STAT News

DECEMBER 2, 2022

A Somerville startup and an academic lab in Seattle say they have developed a way to use artificial intelligence to design proteins that don’t exist in nature. Proteins help people move, digest food, and fight infections — to name a few of their numerous functions. And for some scientists, nature is too limiting.

Protein 111

Protein Scientist Development Drugs 111

Scienmag

APRIL 8, 2021

Credit: © Terence Strick The Mfd protein repairs bacterial DNA, but can also, to scientists’ surprise, promote mutation. Understanding this second “role” of the Mfd protein opens up opportunities for combating antibiotic resistance, and also the resistance of tumours to anti-cancer drugs and therapies.

Protein 98

Protein DNA Scientist Drugs 98

STAT News

OCTOBER 13, 2022

Every two years since 1994, scientists have come together for an experiment — better described as a competition — where teams of computational biologists try to predict what proteins will look like in 3D given their amino acid sequence. In 2020, its successor, AlphaFold2, achieved near-perfect scores.

Protein 111

Protein Scientist Drugs Development 111

NY Times

NOVEMBER 30, 2020

Researchers at DeepMind say they have solved “the protein folding problem,” a task that has bedeviled scientists for more than 50 years.

Protein 123

Protein Scientist Drugs Research 123

Pharmaceutical Technology

SEPTEMBER 14, 2022

API peptides and proteins-based drugs have gained much attention in the past decade. Discover the top API protein and peptide companies in contract marketing. Technologies in the delivery of peptides and proteins. They are promising therapeutics for the treatment of a variety of metabolic and oncological disorders.

Protein 100

Protein Marketing Manufacturing Reagent 100

pharmaphorum

NOVEMBER 12, 2021

Researchers in the US have developed an artificial intelligence-based tool that is able to predict COVID-19 symptoms and suggest which FDA-approved drugs might be used to treat patients. The tool meanwhile could also be applied to new outbreaks of other novel viral infections as they emerge, according to the scientists.

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Doctor Doctors Drugs Gene Expression 135

Scienmag

NOVEMBER 23, 2020

Rice scientists’ atomic resolution protein models reveal new details about protein binding Credit: Illustration by Mingchen Chen/Rice University HOUSTON – (Nov. 23, 2020) – Knowing precisely where proteins are frustrated could go a long way toward making better drugs.

Protein 95

Protein Drugs Scientist 95

pharmaphorum

FEBRUARY 13, 2025

Another AI drug discovery venture has emerged from the Google DeepMind team, Latent Labs, with $50m in funding for its protein design platform.

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Scientist Drugs Protein 76

Medical Xpress

FEBRUARY 9, 2023

Scientists have revealed details of the discovery of new inhibitors of the BCL6 protein, which is involved in driving several cancer types including the blood cancer B-cell lymphoma.

Protein 75

Protein Scientist Drugs Research 75

Pharmaceutical Technology

JANUARY 4, 2023

The China National Medical Products Administration’s (NMPA) Center for Drug Evaluation (CDE) has granted clearance for Transcenta’s investigational new drug (IND) application for its TST003 to treat solid tumours. The Gremlin1 protein was found to promote lineage plasticity while driving castration resistance in prostate cancer.

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Antibody In-Vivo In-Vitro Protein 242

Pharmaceutical Technology

FEBRUARY 23, 2023

Biopharmaceutics is a scientific discipline that examines the interrelationship of the physicochemical properties of the drug, the dosage form in which the drug is given, and the route of administration on the rate and extent of systemic drug absorption ( Applied Biopharmaceutics and Pharmacokinetics, Shargel, Wu-Pong and Yu, 5th Edition ).

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Development Drugs Bioavailability In-Vivo 246

Medical Xpress

APRIL 26, 2023

Cambridge scientists have shown how the brain's ability to clear out toxic proteins is impaired in Huntington's disease and other forms of dementia—and how, in a study in mice, a repurposed HIV drug was able to restore this function, helping prevent this dangerous build-up and slowing progression of the disease.

