October, 2022

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Cloud robotics labs are accelerating drug discovery and development

Pharmaceutical Technology

Drug discovery and development is an incredibly expensive and time-consuming process, taking between 12 and 18 years, and costing on average between $2 billion and $3 billion. Considering the low chances of success, with only 10% of drug candidates making it into clinical development, pharma companies must prevent the increased erosion of profit margins.

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With new startup, immunotherapy pioneer Lieping Chen tries to turn ‘cold’ tumors ‘hot’

Bio Pharma Dive

Chen, who discovered the cancer-protecting protein PD-L1, will work closely with startup Normunity to find targets that can help the immune system reach ‘cold’ tumors.

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Actinium eyes filing as conditioning drug for AML aces trial

pharmaphorum

Actinium Pharma is on course to submit its targeted radiotherapy for acute myeloid leukaemia (AML) patients needing a bone marrow transplant in the US, buoyed by top-line data from a pivotal trial. The New York biotech said today that the SIERRA trial of Iomab-B – an antibody armed with a radioisotope designed to deliver targeted treatment to tumours and spare healthy tissues – met its primary objective.

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Something Toxic Flourishes in Your Brain After Too Much Hard Work

AuroBlog - Aurous Healthcare Clinical Trials blog

A long day in the office can leave you empty of energy and overcome with desire for TV and a takeaway. But you’ve been sitting down all day. So why do you feel as tired as your friends who have physical jobs? Struggling through your list of essential tasks feels ever more grueling as the […].

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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6 Operational Considerations You Need To Know for Psychedelic Trials

Worldwide Clinical Trials

Bringing a psychedelic into a clinical trial setting is complex and requires a thorough operational approach to ensure the study’s success. Having worked in psychedelic research since the advent of industry-sponsored trials, Worldwide Clinical Trials has amassed the expertise needed to execute these studies successfully, recently sharing insights in a webinar titled “ Demystifying Complex Operations in Psychedelic Research ,” available on-demand now.

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Dispensing Pharmacy Packaging Machines: COVID-19 Impact

Pharma Mirror

Finding a reliable supply of bar-coded, unit-dose pharmaceuticals remains difficult despite measures to improve patient safety. The ability to repackage and bar code drugs to the unit of usage is becoming increasingly necessary in health-system pharmacies. Benefits for pharmacies that invest in a high-throughput unit dose packing machine include improved productivity and management of bar-coded medicine stock.

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CAR-T pioneer Carl June on founding biotech startups and cell therapy’s next act

Bio Pharma Dive

The University of Pennsylvania immunologist and inventor of Kymriah spoke with BioPharma Dive about working with pharma, starting companies and the future of the cell therapy field.

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Omicron keeps finding new evolutionary tricks to outsmart our immunity

NPR Health - Shots

SARS-CoV-2 is evolving "rapidly," spawning one new variant after another. But omicron continues to dominate, raising new questions about how evolution of the virus is headed.

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Mouse Study Reveals How to Help Speed Up The Liver’s Self-Regeneration Process

AuroBlog - Aurous Healthcare Clinical Trials blog

The liver is known for its ability to regenerate. It can completely regrow itself even after two-thirds of its mass has been surgically removed. But damage from medications, alcohol abuse, or obesity can eventually cause the liver to fail. Currently, the only effective treatment for end-stage liver disease is transplantation. However, there is a dearth […].

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Boston University researchers’ testing of lab-made version of Covid virus draws government scrutiny

STAT News

Research at Boston University that involved testing a lab-made hybrid version of the SARS-CoV-2 virus is garnering heated headlines alleging the scientists involved could have unleashed a new pathogen. There is no evidence the work, performed under biosecurity level 3 precautions in BU’s National Emerging Infectious Diseases Laboratories, was conducted improperly or unsafely.

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Optimizing Clinical Supply Strategy: Navigating Challenges & Finding Your Ideal Model

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Meet Florence, WHO’s AI-powered digital health worker

pharmaphorum

An artificial intelligence-powered digital health worker has been unveiled by the World Health Organisation (WHO) as its latest tool for disseminating reliable health information to the public. Originally developed by New Zealand tech company Soul Machines with support of the Qatar Ministry of Health, the first version of the virtual health worker was used to combat misinformation about the pandemic.

