Scienmag

MAY 16, 2022

Just as it’s hard to understand a conversation without knowing its context, it can be difficult for biologists to grasp the significance of gene expression without knowing a cell’s environment.

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BioTech 365

APRIL 9, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing … Continue (..)

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XTalks

AUGUST 5, 2020

The detailed complexity of these processes can be captured by creating models that combine correlates of gene and protein expression, providing insight into the molecular composition of tissues. The barcode sequence is followed by a unique molecular identifier, which enables accurate digital counting of gene transcripts.

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Gene Expression Development RNA Drugs 112

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. It’s a great tool for controlling gene expression.”.

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DNA Gene Gene Silencing Genomics 98

Roots Analysis

AUGUST 31, 2023

Overview of Gene Switch The notion that genes might be turned on and off was discovered several decades ago when studies revealed that E. Gene switches are sites on genes where regulatory molecules can bind to trigger transcription process, leading to expression of a particular gene.

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Gene Gene Therapy Gene Expression Regulation 40

Scienmag

NOVEMBER 26, 2020

For the first time, researchers describe how Rho protein really stops gene expression COLUMBUS, Ohio – New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now – precisely how the copying of genetic material that, once started, is properly turned off.

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Gene Expression Genetics Protein Gene 54

XTalks

OCTOBER 8, 2024

The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. A gene contains instructions within our DNA.

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Regulation Genetics Scientist RNA 52

pharmaphorum

JANUARY 13, 2022

That project is focusing not on cancer but metabolic diseases, although MiNA’s in-house efforts have already yielded one clinical candidate that activates the CEBPA gene, which codes for a transcription factor that drives drug resistance in cancer cells.

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Protein Gene Expression Gene Regulation 59

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. These modifications regulate gene expression without altering the sequence or structure of DNA.

DNA 52

DNA Gene Gene Silencing Genomics 52

XTalks

MARCH 22, 2021

The biotech acquisition will also see Takeda getting Maverick’s TAK-280 (MVC-280), an immunotherapy designed to treat patients with B7H3-expressing solid tumors which is expected to enter the clinic later this year. The tool analyzes the differential expression of over 90 genes to distinguish between 50 tumors types and subtypes.

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XTalks

JUNE 18, 2024

c-srRNA: A Temperature-Controllable Innovation Elixirgen Therapeutics’ c-srRNA platform offers a novel approach to controlling gene expression through temperature sensitivity. ZSCAN4 and Telomere Biology Disorders The ZSCAN4 gene produces a protein that plays a crucial role in maintaining telomeres.

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Protein RNA Genetics Gene Expression 52

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. It is important to highlight that IVT mRNAs are structurally similar to natural mRNAs and can be used to express proteins through genetic engineering.

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RNA Protein Genetics Gene Expression 40

The Pharma Data

DECEMBER 27, 2020

STP705 is a small interfering RNA (siRNA) therapy that leverages a dual-targeted inhibitory property and polypeptide nanoparticle (PNP)-enhanced delivery to knock down both TGF-beta1 and COX-2 gene expression. RESTORE-1 is a Phase II trial of an intracerebral AAV-based gene therapy for Parkinson’s disease.

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The Pharma Data

JANUARY 19, 2021

Fulcrum’s proprietary product engine identifies drug targets which can modulate gene expression to treat the known root cause of gene mis-expression.

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Gene Expression Containment Genetics Clinical Development 40

XTalks

DECEMBER 24, 2020

From rare disease drug approvals to treatments involving immunotherapies and gene therapies and awarding of a Nobel Prize to the inventors of the gene-editing tool CRISPR, 2020 was a year of great activity and productivity despite the backdrop of the pandemic. CRISPR Gene Editing Inventors Win Nobel Prize. CRISPR Therapeutics.

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Life Science Vaccine Vaccination Gene 111

The Pharma Data

MAY 13, 2021

Journal of Food Engineering. Opiate-like effects of sugar on gene expression in reward areas of the rat brain. Raghavendra SN, Ramachandra SSR, Rastogi NK, Raghavarao KSMS, Kumar S, Tharanathan RN. Grinding characteristics and hydration properties of coconut residue: A source of dietary fiber. 2006;72(3):281-286. 2004.12.008. .

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