Tue.Mar 12, 2024

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After surprise trial failure, ALS doctors brace for one less treatment option

Bio Pharma Dive

Physicians are preparing for tough conversations with patients on Amylyx Pharmaceuticals’ drug, Relyvrio, while holding out hope it still may help some with the disease.

Doctor 317
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Terns scores FDA orphan designation for CML therapy

Pharmaceutical Technology

TERN-701 is a BCR-ABL tyrosine-kinase inhibitor being studied in a Phase I study, with data expected in H2 this year.

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Extreme Case of Man Who Had 217 COVID Vaccines Surprises Scientists

AuroBlog - Aurous Healthcare Clinical Trials blog

Two hundred and seventeen. That’s how many vaccines a man in Germany claims to have received for COVID-19 in just 29 months – and his body isn’t reacting the way some scientists thought it would.

Scientist 246
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Jaguar Health balances ambitions for human and animal pharmaceuticals

Pharmaceutical Technology

In an exclusive interview, Jaguar Health’s CEO discussed plans for the investigation of crofelemer in human and animal studies.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Should You Let Your Dog Lick Your Face? Here’s The Science

AuroBlog - Aurous Healthcare Clinical Trials blog

Any dog owners reading this will know the joy of getting home and being greeted with utter delight by their pet – tail wagging wildly before enthusiastic but face-drenching licks.

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Allogene taps Arbor in pursuit of ‘off-the-shelf’ CAR-T therapies for autoimmune disease

Bio Pharma Dive

Allogene’s partnership with Arbor is designed to help the company stand out in what’s quickly become one of the industry’s hottest areas of drug research.

Drugs 189

More Trending

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Making Informed Decisions in Your Oncology Study: Understanding Biomarkers

Worldwide Clinical Trials

Every step in a successful oncology study requires critical and carefully thought-out decisions. Biomarkers provide a rapid way to inform many clinical oncology study development decisions, including study endpoints. What are they, how do they work, and how can they benefit your oncology study? What Are Biomarkers, and How Are They Used in Oncology?

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Acadia drug fails schizophrenia trial, setting back company’s expansion plans

Bio Pharma Dive

The setback shuts out Acadia’s top medicine from a large sales opportunity and heightens the biotech’s dependence on a pipeline filled with risky drug prospects.

Drugs 133
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ICR awarded $25m by Cancer Grand Challenges to research solid tumours in children

Pharma Times

Globally, cancer is currently the most leading cause of death due to disease among children

Research 132
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A review of changing regulatory and analytical requirements of free amino acid monographs of the European Pharmacopoeia

Pharmaceutical Technology

Butterworth Laboratories looks at the current amino acid testing landscape since the changes in monographs introduced in 2013.

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Optimizing Clinical Supply Strategy: Navigating Challenges & Finding Your Ideal Model

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Why gut bacteria is the next frontier in medicine

pharmaphorum

Discover why gut bacteria are considered the next frontier in medicine in this informative article. Learn about the importance of the microbiome, its impact on health, and how it relates to conditions like Clostridiales difficile.

Bacteria 126
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Tierra raises $11.4 in Series A round for predictive AI protein maker

Pharmaceutical Technology

The US company is part of a burgeoning artificial intelligence (AI) market in early-stage drug development.

Protein 130
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What do volunteers for research studies do after finding a trial?

Antidote

For many people, participating in a research study presents an interesting opportunity with many benefits to volunteering. While there are many types of clinical research, all with distinct goals and timelines, trial volunteers will follow a similar path when taking part. Read on to learn more about the process.

Trials 119
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J&J seeks label expansion for Tremfya in ulcerative colitis

Pharmaceutical Technology

Johnson & Johnson’s Tremfya is approved for plaque psoriasis and active psoriatic arthritis, with a label for ulcerative colitis now on the horizon.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Changing Faces: Agency, consultancy, and investor hires from February 2024

pharmaphorum

Discover the latest agency, consultancy, and investor hires from February 2024, including personnel from OVID Health, Avalere, WE Communications, and Eurozeo. Stay updated with industry movements and key players.

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Selecta Biosciences files patent for enhanced gene therapy using viral vectors and immunosuppressants

Pharmaceutical Technology

Enhance gene expression and reduce immune responses with Selecta Biosciences' patented method using viral vectors and nanocarriers attached to immunosuppressants. Learn more about this innovative approach for improved therapeutic outcomes.

