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Buoyed by strong mid-stage study results, the biotech will soon start a cardiovascular outcomes trial of a drug designed to target a genetic risk factor called lipoprotein(a).
The need for new medical treatments and drugs has never been greater. But before pharmaceutical companies can go to market with a breakthrough drug, they need to ensure safety and efficacy through clinical trials. Even reaching the clinical trial phase offers no guarantees, as only 12% of such drugs receive U.S.
Obesity, diabetes, and genetics are the primary drivers, and COVID is about to make this exponentially worse. But herein lies the dichotomy that medicine has created: By failing to regularly screen to find the early-stage disease, the number of patients who could participate in drugtrials is limited. About the Author.
Disease doesn’t discriminate, and researchers understand different populations react differently to drugs. Why, then, are clinical trials so stubbornly homogeneous? Clinical trials, however, don’t reflect that diversity. When trial populations don’t match the broader patient base, the treatments they produce aren’t as effective.
The exact cause of pulmonary fibrosis is often unknown, and in such cases, it is referred to as idiopathic pulmonary fibrosis (IPF); however, certain factors can contribute to the development of pulmonary fibrosis, including environmental and occupational exposures, certain medications, autoimmune diseases and genetic predisposition.
Despite these statistics, in the US, Black people only constitute five percent of all clinical trial participants. The overwhelming majority of trial participants nationwide are white. However, the links between race-based genetics and disease are not quite clear. Personalized Medicine.
A significant initiative is the Diversity Convergence project, which brings together multiple organizations, including the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard, FasterCures, a center of the Milken Institute and the National Academies’ Forum on Drug Discovery, Development and Translation.
The successful development and deployment of the mRNA-based COVID-19 vaccines has catalysed the biopharma industry and paved the way to expand this drug modality to new therapeutic areas. Excluding vaccines, there are five mRNA therapeutic products in clinical trial development as of November 2022.
Regeneron resumes enrollment in lymphoma drugtrials ( Reuters ).
Incyte’s vitiligo treatment meets main goal in late-stage trial ( Reuters ).
Clinical trial strategies for rare neurodevelopmental disorders: challenges and opportunities ( Nature ).
Now they fear an increase.
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