Protein 75

Protein Drugs Scientist 75

Medical Xpress

FEBRUARY 16, 2023

Scientists at Scripps Research, with collaborators in Japan, have discovered how a "poisoned" form of a protein could set off a cascade of events that encourage the growth of some cancers. In mice with colon cancer, the drug prevented or dramatically slowed formation of tumors.

Protein 75

Protein Scientist Drugs Research 75

Pharmaceutical Technology

APRIL 26, 2023

The funding and a prize-win from Amgen will support the company’s drug development plans as Singapore continues developing its pharmaceutical market. The company targets disease through mechanisms in the extracellular matrix (ECM), where Albatroz’s medicines target and degrade a protein complex, Calnexin.

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Development Drugs Marketing Protein 256

Scienmag

JULY 22, 2021

New UCLA research identifies TAF12 as a potential cancer drug target FINDINGS Scientists from the UCLA Jonsson Comprehensive Cancer Center have identified a key protein, transcription factor TAF12, that plays a critical role in the formation of a preinitiation complex, which consists of over one hundred proteins that are necessary for the transcription (..)

Scientist 75

Scientist Protein Drugs Research 75

Scienmag

JULY 4, 2022

Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) […].

Scientist 71

Scientist Protein Drugs Medicine 71

Scienmag

MAY 4, 2022

Scientists at Emory have revealed widespread distortions of a cell’s protein interaction machinery resulting from cancer-causing mutations. They developed a process resembling ground-penetrating radar, for its ability to map the hidden landscape of anticancer drug opportunities. The results are published in Cell.

Protein 59

Protein Scientist Development Drugs 59

Pharmaceutical Technology

MAY 19, 2023

The US Supreme Court has unanimously voted in favour of Sanofi and Regeneron in a years-long legal feud with Amgen over the potential patent infringement surrounding the companies’ anti-cholesterol drugs. This marks a milestone in the dispute nearly a decade after the first lawsuit filed by Amgen against the two companies.

Drugs 147

Drugs Antibody Protein Scientist 147

Scienmag

NOVEMBER 17, 2020

Scientists have established a new method to image proteins that could lead to new discoveries in disease through biological tissue and cell analysis and the development of new biomaterials that can be used for the next generation of drug delivery systems and medical devices.

Protein 67

Protein Drug Delivery Systems Drug Delivery Scientist 67

Scienmag

JUNE 29, 2022

In ACS Infectious Diseases, scientists now report that apratoxin S4, an anticancer drug candidate that targets a […]. More than two years into the COVID-19 pandemic, people are realizing that the “new normal” will probably involve learning to co-exist with SARS-CoV-2.

Protein 87

Protein Scientist Drugs Research 87

pharmaphorum

MARCH 26, 2021

There’s a new kid on the block among companies using artificial intelligence in drug discovery, after 1910 Genetics launched today with $26 million in financing. Forty-five years later, scientists discovered the molecular basis of SCD in haemoglobin mutations. million in seed financing led by OpenAI’s Sam Altman.

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Genetics Drugs Protein Scientist 109

Scienmag

JUNE 8, 2021

New structure shows how virus envelope protein hijacks cell-junction protein and promotes viral spread; findings could speed the design of drugs to block severe effects of COVID-19 Credit: Brookhaven National Laboratory UPTON, NY–Scientists at the U.S.

Protein 98

Protein Scientist Drugs Medicine 98

Medical Xpress

FEBRUARY 23, 2023

Scientists at Open Targets, EMBL's European Bioinformatics Institute (EMBL-EBI), and GSK are revealing the shared basis of diseases using a map of interacting human proteins.

Bioinformatics 75

Bioinformatics Drugs Protein Scientist 75

pharmaphorum

DECEMBER 24, 2020

A serotonin sensor designed using Artificial Intelligence (AI) could help scientists study sleep and mental health and potentially find new neurology drugs. The US National Institutes of Health said that the research it had co-funded used AI to transform a bacterial protein into a new research tool.

