals, pet care and sports supplements. Priced at $4.0
A new intracellular drugdelivery centre will be established in the UK to support potential ribonucleic acid (RNA) vaccines and therapeutics , as well as the development of innovative drugdelivery technologies. Another key focus area will be the creation of a framework to develop advanced nano-delivery systems.
Furthermore, a wide variety of drugs and macromolecules, including DNA , proteins, and imaging agents, can be encapsulated in liposomal vesicles due to their unique ability to entrap both lipophilic and hydrophilic substances. The various therapeutic applications of liposomes in drugdelivery have been highlighted in the figure.
There is a rising demand for vaccines, insulin, and many modern medicines used to treat cancer and other chronic diseases. As biologics are mainly administered through the injectable route, the significant growth in the biologics market is expected to drive the injectable drugdelivery and prefilled syringe market in the coming years.
The successful launch of mRNA vaccines during the Covid-19 pandemic has not only spurred mRNA-related research across interdisciplinary groups, but also further validated the use of lipid nanoparticles as delivery approaches.
Owing to their unique size and physicochemical properties ( surface roughness, surface area, surface energy, crystal structure and shape ), nanoparticles can be widely used as a contrasting agent in medical imaging, a vesicle to cross the blood-brain barrier and a carrier for targeted delivery of genes / drugs, proteins, vaccines and antibiotics.
Given the robust pipeline of biologics, which include monoclonal antibodies, vaccines and other protein-based therapeutic products, subcutaneous medications are being investigated for various clinical candidates across different phases of development. You can also download the SAMPLE REPORT on subcutaneous medications by Roots Analysis.
Polyrizon’s focus on intranasal protection aligns with a rapidly expanding market in drugdelivery innovation. The FDA-approved FluMist , featured as one of TIME’s Best Inventions of 2024, exemplifies the appeal of needle-free, self-administered nasal vaccines for influenza.
However, several drugdelivery devices that enable patients to self-administer their respective medications are now available. Subcutaneous drugdelivery systems – the helping hand for patients. The emergence of safer and patient-friendly devices is acting as a strong enabler for subcutaneous delivery of therapeutics.
The 2023 Transdermal and Microneedle DrugDelivery Conference will explore real world applications of microneedles in drugdelivery and strategies for advanced and user-centric device design. Regulation of transdermal delivery systems will be another key theme addressed, in combination with clinical trial optimization.
This includes the rising number of biologic drugs on the market, which are mostly administered parenterally. During the Covid-19 pandemic, large-scale vaccine production placed unprecedented demand on the parenteral packaging industry. The injectable drugs market is currently valued at around $532 billion.
As part of SMi’s leading series of drugdelivery device conferences, the 2022 event will provide insights into the rapidly accelerating market of combination product development with industry, device developer and regulatory perspectives. Uncover the key considerations to ensure optimal lifecycle management for drugdelivery devices.
RELATED: Walgreens, CVS, Amazon and Walmart Compete in Prescription DrugDelivery Factors Behind the CVS Health Clinical Trial Services Closure Speculations are rife in the industry for reasons behind the closure of CVS Health Clinical Trial Services.
During the peak of the Covid-19 pandemic this challenge reached new heights, as pharmaceutical firms around the world mobilised the full might of their resources to try and identify, develop, and trial a wide range of vaccines and therapeutics to alleviate the lethal threat posed by the virus. Decentralised trials continue to be in-demand.
SMi presents the Inaugural: Transdermal and Microneedle DrugDelivery Conference. Latest innovations in drugdelivery beyond the needle. SMi is proud to present the Transdermal and Microneedle DrugDelivery Conference, taking place on the 24th to 25th January 2022, in London. pharmaphorum .
The past year has seen significant developments in the injectables landscape with the rapid introduction and development of vaccines in response to the pandemic, updates in regulations including the EU MDR and FDA guidance on bridging studies, and increasing industry acceptance of connectivity to aid the user experience. 13.00 – 17.00.
For instance, if the trial involves a novel drug-delivery system, the DSMB might include a pharmaceutical scientist. The Role of DSMB in the COVID-19 Pandemic The importance of DSMBs was highlighted during the COVID-19 pandemic when several vaccines were developed and tested in clinical trials at record speed.
Harness Safe & Efficacious Lipid-Based Delivery for Novel Therapeutics Beyond RNA & Hepatic Tissue. The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drugdelivery.
Overcoming the Challenges of mRNA Drug Development Developing mRNA therapeutics for respiratory conditions presents unique challenges, particularly in terms of drugdelivery and stability.
Driven by the increasing need for safe and efficient medical devices and drugdelivery systems, the pharmaceutical polymers / medical grade polymers domain is advancing significantly. Vaccine Adjuvants: Polymers often serve as carriers for releasing the antigen and thereby regulating the immunological responses.
The swift development and deployment of messenger-RNA (mRNA) vaccines against the SARS-CoV-2 virus during the COVID-19 crisis has catapulted the pharmaceuticals industry into a new paradigm. More challenges arise with the formulation of the mRNA delivery agent, like lipid nanoparticles (LNPs).
Abexxa will form part of its broad push into immuno-oncology, focused on cancer vaccines, oncolytic viruses and T-cell engagers, amongst other treatment strategies. Earlier this year, it backed out of a $600 million alliance with CureVac focused on developed mRNA-based vaccines for cancer. Last December, Boehringer paid €1.8
Therefore, myeloid therapies have gained significant attention as a potential adjunct to currently used therapies, such as immune checkpoint inhibitors, dendritic cell vaccines, oncolytic viruses, and chemoradiation to enhance therapeutic response. Our Social Media Platform. Web: [link]. LinkedIn: [link]. Twitter: [link]. Medium: [link].
In addition, in order to address the cell boundary challenge associated with the mRNA COVID-19 vaccines, majority of the deals in this industry have been inked for manufacturing lipid nanoparticles, required to envelop and deliver the mRNA (over 55%). Of these, 90% of the partnerships have been inked with industry players. Web: [link].
Stefan Woxström is the new senior vice president for Europe and Canada at AstraZeneca, moving over from the company’s Japanese division to take over from Iskra Reic , who will now serve as EVP of vaccines and immune therapies. New CEO in at Angelini Pharma. More CEO shakeups.
Synairgen’s SNG001 among the many potential treatments and vaccines to be delivered via Aerogen’s aerosol drugdelivery system Adds to the thousands of COVID-19 patients already safely and effectively treated with Aerogen’s Solo aerosol drugdelivery system in the intensive … Continue reading →
In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines and gene therapies), by the US FDA, have steadily risen. Over the years, the rising popularity of biologics has led to a paradigm shift in the healthcare industry. Our Social Media Platform.
The RNA therapeutics industry has grown at an exponential rate in recent years, with an increased spotlight following the industry’s leading role in developing vaccines against COVID-19 in response to the global pandemic. Delve into the latest innovations in novel RNA delivery and target specificity. Hashtag: #SMiRNA.
Other than the oral insulin , Oramed is developing an oral formulation of a glucagon-like peptide-1 (GLP-1) analogue called ORMD-0901, but that remains in early clinical development, along with an oral COVID-19 vaccine.
This will aid in the production of new raw materials and possible clinical-grade assets to develop mRNA vaccines and therapies for infectious diseases, as well as other ailments with unmet needs. RVAC is currently developing mRNA-based vaccines against infectious diseases such as Covid-19.
In the last few years, researchers have become interested in using in vitro transcribed (IVT) mRNA as a drugdelivery agent. Furthermore, these drug candidates can be used to develop precise and individualized therapies that allow patients to produce therapeutic proteins in their own bodies.
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