Fri.Dec 13, 2024

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Japanese researchers test pioneering drug to regrow teeth

Medical Xpress

People with missing teeth may be able to grow new ones, say Japanese dentists testing a pioneering drug they hope will offer an alternative to dentures and implants.

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FDA accepts Sobi North America’s thrombocytopenia therapy sNDA

Pharmaceutical Technology

The US FDA has accepted Sobi North Americas avatrombopag (DOPTELET) sNDA to treat paediatric immune thrombocytopenia.

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AI-powered blood test can spot earliest sign of breast cancer

Medical Xpress

A new screening method that combines laser analysis with a type of AI is the first of its kind to identify patients in the earliest stage of breast cancer, a study suggests.

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Conduit and Sarborg link to optimise AI drug development

Pharmaceutical Technology

Conduit has signed an agreement with Sarborg to leverage advanced artificial intelligence and cybernetics.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Heart-related side effects of cancer treatment must be addressed as early as possible, experts say

Medical Xpress

The devastating news of a cancer diagnosis understandably makes doctors and patients focus on the cancer itself. However, experts in cardio-oncology from the European Society of Cardiology (ESC) emphasize that heart and cardiovascular health must be included as early as possible in the patient's cancer treatment plan to ensure the best possible outcomes.

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Roche wins Vabysmo prefilled syringe EU approval to intensify Eylea challenge

Pharmaceutical Technology

Roches Vabysmo is now available in prefilled syringes and vials for three retinal conditions.

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A novel, toothy approach to innovating randomization in clinical trials

Pharmaceutical Technology

New eClinical platforms from Merative are helping clinical trials develop effective randomization strategies.

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Light-induced gene therapy disables cancer cells' mitochondria

Medical Xpress

Researchers are shining a light on cancer cells' energy centersliterallyto damage these power sources and trigger widespread cancer cell death. In a new study, scientists combined strategies to deliver energy-disrupting gene therapy using nanoparticles manufactured to zero in only on cancer cells. Experiments showed the targeted therapy is effective at shrinking glioblastoma brain tumors and aggressive breast cancer tumors in mice.

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AIM ImmunoTech gains Netherlands patent for post-Covid fatigue therapy

Pharmaceutical Technology

AIM ImmunoTech has secured a patent from the Netherlands Patent Office for Ampligen, targeting the treatment of post-Covid fatigue.

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Mini-brains reveal how mitochondrial mutations affect brain cells

Medical Xpress

Researchers at the University of Bergen have used advanced stem cell technology to develop mini-brains, also called brain organoids, that can mimic disease processes caused by mitochondrial failure. This could open new avenues for treating serious brain diseases such as epilepsy.

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Optimizing Clinical Supply Strategy: Navigating Challenges & Finding Your Ideal Model

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Risk adjusted net present value: What is the current valuation of Avidity Biosciences’s AOC-1020?

Pharmaceutical Technology

AOC-1020 is an antisense rnai oligonucleotide commercialized by Avidity Biosciences, with a leading Phase II program in Facioscapulohumeral Muscular Dystrophy (FSHD).

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From Yemen to France, research reveals spread of highly drug-resistant cholera strain

Medical Xpress

Scientists from the National Reference Center for Vibrios and Cholera at the Institut Pasteur, in collaboration with the Center hospitalier de Mayotte, have revealed the spread of a highly drug-resistant cholera strain. The study was published on December 11, 2024 in the New England Journal of Medicine.

Drugs 91
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Risk adjusted net present value: What is the current valuation of Cullinan Therapeutics’s CLN-619?

Pharmaceutical Technology

CLN-619 is a monoclonal antibody commercialized by Cullinan Therapeutics, with a leading Phase I program in Ovarian Cancer;Cervical Cancer;Endometrial Cancer.

Antibody 100
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An unexpected side effect: Intermittent fasting may slow hair regrowth

Medical Xpress

Intermittent fasting has proven benefits for metabolic health, but a new study shows that it could slow hair growthat least in mice. Researchers report December 13 in the journal Cell that mice subjected to intermittent fasting regimes showed improved metabolic health but slower hair regeneration compared to mice with 24/7 access to food.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Risk adjusted net present value: What is the current valuation of IN8bio’s INB-400?

Pharmaceutical Technology

INB-400 is a gene-modified cell therapy commercialized by IN8bio, with a leading Phase II program in Recurrent Glioblastoma Multiforme (GBM).

Gene 100
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AI tool analyzes placentas at birth for faster detection of neonatal and maternal problems

Medical Xpress

A newly developed tool that harnesses computer vision and artificial intelligence (AI) may help clinicians rapidly evaluate placentas at birth, potentially improving neonatal and maternal care, according to new research from scientists at Northwestern Medicine and Penn State.