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NHS campaign urges over 900,000 young adults to catch up on missed MMR vaccine

Pharma Times

Between October 2023 and March 2024, the UKHSA said that 733 cases of measles were reported in England

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Indena’s CDMO services: Full manufacturing capabilities for pharma ingredients

Pharmaceutical Technology

In a challenging CDMO framework, Indena has acquired the experience and the equipment to handle high potent NCEs and commercial…

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European Clinical Supply Planning: Balancing Cost, Flexibility and Time

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Avoiding the data swamp: The transformative power of AI

pharmaphorum

In the latest episode of the pharmaphorum podcast, host Nicole Raleigh speaks (virtually) with Nathan Clark, founder and CEO of Ganymede, a modern data platform and Cloud infrastructure for science, to discuss the evolving role of the Cloud in biopharma and some rather revolutionary tools in AI drug discovery.

Drugs 116
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Amid Moderna's 'transition year,' CEO Stéphane Bancel's total pay fell by about 5%

Fierce Pharma

Despite Moderna’s efforts to prove its mRNA thesis beyond COVID-19 in 2023, the post-pandemic hangover took a toll on the company. | Despite Moderna’s efforts to prove its mRNA thesis beyond COVID-19 in 2023, the post-pandemic hangover took a heavy toll on the company. In turn, much of the company’s top brass—including CEO Stéphane Bancel—saw their total compensation fall for the year.

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Review calls for action on bias with medical devices

pharmaphorum

Healthcare systems need to address the impact of racial and ethnic biases in the design and use of medical devices, says an independent UK review.

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Pfizer aims Adcetris for expansion into large B-cell lymphoma after trial win

Fierce Pharma

The antibody-drug conjugate (ADC) Adcetris has given Pfizer’s oncology department its first pivotal trial win from the legacy Seagen portfolio since the $43 billion merger. | The antibody-drug conjugate Adcetris has given Pfizer’s oncology department its first pivotal trial win from the legacy Seagen portfolio since the $43 billion merger.

Trials 111
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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Older Adults’ Experience with Opioid Use, Deprescribing

Pharmaceutical Commerce

A qualitative study explores how these drugs are impacting these patients’ lives, while digging deeper into the possibility of deprescribing, with insight from primary care physicians.

Drugs 111
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Acadia to end Nuplazid testing after schizophrenia trial flop and years of failed expansion efforts

Fierce Pharma

Acacia Pharmaceuticals is calling it quits on future testing of Nuplazid after a string of expansion efforts have come up short. | The company will not conduct any further clinical trials of the drug, which is currently approved to treat Parkinson’s disease psychosis. The decision comes after years of failed expansion bids in other uses.

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Weight Loss Blockbuster Wegovy Wins Expanded Approval for Heart Benefits

XTalks

Novo Nordisk’s blockbuster obesity and weight loss drug Wegovy (semaglutide) has scored a major label expansion after receiving approval from the US Food and Drug Administration (FDA) for a heart indication to reduce the risk of cardiovascular death, heart attack and stroke in adults with cardiovascular disease and either obesity or overweight.

Drugs 105
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Pfizer’s Velsipity heading for NHS use in ulcerative colitis

pharmaphorum

Up to 25,000 patients in England with ulcerative colitis are eligible for treatment with Pfizer’s Velsipity after NICE backed use of the drug on the same day as its MHRA approval.

Drugs 105
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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Adopting New Manufacturing Technologies

Pharmaceutical Commerce

A sit-down with Groovy Singh, CEO of Bright Green Corporation, who describes the waves in the global supply chain the company is making after being authorized to grow cannabis, along with cannabis-related products.

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Acadia pulls trials of pimavanserin after schizophrenia fail

pharmaphorum

Acadia Pharma has abandoned plans to develop Nuplazid for additional indications after the drug failed a phase 3 trial in schizophrenia.

Trials 105
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Top 10 Best Healthcare Companies to Work For in 2024: A Forbes List Breakdown

XTalks

In the dynamic and challenging landscape of the healthcare industry, distinguishing oneself as an employer of choice represents a significant achievement. Forbes’ 2024 “ America’s Best Large Employers ” list showcases those healthcare companies that excel in creating outstanding workplace environments, driving innovation and showing a deep commitment to their employees’ growth and well-being.

Research 103
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AAD: Sanofi showcases data on possible Dupixent successor

pharmaphorum

Sanofi says OX40L inhibitor amlitelimab could be a ‘best-in-class’ maintenance therapy for atopic dermatitis after reporting new phase 2b data

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.