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Amgen to test new way to lower heart risk with large drug trial

Bio Pharma Dive

Buoyed by strong mid-stage study results, the biotech will soon start a cardiovascular outcomes trial of a drug designed to target a genetic risk factor called lipoprotein(a).

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How using AI in clinical trials accelerates drug development

Pharmaceutical Technology

The need for new medical treatments and drugs has never been greater. But before pharmaceutical companies can go to market with a breakthrough drug, they need to ensure safety and efficacy through clinical trials. Even reaching the clinical trial phase offers no guarantees, as only 12% of such drugs receive U.S.

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Fatty liver disease: With little early detection, more challenging drug development

pharmaphorum

Obesity, diabetes, and genetics are the primary drivers, and COVID is about to make this exponentially worse. But herein lies the dichotomy that medicine has created: By failing to regularly screen to find the early-stage disease, the number of patients who could participate in drug trials is limited. About the Author.

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Diseases Don’t Discriminate, So Why Aren’t Clinical Trials More Diverse?

XTalks

Disease doesn’t discriminate, and researchers understand different populations react differently to drugs. Why, then, are clinical trials so stubbornly homogeneous? Clinical trials, however, don’t reflect that diversity. When trial populations don’t match the broader patient base, the treatments they produce aren’t as effective.

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Clinical Trials for Pulmonary Fibrosis: How Can Participation Be Improved?

XTalks

The exact cause of pulmonary fibrosis is often unknown, and in such cases, it is referred to as idiopathic pulmonary fibrosis (IPF); however, certain factors can contribute to the development of pulmonary fibrosis, including environmental and occupational exposures, certain medications, autoimmune diseases and genetic predisposition.

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Why Black People Remain Underrepresented in Clinical Trials

XTalks

Despite these statistics, in the US, Black people only constitute five percent of all clinical trial participants. The overwhelming majority of trial participants nationwide are white. However, the links between race-based genetics and disease are not quite clear. Personalized Medicine.

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Building Inclusive Trials: Insights from CTTI’s Diversity Initiatives

XTalks

A significant initiative is the Diversity Convergence project, which brings together multiple organizations, including the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard, FasterCures, a center of the Milken Institute and the National Academies’ Forum on Drug Discovery, Development and Translation.

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