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Risk adjusted net present value: What is the current valuation of Vigil Neuroscience’s Iluzanebart?

Pharmaceutical Technology

Iluzanebart is a monoclonal antibody commercialized by Vigil Neuroscience, with a leading Phase III program in Neurodegenerative Diseases.

Antibody 100
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A low omega-6, omega-3 rich diet and fish oil may slow prostate cancer growth

Medical Xpress

A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators offers new evidence that dietary changes may help reduce cancer cell growth in patients undergoing active surveillance, a treatment approach that involves regular monitoring of the cancer without immediate intervention.

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European Clinical Supply Planning: Balancing Cost, Flexibility and Time

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Risk adjusted net present value: What is the current valuation of Jazz Pharmaceuticals’s JZP-898?

Pharmaceutical Technology

JZP-898 is a fusion protein commercialized by Jazz Pharmaceuticals, with a leading Phase I program in Metastatic Renal Cell Carcinoma;Metastatic Transitional (Urothelial) Tract Cancer.

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Photocurrent-responsive coating cuts bone-to-implant integration time in half

Medical Xpress

A research team has developed an innovative photocurrent-responsive implant surface to accelerate bone-to-implant integration after orthopedic surgery. The cutting-edge coating has been shown to shorten the integration time to just two weeks, doubling the speed and expediting post-operative recovery, as well as reducing the risk of rejection.

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Risk adjusted net present value: What is the current valuation of Aquestive Therapeutics’s Epinephrine?

Pharmaceutical Technology

Epinephrine is a small molecule commercialized by Aquestive Therapeutics, with a leading Phase III program in Anaphylaxis.

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How DNA shapes reproductive health, fertility and even life expectancy

Medical Xpress

Led by researchers from the University of Oxford's Leverhulme Center for Demographic Science and the University of Iceland, a review, published in Nature Aging, explores how genetic variations can explain differences in reproductive health and longevity.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Risk adjusted net present value: What is the current valuation of Solid Biosciences’s SGT-003?

Pharmaceutical Technology

SGT-003 is a gene therapy commercialized by Solid Biosciences, with a leading Phase II program in Duchenne Muscular Dystrophy.

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Blenrep Combination Extends Survival in Relapsed Multiple Myeloma

XTalks

The DREAMM-7 Phase III trial has spotlighted the potential of Blenrep (belantamab mafodotin) in combination with bortezomib and dexamethasone (BVd) to improve survival outcomes for relapsed or refractory multiple myeloma. Blenrep was previously withdrawn from the US market in 2022 after the DREAMM-3 trial failed to confirm its initial accelerated approval.

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Risk adjusted net present value: What is the current valuation of Tenaya Therapeutics’s TN-401?

Pharmaceutical Technology

TN-401 is a gene therapy commercialized by Tenaya Therapeutics, with a leading Phase I program in Cardiomyopathy.

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Molecular insights unlock a targeted approach to cancer immunotherapy

Medical Xpress

Australian-led research is unlocking new ways for immunotherapy to better target cancer. Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer cells.

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Risk adjusted net present value: What is the current valuation of Forte Biosciences’s FB-102?

Pharmaceutical Technology

FB-102 is a monoclonal antibody commercialized by Forte Biosciences, with a leading Phase I program in Celiac Disease.

Antibody 100
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Farm women's well-being: The unseen 'triple burden'

Medical Xpress

Mental health challenges are a significant and growing concern for the nation's farmers, according to the U.S. Department of Agriculture (USDA). As much as farming is often a family affair, programs and resources to support mental health in agriculture have focused on the primary producers, of whom nearly 64% are men. Women have always played a crucial role in agriculture, yet, Penn State Associate Professor Florence Becot said, their mental health and well-beingmuch like their essential contrib

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Risk adjusted net present value: What is the current valuation of CRISPR Therapeutics’s CTX-131?

Pharmaceutical Technology

CTX-131 is a gene-modified cell therapy commercialized by CRISPR Therapeutics, with a leading Phase II program in Cervical Cancer;Endometrial Cancer.

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Pioneering MRI method spots pre-malignant pancreatic lesions for the first time

Medical Xpress

Precursor lesions of pancreatic cancer are very difficult to characterize with magnetic resonance imaging (MRI). But now, in a new study, researchers led by Noam Shemesh and Carlos Bilreirorespectively, head of the Preclinical MRI lab at Champalimaud Research and a doctor at the Champalimaud Clinical Center's Radiology Departmenthave shown, for the first time, that a particular form of MRI, called Diffusion Tensor Imaging (DTI), is capable of robustly detecting pre-malignant lesions in the pancr

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.