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Development Drugs Protein Genetic Engineering 77

The Pharma Data

APRIL 26, 2022

A drug used to treat asthma and allergies can bind to and block a crucial protein produced by the virus SARS-CoV-2, and reduce viral replication in human immune cells, according to a new study by researchers at the Indian Institute of Science (IISc). “The anti-HIV drug (saquinavir) showed good affinity, but not good stability.”

Protein 52

Protein Drugs Allergies FDA Approval 52

Scienmag

NOVEMBER 17, 2020

Credit: © Andreas Reicher / CeMM Until now, scientists typically studied the changes of proteins and their roles in the cell by using a fluorescent tag to label and follow one protein at a time. This approach limited the number of proteins that could be studied and precluded unbiased discovery approaches.

Protein 52

Protein Scientist Drugs Research 52

Pharmaceutical Technology

JANUARY 25, 2023

Development of PROTACs (PROteolysis TArgeting Chimeras) has advanced fairly rapidly as excitement grows over their potential to selectively degrade proteins that are involved in various diseases, including cancer. PROTACs are a type of heterobifunctional degrader that offers multiple advantages over traditional small molecules.

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Protein Bioavailability Development Scientist 130

BioPharma Reporter

MAY 3, 2023

Protein drugs are notoriously difficult to deliver orally â but scientists have developed a new type of oral capsule that could deliver insulin and other similar drugs.

Insulin 52

Insulin Scientist Development Protein 52

Scienmag

JULY 19, 2021

Scientists collaborate to model the complex protein responsible for SARS-CoV-2 replication, revealing its potential weak spots for drug development Credit: Greg Hura/Berkeley Lab In February 2020, a trio of bio-imaging experts were sitting amiably around a dinner table at a scientific conference in Washington, D.C.,

Protein 96

Protein Scientist Development Drugs 96

Scienmag

MARCH 18, 2021

— Scientists at the University of Wisconsin-Madison have developed a way to use a cell’s own recycling machinery to destroy disease-causing proteins, a technology that could produce entirely new kinds of drugs. MADISON, Wis. By eliminating them, researchers believe […].

Protein 49

Protein Scientist Development Drugs 49

pharmaphorum

JANUARY 11, 2023

A slow journey to drug discovery. Asked about the impetus behind Verseon’s work in the sector, Prakash explained that he began the company “to change the way the world finds new drugs”. Today’s pharmaceutical drug discovery process essentially relies on trial and error,” he expanded. “To Not an unambitious goal.

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Big Data Drugs Clinical Trials Clinical Trials 122

Scienmag

MAY 9, 2022

May 9, 2022) Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children. However, these drugs are subject to treatment resistance. Scientists at St. (Memphis, Tenn.—May A paper on the […].

Protein 89

Protein Scientist Drugs Research 89

Scienmag

OCTOBER 1, 2020

A sweeping study of proteins that modulate cell signaling could lead to a better understanding of myriad diseases–and of what makes us all different. Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.

Protein 75

Protein Scientist Regulation Drugs 75

Scienmag

FEBRUARY 24, 2022

For some time, scientists have been working on the major challenge of developing new therapies against many human diseases. Many of these diseases are caused by the abberant action of certain proteins in our cells that are considered “undruggable”, or difficult to therapeutically target using classical drug discovery methods.

Protein 83

Protein Scientist Development Drugs 83

Pharmaceutical Technology

JULY 5, 2022

Researchers at the UNC School of Medicine have discovered that hepatitis A virus (HAV) replication needs particular interactions between the human protein ZCCHC14 and TENT4 poly(A) polymerases, a group of enzymes. In addition, the scientists later found that the HAV needs TENT4A/B for its replication.

Protein 130

Protein RNA Genomics Genome 130

Scienmag

DECEMBER 28, 2020

iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells Credit: Kyoto University iCeMS In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), discovered that a protein (..)

Protein 40

Protein Drugs Scientist 40

XTalks

JULY 28, 2020

For decades, formulation scientists have relied on the assumption that common pharmaceutical excipients are biologically inert. For example, Advil tablets contain 18 inactive ingredients alongside ibuprofen, the drug’s active pharmaceutical ingredient (API).

Protein 103

Protein Drugs In-Vitro Scientist 103