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Lilly agrees to acquire gene therapy developer Akouos for $610m

Pharmaceutical Technology

Eli Lilly and Company has signed a definitive agreement for the acquisition of all outstanding shares of precision genetic medicine firm Akouos for a total deal value of up to nearly $610m or up to $15.50 for each share in cash. The deal comprises an acquisition value of $12.50 for each share in cash payable at closing along with one non-tradeable contingent value right per share (CVR) of up to another $3 in cash.

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‘In vivo’ cell therapy: expanding beyond CAR-T

Bio Pharma Dive

At least five startups have emerged with new ways to genetically modify immune cells within the body, an approach that, if successful, could widen the field of CAR-T treatment.

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'Where is humanity?' ask the helpless doctors of Ethiopia's embattled Tigray region

NPR Health - Shots

Civil war has blockaded the country's northern region and decimated a hospital system that serves nearly 7 million people. Without basic supplies, power and medicine, thousands are needlessly dying.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Feeling Stressed Before You Get COVID May Increase Your Odds of Developing Long COVID

AuroBlog - Aurous Healthcare Clinical Trials blog

Millions of people are now suffering from long COVID, which presents with a staggering array of possible symptoms that can linger for months, or even years. To provide more answers to this frustratingly relentless condition, researchers have tested an association between mental stresses and long COVID. These stressors include depression, anxiety, and types of distress […].

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Opinion: Maternity care in the U.S. is in crisis. It’s time to call the midwife

STAT News

After pushing for several hours, my patient looks exhausted but happy, clutching her seconds-old newborn to her chest. As I help her put her baby to breast for the first time, she isn’t thinking about anything other than the tiny human blinking up at her. As well she shouldn’t.

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Verge Genomics takes AI-sourced drug for ALS into clinic

pharmaphorum

Verge Genomics has joined a select group of biotechs who have taken a drug discovered and developed using artificial intelligence into human testing. The small-molecule PIKfyve inhibitor – called VRG50635 – has been administered to the first subject in the phase 1 trial involving healthy volunteers, according to the San Francisco-based biotech, which was founded in 2015 by Alice Zhang and Jason Chen.

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Provention and Sanofi enter deal to launch teplizumab for type 1 diabetes

Pharmaceutical Technology

Provention Bio and Sanofi US have signed a co-promotion agreement to launch the former’s lead investigational drug candidate, teplizumab for the delay in the onset of clinical type 1 diabetes (T1D). The agreement aids Provention in leveraging the capabilities and commercial resources of Sanofi to back teplizumab’s launch. The US Food and Drug Administration (FDA) is presently reviewing teplizumab for the delay of clinical T1D in people who are at risk.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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A Versant-backed biotech emerges to take on ‘overlooked’ cancer targets

Bio Pharma Dive

Nested Therapeutics touts a deep bench of scientific leaders and advisers, including Kevan Shokat, whose work drugging KRAS — a cancer-related gene once thought to be undruggable — helped lead to the development of Amgen’s Lumakras.

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Is 'rainbow fentanyl' a threat to your kids this Halloween? Experts say no

NPR Health - Shots

The Drug Enforcement Administration is warning that drug dealers are marketing rainbow-colored fentanyl to kids. Many drug experts say that's likely not happening.

Drugs 145
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We Know How Sperm ‘Remember’ And Pass on Non-DNA-Coded Traits to Embryos

AuroBlog - Aurous Healthcare Clinical Trials blog

Studies in mammals have shown that the ‘memories’ of various environmental effects – such as diet, weight, and stress – can be passed on from fathers to offspring, despite these effects not being coded for in the DNA sequences carried by sperm. Thanks to a 2021 study, we have an explanation for how it’s possible. […].

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Opinion: Messaging — the unrecognized coefficient in pandemic control — matters

STAT News

A little over a century ago, scientists working in laboratories discovered that microbes were the cause of many epidemics. Once they understood that, they began to put their faith more and more in laboratory science. This major transformation, called the bacteriological revolution, began in the 1880s. During this period, diphtheria was one of the leading causes of death among mostly poor children in New York City.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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October 26, 2022: In This Friday’s PCT Grand Rounds, an Update on the HERO Registry

Rethinking Clinical Trials

In this Friday’s PCT Grand Rounds, Emily O’Brien of Duke University and Russell Rothman of Vanderbilt University will present “The HERO (Healthcare Worker Exposure Response & Outcomes) Program: An Online Community to Support Observational Studies, Randomized Trials, and Long-Term Safety Surveillance.” The Grand Rounds session will be held on Friday, October 28, 2022, at 1:00 pm eastern.

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Merck and Moderna partner to develop and sell cancer vaccine

Pharmaceutical Technology

German pharmaceutical firm Merck has extended its partnership with Moderna to jointly develop and sell mRNA-4157/V940, an investigational personalised cancer vaccine (PCV). In 2016, the companies entered a strategic partnership to develop novel messenger RNA (mRNA) based PCVs. They subsequently expanded the collaboration to include the development of antigen mRNA cancer vaccines in 2018.

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Prime Medicine raises $175M in one of the year’s largest biotech IPOs

Bio Pharma Dive

The gene editing startup is one of less than two dozen biotech companies to debut on Wall Street this year, as the pace of IPOs remains far off last year’s trajectory.

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There's a spike in respiratory illness among children — and it's not just COVID

NPR Health - Shots

Sick kids are crowding emergency rooms in parts of the country and some pediatric hospitals say they're running out of beds.

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2022 Research: The Rapid Rise of Ocean Freight Visibility

A research study conducted by The Journal of Commerce and FourKites surveyed hundreds of international shippers, exploring how their usage of global supply chain visibility technology has evolved since the onset of global disruptions caused by COVID-19. For international shippers, ocean freight visibility has evolved from optional to essential and satisfaction with visibility varies greatly depending on how it is obtained and delivered.

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Newly Discovered Gut Microbe Could Be a Trigger For Rheumatoid Arthritis

AuroBlog - Aurous Healthcare Clinical Trials blog

Rheumatoid arthritis affects 1 in 100 people worldwide. It causes inflamed, painful and swollen joints, often in the hands and wrists, and can lead to loss of joint function as well as chronic pain and joint deformities and damage. What causes this condition has been unknown. [link] In our recently published study, my colleagues and […].

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Human neurons implanted in a rodent’s brain lead a rat to water — and make it drink

STAT News

The scientist flicked on a laser, filling the rat’s brain with blue light. The rodent, true to its past two weeks of training, scampered across its glass box to a tiny spout, where it was duly rewarded with a drink of water. From the outside, this would appear to be a pretty run-of-the-mill neuroscience experiment, except for the fact that the neurons directing the rat to its thirst-quenching reward didn’t contain any rat DNA.

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Medication Management in Home Care Settings: A Brief Guide?

Pharma Mirror

Home care is an indispensable aspect of the health care system that provides individuals with long-term support and services, allowing them to remain in their homes instead of being placed in nursing facilities or hospitals. Medication management is one of the most crucial components of in-home care because it enables the proper execution of treatment plans for various patients.

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Pfizer acquires Global Blood Therapeutics for $5.4bn

Pharmaceutical Technology

Pfizer has acquired all the outstanding shares of the common stock of biopharmaceutical firm Global Blood Therapeutics (GBT) in a deal worth nearly $5.4bn. The total enterprise value comprised debt and the net of cash acquired. With the latest acquisition, GBT became a wholly-owned Pfizer subsidiary. GBT discovers and develops life-changing therapies for ailments with an initial focus on sickle cell disease (SCD).

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An Innovative & Creative Problem Solver Approach to Selling in the Medical Device Space

Speaker: Steve Goldstein, Sales Leader

Are you currently in sales, or involved in a business that depends on strong sales results? What about the extremely competitive world of medical device sales? What are some of the top challenges your customers face and how do you approach understanding what’s most important to them? Join Steve Goldstein, Sales Success Coach, Motivational Speaker and Medical Device Sales Leader from Gold Selling LLC., to discover critical strategies and approaches you can take to engage your customers, achieve g